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Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1
How I treat high-risk myeloma
Low forced expiratory volume is associated with earlier death in sickle cell anemia
The effect of long-term ruxolitinib treatment on JAK2p.V617F allele burden in patients with myelofibrosis
Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study
Issue Archive
Table of Contents
INSIDE BLOOD COMMENTARIES
PLENARY PAPER
IMMUNOBIOLOGY
Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1
Clinical Trials & Observations
Julien Record,Dessislava Malinova,Helen L. Zenner,Vincent Plagnol,Karolin Nowak,Farhatullah Syed,Gerben Bouma,James Curtis,Kimberly Gilmour,Catherine Cale,Scott Hackett,Guillaume Charras,Dale Moulding,Sergey Nejentsev,Adrian J. Thrasher,Siobhan O. Burns
HOW I TREAT
How I treat high-risk myeloma
Clinical Trials & Observations
CLINICAL TRIALS AND OBSERVATIONS
Low forced expiratory volume is associated with earlier death in sickle cell anemia
Clinical Trials & Observations
The effect of long-term ruxolitinib treatment on JAK2p.V617F allele burden in patients with myelofibrosis
Clinical Trials & Observations
Brief Report
LYMPHOID NEOPLASIA
Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib
Baohua Sun,Bhavin Shah,Warren Fiskus,Jun Qi,Kimal Rajapakshe,Cristian Coarfa,Li Li,Santhana G. T. Devaraj,Sunil Sharma,Liang Zhang,Michael L. Wang,Dyana T. Saenz,Stephanie Krieger,James E. Bradner,Kapil N. Bhalla
MYELOID NEOPLASIA
Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study
Clinical Trials & Observations
Hiroto Inaba,Yinmei Zhou,Oussama Abla,Souichi Adachi,Anne Auvrignon,H. Berna Beverloo,Eveline de Bont,Tai-Tsung Chang,Ursula Creutzig,Michael Dworzak,Sarah Elitzur,Alcira Fynn,Erik Forestier,Henrik Hasle,Der-Cherng Liang,Vincent Lee,Franco Locatelli,Riccardo Masetti,Barbara De Moerloose,Dirk Reinhardt,Laura Rodriguez,Nadine Van Roy,Shuhong Shen,Takashi Taga,Daisuke Tomizawa,Allen E. J. Yeoh,Martin Zimmermann,Susana C. Raimondi
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects
Kate H. Gartlan,Kate A. Markey,Antiopi Varelias,Mark D. Bunting,Motoko Koyama,Rachel D. Kuns,Neil C. Raffelt,Stuart D. Olver,Katie E. Lineburg,Melody Cheong,Bianca E. Teal,Mary Lor,Iain Comerford,Michele W. L. Teng,Mark J. Smyth,James McCluskey,Jamie Rossjohn,Brigitta Stockinger,Glen M. Boyle,Steven W. Lane,Andrew D. Clouston,Shaun R. McColl,Kelli P. A. MacDonald,Geoffrey R. Hill
GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells
Brent H. Koehn,Petya Apostolova,Jessica M. Haverkamp,Jeffrey S. Miller,Valarie McCullar,Jakub Tolar,David H. Munn,William J. Murphy,Willie June Brickey,Jonathan S. Serody,Dmitry I. Gabrilovich,Vincenzo Bronte,Peter J. Murray,Jenny P.-Y. Ting,Robert Zeiser,Bruce R. Blazar
BLOOD WORK
CORRESPONDENCE
U-shaped mortality curve associated with platelet count among older people: a community-based cohort study
Ming-Tsun Tsai,on behalf of the Taiwan Geriatric Kidney Disease Research Group,Yung-Tai Chen,on behalf of the Taiwan Geriatric Kidney Disease Research Group,Chi-Hung Lin,on behalf of the Taiwan Geriatric Kidney Disease Research Group,Tung-Po Huang,on behalf of the Taiwan Geriatric Kidney Disease Research Group,Der-Cherng Tarng,on behalf of the Taiwan Geriatric Kidney Disease Research Group
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Cover Image
Cover Image
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Podosomes are dense F-actin structures (green) surrounded by vinculin rings (red) that are formed in monocytes, macrophages, and dendritic cells during migration. Treatment of the human monocytic THP1 cell line with control scrambled short hairpin RNA (shRNA) does not perturb podosome formation. However, cells treated with shRNA against the transcriptional regulator MKL1 have very little F-actin and are unable to form podosomes. See the article by Record et al on page 1527.
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