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Journal Articles

Landscape of Secondary Genetic Lesions in Acute Myeloid Leukemia with Inv(16)/ CBFB-MYH11

Annette Fasan, PhD, Claudia Haferlach, MD, Karolína Perglerová, Sonja Schindela, Susanne Schnittger, PhD, Wolfgang Kern, MD, Torsten Haferlach

Blood (2015) 126 (23): 801.

https://doi.org/10.1182/blood.V126.23.801.801

Published: 2015

Journal Articles

Prognosis of Mecom(EVI1)- rearranged MDS and AML Patients Strongly Depends on Accompanying Molecular Mutations but Not on Blast Counts

Tamara Alpermann, Claudia Haferlach, MD, Annette Fasan, PhD, Sonja Schindela, Wolfgang Kern, MD, Torsten Haferlach

Blood (2015) 126 (23): 1372.

https://doi.org/10.1182/blood.V126.23.1372.1372

Published: 2015

Journal Articles

Three Steps to the Diagnosis of Adult Ph-like ALL

Annette Fasan, PhD, Wolfgang Kern, MD, Niroshan Nadarajah, M.Sc., Simone Weber, Sonja Schindela, Nicole Schlenther, Susanne Schnittger, PhD, Torsten Haferlach, Claudia Haferlach, MD

Blood (2015) 126 (23): 2610.

https://doi.org/10.1182/blood.V126.23.2610.2610

Published: 2015

Journal Articles

Unraveling The Molecular and Metabolic Basis For Glutamine Addiction In Leukemias

Polina Matre, PhD, Ismael Samudio, PhD, Rodrigo Jacamo, PhD, Ying Wang, Jing Wang, R Eric Davis, Xiaohua Su, Sonja Schindela, Rachel Newman, Jianhua Hu, Torsten Haferlach, MD, Michael Andreeff, MD, PhD, Elsa R. Flores, Aaron Schimmer, PhD, MD, Marina Konopleva, MD, PhD

Blood (2013) 122 (21): 606.

https://doi.org/10.1182/blood.V122.21.606.606

Published: 2013

Journal Articles

Analysis For Loss Of 13q Heterozygosity Using STR Or SNP Analysis Can Replace Analysis Of FLT3 -ITD To Detect Prognostically Adverse AML

Susanne Schnittger, PhD, Simone Weber, Sonja Schindela, Andreas Roller, PhD, Tamara Alpermann, Alexander Kohlmann, PhD, Wolfgang Kern, MD, Claudia Haferlach, MD, Torsten Haferlach, MD

Blood (2013) 122 (21): 805.

https://doi.org/10.1182/blood.V122.21.805.805

Published: 2013

Journal Articles

Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype

Blood (2011) 118 (23): 6153–6163.

https://doi.org/10.1182/blood-2011-07-365320

Published: 2011

Includes: Supplemental data

Journal Articles

Identification and Characterization of Three Novel Cytogenetically Cryptic EVI1 Rearrangements Identified in 27 AML Patients All Predicting An Unfavorable Outcome

Claudia Haferlach, MD, Vera Grossmann, MSc, Melanie Zenger, Sonja Schindela, Alexander Kohlmann, PhD, Wolfgang Kern, MD, Torsten Haferlach, MD, Susanne Schnittger, PhD

Blood (2011) 118 (21): 1461.

https://doi.org/10.1182/blood.V118.21.1461.1461

Published: 2011

Journal Articles

Sensitive Monitoring of Minimal Residual Disease Status in CEBPA -Mutated Acute Myeloid Leukemia Using Amplicon Deep-Sequencing

Alexander Kohlmann, PhD, Vera Grossmann, MSc, Annette Fasan, PhD, Elisa Stopp, Tamara Alpermann, Sonja Schindela, Wolfgang Kern, MD, Claudia Haferlach, MD, Torsten Haferlach, MD, Susanne Schnittger, PhD

Blood (2011) 118 (21): 2517.

https://doi.org/10.1182/blood.V118.21.2517.2517

Published: 2011

Journal Articles

Comprehensive Molecular Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Mutations in 76 (97.4%) of 78 Patients

Vera Grossmann, MSc, Alexander Kohlmann, PhD, Sandra Weissmann, PhD, Susanne Schnittger, PhD, Valentina Artusi, MSc, Sonja Schindela, Kathrin Stadler, Torsten Haferlach, MD, Wolfgang Kern, MD, Claudia Haferlach, MD

Blood (2011) 118 (21): 2548.

https://doi.org/10.1182/blood.V118.21.2548.2548

Published: 2011

Journal Articles

The Role of Different Genetic Subtypes In CEBPA Mutated AML

Susanne Schnittger, PhD, Tamara Alpermann, Christiane Eder, PhD, Sonja Schindela, Vera Grossmann, MA, Wolfgang Kern, MD, Torsten Haferlach, MD, Claudia Haferlach, MD

Blood (2010) 116 (21): 752.

https://doi.org/10.1182/blood.V116.21.752.752

Published: 2010

Journal Articles

A Comprehensive Deep-Sequencing Study of Blast Crisis Chronic Myeloid Leukemia (CML) Reveals New Insights Into Molecular Heterogeneity and Detects Mutations In 12 Different Genes In 82.5% of Cases

Vera Grossmann, MA, Christiane Eder, PhD, Sonja Schindela, Alexander Kohlmann, PhD, Sandra Wille, PhD, Susanne Schnittger, PhD, Wolfgang Kern, MD, Martin C. Müller, Andreas Hochhaus, MD, Torsten Haferlach, MD, Claudia Haferlach, MD

Blood (2010) 116 (21): 884.

https://doi.org/10.1182/blood.V116.21.884.884

Published: 2010

Journal Articles

Impact of Expression of BAALC , CDKN1B, ERG , EVI1 , and MN1 on Prognosis and Their Association with Karyotype, FLT3 -ITD, NPM1 and MLL -PTD Status In Adult AML: A Comprehensive Study on 286 Cases

Claudia Haferlach, MD, Alexander Kohlmann, PhD, Sonja Schindela, Tamara Alpermann, Wolfgang Kern, MD, Susanne Schnittger, PhD, Torsten Haferlach, MD

Blood (2010) 116 (21): 953.

https://doi.org/10.1182/blood.V116.21.953.953

Published: 2010

Journal Articles

Ultra-Deep Next-Generation Sequencing Detects RUNX1 Mutations with Unprecedented Sensitivity and Allows to Monitor Minimal Residual Disease In 116 Samples From MDS and AML Patients

Alexander Kohlmann, PhD, Vera Grossmann, MA, Sonja Schindela, Wolfgang Kern, MD, Claudia Haferlach, MD, Torsten Haferlach, MD, Susanne Schnittger, PhD

Blood (2010) 116 (21): 1691.

https://doi.org/10.1182/blood.V116.21.1691.1691

Published: 2010

Journal Articles

Robust and Sensitive Detection of Insertions, Deletions and Point Mutations In CEBPA , a GC-Rich Content Gene, Using 454 Next-Generation Deep-Sequencing (NGS).

Vera Grossmann, MA, Susanne Schnittger, PhD, Sonja Schindela, Hans-Ulrich Klein, MA, Christiane Eder, PhD, Martin Dugas, MD, Wolfgang Kern, MD, Claudia Haferlach, MD, Torsten Haferlach, MD, Alexander Kohlmann, PhD

Blood (2010) 116 (21): 1657.

https://doi.org/10.1182/blood.V116.21.1657.1657

Published: 2010

Journal Articles

Targeted Next-Generation Sequencing and Genome-Wide High-Resolution Copy Number DNA Arrays Allow the Identification of Five Novel RUNX1 Fusions In Hematological Malignancies.

Vera Grossmann, Alexander Kohlmann, PhD, Hans-Ulrich Klein, MA, Sonja Schindela, Susanne Schnittger, PhD, Martin Dugas, MD, Wolfgang Kern, MD, Torsten Haferlach, MD, Claudia Haferlach, MD

Blood (2010) 116 (21): 1193.

https://doi.org/10.1182/blood.V116.21.1193.1193

Published: 2010

Journal Articles

Next-Generation Sequencing (NGS) in CMML, MDS and AML Detects Molecular Mutations in Oncogenes and Allows the Identification of Balanced Chromosomal Abnormalities with Extraordinary Sensitivity and Specificity.

Vera Grossmann, MA, Alexander Kohlmann, PhD, Claudia Haferlach, MD, Hans-Ulrich Klein, MA, Martin Dugas, MD, Frank Dicker, PhD, Beray Kazak, Sonja Schindela, Susanne Schnittger, PhD, Wolfgang Kern, MD, Torsten Haferlach, MD

Blood (2009) 114 (22): 144.

https://doi.org/10.1182/blood.V114.22.144.144

Published: 2009

Journal Articles

An Accumulation of Cytogenetic and Molecular Genetic Events Characterizes the Progression From MDS to Secondary AML: An Analysis of Paired Samples in 38 Patients Analyzed by Cytogenetics, Mutation Analysis and SNP Microarrays.

Johanna Flach, Sonja Schindela, Frank Dicker, PhD, Susanne Schnittger, PhD, Beray Kazak, Alexander Kohlmann, PhD, Wolfgang Kern, MD, Torsten Haferlach, MD, Claudia Haferlach, MD

Blood (2009) 114 (22): 1748.

https://doi.org/10.1182/blood.V114.22.1748.1748

Published: 2009

Journal Articles

AML with CBFB-MYH11 Rearrangement Is Characterized by RAS Pathway Alterations in 92% of Cases and Demonstrates a High Frequency of NF1 Deletions.

Claudia Haferlach, MD, Frank Dicker, PhD, Alexander Kohlmann, PhD, Sonja Schindela, Tamara Weiss, Wolfgang Kern, MD, Susanne Schnittger, PhD, Torsten Haferlach, MD

Blood (2009) 114 (22): 272.

https://doi.org/10.1182/blood.V114.22.272.272

Published: 2009

Journal Articles

Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 75% of Chronic Myelomonocytic Leukemia (CMML) by Detecting Frequent Alterations in TET2 , RUNX1 , CBL , and RAS .

Alexander Kohlmann, PhD, Vera Grossmann, MA, Claudia Haferlach, MD, Beray Kazak, Sonja Schindela, Hans-Ulrich Klein, Tamara Weiss, Frank Dicker, PhD, Susanne Schnittger, PhD, Martin Dugas, MD, Wolfgang Kern, MD, Torsten Haferlach, MD

Blood (2009) 114 (22): 417.

https://doi.org/10.1182/blood.V114.22.417.417

Published: 2009

Journal Articles

TET2 Mutations Are Not Specific for Certain MPN Entities but More Likely Seem to Indicate Disease Progression.

Susanne Schnittger, PhD, Claudia Tschulik, Nicole Wendland, Sonja Schindela, Frank Dicker, PhD, Wolfgang Kern, MD, Torsten Haferlach, MD, Claudia Haferlach, MD

Blood (2009) 114 (22): 438.

https://doi.org/10.1182/blood.V114.22.438.438

Published: 2009

NARROW

Landscape of Secondary Genetic Lesions in Acute Myeloid Leukemia with Inv(16)/ CBFB-MYH11

Prognosis of Mecom(EVI1)- rearranged MDS and AML Patients Strongly Depends on Accompanying Molecular Mutations but Not on Blast Counts

Three Steps to the Diagnosis of Adult Ph-like ALL

Unraveling The Molecular and Metabolic Basis For Glutamine Addiction In Leukemias

Analysis For Loss Of 13q Heterozygosity Using STR Or SNP Analysis Can Replace Analysis Of FLT3 -ITD To Detect Prognostically Adverse AML

Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype

Identification and Characterization of Three Novel Cytogenetically Cryptic EVI1 Rearrangements Identified in 27 AML Patients All Predicting An Unfavorable Outcome

Sensitive Monitoring of Minimal Residual Disease Status in CEBPA -Mutated Acute Myeloid Leukemia Using Amplicon Deep-Sequencing

Comprehensive Molecular Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Mutations in 76 (97.4%) of 78 Patients

The Role of Different Genetic Subtypes In CEBPA Mutated AML

A Comprehensive Deep-Sequencing Study of Blast Crisis Chronic Myeloid Leukemia (CML) Reveals New Insights Into Molecular Heterogeneity and Detects Mutations In 12 Different Genes In 82.5% of Cases

Impact of Expression of BAALC , CDKN1B, ERG , EVI1 , and MN1 on Prognosis and Their Association with Karyotype, FLT3 -ITD, NPM1 and MLL -PTD Status In Adult AML: A Comprehensive Study on 286 Cases

Ultra-Deep Next-Generation Sequencing Detects RUNX1 Mutations with Unprecedented Sensitivity and Allows to Monitor Minimal Residual Disease In 116 Samples From MDS and AML Patients

Robust and Sensitive Detection of Insertions, Deletions and Point Mutations In CEBPA , a GC-Rich Content Gene, Using 454 Next-Generation Deep-Sequencing (NGS).

Targeted Next-Generation Sequencing and Genome-Wide High-Resolution Copy Number DNA Arrays Allow the Identification of Five Novel RUNX1 Fusions In Hematological Malignancies.

Next-Generation Sequencing (NGS) in CMML, MDS and AML Detects Molecular Mutations in Oncogenes and Allows the Identification of Balanced Chromosomal Abnormalities with Extraordinary Sensitivity and Specificity.

An Accumulation of Cytogenetic and Molecular Genetic Events Characterizes the Progression From MDS to Secondary AML: An Analysis of Paired Samples in 38 Patients Analyzed by Cytogenetics, Mutation Analysis and SNP Microarrays.

AML with CBFB-MYH11 Rearrangement Is Characterized by RAS Pathway Alterations in 92% of Cases and Demonstrates a High Frequency of NF1 Deletions.

Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 75% of Chronic Myelomonocytic Leukemia (CMML) by Detecting Frequent Alterations in TET2 , RUNX1 , CBL , and RAS .

TET2 Mutations Are Not Specific for Certain MPN Entities but More Likely Seem to Indicate Disease Progression.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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