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Journal Articles

B-cell receptor signaling and genetic lesions in TP53 and CDKN2A/CDKN2B cooperate in Richter transformation

Supriya Chakraborty, Claudio Martines, Fabiola Porro, Ilaria Fortunati, Alice Bonato, Marija Dimishkovska, Silvano Piazza, Brijesh S. Yadav, Idanna Innocenti, Rosa Fazio, Tiziana Vaisitti, Silvia Deaglio, Alberto Zamò, Aleksandar J. Dimovski, Luca Laurenti, Dimitar G. Efremov
Journal: Blood
Blood (2021) 138 (12): 1053–1066.
https://doi.org/10.1182/blood.2020008276
Published: 2021
Includes: Supplemental data
Journal Articles

What’s new in the pathogenesis and treatment of therapy-related myeloid neoplasms

Maria Teresa Voso, Giulia Falconi, Emiliano Fabiani
Journal: Blood
Blood (2021) 138 (9): 749–757.
https://doi.org/10.1182/blood.2021010764
Published: 2021
Journal Articles

CLL-IPI: valid in the era of oral inhibitors?

Nadine Kutsch
Journal: Blood
Blood (2021) 138 (2): 106–107.
https://doi.org/10.1182/blood.2021011937
Published: 2021
Journal Articles

Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death

Ana Domostegui, Suresh Peddigari, Carol A. Mercer, Flavia Iannizzotto, Marta L. Rodriguez, Marta Garcia-Cajide, Virginia Amador, Sarah T. Diepstraten, Gemma L. Kelly, Ramón Salazar, Sara C. Kozma, Eric P. Kusnadi, Jian Kang, Antonio Gentilella, Richard B. Pearson, George Thomas, Joffrey Pelletier
Journal: Blood
Blood (2021) 137 (24): 3351–3364.
https://doi.org/10.1182/blood.2020007452
Published: 2021
Includes: Supplemental data
Journal Articles

Targeting MCL-1 and BCL-2: a 1-2 punch

Jennifer R. Brown
Journal: Blood
Blood (2021) 137 (20): 2711–2712.
https://doi.org/10.1182/blood.2021012001
Published: 2021
Journal Articles

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Rachel Thijssen, Sarah T. Diepstraten, Donia Moujalled, Edward Chew, Christoffer Flensburg, Melissa X. Shi, Michael A. Dengler, Veronique Litalien, Sarah MacRaild, Maoshan Chen, Natasha S. Anstee, Boris Reljić, Sarah S. Gabriel, Tirta M. Djajawi, Chris D. Riffkin, Brandon J. Aubrey, Catherine Chang, Lin Tai, Zhen Xu, Thomas Morley, Giovanna Pomilio, Claudia Bruedigam, Axel Kallies, David A. Stroud, Ashish Bajel, Ruth M. Kluck, Steven W. Lane, Marie Schoumacher, Sébastien Banquet, Ian J. Majewski, Andreas Strasser, Andrew W. Roberts, David C. S. Huang, Fiona C. Brown, Gemma L. Kelly, Andrew H. Wei
Journal: Blood
Blood (2021) 137 (20): 2721–2735.
https://doi.org/10.1182/blood.2020010167
Published: 2021
Includes: Supplemental data
Journal Articles

Mutational landscape of gray zone lymphoma

Clémentine Sarkozy, Stacy S. Hung, Elizabeth A. Chavez, Gerben Duns, Katsuyoshi Takata, Lauren C. Chong, Tomohiro Aoki, Aixiang Jiang, Tomoko Miyata-Takata, Adèle Telenius, Graham W. Slack, Thierry Jo Molina, Susana Ben-Neriah, Pedro Farinha, Peggy Dartigues, Diane Damotte, Anja Mottok, Gilles A. Salles, Rene-Olivier Casasnovas, Kerry J. Savage, Camille Laurent, David W. Scott, Alexandra Traverse-Glehen, Christian Steidl
Journal: Blood
Blood (2021) 137 (13): 1765–1776.
https://doi.org/10.1182/blood.2020007507
Published: 2021
Includes: Supplemental data
Journal Articles

Modeling and targeting of erythroleukemia by hematopoietic genome editing

Ilaria Iacobucci, Chunxu Qu, Elena Varotto, Laura J. Janke, Xu Yang, Aman Seth, Anang Shelat, Jake D. Friske, Reiji Fukano, Jiyang Yu, Burgess B. Freeman, III, James A. Kennedy, Adam S. Sperling, Rena Zheng, Yingzhe Wang, Harini Jogiraju, Kirsten M. Dickerson, Debbie Payne-Turner, Sarah M. Morris, Emily S. Hollis, Nina Ghosn, Georgia E. Haggard, R. Coleman Lindsley, Benjamin L. Ebert, Charles G. Mullighan
Journal: Blood
Blood (2021) 137 (12): 1628–1640.
https://doi.org/10.1182/blood.2020009103
Published: 2021
Includes: Supplemental data
Journal Articles

Deletion 17p: a matter of size and number?

Sonja Zweegman, Niels W. C. J. van de Donk
Journal: Blood
Blood (2021) 137 (9): 1135–1136.
https://doi.org/10.1182/blood.2020009102
Published: 2021
Journal Articles

del(17p) without TP53 mutation confers a poor prognosis in intensively treated newly diagnosed patients with multiple myeloma

Clinical Trials & Observations Brief Report
Jill Corre, Aurore Perrot, Denis Caillot, Karim Belhadj, Cyrille Hulin, Xavier Leleu, Mohamad Mohty, Thierry Facon, Laure Buisson, Laura Do Souto, Romain Lannes, Stephanie Dufrechou, Naïs Prade, Frederique Orsini-Piocelle, Laurent Voillat, Arnaud Jaccard, Lionel Karlin, Margaret Macro, Sabine Brechignac, Mamoun Dib, Laurence Sanhes, Jean Fontan, Lauriane Clement-Filliatre, Jean-Pierre Marolleau, Stephane Minvielle, Philippe Moreau, Hervé Avet-Loiseau
Journal: Blood
Blood (2021) 137 (9): 1192–1195.
https://doi.org/10.1182/blood.2020008346
Published: 2021
Includes: Supplemental data
Journal Articles

Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers

Alexandre Fagnan, Frederik Otzen Bagger, Maria-Riera Piqué-Borràs, Cathy Ignacimouttou, Alexis Caulier, Cécile K. Lopez, Elie Robert, Benjamin Uzan, Véronique Gelsi-Boyer, Zakia Aid, Cécile Thirant, Ute Moll, Samantha Tauchmann, Amina Kurtovic-Kozaric, Jaroslaw Maciejewski, Christine Dierks, Orietta Spinelli, Silvia Salmoiraghi, Thomas Pabst, Kazuya Shimoda, Virginie Deleuze, Hélène Lapillonne, Connor Sweeney, Véronique De Mas, Betty Leite, Zahra Kadri, Sébastien Malinge, Stéphane de Botton, Jean-Baptiste Micol, Benjamin Kile, Catherine L. Carmichael, Ilaria Iacobucci, Charles G. Mullighan, Martin Carroll, Peter Valent, Olivier A. Bernard, Eric Delabesse, Paresh Vyas, Daniel Birnbaum, Eduardo Anguita, Loïc Garçon, Eric Soler, Juerg Schwaller, Thomas Mercher
Journal: Blood
Blood (2020) 136 (6): 698–714.
https://doi.org/10.1182/blood.2019003062
Published: 2020
Includes: Supplemental data
Journal Articles

The different flavors and splices of MCL

Oliver Weigert
Journal: Blood
Blood (2020) 136 (5): 526–527.
https://doi.org/10.1182/blood.2020005591
Published: 2020
Journal Articles

Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing

Prasath Pararajalingam, Krysta M. Coyle, Sarah E. Arthur, Nicole Thomas, Miguel Alcaide, Barbara Meissner, Merrill Boyle, Quratulain Qureshi, Bruno M. Grande, Christopher Rushton, Graham W. Slack, Andrew J. Mungall, Constantine S. Tam, Rishu Agarwal, Sarah-Jane Dawson, Georg Lenz, Sriram Balasubramanian, Randy D. Gascoyne, Christian Steidl, Joseph Connors, Diego Villa, Timothy E. Audas, Marco A. Marra, Nathalie A. Johnson, David W. Scott, Ryan D. Morin
Journal: Blood
Blood (2020) 136 (5): 572–584.
https://doi.org/10.1182/blood.2019002385
Published: 2020
Includes: Supplemental data
Journal Articles

Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax

Clinical Trials & Observations
Eugen Tausch, Christof Schneider, Sandra Robrecht, Can Zhang, Anna Dolnik, Johannes Bloehdorn, Jasmin Bahlo, Othman Al-Sawaf, Matthias Ritgen, Anna-Maria Fink, Barbara Eichhorst, Karl-Anton Kreuzer, Maneesh Tandon, Kathryn Humphrey, Yanwen Jiang, William Schary, Lars Bullinger, Daniel Mertens, Michele Porro Lurà, Michael Kneba, Hartmut Döhner, Kirsten Fischer, Michael Hallek, Stephan Stilgenbauer
Journal: Blood
Blood (2020) 135 (26): 2402–2412.
https://doi.org/10.1182/blood.2019004492
Published: 2020
Includes: Supplemental data
Journal Articles

A predictive tool for early-stage CLL

Constantine S. Tam, John F. Seymour
Journal: Blood
Blood (2020) 135 (21): 1820–1821.
https://doi.org/10.1182/blood.2020005426
Published: 2020
Journal Articles

Baseline TP53 mutations in adults with SCD developing myeloid malignancy following hematopoietic cell transplantation

Clinical Trials & Observations
Jack Y. Ghannam, Xin Xu, Irina Maric, Laura Dillon, Yuesheng Li, Matthew M. Hsieh, Christopher S. Hourigan, Courtney D. Fitzhugh
Journal: Blood
Blood (2020) 135 (14): 1185–1188.
https://doi.org/10.1182/blood.2019004001
Published: 2020
Journal Articles

Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

Benshang Li, Samuel W. Brady, Xiaotu Ma, Shuhong Shen, Yingchi Zhang, Yongjin Li, Karol Szlachta, Li Dong, Yu Liu, Fan Yang, Ningling Wang, Diane A. Flasch, Matthew A. Myers, Heather L. Mulder, Lixia Ding, Yanling Liu, Liqing Tian, Kohei Hagiwara, Ke Xu, Xin Zhou, Edgar Sioson, Tianyi Wang, Liu Yang, Jie Zhao, Hui Zhang, Ying Shao, Hongye Sun, Lele Sun, Jiaoyang Cai, Hui-Ying Sun, Ting-Nien Lin, Lijuan Du, Hui Li, Michael Rusch, Michael N. Edmonson, John Easton, Xiaofan Zhu, Jingliao Zhang, Cheng Cheng, Benjamin J. Raphael, Jingyan Tang, James R. Downing, Ludmil B. Alexandrov, Bin-Bing S. Zhou, Ching-Hon Pui, Jun J. Yang, Jinghui Zhang
Journal: Blood
Blood (2020) 135 (1): 41–55.
https://doi.org/10.1182/blood.2019002220
Published: 2020
Includes: Supplemental data
Journal Articles

Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53

CME
Elise Chapiro, Elodie Pramil, M’boyba Diop, Damien Roos-Weil, Clémentine Dillard, Clémentine Gabillaud, Karim Maloum, Catherine Settegrana, Lucile Baseggio, Jean-François Lesesve, Mélanie Yon, Ludovic Jondreville, Claude Lesty, Frédéric Davi, Magali Le Garff-Tavernier, Nathalie Droin, Philippe Dessen, Caroline Algrin, Véronique Leblond, Jean Gabarre, Simon Bouzy, Virginie Eclache, Baptiste Gaillard, Evelyne Callet-Bauchu, Marc Muller, Christine Lefebvre, Nathalie Nadal, Antoine Ittel, Stéphanie Struski, Marie-Agnès Collonge-Rame, Benoit Quilichini, Sandra Fert-Ferrer, Nathalie Auger, Isabelle Radford-Weiss, Lena Wagner, Sebastian Scheinost, Thorsten Zenz, Santos A. Susin, Olivier A. Bernard, Florence Nguyen-Khac
Journal: Blood
Blood (2019) 134 (21): 1821–1831.
https://doi.org/10.1182/blood.2019001187
Published: 2019
Includes: Supplemental data
Journal Articles

Interrogation of Individual CLL Loss-of-Function Lesions By CRISPR In Vivo Editing Reveals Common and Unique Pathway Alterations

Elisa Ten Hacken, PhD, Shanye Yin, PhD, Kendell Clement, PhD, Robert A. Redd, MS, Maria Hernandez-Sanchez, PhD, Shuqiang Li, PhD, Michaela Gruber, MD PhD, Heather Joyal, Geoffrey Fell, MS, Shu Wang, Jose Jacob, James Flynn, David Ruff, Keith W. Jones, Lili Wang, MD PhD, Donna S Neuberg, ScD, Luca Pinello, PhD, Kenneth J. Livak, PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 684.
https://doi.org/10.1182/blood-2019-127673
Published: 2019
Journal Articles

Distinct Evolutionary Patterns in Chronic Lymphocytic Leukemia (CLL) during Resistance to Graft-Versus-Leukemia (GvL)

Pavan Bachireddy, MD, Christina Ennis, BA, Vinhkhang N Nguyen, BSc, Nikolas Barkas, PhD, Sachet Shukla, PhD, Kendell Clement, PhD, Samuel Freeman, BSc, Satyen H Gohil, PhD, M.B.,B.S., Natalie Bavli, MD, Liudmila Elagina, PhD, Ignaty Leshchiner, PhD, Jennifer R. Brown, MD PhD, Gad Getz, PhD, Vincent T. Ho, MD, Donna S Neuberg, ScD, Robert J. Soiffer, MD, Jerome Ritz, MD, Edwin P. Alyea, III, MD, Peter Kharchenko, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 516.
https://doi.org/10.1182/blood-2019-129520
Published: 2019