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Roberta Pacini
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Journal Articles

Novel NPM1 exon 5 mutations and gene fusions leading to aberrant cytoplasmic nucleophosmin in AML

Brief Report
Maria Paola Martelli, Roberta Rossi, Alessandra Venanzi, Manja Meggendorfer, Vincenzo Maria Perriello, Giovanni Martino, Orietta Spinelli, Raffaella Ciurnelli, Emanuela Varasano, Lorenzo Brunetti, Stefano Ascani, Corinne Quadalti, Valeria Cardinali, Federica Mezzasoma, Ilaria Gionfriddo, Francesca Milano, Roberta Pacini, Alessia Tabarrini, Barbara Bigerna, Francesco Albano, Giorgina Specchia, Calogero Vetro, Francesco Di Raimondo, Ombretta Annibali, Giuseppe Avvisati, Alessandro Rambaldi, Franca Falzetti, Enrico Tiacci, Paolo Sportoletti, Torsten Haferlach, Claudia Haferlach, Brunangelo Falini
Journal: Blood
Blood (2021) 138 (25): 2696–2701.
https://doi.org/10.1182/blood.2021012732
Published: 2021
Includes: Supplemental data
Journal Articles

Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma

Enrico Tiacci, Erik Ladewig, Gianluca Schiavoni, Alex Penson, Elisabetta Fortini, Valentina Pettirossi, Yuchun Wang, Ariele Rosseto, Alessandra Venanzi, Sofija Vlasevska, Roberta Pacini, Simonetta Piattoni, Alessia Tabarrini, Alessandra Pucciarini, Barbara Bigerna, Alessia Santi, Alessandro M. Gianni, Simonetta Viviani, Antonello Cabras, Stefano Ascani, Barbara Crescenzi, Cristina Mecucci, Laura Pasqualucci, Raul Rabadan, Brunangelo Falini
Journal: Blood
Blood (2018) 131 (22): 2454–2465.
https://doi.org/10.1182/blood-2017-11-814913
Published: 2018
Includes: Supplemental data
Journal Articles

Arsenic trioxide and all- trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1 -mutated AML cells

Maria Paola Martelli, Ilaria Gionfriddo, Federica Mezzasoma, Francesca Milano, Sara Pierangeli, Floriana Mulas, Roberta Pacini, Alessia Tabarrini, Valentina Pettirossi, Roberta Rossi, Calogero Vetro, Lorenzo Brunetti, Paolo Sportoletti, Enrico Tiacci, Francesco Di Raimondo, Brunangelo Falini
Journal: Blood
Blood (2015) 125 (22): 3455–3465.
https://doi.org/10.1182/blood-2014-11-611459
Published: 2015
Includes: Supplemental data
Journal Articles

Constant Activation of the RAF-MEK-ERK Pathway As a Diagnostic and Therapeutic Target in Hairy Cell Leukemia.

Enrico Tiacci, Gianluca Schiavoni, Maria Paola Martelli, Emanuela Boveri, Roberta Pacini, Alessia Tabarrini, Silvia Zibellini, Alessia Santi, Valentina Pettirossi, Elisabetta Fortini, Stefano Ascani, Luca Arcaini, Giorgio Inghirami, Marco Paulli, Brunangelo Falini
Journal: Blood
Blood (2012) 120 (21): 2657.
https://doi.org/10.1182/blood.V120.21.2657.2657
Published: 2012
Journal Articles

CD34 + cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice

Maria Paola Martelli, Valentina Pettirossi, Christian Thiede, Elisabetta Bonifacio, Federica Mezzasoma, Debora Cecchini, Roberta Pacini, Alessia Tabarrini, Raffaella Ciurnelli, Ilaria Gionfriddo, Nicla Manes, Roberta Rossi, Linda Giunchi, Uta Oelschlägel, Lorenzo Brunetti, Marica Gemei, Mario Delia, Giorgina Specchia, Arcangelo Liso, Mauro Di Ianni, Francesco Di Raimondo, Franca Falzetti, Luigi Del Vecchio, Massimo F. Martelli, Brunangelo Falini
Journal: Blood
Blood (2010) 116 (19): 3907–3922.
https://doi.org/10.1182/blood-2009-08-238899
Published: 2010
Includes: Supplemental data
Journal Articles

Dissecting the Hierarchical Level of Hematopoietic Progenitors' Involvement in AML with NPM1 Gene Mutation and Their Engraftment Potential in Immunocompromised Mice.

Maria Paola Martelli, Valentina Pettirossi, Christian Thiede, Elisabetta Bonifacio, Mauro Di Ianni, Ilaria Gionfriddo, Debora Cecchini, Roberta Pacini, Alessia Tabarrini, Federica Mezzasoma, Roberta Rossi, Linda Giunchi, Uta Oelschlägel, Lorenzo Brunetti, Marica Gemei, Raffaella Ciurnelli, Federica Cecchetti, Luca De Carolis, Arcangelo Liso, Francesco Di Raimondo, MD, Massimo F Martelli, Brunangelo Falini, MD
Journal: Blood
Blood (2009) 114 (22): 480.
https://doi.org/10.1182/blood.V114.22.480.480
Published: 2009
Journal Articles

Evidence for CD34+ Hematopoietic Progenitor Cell Involvement in Acute Myeloid Leukemia with NPM1 Gene Mutation: Implications for the Cell of Origin

Maria Paola Martelli, Valentina Pettirossi, Elisabetta Bonifacio, Federica Mezzasoma, Nicla Manes, Debora Cecchini, Maruska Capanni, Ilaria Gionfriddo, Arcangelo Liso, Roberta Pacini, Manola Carini, Giorgina Specchia, Massimo F Martelli, Brunangelo Falini
Journal: Blood
Blood (2008) 112 (11): 307.
https://doi.org/10.1182/blood.V112.11.307.307
Published: 2008
Journal Articles

Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: impact on WHO classification

Clinical Trials & Observations
Laura Pasqualucci, Arcangelo Liso, Maria Paola Martelli, Niccolò Bolli, Roberta Pacini, Alessia Tabarrini, Manola Carini, Barbara Bigerna, Alessandra Pucciarini, Roberta Mannucci, Ildo Nicoletti, Enrico Tiacci, Giovanna Meloni, Giorgina Specchia, Nicola Cantore, Francesco Di Raimondo, Stefano Pileri, Cristina Mecucci, Franco Mandelli, Massimo Fabrizio Martelli, Brunangelo Falini
Journal: Blood
Blood (2006) 108 (13): 4146–4155.
https://doi.org/10.1182/blood-2006-06-026716
Published: 2006
Includes: Supplemental data
Journal Articles

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia

Clinical Trials & Observations
Brunangelo Falini, Maria Paola Martelli, Niccolò Bolli, Rossella Bonasso, Emanuela Ghia, Maria Teresa Pallotta, Daniela Diverio, Ildo Nicoletti, Roberta Pacini, Alessia Tabarrini, Barbara Verducci Galletti, Roberta Mannucci, Giovanni Roti, Roberto Rosati, Giorgina Specchia, Arcangelo Liso, Enrico Tiacci, Myriam Alcalay, Lucilla Luzi, Sara Volorio, Loris Bernard, Anna Guarini, Sergio Amadori, Franco Mandelli, Fabrizio Pane, Francesco Lo-Coco, Giuseppe Saglio, Pier-Giuseppe Pelicci, Massimo F. Martelli, Cristina Mecucci, for the GIMEMA Acute Leukemia Working Party
Journal: Blood
Blood (2006) 108 (6): 1999–2005.
https://doi.org/10.1182/blood-2006-03-007013
Published: 2006
Journal Articles

Tumor protein D52 (TPD52): a novel B-cell/plasma-cell molecule with unique expression pattern and Ca 2+ -dependent association with annexin VI

Enrico Tiacci, Pier-Luigi Orvietani, Barbara Bigerna, Alessandra Pucciarini, Garry L. Corthals, Valentina Pettirossi, Maria P. Martelli, Arcangelo Liso, Roberta Benedetti, Roberta Pacini, Niccolò Bolli, Stefano Pileri, Karen Pulford, Marcello Gambacorta, Antonino Carbone, Carla Pasquarello, Alexander Scherl, Helen Robertson, Maria Teresa Sciurpi, Giovanni Alunni-Bistocchi, Luciano Binaglia, Jennifer A. Byrne, Brunangelo Falini
Journal: Blood
Blood (2005) 105 (7): 2812–2820.
https://doi.org/10.1182/blood-2004-07-2630
Published: 2005
Journal Articles

Tumor Protein D52 (TPD52): A Novel B Cell/Plasma Cell Molecule Identified through a Proteomic Approach and Characterized by Unique Expression Pattern and Ca 2+ -Dependent Association with Annexin VI.

Enrico Tiacci, Pier-Luigi Orvietani, Barbara Bigerna, Alessandra Pucciarini, Roberta Pacini, Garry Corthals, Valentina Pettirossi, Maria Paola Martelli, Arcangelo Liso, Niccolo Bolli, Alessia Tabarrini, Federica Frenguelli, Roberta Benedetti, Stefano Pileri, Jennyfer A. Byrne, Brunangelo Falini
Journal: Blood
Blood (2004) 104 (11): 3652.
https://doi.org/10.1182/blood.V104.11.3652.3652
Published: 2004
Journal Articles

A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells

Brunangelo Falini, Marco Fizzotti, Alessandra Pucciarini, Barbara Bigerna, Teresa Marafioti, Marcello Gambacorta, Roberta Pacini, Cristina Alunni, Laura Natali–Tanci, Barbara Ugolini, Carla Sebastiani, Giorgio Cattoretti, Stefano Pileri, Riccardo Dalla-Favera, Harald Stein
Journal: Blood
Blood (2000) 95 (6): 2084–2092.
https://doi.org/10.1182/blood.V95.6.2084
Published: 2000