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Vaibhav Kapuria
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Journal Articles

Deubiquitinase Usp9X Regulates Cell Survival and Metabolic Signal Transduction in Multiple Myeloma Cells

Luke F. Peterson, PhD, Hanshi Sun, PhD, Vaibhav Kapuria, Ph.D., Malathi Kandarpa, PhD, Moshe Talpaz, MD, Andrzej J Jakubowiak, MD, PhD, Nicholas Donato, PhD
Journal: Blood
Blood (2011) 118 (21): 1835.
https://doi.org/10.1182/blood.V118.21.1835.1835
Published: 2011
Journal Articles

Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis

Hanshi Sun, Vaibhav Kapuria, Luke F. Peterson, Dexing Fang, William G. Bornmann, Geoffrey Bartholomeusz, Moshe Talpaz, Nicholas J. Donato
Journal: Blood
Blood (2011) 117 (11): 3151–3162.
https://doi.org/10.1182/blood-2010-03-276477
Published: 2011
Includes: Supplemental data
Journal Articles

Inhibition of Usp9x Deubiquitinase Activity by WP1130 Reduces Mcl-1 Levels and Induces Apoptosis In Cells From Patients with Plasma Cell Dyscrasia and Drug-Refractory Multiple Myeloma

Hanshi Sun, PhD, Vaibhav Kapuria, Ph.D., Luke F. Peterson, PhD, Diane Giannola, Kandarpa Malathi, Ph.D., Moshe Talpaz, MD, Andrzej J Jakubowiak, MD, PhD, Nicholas Donato, PhD
Journal: Blood
Blood (2010) 116 (21): 3005.
https://doi.org/10.1182/blood.V116.21.3005.3005
Published: 2010
Journal Articles

De-Ubiquitinase Inhibition by WP1130 Induces Formation of Aggresomes, Engages Autophagy and Activates Apoptosis in B-Cell Malignancies.

Vaibhav Kapuria, Luke F Peterson, PhD, Moshe Talpaz, MD, Nicholas J Donato
Journal: Blood
Blood (2009) 114 (22): 3769.
https://doi.org/10.1182/blood.V114.22.3769.3769
Published: 2009
Journal Articles

WP1130 Inhibits Signaling through BCR-ABL Ubiquitination and Cytoplasmic to Aggresome Trafficking to Induce Apoptosis of CML Cells.

Nicholas J Donato, Ph.D., Hanshi Sun, Ph.D., Vaibhav Kapuria, Luke F Peterson, PhD, Geoffrey Bartholomeusz, Ph.D., William G. Bornmann, Ph.D., Moshe Talpaz, M.D.
Journal: Blood
Blood (2009) 114 (22): 3303.
https://doi.org/10.1182/blood.V114.22.3303.3303
Published: 2009
Journal Articles

Inhibition of Cytokine Signaling through Activation of Jak2 Ubiquitination by WP1130.

Vaibhav Kapuria, Luke F Peterson, PhD, William Bornmann, Ph.D., Moshe Talpaz, MD, Nicholas J Donato
Journal: Blood
Blood (2009) 114 (22): 2907.
https://doi.org/10.1182/blood.V114.22.2907.2907
Published: 2009
Journal Articles

WP-1130 Induces Apoptosis in Multiple Myeloma Cells by Inactivation of Jak2 and Syk Tyrosine Kinases Via a Novel Mechanism of Selective Protein Trafficking

Daniel Lebovic, Vaibhav Kapuria, Malathi Hari, Moshe Talpaz, Andrzej Jakubowiak, Nicholas Donato
Journal: Blood
Blood (2008) 112 (11): 2661.
https://doi.org/10.1182/blood.V112.11.2661.2661
Published: 2008
Journal Articles

A Novel Small-Molecule Approach To Inhibit Jak2 Tyrosine Kinase Signaling.

Vaibhav Kapuria, MS, Geoffrey Bartholomeusz, PhD, Ling-Yuan Kong, PhD, William Bornmann, PhD, Zhenghong Peng, PhD, Ashutosh Pal, PhD, David Maxwell, PhD, Moshe Talpaz, MD, Nicholas Donato, PhD
Journal: Blood
Blood (2007) 110 (11): 1556.
https://doi.org/10.1182/blood.V110.11.1556.1556
Published: 2007
Journal Articles

Degrasyn-Induced Trafficking of BCR-ABL as a Novel Mechanism of Kinase Inactivation.

Nicholas Donato, PhD, Vaibhav Kapuria, MS, Hanshi Sun, PhD, David Maxwell, PhD, Geoffrey Bartholomeusz, PhD, William Bornmann, PhD, Zhenghong Peng, PhD, Ashutosh Pal, PhD, Moshe Talpaz, MD
Journal: Blood
Blood (2007) 110 (11): 1003.
https://doi.org/10.1182/blood.V110.11.1003.1003
Published: 2007
Journal Articles

Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells

Geoffrey A. Bartholomeusz, Moshe Talpaz, Vaibhav Kapuria, Ling Yuan Kong, Shimei Wang, Zeev Estrov, Waldemar Priebe, Ji Wu, Nicholas J. Donato
Journal: Blood
Blood (2007) 109 (8): 3470–3478.
https://doi.org/10.1182/blood-2006-02-005579
Published: 2007
Journal Articles

Inhibition of JAK2/STAT Signaling by Degrasyn through a Novel Mechanism.

Vaibhav Kapuria, MS, Geoffrey Bartholomeusz, Ph.D., William Bornmann, Ph.D., Ling Y. Kong, M.D., Moshe Talpaz, M.D., Nicholas J. Donato, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 3423.
https://doi.org/10.1182/blood.V108.11.3423.3423
Published: 2006
Journal Articles

Antitumor Activity and Mechanism of Action of a Novel Stat3 Inhibitor, WP1066, Against Human B-Cell Non-Hodgkin’s Lymphoma and Multiple Myeloma.

Ling-Yuan Kong, MD, PhD, Vaibhav Kapuria, Geoffrey Bartholomeusz, PhD, Moshe Talpaz, MD, Waldemar Priebe, PhD, Nicholas J. Donato, PhD
Journal: Blood
Blood (2005) 106 (11): 1489.
https://doi.org/10.1182/blood.V106.11.1489.1489
Published: 2005