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Prognostic relevance of 18-F FDG PET/CT in newly diagnosed multiple myeloma patients treated with up-front autologous transplantation
Prospective measurement of Epstein-Barr virus–DNA in plasma and peripheral blood mononuclear cells of extranodal NK/T-cell lymphoma, nasal type
Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia
Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia
Autologous peripheral blood stem cell transplantation for acute myeloid leukemia
Issue Archive
December 1 2011
In this Issue
Table of Contents
Inside Blood
Blood Work
Plenary Paper
PLENARY PAPER
Prognostic relevance of 18-F FDG PET/CT in newly diagnosed multiple myeloma patients treated with up-front autologous transplantation
Clinical Trials & Observations
Elena Zamagni,Francesca Patriarca,Cristina Nanni,Beatrice Zannetti,Emanuela Englaro,Annalisa Pezzi,Paola Tacchetti,Silvia Buttignol,Giulia Perrone,Annamaria Brioli,Lucia Pantani,Carolina Terragna,Francesca Carobolante,Michele Baccarani,Renato Fanin,Stefano Fanti,Michele Cavo
Review Articles
Clinical Trials and Observations
Prospective measurement of Epstein-Barr virus–DNA in plasma and peripheral blood mononuclear cells of extranodal NK/T-cell lymphoma, nasal type
Clinical Trials & Observations
Ritsuro Suzuki,Motoko Yamaguchi,Koji Izutsu,Go Yamamoto,Kenzo Takada,Yasuaki Harabuchi,Yasushi Isobe,Hiroshi Gomyo,Tadashi Koike,Masataka Okamoto,Rie Hyo,Junji Suzumiya,Shigeo Nakamura,Keisei Kawa,Kazuo Oshimi,the NK-cell Tumor Study Group
Gene Therapy
Antitumor activity and long-term fate of chimeric antigen receptor–positive T cells in patients with neuroblastoma
Chrystal U. Louis,Barbara Savoldo,Gianpietro Dotti,Martin Pule,Eric Yvon,G. Doug Myers,Claudia Rossig,Heidi V. Russell,Oumar Diouf,Enli Liu,Hao Liu,Meng-Fen Wu,Adrian P. Gee,Zhuyong Mei,Cliona M. Rooney,Helen E. Heslop,Malcolm K. Brenner
Hematopoiesis and Stem Cells
Immunobiology
CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death
Sara Serra,Alberto L. Horenstein,Tiziana Vaisitti,Davide Brusa,Davide Rossi,Luca Laurenti,Giovanni D'Arena,Marta Coscia,Claudio Tripodo,Giorgio Inghirami,Simon C. Robson,Gianluca Gaidano,Fabio Malavasi,Silvia Deaglio
Lymphoid Neoplasia
Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia
Clinical Trials & Observations
Nobuko Hijiya,Blythe Thomson,Michael S. Isakoff,Lewis B. Silverman,Peter G. Steinherz,Michael J. Borowitz,Richard Kadota,Todd Cooper,Violet Shen,Gary Dahl,Jaideep V. Thottassery,Sima Jeha,Kelly Maloney,Jo-Anne Paul,Elly Barry,William L. Carroll,Paul S. Gaynon
AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia
Tasneem Motiwala,Nicola Zanesi,Jharna Datta,Satavisha Roy,Huban Kutay,Allyn M. Checovich,Mohamed Kaou,Yiming Zhong,Amy J. Johnson,David M. Lucas,Nyla A. Heerema,John Hagan,Xiaokui Mo,David Jarjoura,John C. Byrd,Carlo M. Croce,Samson T. Jacob
Myeloid Neoplasia
Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia
Clinical Trials & Observations
Bob Löwenberg,Petra Muus,Gert Ossenkoppele,Philippe Rousselot,Jean-Yves Cahn,Norbert Ifrah,Giovanni Martinelli,Sergio Amadori,Ellin Berman,Pieter Sonneveld,Mojca Jongen-Lavrencic,Sophie Rigaudeau,Paul Stockman,Alison Goudie,Stefan Faderl,Elias Jabbour,Hagop Kantarjian
Autologous peripheral blood stem cell transplantation for acute myeloid leukemia
Clinical Trials & Observations
Edo Vellenga,Wim van Putten,Gert J. Ossenkoppele,Leo F. Verdonck,Matthias Theobald,Jan J. Cornelissen,Peter C. Huijgens,Johan Maertens,Alois Gratwohl,Ron Schaafsma,Urs Schanz,Carlos Graux,Harry C. Schouten,Augustin Ferrant,Mario Bargetzi,Martin F. Fey,Bob Löwenberg,for the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON), and Swiss Group for Clinical Cancer Research Collaborative Group (SAKK)
Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype
Vera Grossmann,Enrico Tiacci,Antony B. Holmes,Alexander Kohlmann,Maria Paola Martelli,Wolfgang Kern,Ariele Spanhol-Rosseto,Hans-Ulrich Klein,Martin Dugas,Sonja Schindela,Vladimir Trifonov,Susanne Schnittger,Claudia Haferlach,Renato Bassan,Victoria A. Wells,Orietta Spinelli,Joseph Chan,Roberta Rossi,Stefano Baldoni,Luca De Carolis,Katharina Goetze,Hubert Serve,Rudolf Peceny,Karl-Anton Kreuzer,Daniel Oruzio,Giorgina Specchia,Francesco Di Raimondo,Francesco Fabbiano,Marco Sborgia,Arcangelo Liso,Laurent Farinelli,Alessandro Rambaldi,Laura Pasqualucci,Raul Rabadan,Torsten Haferlach,Brunangelo Falini
Phagocytes, Granulocytes, and Myelopoiesis
Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance
Daniel Kreisel,Seiichiro Sugimoto,Jihong Zhu,Ruben Nava,Wenjun Li,Mikio Okazaki,Sumiharu Yamamoto,Mohsen Ibrahim,Howard J. Huang,Kelsey A. Toth,Jon H. Ritter,Alexander S. Krupnick,Mark J. Miller,Andrew E. Gelman
Platelets and Thrombopoiesis
Red Cells, Iron, and Erythropoiesis
Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia
Pekka Jaako,Johan Flygare,Karin Olsson,Ronan Quere,Mats Ehinger,Adrianna Henson,Steven Ellis,Axel Schambach,Christopher Baum,Johan Richter,Jonas Larsson,David Bryder,Stefan Karlsson
Transplantation
Vascular Biology
D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion
Kit Ming Lee,Clive S. McKimmie,Derek S. Gilchrist,Kenneth J. Pallas,Robert J. Nibbs,Paul Garside,Victoria McDonald,Christopher Jenkins,Richard Ransohoff,LiPing Liu,Simon Milling,Vuk Cerovic,Gerard J. Graham
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Cover Image
Cover Image
![issue cover]()
The image shows a high endothelial venule (HEV) in a lymph node section from a ubiquitin-GFP chimeric mouse (green) stained for ICAM-1 (red) and sytox 63/nuclei (blue). Green radio-resistant endothelial HEV cells create pockets in which blood-circulating lymphocytes accumulate before accessing the parenchyma. In addition to being passive entry doors for lymphocytes, HEVs are traffic control checkpoints able to create “waiting areas” in which lymphocytes accumulate and are held until space is made available to them in the parenchyma as a consequence of lymphocytes egress. See the article by Mionnet et al on page 6115.
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