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Issue Archive

Volume 125, Issue 16
April 16 2015
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Finally moving forward in adult ALL
Clinical Trials & Observations
Mark R. Litzow
View Articletitled, Finally moving forward in adult ALL
INSIDE BLOOD COMMENTARY
Three years of ibrutinib in CLL
Clinical Trials & Observations
Francesco Forconi
View Articletitled, Three years of ibrutinib in CLL
INSIDE BLOOD COMMENTARY
TIF-IA and Ebp1 regulate RNA synthesis in T cells
Aurore Saudemont
View Articletitled, TIF-IA and Ebp1 regulate RNA synthesis in T cells
INSIDE BLOOD COMMENTARY
The traumatic side of fibrinolysis
Robert L. Medcalf
View Articletitled, The traumatic side of fibrinolysis
INSIDE BLOOD COMMENTARY
Platelets: connecting clotting and lysis
Paul Y. Kim
View Articletitled, Platelets: connecting clotting and lysis

PERSPECTIVES

Current challenges in clinical development of “targeted therapies”: the case of acute myeloid leukemia
Clinical Trials & Observations
Elihu Estey,Ross L. Levine,Bob Löwenberg
View Articletitled, Current challenges in clinical development of “targeted therapies”: the case of acute myeloid leukemia

BLOOD FORUM

The role of hematologists in a changing United States health care system
Paul J. Wallace,Nathan T. Connell,Janis L. Abkowitz
View Articletitled, The role of hematologists in a changing United States health care system

BLOOD SPOTLIGHT

Lenalidomide in non-Hodgkin lymphoma: biological perspectives and therapeutic opportunities
Clinical Trials & Observations
Athena Kritharis,Michael Coyle,Jaya Sharma,Andrew M. Evens
View Articletitled, Lenalidomide in non-Hodgkin lymphoma: biological perspectives and therapeutic opportunities
Supplemental data

HOW I TREAT

How I treat mixed-phenotype acute leukemia
Clinical Trials & Observations
Ofir Wolach,Richard M. Stone
View Articletitled, How I treat mixed-phenotype acute leukemia

CLINICAL TRIALS AND OBSERVATIONS

Role of allogeneic stem cell transplantation in adult patients with Ph-negative acute lymphoblastic leukemia
CME Clinical Trials & Observations
Nathalie Dhédin,Anne Huynh,Sébastien Maury,Reza Tabrizi,Kheira Beldjord,Vahid Asnafi,Xavier Thomas,Patrice Chevallier,Stéphanie Nguyen,Valérie Coiteux,Jean-Henri Bourhis,Yosr Hichri,Martine Escoffre-Barbe,Oumedaly Reman,Carlos Graux,Yves Chalandon,Didier Blaise,Urs Schanz,Véronique Lhéritier,Jean-Yves Cahn,Hervé Dombret,Norbert Ifrah,on behalf of the GRAALL group
View Articletitled, Role of allogeneic stem cell transplantation in adult patients with Ph-negative acute lymphoblastic leukemia
Supplemental data
Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib
Clinical Trials & Observations
John C. Byrd,Richard R. Furman,Steven E. Coutre,Jan A. Burger,Kristie A. Blum,Morton Coleman,William G. Wierda,Jeffrey A. Jones,Weiqiang Zhao,Nyla A. Heerema,Amy J. Johnson,Yun Shaw,Elizabeth Bilotti,Cathy Zhou,Danelle F. James,Susan O'Brien
View Articletitled, Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib
Supplemental data

IMMUNOBIOLOGY

DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia
Alexandre Bignon,Alexis Régent,Laurence Klipfel,Aude Desnoyer,Pierre de la Grange,Valérie Martinez,Olivier Lortholary,Ali Dalloul,Luc Mouthon,Karl Balabanian
View Articletitled, DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia
Supplemental data
Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1
Le Xuan Truong Nguyen,Yunqin Lee,Lenore Urbani,Paul J. Utz,Anne W. Hamburger,John B. Sunwoo,Beverly S. Mitchell
View Articletitled, Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1
Supplemental data

LYMPHOID NEOPLASIA

Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation
Lapo Alinari,Kiran V. Mahasenan,Fengting Yan,Vrajesh Karkhanis,Ji-Hyun Chung,Emily M. Smith,Carl Quinion,Porsha L. Smith,Lisa Kim,John T. Patton,Rosa Lapalombella,Bo Yu,Yun Wu,Satavisha Roy,Alessandra De Leo,Stefano Pileri,Claudio Agostinelli,Leona Ayers,James E. Bradner,Selina Chen-Kiang,Olivier Elemento,Tasneem Motiwala,Sarmila Majumder,John C. Byrd,Samson Jacob,Said Sif,Chenglong Li,Robert A. Baiocchi
View Articletitled, Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation
Supplemental data

MYELOID NEOPLASIA

MEIS1 regulates an HLF–oxidative stress axis in MLL-fusion gene leukemia
Jayeeta Roychoudhury,Jason P. Clark,Gabriel Gracia-Maldonado,Zeenath Unnisa,Mark Wunderlich,Kevin A. Link,Nupur Dasgupta,Bruce Aronow,Gang Huang,James C. Mulloy,Ashish R. Kumar
View Articletitled, MEIS1 regulates an HLF–oxidative stress axis in MLL-fusion gene leukemia
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Elucidation of the EP defect in Diamond-Blackfan anemia by characterization and prospective isolation of human EPs
Brief Report
Deena Iskander,Bethan Psaila,Gareth Gerrard,Aristeidis Chaidos,Hui En Foong,Yvonne Harrington,Leena C. Karnik,Irene Roberts,Josu de la Fuente,Anastasios Karadimitris
View Articletitled, Elucidation of the EP defect in Diamond-Blackfan anemia by characterization and prospective isolation of human EPs
Supplemental data

THROMBOSIS AND HEMOSTASIS

Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice
Nuha Hijazi,Rami Abu Fanne,Rinat Abramovitch,Serge Yarovoi,Muhamed Higazi,Suhair Abdeen,Maamon Basheer,Emad Maraga,Douglas B. Cines,Abd Al-Roof Higazi
View Articletitled, Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice
Supplemental data
Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow
Claire S. Whyte,Frauke Swieringa,Tom G. Mastenbroek,Ausra S. Lionikiene,Marcus D. Lancé,Paola E. J. van der Meijden,Johan W. M. Heemskerk,Nicola J. Mutch
View Articletitled, Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow
Supplemental data

TRANSPLANTATION

Prognostic value of FDG-PET prior to autologous stem cell transplantation for relapsed and refractory diffuse large B-cell lymphoma
Clinical Trials & Observations Brief Report
Craig S. Sauter,Matthew J. Matasar,Jessica Meikle,Heiko Schoder,Gary A. Ulaner,Jocelyn C. Migliacci,Patrick Hilden,Sean M. Devlin,Andrew D. Zelenetz,Craig H. Moskowitz
View Articletitled, Prognostic value of FDG-PET prior to autologous stem cell transplantation for relapsed and refractory diffuse large B-cell lymphoma

BLOOD WORK

Concurrent copper and iron deficiency in a gastric bypass patient: a great mimicker of MDS
Rebecca J. Sonu,Hooman H. Rashidi
View Articletitled, Concurrent copper and iron deficiency in a gastric bypass patient: a great mimicker of MDS

ERRATA

Verneris MR, Karami M, Baker J, Jayaswal A, Negrin RS. Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells. Blood. 2004;103(8):3065-3072.
View Articletitled, Verneris MR, Karami M, Baker J, Jayaswal A, Negrin RS. Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8<sup>+</sup> T cells. <em>Blood</em>. 2004;103(8):3065-3072.
Hanna J, Mussaffi H, Steuer G, et al. Functional aberrant expression of CCR2 receptor on chronically activated NK cells in patients with TAP-2 deficiency. Blood. 2005;106(10):3465-3473.
View Articletitled, Hanna J, Mussaffi H, Steuer G, et al. Functional aberrant expression of CCR2 receptor on chronically activated NK cells in patients with TAP-2 deficiency. <em>Blood</em>. 2005;106(10):3465-3473.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

SCT in high-risk Ph-negative adult ALL
CME
View Articletitled, SCT in high-risk Ph-negative adult ALL
All Issues

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Asciminib is a novel inhibitor of ABL1 and ABL2 gene fusions in ALL but requires the ABL SH3 domain for efficacy
NGS-based stratification refines the risk stratification in T-ALL and identifies a Very High-Risk subgroup of patients
Foxo1 is an iron-responsive transcriptional factor regulating systemic iron homeostasis
How I Treat Low-risk Polycythemia Vera Patients who Require Cytoreduction
How I manage major hemorrhage

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