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Volume 97, Issue 3

February 1 2001

In this Issue

INSIDE BLOOD
REVIEW ARTICLES
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

Telomerase and T-cell function

Peter M. Lansdorp

View Articletitled, Telomerase and T-cell function

REVIEW ARTICLES

Nucleotide receptors: an emerging family of regulatory molecules in blood cells

Francesco Di Virgilio,Paola Chiozzi,Davide Ferrari,Simonetta Falzoni,Juana M. Sanz,Anna Morelli,Maurizia Torboli,Giorgio Bolognesi,O. Roberto Baricordi

View Articletitled, Nucleotide receptors: an emerging family of regulatory molecules in blood cells

CHEMOKINES

Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) αβ⁺CD8⁺ single-positive T cells, TCRγδ⁺T cells, and natural killer–type cells in human thymus

Paola Romagnani,Francesco Annunziato,Elena Lazzeri,Lorenzo Cosmi,Chiara Beltrame,Laura Lasagni,Grazia Galli,Michela Francalanci,Roberto Manetti,Fabio Marra,Vittorio Vanini,Enrico Maggi,Sergio Romagnani

View Articletitled, Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) αβ+CD8+ single-positive T cells, TCRγδ+ T cells, and natural killer–type cells in human thymus

SHP2 and cbl participate in α-chemokine receptor CXCR4–mediated signaling pathways

Rebecca D. Chernock,Rama P. Cherla,Ramesh K. Ganju

View Articletitled, SHP2 and cbl participate in α-chemokine receptor CXCR4–mediated signaling pathways

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

A 2-step comprehensive high-dose chemoradiotherapy second-line program for relapsed and refractory Hodgkin disease: analysis by intent to treat and development of a prognostic model
Clinical Trials & Observations

Craig H. Moskowitz,Stephen D. Nimer,Andrew D. Zelenetz,Tania Trippett,Eric E. Hedrick,Daniel A. Filippa,Diane Louie,Maria Gonzales,Janine Walits,Nancy Coady-Lyons,Jing Qin,Richard Frank,Joseph R. Bertino,Andre Goy,Ariela Noy,James P. O'Brien,David Straus,Carol S. Portlock,Joachim Yahalom

View Articletitled, A 2-step comprehensive high-dose chemoradiotherapy second-line program for relapsed and refractory Hodgkin disease: analysis by intent to treat and development of a prognostic model

Prognostic significance of tumor burden in the blood of patients with erythrodermic primary cutaneous T-cell lymphoma
Clinical Trials & Observations

Julia J. Scarisbrick,Sean Whittaker,Alun V. Evans,Elisabeth A. Fraser-Andrews,Fiona J. Child,Alan Dean,Robin Russell-Jones

View Articletitled, Prognostic significance of tumor burden in the blood of patients with erythrodermic primary cutaneous T-cell lymphoma

Melphalan and purine analog–containing preparative regimens: reduced-intensity conditioning for patients with hematologic malignancies undergoing allogeneic progenitor cell transplantation
Clinical Trials & Observations

Sergio Giralt,Peter F. Thall,Issa Khouri,Xuemei Wang,Ira Braunschweig,Cindy Ippolitti,David Claxton,Michele Donato,Jill Bruton,Agueda Cohen,Marilyn Davis,Borje S. Andersson,Paolo Anderlini,James Gajewski,Steven Kornblau,Michael Andreeff,Donna Przepiorka,Naoto T. Ueno,Jeff Molldrem,Richard Champlin

View Articletitled, Melphalan and purine analog–containing preparative regimens: reduced-intensity conditioning for patients with hematologic malignancies undergoing allogeneic progenitor cell transplantation

HEMATOPOIESIS

Investigating the platelet-sparing mechanism of paclitaxel/carboplatin combination chemotherapy

Esther Pertusini,Janina Ratajczak,Marcin Majka,David Vaughn,Mariusz Z. Ratajczak,Alan M. Gewirtz

View Articletitled, Investigating the platelet-sparing mechanism of paclitaxel/carboplatin combination chemotherapy

Inhibitory effect of the transcription factor encoded by the mutant mi microphthalmia allele on transactivation of mouse mast cell protease 7 gene

Hideki Ogihara,Eiichi Morii,Dae-Ki Kim,Keisuke Oboki,Yukihiko Kitamura

View Articletitled, Inhibitory effect of the transcription factor encoded by the mutant mi microphthalmia allele on transactivation of mouse mast cell protease 7 gene

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

CD13/APN is activated by angiogenic signals and is essential for capillary tube formation

Shripad V. Bhagwat,Johanna Lahdenranta,Ricardo Giordano,Wadih Arap,Renata Pasqualini,Linda H. Shapiro

View Articletitled, CD13/APN is activated by angiogenic signals and is essential for capillary tube formation

Changes in the biomechanical properties of neutrophils and endothelial cells during adhesion

Qin Wang,Eddie T. Chiang,Mark Lim,Jean Lai,Rick Rogers,Paul A. Janmey,David Shepro,Claire M. Doerschuk

View Articletitled, Changes in the biomechanical properties of neutrophils and endothelial cells during adhesion

Circulating factor VIII immune complexes in patients with type 2 acquired hemophilia A and protection from activated protein C–mediated proteolysis

Keiji Nogami,Midori Shima,John C. Giddings,Kazuya Hosokawa,Masanori Nagata,Seiki Kamisue,Hiroshi Suzuki,Masaru Shibata,Evgueni L. Saenko,Ichiro Tanaka,Akira Yoshioka

View Articletitled, Circulating factor VIII immune complexes in patients with type 2 acquired hemophilia A and protection from activated protein C–mediated proteolysis

Phosphatidylinositol 3-kinase–dependent translocation of phospholipase Cγ2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation

Régis Bobe,Jonathan I. Wilde,Petra Maschberger,Kanamarlapudi Venkateswarlu,Peter J. Cullen,Wolfgang Siess,Steve P. Watson

View Articletitled, Phosphatidylinositol 3-kinase–dependent translocation of phospholipase Cγ2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation

Hemophilia A mutations associated with 1-stage/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa

Steven W. Pipe,Evgueni L. Saenko,Angela N. Eickhorst,Geoffrey Kemball-Cook,Randal J. Kaufman

View Articletitled, Hemophilia A mutations associated with 1-stage/2-stage activity discrepancy disrupt protein-protein interactions within the triplicated A domains of thrombin-activated factor VIIIa

Oncostatin M promotes biphasic tissue factor expression in smooth muscle cells: evidence for Erk-1/2 activation

Toshiya Nishibe,Graham Parry,Atsushi Ishida,Salim Aziz,Jacqueline Murray,Yatin Patel,Salman Rahman,Kurt Strand,Keiko Saito,Yuji Saito,William P. Hammond,Geoffrey F. Savidge,Nigel Mackman,Errol S. Wijelath

View Articletitled, Oncostatin M promotes biphasic tissue factor expression in smooth muscle cells: evidence for Erk-1/2 activation

IMMUNOBIOLOGY

The flow cytometric analysis of telomere length in antigen-specific CD8⁺ T cells during acute Epstein-Barr virus infection

Fiona J. Plunkett,Maria Vieira D. Soares,Nicola Annels,Andrew Hislop,Kamal Ivory,Mark Lowdell,Mike Salmon,Alan Rickinson,Arne N. Akbar

View Articletitled, The flow cytometric analysis of telomere length in antigen-specific CD8+ T cells during acute Epstein-Barr virus infection

NEOPLASIA

Characterization of novel natural killer (NK)–cell and γδ T-cell lines established from primary lesions of nasal T/NK-cell lymphomas associated with the Epstein-Barr virus

Hiroshi Nagata,Akiyoshi Konno,Nobuhiro Kimura,Yu Zhang,Michiko Kimura,Ayako Demachi,Teruaki Sekine,Kohtaro Yamamoto,Norio Shimizu

View Articletitled, Characterization of novel natural killer (NK)–cell and γδ T-cell lines established from primary lesions of nasal T/NK-cell lymphomas associated with the Epstein-Barr virus

B-cell development in progressively transformed germinal centers: similarities and differences compared with classical germinal centers and lymphocyte-predominant Hodgkin disease

Andreas Bräuninger,Wentao Yang,Hans-Heinrich Wacker,Klaus Rajewsky,Ralf Küppers,Martin-Leo Hansmann

View Articletitled, B-cell development in progressively transformed germinal centers: similarities and differences compared with classical germinal centers and lymphocyte-predominant Hodgkin disease

Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3

Tessa L. Holyoake,Xiaoyan Jiang,Heather G. Jorgensen,Susan Graham,Michael J. Alcorn,Chris Laird,Allen C. Eaves,Connie J. Eaves

View Articletitled, Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3

Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

Marta Chesi,Leslie A. Brents,Sarah A. Ely,Carlos Bais,Davide F. Robbiani,Enrique A. Mesri,W. Michael Kuehl,P. Leif Bergsagel

View Articletitled, Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

Breakage and fusion of the TEL (ETV6) gene in immature B lymphocytes induced by apoptogenic signals

Minenori Eguchi-Ishimae,Mariko Eguchi,Eiichi Ishii,Sumio Miyazaki,Kazuhiro Ueda,Nanao Kamada,Shuki Mizutani

View Articletitled, Breakage and fusion of the TEL (ETV6) gene in immature B lymphocytes induced by apoptogenic signals

Expression profile of MUM1/IRF4, BCL-6, and CD138/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus–related lymphomas

Antonino Carbone,Annunziata Gloghini,Luigi M. Larocca,Daniela Capello,Francesco Pierconti,Vincenzo Canzonieri,Umberto Tirelli,Riccardo Dalla-Favera,Gianluca Gaidano

View Articletitled, Expression profile of MUM1/IRF4, BCL-6, and CD138/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus–related lymphomas

Interleukin-4 variant (BAY 36-1677) selectively induces apoptosis in acute lymphoblastic leukemia cells

Kleebsabai Srivannaboon,Armen B. Shanafelt,Elisabetta Todisco,Carla P. Forte,Frederick G. Behm,Susana C. Raimondi,Ching-Hon Pui,Dario Campana

View Articletitled, Interleukin-4 variant (BAY 36-1677) selectively induces apoptosis in acute lymphoblastic leukemia cells

Retrovirus insertion and transcriptional activation of the multidrug-resistance gene in leukemias treated by a chemotherapeutic agent in vivo

Jun Nagayama,Mayumi Iino,Yasuhiro Tada,Hitoshi Kusaba,Akira Kiue,Koichi Ohshima,Michihiko Kuwano,Morimasa Wada

View Articletitled, Retrovirus insertion and transcriptional activation of the multidrug-resistance gene in leukemias treated by a chemotherapeutic agent in vivo

PHAGOCYTES

A novel syndrome of variant leukocyte adhesion deficiency involving defects in adhesion mediated by β₁ and β₂ integrins

Estelle S. Harris,Ann O. Shigeoka,Wenhua Li,Roberta H. Adams,Stephen M. Prescott,Thomas M. McIntyre,Guy A. Zimmerman,Diane E. Lorant

View Articletitled, A novel syndrome of variant leukocyte adhesion deficiency involving defects in adhesion mediated by β1 and β2 integrins

Plasminogen-mediated matrix invasion and degradation by macrophages is dependent on surface expression of annexin II

Domenick J. Falcone,Wolfgang Borth,K. M. Faisal Khan,Katherine A. Hajjar

View Articletitled, Plasminogen-mediated matrix invasion and degradation by macrophages is dependent on surface expression of annexin II

Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans

Asako Sawano,Shinobu Iwai,Yoshiko Sakurai,Mikito Ito,Kenya Shitara,Tatsutoshi Nakahata,Masabumi Shibuya

View Articletitled, Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans

RED CELLS

Desferrioxamine-chelatable iron, a component of serum non–transferrin-bound iron, used for assessing chelation therapy: Presented in preliminary form at the 10th International Conference on Oral Chelators symposium on iron chelators held in Limassol, Cyprus, March 2000 (Transfusion Science, in press).

William Breuer,Marieke J. J. Ermers,Pensri Pootrakul,Ayala Abramov,Chaim Hershko,Z. Ioav Cabantchik

View Articletitled, Desferrioxamine-chelatable iron, a component of serum non–transferrin-bound iron, used for assessing chelation therapy: Presented in preliminary form at the 10th International Conference on Oral Chelators symposium on iron chelators held in Limassol, Cyprus, March 2000 (Transfusion Science, in press).

TRANSPLANTATION

In vitro migratory capacity of CD34⁺ cells is related to hematopoietic recovery after autologous stem cell transplantation

Carlijn Voermans,Marisha L. K. Kooi,Sjoerd Rodenhuis,Hans van der Lelie,C. Ellen van der Schoot,Winald R. Gerritsen

View Articletitled, In vitro migratory capacity of CD34+ cells is related to hematopoietic recovery after autologous stem cell transplantation

BRIEF REPORTS

Multiplex reverse transcriptase–polymerase chain reaction screening in childhood acute myeloblastic leukemia
Brief Report

Sabine Strehl,Margit König,Georg Mann,Oskar A. Haas

View Articletitled, Multiplex reverse transcriptase–polymerase chain reaction screening in childhood acute myeloblastic leukemia

Full hematopoietic engraftment after allogeneic bone marrow transplantation without cytoreduction in a child with severe combined immunodeficiency
Clinical Trials & Observations Brief Report

Ronald J. Rubocki,Jennifer R. Parsa,Michael S. Hershfield,Warren G. Sanger,Samuel J. Pirruccello,Ines Santisteban,Bruce G. Gordon,Sarah E. Strandjord,Phyllis I. Warkentin,Peter F. Coccia

View Articletitled, Full hematopoietic engraftment after allogeneic bone marrow transplantation without cytoreduction in a child with severe combined immunodeficiency

Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura
Clinical Trials & Observations Brief Report

Giovanni Emilia,Giuseppe Longo,Mario Luppi,Giovanna Gandini,Monica Morselli,Leonardo Ferrara,Sergio Amarri,Katia Cagossi,Giuseppe Torelli

View Articletitled, Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura

Human erythroid porphobilinogen deaminase exists in 2 splice variants
Brief Report

Alexander N. Gubin,Jeffery L. Miller

View Articletitled, Human erythroid porphobilinogen deaminase exists in 2 splice variants

Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions
Brief Report

Ralf Küppers,Andreas Bräuninger,Markus Müschen,Verena Distler,Martin-Leo Hansmann,Klaus Rajewsky

View Articletitled, Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions

Cytogenetic, interphase, and multicolor fluorescence in situ hybridization analyses in primary plasma cell leukemia: a study of 40 patients at diagnosis, on behalf of the Intergroupe Francophone du Myélome and the Groupe Français de Cytogénétique Hématologique
Brief Report

Hervé Avet-Loiseau,Axelle Daviet,Christophe Brigaudeau,Evelyne Callet-Bauchu,Christine Terré,Marina Lafage-Pochitaloff,François Désangles,Sylvie Ramond,Pascaline Talmant,Régis Bataille

View Articletitled, Cytogenetic, interphase, and multicolor fluorescence in situ hybridization analyses in primary plasma cell leukemia: a study of 40 patients at diagnosis, on behalf of the Intergroupe Francophone du Myélome and the Groupe Français de Cytogénétique Hématologique

Macrothrombocytopenia with abnormal demarcation membranes in megakaryocytes and neutropenia with a complete lack of sialyl–Lewis-X antigen in leukocytes—a new syndrome?
Brief Report

Thiebaut-Noel Willig,Jeanine Breton-Gorius,Carole Elbim,Vincent Mignotte,Cecile Kaplan,Rosella Mollicone,Catherine Pasquier,Anne Filipe,Francoise Miélot,Jean-Pierre Cartron,Marie-Anne Gougerot-Pocidalo,Najet Debili,Josette Guichard,Jean-Paul Dommergues,Narla Mohandas,Gil Tchernia

View Articletitled, Macrothrombocytopenia with abnormal demarcation membranes in megakaryocytes and neutropenia with a complete lack of sialyl–Lewis-X antigen in leukocytes—a new syndrome?

CORRESPONDENCE

Granulocyte colony-stimulating factor receptor mutations in a patient with acute lymphoblastic leukemia secondary to severe congenital neutropenia

Manuela Germeshausen,Matthias Ballmaier,Harald Schulze,Karl Welte,Thomas Flohr,Klaus Beiske,Ingebjørg Storm-Mathisen,Tore G. Abrahamsen

View Articletitled, Granulocyte colony-stimulating factor receptor mutations in a patient with acute lymphoblastic leukemia secondary to severe congenital neutropenia

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Issue Archive

Table of Contents

INSIDE BLOOD

REVIEW ARTICLES

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

A 2-step comprehensive high-dose chemoradiotherapy second-line program for relapsed and refractory Hodgkin disease: analysis by intent to treat and development of a prognostic model Clinical Trials & Observations

Prognostic significance of tumor burden in the blood of patients with erythrodermic primary cutaneous T-cell lymphoma Clinical Trials & Observations

Melphalan and purine analog–containing preparative regimens: reduced-intensity conditioning for patients with hematologic malignancies undergoing allogeneic progenitor cell transplantation Clinical Trials & Observations

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

NEOPLASIA

PHAGOCYTES

RED CELLS

TRANSPLANTATION

BRIEF REPORTS

Multiplex reverse transcriptase–polymerase chain reaction screening in childhood acute myeloblastic leukemia Brief Report

Full hematopoietic engraftment after allogeneic bone marrow transplantation without cytoreduction in a child with severe combined immunodeficiency Clinical Trials & Observations Brief Report

Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura Clinical Trials & Observations Brief Report

Human erythroid porphobilinogen deaminase exists in 2 splice variants Brief Report

Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions Brief Report

Cytogenetic, interphase, and multicolor fluorescence in situ hybridization analyses in primary plasma cell leukemia: a study of 40 patients at diagnosis, on behalf of the Intergroupe Francophone du Myélome and the Groupe Français de Cytogénétique Hématologique Brief Report

Macrothrombocytopenia with abnormal demarcation membranes in megakaryocytes and neutropenia with a complete lack of sialyl–Lewis-X antigen in leukocytes—a new syndrome? Brief Report