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Issue Archive

Volume 117, Issue 15
April 14 2011
Issue Cover

Table of Contents

INSIDE BLOOD

THROMBOSIS & HEMOSTASIS
Taking the brakes off?
James H. Morrissey
View Articletitled, Taking the brakes off?
PLATELETS & THROMBOPOIESIS
Young maybe, but surely not immature
Nicolas Pineault
View Articletitled, Young maybe, but surely not immature
VASCULAR BIOLOGY
uPAR in angiogenesis regulation
Mario Del Rosso
View Articletitled, uPAR in angiogenesis regulation

REVIEW ARTICLE

Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities
Andrew Wilber,Arthur W. Nienhuis,Derek A. Persons
View Articletitled, Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities

HOW I TREAT

How I treat: diagnosing and managing “in situ” lymphoma
Clinical Trials & Observations
Antonino Carbone,Armando Santoro
View Articletitled, How I treat: diagnosing and managing “in situ” lymphoma

CLINICAL TRIALS AND OBSERVATIONS

Type of skin eruption is an independent prognostic indicator for adult T-cell leukemia/lymphoma
Clinical Trials & Observations
Yu Sawada,Ryosuke Hino,Kayo Hama,Shun Ohmori,Haruna Fueki,Shigenori Yamada,Shoko Fukamachi,Makiko Tajiri,Rieko Kubo,Manabu Yoshioka,Daiki Nakashima,Kazunari Sugita,Ryutaro Yoshiki,Takatoshi Shimauchi,Tomoko Mori,Kunio Izu,Miwa Kobayashi,Motonobu Nakamura,Yoshiki Tokura
View Articletitled, Type of skin eruption is an independent prognostic indicator for adult T-cell leukemia/lymphoma
The JAK2 46/1 haplotype in Budd-Chiari syndrome and portal vein thrombosis
Clinical Trials & Observations
Jasper H. Smalberg,Edith Koehler,Sarwa Darwish Murad,Aurelie Plessier,Susana Seijo,Jonel Trebicka,Massimo Primignani,Moniek P. M. de Maat,Juan-Carlos Garcia-Pagan,Dominique C. Valla,Harry L. A. Janssen,Frank W. G. Leebeek,for the European Network for Vascular Disorders of the Liver (EN-Vie)
View Articletitled, The <em>JAK2</em> 46/1 haplotype in Budd-Chiari syndrome and portal vein thrombosis
Supplemental data
JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma
Clinical Trials & Observations
Katrien Van Roosbroeck,Luk Cox,Thomas Tousseyn,Idoya Lahortiga,Olga Gielen,Barbara Cauwelier,Pascale De Paepe,Gregor Verhoef,Peter Marynen,Peter Vandenberghe,Chris De Wolf-Peeters,Jan Cools,Iwona Wlodarska
View Articletitled, <em>JAK2</em> rearrangements, including the novel <em>SEC31A-JAK2</em> fusion, are recurrent in classical Hodgkin lymphoma
Supplemental data
LDOC1 mRNA is differentially expressed in chronic lymphocytic leukemia and predicts overall survival in untreated patients
Clinical Trials & Observations
Hatice Duzkale,Carmen D. Schweighofer,Kevin R. Coombes,Lynn L. Barron,Alessandra Ferrajoli,Susan O'Brien,William G. Wierda,John Pfeifer,Tadeusz Majewski,Bogdan A. Czerniak,Jeffrey L. Jorgensen,L. Jeffrey Medeiros,Emil J Freireich,Michael J. Keating,Lynne V. Abruzzo
View Articletitled, <em>LDOC1</em> mRNA is differentially expressed in chronic lymphocytic leukemia and predicts overall survival in untreated patients
Supplemental data

GENE THERAPY

Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo
Paris Margaritis,Elise Roy,Armida Faella,Harre D. Downey,Lacramioara Ivanciu,Giulia Pavani,Shangzhen Zhou,Ralph M. Bunte,Katherine A. High
View Articletitled, Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Dendritic cells with lymphocyte-stimulating activity differentiate from human CD133 positive precursors
Maria Ida Bonetti,Laura Pieri,Lola Domenici,Serena Urbani,Giovanni Romano,Alessandra Aldinucci,Clara Ballerini,Monica Monici,Riccardo Saccardi,Venere Basile,Alberto Bosi,Paolo Romagnoli
View Articletitled, Dendritic cells with lymphocyte-stimulating activity differentiate from human CD133 positive precursors
cpsf1 is required for definitive HSC survival in zebrafish
Niccolò Bolli,Elspeth M. Payne,Jennifer Rhodes,Evisa Gjini,Adam B. Johnston,Feng Guo,Jeong-Soo Lee,Rodney A. Stewart,John P. Kanki,Aye T. Chen,Yi Zhou,Leonard I. Zon,A. Thomas Look
View Articletitled, <em>cpsf1</em> is required for definitive HSC survival in zebrafish
Supplemental data
Human induced pluripotent stem cells are capable of B-cell lymphopoiesis
Brief Report
Lee Carpenter,Ram Malladi,Cheng-Tao Yang,Anna French,Katherine J. Pilkington,Richard W. Forsey,Jackie Sloane-Stanley,Kathryn M. Silk,Timothy J. Davies,Paul J. Fairchild,Tariq Enver,Suzanne M. Watt
View Articletitled, Human induced pluripotent stem cells are capable of B-cell lymphopoiesis
Supplemental data
Development of IL-22–producing NK lineage cells from umbilical cord blood hematopoietic stem cells in the absence of secondary lymphoid tissue
Brief Report
Qin Tang,Yong-Oon Ahn,Peter Southern,Bruce R. Blazar,Jeffery S. Miller,Michael R. Verneris
View Articletitled, Development of IL-22–producing NK lineage cells from umbilical cord blood hematopoietic stem cells in the absence of secondary lymphoid tissue
Supplemental data
Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes
Zhi-Jian Liu,Joseph Italiano, Jr,Francisca Ferrer-Marin,Ravi Gutti,Matthew Bailey,Brandon Poterjoy,Lisa Rimsza,Martha Sola-Visner
View Articletitled, Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes
Supplemental data
Normal bone marrow signal-transduction profiles: a requisite for enhanced detection of signaling dysregulations in AML
e-blood
James Marvin,Suchitra Swaminathan,Geoffrey Kraker,Amy Chadburn,James Jacobberger,Charles Goolsby
View Articletitled, Normal bone marrow signal-transduction profiles: a requisite for enhanced detection of signaling dysregulations in AML
High-resolution kinetics of cytokine signaling in human CD34/CD117-positive cells in unfractionated bone marrow
e-blood
Philip G. Woost,Luis A. Solchaga,Howard J. Meyerson,T. Vincent Shankey,Charles L. Goolsby,James W. Jacobberger
View Articletitled, High-resolution kinetics of cytokine signaling in human CD34/CD117-positive cells in unfractionated bone marrow
Supplemental data
Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells
e-blood
Motohiko Oshima,Mitsuhiro Endoh,Takaho A. Endo,Tetsuro Toyoda,Yaeko Nakajima-Takagi,Fumihiro Sugiyama,Haruhiko Koseki,Michael Kyba,Atsushi Iwama,Mitsujiro Osawa
View Articletitled, Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells
Supplemental data

IMMUNOBIOLOGY

Unique progenitors in mouse lymph node develop into CD127+ NK cells: thymus-dependent and thymus-independent pathways
Claudia Luther,Kathrin Warner,Fumio Takei
View Articletitled, Unique progenitors in mouse lymph node develop into CD127<sup>+</sup> NK cells: thymus-dependent and thymus-independent pathways
Supplemental data
Negative regulation of mTOR activation by diacylglycerol kinases
Balachandra K. Gorentla,Chi-Keung Wan,Xiao-Ping Zhong
View Articletitled, Negative regulation of mTOR activation by diacylglycerol kinases
Development of an IL-15–autocrine CD8 T-cell leukemia in IL-15–transgenic mice requires the cis expression of IL-15Rα
Noriko Sato,Helen Sabzevari,Song Fu,Wei Ju,Michael N. Petrus,Richard N. Bamford,Thomas A. Waldmann,Yutaka Tagaya
View Articletitled, Development of an IL-15–autocrine CD8 T-cell leukemia in IL-15–transgenic mice requires the <em>cis</em> expression of IL-15Rα
Supplemental data
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response
Sandra Gardam,Vivian M. Turner,Holly Anderton,Sandhya Limaye,Antony Basten,Frank Koentgen,David L. Vaux,John Silke,Robert Brink
View Articletitled, Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response
Supplemental data
Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis
e-blood
Janos Sumegi,Michael G. Barnes,Shawnagay V. Nestheide,Susan Molleran-Lee,Joyce Villanueva,Kejian Zhang,Kimberly A. Risma,Alexei A. Grom,Alexandra H. Filipovich
View Articletitled, Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis
Supplemental data

LYMPHOID NEOPLASIA

c-JUN promotes BCR-ABL–induced lymphoid leukemia by inhibiting methylation of the 5′ region of Cdk6
Karoline Kollmann,Gerwin Heller,Rene Georg Ott,Ruth Scheicher,Eva Zebedin-Brandl,Christine Schneckenleithner,Olivia Simma,Wolfgang Warsch,Eva Eckelhart,Andrea Hoelbl,Martin Bilban,Sabine Zöchbauer-Müller,Marcos Malumbres,Veronika Sexl
View Articletitled, c-JUN promotes BCR-ABL–induced lymphoid leukemia by inhibiting methylation of the 5′ region of <em>Cdk6</em>
Supplemental data

MYELOID NEOPLASIA

C/EBPα and C/EBPα oncoproteins regulate nfkb1 and displace histone deacetylases from NF-κB p50 homodimers to induce NF-κB target genes
Ido Paz-Priel,Simone Houng,Julia Dooher,Alan D. Friedman
View Articletitled, C/EBPα and C/EBPα oncoproteins regulate <em>nfkb1</em> and displace histone deacetylases from NF-κB p50 homodimers to induce NF-κB target genes
Regulation of S100A10 by the PML-RAR-α oncoprotein
Paul A. O'Connell,Patricia A. Madureira,Jason N. Berman,Robert S. Liwski,David M. Waisman
View Articletitled, Regulation of S100A10 by the PML-RAR-α oncoprotein
Supplemental data
Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions
e-blood
Samuel Quentin,Wendy Cuccuini,Raphael Ceccaldi,Olivier Nibourel,Corinne Pondarre,Marie-Pierre Pagès,Nadia Vasquez,Catherine Dubois d'Enghien,Jérôme Larghero,Régis Peffault de Latour,Vanderson Rocha,Jean-Hugues Dalle,Pascale Schneider,Mauricette Michallet,Gérard Michel,André Baruchel,François Sigaux,Eliane Gluckman,Thierry Leblanc,Dominique Stoppa-Lyonnet,Claude Preudhomme,Gérard Socié,Jean Soulier
View Articletitled, Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic <em>RUNX1/AML1</em> lesions
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

A novel mechanism for egress of malarial parasites from red blood cells
Manouk Abkarian,Gladys Massiera,Laurence Berry,Magali Roques,Catherine Braun-Breton
View Articletitled, A novel mechanism for egress of malarial parasites from red blood cells
Supplemental data
Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S
Felicity N. E. Gavins,Janice Russell,Elena L. Senchenkova,Lidiana De Almeida Paula,Amílcar S. Damazo,Charles T. Esmon,Daniel Kirchhofer,Robert P. Hebbel,D. Neil Granger
View Articletitled, Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S

THROMBOSIS AND HEMOSTASIS

Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation
Jessica L. MacQuarrie,Alan R. Stafford,Jonathan W. Yau,Beverly A. Leslie,Trang T. Vu,James C. Fredenburgh,Jeffrey I. Weitz
View Articletitled, Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation
Supplemental data

VASCULAR BIOLOGY

Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence
Sunday S. Oladipupo,Song Hu,Andrea C. Santeford,Junjie Yao,Joanna R. Kovalski,Ralph V. Shohet,Konstantin Maslov,Lihong V. Wang,Jeffrey M. Arbeit
View Articletitled, Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence
Supplemental data
Density enhanced phosphatase-1 down-regulates urokinase receptor surface expression in confluent endothelial cells
Patrick M. Brunner,Patricia C. Heier,Judit Mihaly-Bison,Ute Priglinger,Bernd R. Binder,Gerald W. Prager
View Articletitled, Density enhanced phosphatase-1 down-regulates urokinase receptor surface expression in confluent endothelial cells
  • Cover Image

    Cover Image

    issue cover

    “In situ” follicular lymphoma is identifiable by the strong expression of BCL2 and CD10. Immunohistochemistry shows strong positive staining for BCL2 and CD10 in the majority of follicles. The BCL2 expression is much brighter than in the surrounding mantle cells. The CD10+ cells are confined only to germinal centers and are not seen in the interfollicular region or elsewhere in the lymph node. See the article by Carbone and Santoro on page 3954.

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