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Journal Articles

Tuned IL3-Zetakine Coupled to a CD33 Costimulatory Receptor As a Dual CAR for Safer and Selective Targeting of Acute Myeloid Leukemia

Vincenzo Maria Perriello, Maria Caterina Rotiroti, Ilaria Pisani, Stefania Galimberti, Gaia Alberti, Giulia Pianigiani, Valerio Ciaurro, Andrea Marra, Marcella Sabino, Valentina Tini, Federica Mezzasoma, Francesco Morena, Sabata Martino, Domenico Salerno, Julian François Ashby, Brittany Wingham, Marta Serafini, Maria Paola Martelli, Brunangelo Falini, Andrea Biondi, Sarah Tettamanti
Journal: Blood
Blood (2022) 140 (Supplement 1): 10237–10238.
https://doi.org/10.1182/blood-2022-166555
Published: 2022
Journal Articles

Novel NPM1 exon 5 mutations and gene fusions leading to aberrant cytoplasmic nucleophosmin in AML

Brief Report
Maria Paola Martelli, Roberta Rossi, Alessandra Venanzi, Manja Meggendorfer, Vincenzo Maria Perriello, Giovanni Martino, Orietta Spinelli, Raffaella Ciurnelli, Emanuela Varasano, Lorenzo Brunetti, Stefano Ascani, Corinne Quadalti, Valeria Cardinali, Federica Mezzasoma, Ilaria Gionfriddo, Francesca Milano, Roberta Pacini, Alessia Tabarrini, Barbara Bigerna, Francesco Albano, Giorgina Specchia, Calogero Vetro, Francesco Di Raimondo, Ombretta Annibali, Giuseppe Avvisati, Alessandro Rambaldi, Franca Falzetti, Enrico Tiacci, Paolo Sportoletti, Torsten Haferlach, Claudia Haferlach, Brunangelo Falini
Journal: Blood
Blood (2021) 138 (25): 2696–2701.
https://doi.org/10.1182/blood.2021012732
Published: 2021
Includes: Supplemental data
Journal Articles

Acute Myeloid Leukemia with Mutated NPM1 Is Dependent on the Cytoplasmic Localization of NPM1c

Lorenzo Brunetti, MD, Michael Gundry, Anna Guzman, Ilaria Gionfriddo, PhD, Federica Mezzasoma, PhD, Francesca Milano, PhD, Maria Paola Martelli, MD PhD, Brunangelo Falini, MD, Margaret Goodell, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 877.
https://doi.org/10.1182/blood.V130.Suppl_1.877.877
Published: 2017
Journal Articles

Arsenic trioxide and all- trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1 -mutated AML cells

Maria Paola Martelli, Ilaria Gionfriddo, Federica Mezzasoma, Francesca Milano, Sara Pierangeli, Floriana Mulas, Roberta Pacini, Alessia Tabarrini, Valentina Pettirossi, Roberta Rossi, Calogero Vetro, Lorenzo Brunetti, Paolo Sportoletti, Enrico Tiacci, Francesco Di Raimondo, Brunangelo Falini
Journal: Blood
Blood (2015) 125 (22): 3455–3465.
https://doi.org/10.1182/blood-2014-11-611459
Published: 2015
Includes: Supplemental data
Journal Articles

Histone Deacetylase Inhibitors Induce Cell Growth Inhibition and Apoptosis in NPM1 -Mutated AML Cells: A Possible Role for Epigenetic Therapies in AML Carrying NPM1 Gene Mutations

Ilaria Gionfriddo, Federica Mezzasoma, Federica Cecchetti, Roberta Rossi, Francesca Strozzini, Francesco Di Raimondo, MD, Valentina Pettirossi, PhD, Brunangelo Falini, MD, Maria Paola Martelli, MD
Journal: Blood
Blood (2011) 118 (21): 2621.
https://doi.org/10.1182/blood.V118.21.2621.2621
Published: 2011
Journal Articles

CD34 + cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice

Maria Paola Martelli, Valentina Pettirossi, Christian Thiede, Elisabetta Bonifacio, Federica Mezzasoma, Debora Cecchini, Roberta Pacini, Alessia Tabarrini, Raffaella Ciurnelli, Ilaria Gionfriddo, Nicla Manes, Roberta Rossi, Linda Giunchi, Uta Oelschlägel, Lorenzo Brunetti, Marica Gemei, Mario Delia, Giorgina Specchia, Arcangelo Liso, Mauro Di Ianni, Francesco Di Raimondo, Franca Falzetti, Luigi Del Vecchio, Massimo F. Martelli, Brunangelo Falini
Journal: Blood
Blood (2010) 116 (19): 3907–3922.
https://doi.org/10.1182/blood-2009-08-238899
Published: 2010
Includes: Supplemental data
Journal Articles

Dissecting the Hierarchical Level of Hematopoietic Progenitors' Involvement in AML with NPM1 Gene Mutation and Their Engraftment Potential in Immunocompromised Mice.

Maria Paola Martelli, Valentina Pettirossi, Christian Thiede, Elisabetta Bonifacio, Mauro Di Ianni, Ilaria Gionfriddo, Debora Cecchini, Roberta Pacini, Alessia Tabarrini, Federica Mezzasoma, Roberta Rossi, Linda Giunchi, Uta Oelschlägel, Lorenzo Brunetti, Marica Gemei, Raffaella Ciurnelli, Federica Cecchetti, Luca De Carolis, Arcangelo Liso, Francesco Di Raimondo, MD, Massimo F Martelli, Brunangelo Falini, MD
Journal: Blood
Blood (2009) 114 (22): 480.
https://doi.org/10.1182/blood.V114.22.480.480
Published: 2009
Journal Articles

Evidence for CD34+ Hematopoietic Progenitor Cell Involvement in Acute Myeloid Leukemia with NPM1 Gene Mutation: Implications for the Cell of Origin

Maria Paola Martelli, Valentina Pettirossi, Elisabetta Bonifacio, Federica Mezzasoma, Nicla Manes, Debora Cecchini, Maruska Capanni, Ilaria Gionfriddo, Arcangelo Liso, Roberta Pacini, Manola Carini, Giorgina Specchia, Massimo F Martelli, Brunangelo Falini
Journal: Blood
Blood (2008) 112 (11): 307.
https://doi.org/10.1182/blood.V112.11.307.307
Published: 2008