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Journal Articles

RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells

Free
Brian Estevez, Sara Borst, Danuta Jarocha, Varun Sudunagunta, Michael Gonzalez, James Garifallou, Hakon Hakonarson, Peng Gao, Kai Tan, Paul Liu, Sumedha Bagga, Nicholas Holdreith, Wei Tong, Nancy Speck, Deborah L. French, Paul Gadue, Mortimer Poncz
Journal: Blood
Blood (2021) 137 (19): 2662–2675.
https://doi.org/10.1182/blood.2020006389
Published: 2021
Includes: Supplemental data
Journal Articles

Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL

Free
Praveen Anand, Amy Guillaumet-Adkins, Valeriya Dimitrova, Huiyoung Yun, Yotam Drier, Noori Sotudeh, Anna Rogers, Madhu M. Ouseph, Monica Nair, Sayalee Potdar, Randi Isenhart, Jake A. Kloeber, Tushara Vijaykumar, Leili Niu, Tiffaney Vincent, Guangwu Guo, Julia Frede, Marian H. Harris, Andrew E. Place, Lewis B. Silverman, David T. Teachey, Andrew A. Lane, Daniel J. DeAngelo, Jon C. Aster, Bradley E. Bernstein, Jens G. Lohr, Birgit Knoechel
Journal: Blood
Blood (2021) 137 (18): 2463–2480.
https://doi.org/10.1182/blood.2019004547
Published: 2021
Includes: Supplemental data
Journal Articles

Developmental trajectory of prehematopoietic stem cell formation from endothelium

Free
Qin Zhu, Peng Gao, Joanna Tober, Laura Bennett, Changya Chen, Yasin Uzun, Yan Li, Elizabeth D. Howell, Melanie Mumau, Wenbao Yu, Bing He, Nancy A. Speck, Kai Tan
Journal: Blood
Blood (2020) 136 (7): 845–856.
https://doi.org/10.1182/blood.2020004801
Published: 2020
Includes: Supplemental data
Journal Articles

Single-Cell Characterization of the Multiple Myeloma (MM) Immune Microenvironment Identifies CD27-Negative T Cells As Potential Source of Tumor-Reactive Lymphocytes

Free
Cirino Botta, MD, Cristina Pérez Ruiz, Ibai Goicoechea, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Lourdes Cordon, Aintzane Zabaleta, PhD, Leire Burgos, Catarina Maia, Sara Rodríguez, PhD, Idoia Rodriguez, Sarai Sarvide, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Laura Rosinol Dachs, Albert Oriol, MD, María Jesús Blanchard, Rafael Rios, MD PhD, Anna Sureda, MD PhD, Rafael Martínez, Jesús Martín, Joan Bargay, MD PhD, Javier De La Rubia, Marco Rossi, MD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD, Massimo Gentile, Juana Merino, Felipe Prosper, MD PhD, Alberto Orfao, MD PhD, Maria-Victoria Mateos, Juan-José Lahuerta, MD PhD, Joan Bladé, MD PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 506.
https://doi.org/10.1182/blood-2019-123974
Published: 2019
Journal Articles

Gata2 Expression and Function in PML-RARA- driven Preleukemia and APL

Free
Casey D.S. Katerndahl, PhD, Timothy J Ley, MD, Michelle A Cai, Timothy P Rooney, Jr., Sai Mukund Ramakrishnan, MS, Sridhar Nonavinkere Srivatsan, MS, Christopher A Miller, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 534.
https://doi.org/10.1182/blood-2019-131883
Published: 2019
Journal Articles

Dissecting Heterogeneity of Tumor Cells and Their Microenvironment in Refractory Multiple Myeloma

Free
Stephan M Tirier, PhD, Jan-Philipp Mallm, PhD, Nicola Casiraghi, PhD, Hana Susak, PhD, Nicola Giesen, MD, Alexandra M Poos, PhD, Katharina Bauer, Anja Baumann, Lukas John, MD, Jing Xu, PhD, Lara Klett, MSc, Carsten Müller-Tidow, MD, Benedikt Brors, PhD, Hartmut Goldschmidt, MD, Niels Weinhold, PhD, Oliver Stegle, PhD, Karsten Rippe, PhD, Marc S. Raab, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 571.
https://doi.org/10.1182/blood-2019-128625
Published: 2019
Journal Articles

T Cell Determinants of Response and Resistance to PD-1 Blockade in Richter's Transformation

Free
Erin Parry, MD PhD, Camilla K Lemvigh, MSc, Annabelle J Anandappa, MD, Shuqiang Li, PhD, Lillian Werner, MS, Ana Lako, Noelia Purroy, MD PhD, Satyen H Gohil, PhD, M.B.,B.S., Giacomo Oliveira, PhD, Pavan Bachireddy, MD, Teddy Huang, Ignaty Leshchiner, PhD, Aina Zurita Martinez, Lars Ronn Olsen, PhD, Kenneth Livak, PhD, Gad Getz, PhD, Donna S Neuberg, ScD, Scott J Rodig, MD PhD, William G. Wierda, MD PhD, Peter Kharchenko, PhD, Nitin Jain, MD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 680.
https://doi.org/10.1182/blood-2019-125904
Published: 2019
Journal Articles

Analysis of Deficiency of Adenosine Deaminase 2 Pathogenesis Based on Single Cell RNA Sequencing of Monocytes

Free
Naoki Watanabe, Shouguo Gao, PhD, Sachiko Kajigaya, Carrie Diamond, MD, Lemlem Alemu, BS, Amanda Ombrello, MD, Neal S. Young, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2317.
https://doi.org/10.1182/blood-2019-123859
Published: 2019
Journal Articles

A Unique Crosstalk between Tumor Cells and Hematopoietic Stem Cells Reveals a Myeloid Differentiation Pattern Signature Contributing to Metastasis

Free
Ksenia Magidey, PhD, Ksenya Kveler, PhD, Rachelly Normand, PhD, Tongwu Zhang, PhD, Michael Timaner, PhD, Ziv Raviv, PhD, Brian James, PhD, Roi Gazit, PhD, Ze'ev Ronai, PhD, Shai Shen-Orr, PhD, Yuval Shaked, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2465.
https://doi.org/10.1182/blood-2019-128126
Published: 2019
Journal Articles

VISTA Is a Novel Regulator of Macrophage Biology

Free
Parth Shah, MD, Mohamed Eltanbouly, BSc, Nicole Smits, Aurelien Sarde, Randolph Noelle, Rodwell Mabaera, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2320.
https://doi.org/10.1182/blood-2019-131310
Published: 2019
Journal Articles

Single Cell Transcriptomics Predicts Relapse in Infants with Acute Lymphoblastic Leukemia

Free
Tito Candelli, PhD, Pauline Schneider, Patricia Garrido Castro, PhD, Luke A Jones, PhD, Rob Pieters, MDPhDMSc, Thanasis Margaritis, PhD, Ronald W. Stam, PhD, Frank C.P. Holstege, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3951.
https://doi.org/10.1182/blood-2019-123052
Published: 2019
Journal Articles

T-Cell Clonal Expansion and Activation Associated with Durable Clinical Response to Dual BTK and CDK4/6 Inhibitor Therapy in Mantle Cell Lymphoma

Free
Christina Y. Lee, MD, Maurizio Di Liberto, PhD, Yang Hu, PhD, Xiangao Huang, PhD, Nancy L Bartlett, MD, Kami J. Maddocks, MD, John P. Leonard, MD, Nils-Petter Rudqvist, PhD, Lorenzo Galluzzi, PhD, Peter Martin, FRCPC, MD MS, Olivier Elemento, PhD, Selina Chen-Kiang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3973.
https://doi.org/10.1182/blood-2019-122322
Published: 2019
Journal Articles

Nascent Transcript and Single Cell Rnaseq Analysis Defines the Mechanism of Action of the LSD1 Inhibitor INCB059872 in Myeloid Leukemia

Free
Gretchen Johnston, Haley E. Ramsey, PhDMSc, Kristy Stengel, PhD, Shilpa Sampathi, PhD, Pankaj Acharya, PhD, Maria Arrate, MSc, Matthew C. Stubbs, PhD, Timothy Burn, PhD, Scott Hiebert, PhD, Michael R. Savona, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2509.
https://doi.org/10.1182/blood-2019-130458
Published: 2019
Journal Articles

Single Cell Profiling of DNMT3A-Mutant Progenitors Reveals LY86 As a Novel Pre-Leukemia Marker and Potential Therapeutic Target

Free
Mira Jeong, PhD, Sangbae Kim, PhD, Yumei Li, PhD, Rui Chen, PhD, Premal Lulla, MBBS, Margaret Goodell, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2724.
https://doi.org/10.1182/blood-2019-123597
Published: 2019
Journal Articles

Transcriptome Based Projection of Single Cells to Uncover Development and Heterogeneity of Abnormal Hematopoietic Cells

Free
Parashar Dhapola, MSc, Mikael Sommarin, Mohamed Eldeeb, MSc, Amol Ugale, PhD, David Bryder, PhD, Göran Karlsson, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2520.
https://doi.org/10.1182/blood-2019-130587
Published: 2019
Journal Articles

Development of a Novel Deep Transfer Learning Framework to Characterize Inter- and Intra-Tumor Heterogeneity in Myeloma Patients

Free
Travis S Johnson, MS, Christina Y Yu, BSc, Chuanpeng Dong, MS, Tongxin Wang, BS, Mohammad Issam Abu Zaid, MBBS, Rafat Abonour, MD, G. David Roodman, MD PhD, Yunlong Liu, PhD, Kun Huang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3075.
https://doi.org/10.1182/blood-2019-130452
Published: 2019
Journal Articles

Single-Cell RNA Sequencing of Healthy Human Marrow Hematopoietic Cells

Free
Xin Zhao, MD PhD, Shouguo Gao, PhD, Sachiko Kajigaya, PhD, Qingguo Liu, MD PhD, Zhijie Wu, MD, Xingmin Feng, PhD, Fengkui Zhang, MD, Neal S. Young, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4997.
https://doi.org/10.1182/blood-2019-123249
Published: 2019
Journal Articles

Lung-Resident Megakaryocytes Display Distinct Transcriptional and Functional Properties

Free
Anthony K Yeung, BS, Carlos Villacorta-Martin, MSc, Stephanie Hon, MD, Todd W Dowrey, BS, George J Murphy, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4999.
https://doi.org/10.1182/blood-2019-127200
Published: 2019
Journal Articles

Kydar Multicenter Trial of Quadruple Regimen for Induction Resistant Myeloma Combined with Translational Single-Cell Analysis Identifies Potential Drivers of Advanced Resistance, Including Novel Immune Checkpoints

Free
Yael C Cohen, MD, Mor Zada, MSc, Moshe E. Gatt, MD, Noa Lavi, MD, Chezi Ganzel, MD, Shuang-Yin Wang, Assaf Weiner, PhD, Guy Ledergor, MD, Evgeni Chubar, MD, Ory Rouvio, MD, Iuliana Vaxman, MDBA, Mouna Ballan, MD, Tamar Tadmor, MD, Anatoly Nemets, MD, Osnat Jarchowcky Dolberg, Olga Shvetz, MD, Ofer Shpilberg, MD MPH, Nagib Deli, MD, Irit Avivi, Ido Amit, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 982.
https://doi.org/10.1182/blood-2019-129618
Published: 2019
Journal Articles

Single-Cell RNA Sequencing Reveals Distinct Hematopoietic Stem Cell Hierarchies in MDS

Free
Irene Ganan-Gomez, PhD, Hui Yang, PhDMD, Feiyang Ma, Bs, Matteo Pellegrini, PhD, Karen Clise-Dwyer, PhD, Guillermo Garcia-Manero, MD, Simona Colla, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 771.
https://doi.org/10.1182/blood-2019-128798
Published: 2019