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Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project
Superior outcomes associated with complete response in newly diagnosed multiple myeloma patients treated with nonintensive therapy: analysis of the phase 3 VISTA study of bortezomib plus melphalan-prednisone versus melphalan-prednisone
Treatment of progression of Philadelphia-negative myeloproliferative neoplasms to myelodysplastic syndrome or acute myeloid leukemia by azacitidine: a report on 54 cases on the behalf of the Groupe Francophone des Myelodysplasies (GFM)
Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710
Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS)
Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome
Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value
Outcomes of pediatric bone marrow transplantation for leukemia and myelodysplasia using matched sibling, mismatched related, or matched unrelated donors
Issue Archive
November 11 2010
In this Issue
Table of Contents
Inside blood
Plenary Paper
PLENARY PAPER
A novel latent membrane 2 transcript expressed in Epstein-Barr virus–positive NK- and T-cell lymphoproliferative disease encodes a target for cellular immunotherapy
Christopher P. Fox,Tracey A. Haigh,Graham S. Taylor,Heather M. Long,Steven P. Lee,Claire Shannon-Lowe,Simon O'Connor,Catherine M. Bollard,Javeed Iqbal,Wing C. Chan,Alan B. Rickinson,Andrew I. Bell,Martin Rowe
Review Article
How I treat
Clinical Trials and Observations
Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project
Clinical Trials & Observations
Milena Sant,Claudia Allemani,Carmen Tereanu,Roberta De Angelis,Riccardo Capocaccia,Otto Visser,Rafael Marcos-Gragera,Marc Maynadié,Arianna Simonetti,Jean-Michel Lutz,Franco Berrino,and the HAEMACARE Working Group
Superior outcomes associated with complete response in newly diagnosed multiple myeloma patients treated with nonintensive therapy: analysis of the phase 3 VISTA study of bortezomib plus melphalan-prednisone versus melphalan-prednisone
Clinical Trials & Observations
Jean-Luc Harousseau,Antonio Palumbo,Paul G. Richardson,Rudolf Schlag,Meletios A. Dimopoulos,Ofer Shpilberg,Martin Kropff,Alain Kentos,Michele Cavo,Anatoly Golenkov,Mieczyslaw Komarnicki,Maria-Victoria Mateos,Dixie-Lee Esseltine,Andrew Cakana,Kevin Liu,William Deraedt,Helgi van de Velde,Jesús F. San Miguel
Gene therapy
Hematopoiesis and Stem Cells
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes
Yuliang Wu,Joshua A. Sommers,Avvaru N. Suhasini,Thomas Leonard,Julianna S. Deakyne,Alexander V. Mazin,Kazuo Shin-ya,Hiroyuki Kitao,Robert M. Brosh, Jr
Immunobiology
Highly active antiretroviral treatment against STLV-1 infection combining reverse transcriptase and HDAC inhibitors
Philippe V. Afonso,Mourad Mekaouche,Franck Mortreux,Frédéric Toulza,Antoine Moriceau,Eric Wattel,Antoine Gessain,Charles R. M. Bangham,Guy Dubreuil,Yves Plumelle,Olivier Hermine,Jérome Estaquier,Renaud Mahieux
Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits
Valerio W. Valeri,Anna Hryniewicz,Vibeke Andresen,Kathy Jones,Claudio Fenizia,Izabela Bialuk,Hye Kyung Chung,Risaku Fukumoto,Robyn Washington Parks,Maria Grazia Ferrari,Christophe Nicot,Valentina Cecchinato,Frank Ruscetti,Genoveffa Franchini
Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome
Lis R. V. Antonelli,Yolanda Mahnke,Jessica N. Hodge,Brian O. Porter,Daniel L. Barber,Rebecca DerSimonian,Jamieson H. Greenwald,Gregg Roby,JoAnn Mican,Alan Sher,Mario Roederer,Irini Sereti
Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti–human DEC205 monoclonal antibody
Cheolho Cheong,Jae-Hoon Choi,Laura Vitale,Li-Zhen He,Christine Trumpfheller,Leonia Bozzacco,Yoonkyung Do,Godwin Nchinda,Sung Ho Park,Durga Bhavani Dandamudi,Elina Shrestha,Maggi Pack,Han-Woong Lee,Tibor Keler,Ralph M. Steinman,Chae Gyu Park
Evidence of dysregulation of dendritic cells in primary HIV infection
Rachel Lubong Sabado,Meagan O'Brien,Abhignya Subedi,Li Qin,Nan Hu,Elizabeth Taylor,Oliver Dibben,Andrea Stacey,Jacques Fellay,Kevin V. Shianna,Frederick Siegal,Michael Shodell,Kokila Shah,Marie Larsson,Jeffrey Lifson,Arthur Nadas,Michael Marmor,Richard Hutt,David Margolis,Donald Garmon,Martin Markowitz,Fred Valentine,Persephone Borrow,Nina Bhardwaj
Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education
Niklas K. Björkström,Peggy Riese,Frank Heuts,Sandra Andersson,Cyril Fauriat,Martin A. Ivarsson,Andreas T. Björklund,Malin Flodström-Tullberg,Jakob Michaëlsson,Martin E. Rottenberg,Carlos A. Guzmán,Hans-Gustaf Ljunggren,Karl-Johan Malmberg
Lymphoid Neoplasia
Myeloid Neoplasia
Treatment of progression of Philadelphia-negative myeloproliferative neoplasms to myelodysplastic syndrome or acute myeloid leukemia by azacitidine: a report on 54 cases on the behalf of the Groupe Francophone des Myelodysplasies (GFM)
Clinical Trials & Observations
Sylvain Thepot,Raphael Itzykson,Valerie Seegers,Emmanuel Raffoux,Bruno Quesnel,Yasmine Chait,Lucile Sorin,Francois Dreyfus,Thomas Cluzeau,Jacques Delaunay,Laurence Sanhes,Virginie Eclache,Caroline Dartigeas,Pascal Turlure,Stephanie Harel,Celia Salanoubat,Jean-Jacques Kiladjian,Pierre Fenaux,Lionel Adès
Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710
Clinical Trials & Observations
Bayard L. Powell,Barry Moser,Wendy Stock,Robert E. Gallagher,Cheryl L. Willman,Richard M. Stone,Jacob M. Rowe,Steven Coutre,James H. Feusner,John Gregory,Stephen Couban,Frederick R. Appelbaum,Martin S. Tallman,Richard A. Larson
Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS)
Clinical Trials & Observations
Timothy P. Hughes,Andreas Hochhaus,Susan Branford,Martin C. Müller,Jaspal S. Kaeda,Letizia Foroni,Brian J. Druker,François Guilhot,Richard A. Larson,Stephen G. O'Brien,Marc S. Rudoltz,Manisha Mone,Elisabeth Wehrle,Vijay Modur,John M. Goldman,Jerald P. Radich,on behalf of the IRIS investigators
Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome
Brief Report
Gudrun Göhring,Kyra Michalova,H. Berna Beverloo,David Betts,Jochen Harbott,Oskar A. Haas,Gitte Kerndrup,Laura Sainati,Eva Bergstraesser,Henrik Hasle,Jan Starý,Monika Trebo,Marry M. van den Heuvel-Eibrink,Marco Zecca,Elisabeth R. van Wering,Alexandra Fischer,Peter Noellke,Brigitte Strahm,Franco Locatelli,Charlotte M. Niemeyer,Brigitte Schlegelberger
CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice
Maria Paola Martelli,Valentina Pettirossi,Christian Thiede,Elisabetta Bonifacio,Federica Mezzasoma,Debora Cecchini,Roberta Pacini,Alessia Tabarrini,Raffaella Ciurnelli,Ilaria Gionfriddo,Nicla Manes,Roberta Rossi,Linda Giunchi,Uta Oelschlägel,Lorenzo Brunetti,Marica Gemei,Mario Delia,Giorgina Specchia,Arcangelo Liso,Mauro Di Ianni,Francesco Di Raimondo,Franca Falzetti,Luigi Del Vecchio,Massimo F. Martelli,Brunangelo Falini
Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value
Clinical Trials & Observations
Alexander E. Smith,Azim M. Mohamedali,Austin Kulasekararaj,ZiYi Lim,Joop Gäken,Nicholas C. Lea,Bartlomiej Przychodzen,Syed A. Mian,Erick E. Nasser,Claire Shooter,Nigel B. Westwood,Corinna Strupp,Norbert Gattermann,Jaroslaw P. Maciejewski,Ulrich Germing,Ghulam J. Mufti
Phagocytes, Granulocytes, and Myelopoiesis
An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation
Kelli P. A. MacDonald,James S. Palmer,Stephen Cronau,Elke Seppanen,Stuart Olver,Neil C. Raffelt,Rachel Kuns,Allison R. Pettit,Andrew Clouston,Brandon Wainwright,Dan Branstetter,Jeffrey Smith,Raymond J. Paxton,Douglas Pat Cerretti,Lynn Bonham,Geoffrey R. Hill,David A. Hume
Platelets and Thrombopoiesis
Red Cells, Iron, and Erythropoiesis
Thrombosis and Hemostasis
Transplantation
Outcomes of pediatric bone marrow transplantation for leukemia and myelodysplasia using matched sibling, mismatched related, or matched unrelated donors
Clinical Trials & Observations
Peter J. Shaw,Fangyu Kan,Kwang Woo Ahn,Stephen R. Spellman,Mahmoud Aljurf,Mouhab Ayas,Michael Burke,Mitchell S. Cairo,Allen R. Chen,Stella M. Davies,Haydar Frangoul,James Gajewski,Robert Peter Gale,Kamar Godder,Gregory A. Hale,Martin B.A. Heemskerk,John Horan,Naynesh Kamani,Kimberly A. Kasow,Ka Wah Chan,Stephanie J. Lee,Wing H. Leung,Victor A. Lewis,David Miklos,Machteld Oudshoorn,Effie W. Petersdorf,Olle Ringdén,Jean Sanders,Kirk R. Schultz,Adriana Seber,Michelle Setterholm,Donna A. Wall,Lolie Yu,Michael A. Pulsipher
Vascular Biology
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Cover Image
Cover Image
![issue cover]()
The image shows a fluorescence overlay of cytocentrifuged embryonic blood cells from E13.5 ε-globin::H2B-GFP;Eklf+/− transgenic mouse embryos stained with Ter119. Ter119 (red) is expressed on the enucleated definitive erythrocytes on the periphery of the cluster but not on the larger, nucleated primitive erythroblasts (EryP) in the center (green nuclei). See the article by Isern et al on page 3972.
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