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Issue Archive

Volume 128, Issue 4
July 28 2016
Issue Cover

Table of Contents

BLOOD FLASHBACK

Dameshek W. Chronic lymphocytic leukemia—an accumulative disease of immunologically incompetent lymphocytes. Blood. 1967;29(4):566-584.
View Articletitled, Dameshek W. Chronic lymphocytic leukemia—an accumulative disease of immunologically incompetent lymphocytes. <em>Blood</em>. 1967;29(4):<span class="related-article">566-584</span>.

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Dampening neutrophil integrins
Rodger P. McEver
View Articletitled, Dampening neutrophil integrins
INSIDE BLOOD COMMENTARY
IL-4 regulates B-cell receptor signaling in CLL
Dimitar G. Efremov
View Articletitled, IL-4 regulates B-cell receptor signaling in CLL
INSIDE BLOOD COMMENTARY
Two strikes against CLL
Rosa Lapalombella
View Articletitled, Two strikes against CLL

BLOOD SPOTLIGHT

Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment
Sarah D. Cramer,Peter D. Aplan,Scott K. Durum
View Articletitled, Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment

REVIEW ARTICLE

The Rap1-RIAM-talin axis of integrin activation and blood cell function
Frederic Lagarrigue,Chungho Kim,Mark H. Ginsberg
View Articletitled, The Rap1-RIAM-talin axis of integrin activation and blood cell function

HOW I TREAT

How I treat acute myeloid leukemia presenting with preexisting comorbidities
Yishai Ofran,Martin S. Tallman,Jacob M. Rowe
View Articletitled, How I treat acute myeloid leukemia presenting with preexisting comorbidities

CLINICAL TRIALS AND OBSERVATIONS

Safety and efficacy of pomalidomide plus low-dose dexamethasone in STRATUS (MM-010): a phase 3b study in refractory multiple myeloma
Clinical Trials & Observations
Meletios A. Dimopoulos,Antonio Palumbo,Paolo Corradini,Michele Cavo,Michel Delforge,Francesco Di Raimondo,Katja C. Weisel,Albert Oriol,Markus Hansson,Angelo Vacca,María Jesús Blanchard,Hartmut Goldschmidt,Chantal Doyen,Martin Kaiser,Mario Petrini,Pekka Anttila,Anna Maria Cafro,Reinier Raymakers,Jesus San-Miguel,Felipe de Arriba,Stefan Knop,Christoph Röllig,Enrique M. Ocio,Gareth Morgan,Neil Miller,Mathew Simcock,Teresa Peluso,Jennifer Herring,Lars Sternas,Mohamed H. Zaki,Philippe Moreau
View Articletitled, Safety and efficacy of pomalidomide plus low-dose dexamethasone in STRATUS (MM-010): a phase 3b study in refractory multiple myeloma
Impact of complete molecular response on survival in patients with Philadelphia chromosome–positive acute lymphoblastic leukemia
Clinical Trials & Observations Brief Report
Nicholas J. Short,Elias Jabbour,Koji Sasaki,Keyur Patel,Susan M. O’Brien,Jorge E. Cortes,Rebecca Garris,Ghayas C. Issa,Guillermo Garcia-Manero,Rajyalakshmi Luthra,Deborah Thomas,Hagop Kantarjian,Farhad Ravandi
View Articletitled, Impact of complete molecular response on survival in patients with Philadelphia chromosome–positive acute lymphoblastic leukemia
Supplemental data

HEMATOPOIESIS AND STEM CELLS

GATA2 regulates dendritic cell differentiation
Koichi Onodera,Tohru Fujiwara,Yasushi Onishi,Ari Itoh-Nakadai,Yoko Okitsu,Noriko Fukuhara,Kenichi Ishizawa,Ritsuko Shimizu,Masayuki Yamamoto,Hideo Harigae
View Articletitled, GATA2 regulates dendritic cell differentiation
Supplemental data

IMMUNOBIOLOGY

Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies
Marianna Sabatino,Jinhui Hu,Michele Sommariva,Sanjivan Gautam,Vicki Fellowes,James D. Hocker,Sean Dougherty,Haiying Qin,Christopher A. Klebanoff,Terry J. Fry,Ronald E. Gress,James N. Kochenderfer,David F. Stroncek,Yun Ji,Luca Gattinoni
View Articletitled, Generation of clinical-grade CD19-specific CAR-modified CD8<sup>+</sup> memory stem cells for the treatment of human B-cell malignancies
Supplemental data
GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimer
Annette Artz,Stefan Butz,Dietmar Vestweber
View Articletitled, GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimer
Supplemental data

LYMPHOID NEOPLASIA

Extracellular vesicles released by CD40/IL-4–stimulated CLL cells confer altered functional properties to CD4+ T cells
Dawn T. Smallwood,Benedetta Apollonio,Shaun Willimott,Larissa Lezina,Afaf Alharthi,Ashley R. Ambrose,Giulia De Rossi,Alan G. Ramsay,Simon D. Wagner
View Articletitled, Extracellular vesicles released by CD40/IL-4–stimulated CLL cells confer altered functional properties to CD4<sup>+</sup> T cells
Supplemental data
IL-4 rescues surface IgM expression in chronic lymphocytic leukemia
Benchang Guo,Lu Zhang,Nicholas Chiorazzi,Thomas L. Rothstein
View Articletitled, IL-4 rescues surface IgM expression in chronic lymphocytic leukemia
Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration
Marta Pasikowska,Elisabeth Walsby,Benedetta Apollonio,Kirsty Cuthill,Elizabeth Phillips,Eve Coulter,Maria Serena Longhi,Yun Ma,Deborah Yallop,Linda D. Barber,Piers Patten,Chris Fegan,Alan G. Ramsay,Chris Pepper,Stephen Devereux,Andrea G. S. Buggins
View Articletitled, Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration
Supplemental data
Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia
Rachel Thijssen,Johanna ter Burg,Brett Garrick,Gregor G. W. van Bochove,Jennifer R. Brown,Stacey M. Fernandes,María Solé Rodríguez,Jean-Marie Michot,Michael Hallek,Barbara Eichhorst,Hans Christian Reinhardt,Johanna Bendell,Ingrid A. M. Derks,Roel J. W. van Kampen,Kristen Hege,Marie José Kersten,Torsten Trowe,Ellen H. Filvaroff,Eric Eldering,Arnon P. Kater
View Articletitled, Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia
Supplemental data

THROMBOSIS AND HEMOSTASIS

Characterization of aberrant splicing of von Willebrand factor in von Willebrand disease: an underrecognized mechanism
Lindsey Hawke,Mackenzie L. Bowman,Man-Chiu Poon,Mary-Frances Scully,Georges-Etienne Rivard,Paula D. James
View Articletitled, Characterization of aberrant splicing of von Willebrand factor in von Willebrand disease: an underrecognized mechanism
Supplemental data

TRANSPLANTATION

Prognostic impact of cytogenetic aberrations in AL amyloidosis patients after high-dose melphalan: a long-term follow-up study
Clinical Trials & Observations
Tilmann Bochtler,Ute Hegenbart,Christina Kunz,Axel Benner,Christoph Kimmich,Anja Seckinger,Dirk Hose,Hartmut Goldschmidt,Martin Granzow,Peter Dreger,Anthony D. Ho,Anna Jauch,Stefan O. Schönland
View Articletitled, Prognostic impact of cytogenetic aberrations in AL amyloidosis patients after high-dose melphalan: a long-term follow-up study
Supplemental data

BLOOD WORK

You GATA look at the marrow!
David Buchbinder,Aaron Sassoon
View Articletitled, You GATA look at the marrow!
CML with complex chromosome rearrangements and dysplastic megakaryocytes
Zhaodong Xu,Jean McGowan-Jordan
View Articletitled, CML with complex chromosome rearrangements and dysplastic megakaryocytes

ERRATA

Schwartz CL, Constine LS, Villaluna D, et al. A risk-adapted, response-based approach using ABVE-PC for children and adolescents with intermediate- and high-risk Hodgkin lymphoma: the results of P9425. Blood. 2009;114(10):2051-2059.
View Articletitled, Schwartz CL, Constine LS, Villaluna D, et al. A risk-adapted, response-based approach using ABVE-PC for children and adolescents with intermediate- and high-risk Hodgkin lymphoma: the results of P9425. <em>Blood.</em> 2009;114(10):2051-2059.
  • Cover Image

    Cover Image

    issue cover

    The confocal image shows CD4+ T cells forming enhanced F-actin (in red) immunological synapse interactions with chronic lymphocytic leukemia (CLL) cells (in blue). Extracellular vesicles released from CD40/IL-4–stimulated CLL cells confer this altered functional property to autologous CD4+ T cells. The cover figure is derived from Figure 4A in the article by Smallwood et al on page 542.

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  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkBack Matter
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