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Issue Archive

Volume 127, Issue 5
February 4 2016
Blood Cover Image for Volume 127, Issue 5

Table of Contents

ANNIVERSARY EDITORIAL

Blood’s 70th anniversary: reflections of a past editor, 1983-1987
John W. Adamson
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BLOOD FLASHBACK

Reissmann KR. Studies on the mechanism of erythropoietic stimulation in parabiotic rats during hypoxia. Blood. 1950;5(4):372-380.
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INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Collagen binding to OSCAR: the odd couple
Bo An,Barbara Brodsky
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INSIDE BLOOD COMMENTARY
Does my patient have HIT? There should be an app for that
Clinical Trials & Observations
Adam Cuker
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INSIDE BLOOD COMMENTARY
Opposite RHOA functions within the ATLL category
Shumpei Ishikawa
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INSIDE BLOOD COMMENTARY
A binding relationship with thrombin
Jerry Ware
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INSIDE BLOOD COMMENTARY
HDL/ApoA-I: role in VWF-dependent thrombosis
Augusto B. Federici
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PLENARY PAPER

IMMUNOBIOLOGY
Structural basis for collagen recognition by the immune receptor OSCAR
Long Zhou,Jennifer M. Hinerman,Michal Blaszczyk,Jeanette L. C. Miller,Deborah G. Conrady,Alexander D. Barrow,Dimitri Y. Chirgadze,Dominique Bihan,Richard W. Farndale,Andrew B. Herr
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Supplemental data

REVIEW ARTICLE

Natural heterogeneity of α2-antiplasmin: functional and clinical consequences
Shiraazkhan Abdul,Frank W. G. Leebeek,Dingeman C. Rijken,Shirley Uitte de Willige
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CLINICAL TRIALS AND OBSERVATIONS

Diagnostic value of immunoassays for heparin-induced thrombocytopenia: a systematic review and meta-analysis
Clinical Trials & Observations
Michael Nagler,Lucas M. Bachmann,Hugo ten Cate,Arina ten Cate-Hoek
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Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia
Clinical Trials & Observations
Seth E. Karol,Leonard A. Mattano, Jr,Wenjian Yang,Kelly W. Maloney,Colton Smith,ChengCheng Liu,Laura B. Ramsey,Christian A. Fernandez,Tamara Y. Chang,Geoffrey Neale,Cheng Cheng,Elaine Mardis,Robert Fulton,Paul Scheet,F. Anthony San Lucas,Eric C. Larsen,Mignon L. Loh,Elizabeth A. Raetz,Stephen P. Hunger,Meenakshi Devidas,Mary V. Relling
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GENE THERAPY

Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII
Oscar A. Marcos-Contreras,Shannon M. Smith,Dwight A. Bellinger,Robin A. Raymer,Elizabeth Merricks,Armida Faella,Giulia Pavani,Shangzhen Zhou,Timothy C. Nichols,Katherine A. High,Paris Margaritis
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HEMATOPOIESIS AND STEM CELLS

Essential control of early B-cell development by Mef2 transcription factors
Julia Herglotz,Ludmilla Unrau,Friderike Hauschildt,Meike Fischer,Neele Kriebitzsch,Malik Alawi,Daniela Indenbirken,Michael Spohn,Ursula Müller,Marion Ziegler,Wolfgang Schuh,Hans-Martin Jäck,Carol Stocking
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LYMPHOID NEOPLASIA

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells
Marwan Kwok,Nicholas Davies,Angelo Agathanggelou,Edward Smith,Ceri Oldreive,Eva Petermann,Grant Stewart,Jeff Brown,Alan Lau,Guy Pratt,Helen Parry,Malcolm Taylor,Paul Moss,Peter Hillmen,Tatjana Stankovic
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Variegated RHOA mutations in adult T-cell leukemia/lymphoma
Yasunobu Nagata,Kenji Kontani,Terukazu Enami,Keisuke Kataoka,Ryohei Ishii,Yasushi Totoki,Tatsuki R. Kataoka,Masahiro Hirata,Kazuhiro Aoki,Kazumi Nakano,Akira Kitanaka,Mamiko Sakata-Yanagimoto,Sachiko Egami,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Yusuke Shiozawa,Tetsuichi Yoshizato,Hiromichi Suzuki,Ayana Kon,Kenichi Yoshida,Yusuke Sato,Aiko Sato-Otsubo,Masashi Sanada,Wataru Munakata,Hiromi Nakamura,Natsuko Hama,Satoru Miyano,Osamu Nureki,Tatsuhiro Shibata,Hironori Haga,Kazuya Shimoda,Toshiaki Katada,Shigeru Chiba,Toshiki Watanabe,Seishi Ogawa
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Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma
Nitin K. Agarwal,Chae H. Kim,Kranthi Kunkalla,Hiroyasu Konno,Youley Tjendra,Deukwoo Kwon,Marzenna Blonska,Goldi A. Kozloski,Vincent T. Moy,Ramiro E. Verdun,Glen N. Barber,Izidore S. Lossos,Francisco Vega
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MYELOID NEOPLASIA

Targeting of the bone marrow microenvironment improves outcome in a murine model of myelodysplastic syndrome
Sophia R. Balderman,Allison J. Li,Corey M. Hoffman,Benjamin J. Frisch,Alexandra N. Goodman,Mark W. LaMere,Mary A. Georger,Andrew G. Evans,Jane L. Liesveld,Michael W. Becker,Laura M. Calvi
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PLATELETS AND THROMBOPOIESIS

Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation
Brian Estevez,Kyungho Kim,M. Keegan Delaney,Aleksandra Stojanovic-Terpo,Bo Shen,Changgeng Ruan,Jaehyung Cho,Zaverio M. Ruggeri,Xiaoping Du
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THROMBOSIS AND HEMOSTASIS

High-density lipoprotein modulates thrombosis by preventing von Willebrand factor self-association and subsequent platelet adhesion
Dominic W. Chung,Junmei Chen,Minhua Ling,Xiaoyun Fu,Teri Blevins,Scott Parsons,Jennie Le,Jeff Harris,Thomas R. Martin,Barbara A. Konkle,Ying Zheng,José A. López
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TRANSPLANTATION

Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD
Ana C. Alho,Haesook T. Kim,Marie J. Chammas,Carol G. Reynolds,Tiago R. Matos,Edouard Forcade,Jennifer Whangbo,Sarah Nikiforow,Corey S. Cutler,John Koreth,Vincent T. Ho,Philippe Armand,Joseph H. Antin,Edwin P. Alyea,Joao F. Lacerda,Robert J. Soiffer,Jerome Ritz
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LETTERS TO BLOOD

Lack of association between blood donor age and survival of transfused patients
Senthil K. Vasan,Flaminia Chiesa,Klaus Rostgaard,Patrik K. E. Magnusson,Märit Halmin,Kaspar René Nielsen,Kjell Einar Titlestad,Henrik Hjalgrim,Gustaf Edgren
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BLOOD WORK

Morphology in mucopolysaccharidosis type III: specific diagnostic features
Robin M. Ireland
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  • Cover Image

    Cover Image

    issue cover

    The osteoclast-associated receptor (OSCAR) is a collagen-binding immune receptor expressed on osteoclasts, monocytes, and dendritic cells. The crystal structure of OSCAR (white surface) is shown bound to a consensus collagen triple-helical peptide (blue coils). Mutagenesis of tyrosine residues Tyr-137, Tyr-171, and Tyr-179 (yellow) to phenylalanine-disrupted binding of the collagen peptide, indicating that the C-terminal Ig-like domain contains the primary collagen-binding site. See the article by Zhou et al on page 529.

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