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Issue Archive

Volume 123, Issue 3
January 16 2014
Issue Cover

Table of Contents

INSIDE BLOOD

INSIDE BLOOD
Of mice, men, and HTLV-1
Madeleine Duc Dodon
View Articletitled, Of mice, men, and HTLV-1
CLINICAL TRIALS & OBSERVATIONS
A longer acting rFVIII, safe and effective
Clinical Trials & Observations
Jeanne M. Lusher
View Articletitled, A longer acting rFVIII, safe and effective
INSIDE BLOOD
Determining the significance of MGUS
Giampaolo Merlini
View Articletitled, Determining the significance of MGUS
PHAGOCYTES, GRANULOCYTES, & MYELOPOIESIS
Neutrophil survival in the death zone
Ben A. Croker
View Articletitled, Neutrophil survival in the death zone
THROMBOSIS & HEMOSTASIS
Preventing pregnancy loss
Jean M. Connors
View Articletitled, Preventing pregnancy loss
TRANSPLANTATION
New molecule for mobilizing marrow stem cells
Sakura Hosoba,Edmund K. Waller
View Articletitled, New molecule for mobilizing marrow stem cells
VASCULAR BIOLOGY
Secreting von Willebrand factor in a Gα-SNAP
Brant E. Isakson
View Articletitled, Secreting von Willebrand factor in a G<strong>α</strong>-SNAP

BLOOD WORK

Refractory anemia with ring sideroblasts associated with thrombocytosis (RARS-T)
Muhajir Mohamed
View Articletitled, Refractory anemia with ring sideroblasts associated with thrombocytosis (RARS-T)
Acute myeloid leukemia relapse first presenting in the cerebrospinal fluid
Cyrus C. Hsia,Alejandro Lazo-Langner
View Articletitled, Acute myeloid leukemia relapse first presenting in the cerebrospinal fluid

PLENARY PAPER

Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A
Clinical Trials & Observations
Johnny Mahlangu,Jerry S. Powell,Margaret V. Ragni,Pratima Chowdary,Neil C. Josephson,Ingrid Pabinger,Hideji Hanabusa,Naresh Gupta,Roshni Kulkarni,Patrick Fogarty,David Perry,Amy Shapiro,K. John Pasi,Shashikant Apte,Ivan Nestorov,Haiyan Jiang,Shuanglian Li,Srividya Neelakantan,Lynda M. Cristiano,Jaya Goyal,Jurg M. Sommer,Jennifer A. Dumont,Nigel Dodd,Karen Nugent,Gloria Vigliani,Alvin Luk,Aoife Brennan,Glenn F. Pierce,for the A-LONG Investigators
View Articletitled, Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A
Supplemental data

HOW I TREAT

How I treat unexplained refractory iron deficiency anemia
Chaim Hershko,Clara Camaschella
View Articletitled, How I treat unexplained refractory iron deficiency anemia

CLINICAL TRIALS AND OBSERVATIONS

Early assessment of minimal residual disease identifies patients at very high relapse risk in NPM-ALK–positive anaplastic large-cell lymphoma
Clinical Trials & Observations Brief Report
Christine Damm-Welk,Lara Mussolin,Martin Zimmermann,Marta Pillon,Wolfram Klapper,Ilske Oschlies,Emanuele S. G. d’Amore,Alfred Reiter,Wilhelm Woessmann,Angelo Rosolen
View Articletitled, Early assessment of minimal residual disease identifies patients at very high relapse risk in <em>NPM-ALK</em>–positive anaplastic large-cell lymphoma
Supplemental data

LYMPHOID NEOPLASIA

Monoclonal gammopathy of undetermined significance and risk of lymphoid and myeloid malignancies: 728 cases followed up to 30 years in Sweden
CME
Ingemar Turesson,Stephanie A. Kovalchik,Ruth M. Pfeiffer,Sigurdur Y. Kristinsson,Lynn R. Goldin,Mark T. Drayson,Ola Landgren
View Articletitled, Monoclonal gammopathy of undetermined significance and risk of lymphoid and myeloid malignancies: 728 cases followed up to 30 years in Sweden
Supplemental data
An animal model of adult T-cell leukemia: humanized mice with HTLV-1–specific immunity
Kenta Tezuka,Runze Xun,Mami Tei,Takaharu Ueno,Masakazu Tanaka,Norihiro Takenouchi,Jun-ichi Fujisawa
View Articletitled, An animal model of adult T-cell leukemia: humanized mice with HTLV-1–specific immunity
Supplemental data

MYELOID NEOPLASIA

CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell–engaging antibody AMG 330
Christina Krupka,Peter Kufer,Roman Kischel,Gerhard Zugmaier,Jan Bögeholz,Thomas Köhnke,Felix S. Lichtenegger,Stephanie Schneider,Klaus H. Metzeler,Michael Fiegl,Karsten Spiekermann,Patrick A. Baeuerle,Wolfgang Hiddemann,Gert Riethmüller,Marion Subklewe
View Articletitled, CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell–engaging antibody AMG 330
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish
A. A. Roger Thompson,Philip M. Elks,Helen M. Marriott,Suttida Eamsamarng,Kathryn R. Higgins,Amy Lewis,Lynne Williams,Selina Parmar,Gary Shaw,Emmet E. McGrath,Federico Formenti,Fredericus J. Van Eeden,Vuokko L. Kinnula,Christopher W. Pugh,Ian Sabroe,David H. Dockrell,Edwin R. Chilvers,Peter A. Robbins,Melanie J. Percy,M. Celeste Simon,Randall S. Johnson,Stephen A. Renshaw,Moira K. B. Whyte,Sarah R. Walmsley
View Articletitled, Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease
John D. Belcher,Chunsheng Chen,Julia Nguyen,Liming Milbauer,Fuad Abdulla,Abdu I. Alayash,Ann Smith,Karl A. Nath,Robert P. Hebbel,Gregory M. Vercellotti
View Articletitled, Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease
Supplemental data
RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling
Brief Report
Katarina Kapralova,Lucie Lanikova,Felipe Lorenzo,Jihyun Song,Monika Horvathova,Vladimir Divoky,Josef T. Prchal
View Articletitled, <em>RUNX1</em> and <em>NF-E2</em> upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling

THROMBOSIS AND HEMOSTASIS

Platelet gene therapy corrects the hemophilic phenotype in immunocompromised hemophilia A mice transplanted with genetically manipulated human cord blood stem cells
Qizhen Shi,Erin L. Kuether,Yingyu Chen,Jocelyn A. Schroeder,Scot A. Fahs,Robert R. Montgomery
View Articletitled, Platelet gene therapy corrects the hemophilic phenotype in immunocompromised hemophilia A mice transplanted with genetically manipulated human cord blood stem cells
Supplemental data
Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH-APS observational study
Sylvie Bouvier,Éva Cochery-Nouvellon,Géraldine Lavigne-Lissalde,Érick Mercier,Tess Marchetti,Jean-Pierre Balducchi,Pierre Marès,Jean-Christophe Gris
View Articletitled, Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH-APS observational study
Comparative incidence of pregnancy outcomes in thrombophilia-positive women from the NOH-APS observational study
Sylvie Bouvier,Éva Cochery-Nouvellon,Géraldine Lavigne-Lissalde,Érick Mercier,Pascale Fabbro-Peray,Jean-Pierre Balducchi,Pierre Marès,Jean-Christophe Gris
View Articletitled, Comparative incidence of pregnancy outcomes in thrombophilia-positive women from the NOH-APS observational study

TRANSFUSION MEDICINE

Allogeneic platelet transfusions prevent murine T-cell–mediated immune thrombocytopenia
Li Guo,Lei Yang,Edwin R. Speck,Rukhsana Aslam,Michael Kim,Christopher G. J. McKenzie,Alan H. Lazarus,Heyu Ni,Ming Hou,John Freedman,John W. Semple
View Articletitled, Allogeneic platelet transfusions prevent murine T-cell–mediated immune thrombocytopenia
Supplemental data

TRANSPLANTATION

Small molecule Me6TREN mobilizes hematopoietic stem/progenitor cells by activating MMP-9 expression and disrupting SDF-1/CXCR4 axis
Jing Zhang,Xiangliang Ren,Wei Shi,Sihan Wang,Haixu Chen,Bowen Zhang,Zhidong Wang,Yong Zhou,Lin Chen,Rui Zhang,Yang Lv,Junnian Zhou,Xue Nan,Lijuan He,Wen Yue,Yanhua Li,Xuetao Pei
View Articletitled, Small molecule Me6TREN mobilizes hematopoietic stem/progenitor cells by activating MMP-9 expression and disrupting SDF-1/CXCR4 axis
Supplemental data

VASCULAR BIOLOGY

G protein–dependent basal and evoked endothelial cell vWF secretion
Luiza Rusu,Alexandra Andreeva,David J. Visintine,Kyungho Kim,Stephen M. Vogel,Aleksandra Stojanovic-Terpo,Olga Chernaya,Guoquan Liu,Farnaz R. Bakhshi,Sandra L. Haberichter,Hiroko Iwanari,Osamu Kusano-Arai,Nobuchika Suzuki,Takao Hamakubo,Tohru Kozasa,Jaehyung Cho,Xiaoping Du,Richard D. Minshall
View Articletitled, G protein–dependent basal and evoked endothelial cell vWF secretion
Supplemental data

CORRESPONDENCE

Patient-reported outcomes for the myelodysplastic syndromes: a new MDS-specific measure of quality of life
Clinical Trials & Observations
Gregory A. Abel,Robert Klaassen,Stephanie J. Lee,Nancy L. Young,Laura Cannella,David P. Steensma,Fabio Efficace
View Articletitled, Patient-reported outcomes for the myelodysplastic syndromes: a new MDS-specific measure of quality of life
A highly specific blood test for vCJD
Graham S. Jackson,Jesse Burk-Rafel,Julie A. Edgeworth,Anita Sicilia,Sabah Abdilahi,Justine Korteweg,Jonathan Mackey,Claire Thomas,Guosu Wang,Simon Mead,John Collinge
View Articletitled, A highly specific blood test for vCJD
Application of CIBMTR risk score to NIH chronic GVHD at individual centers
Yoshihiro Inamoto,Dennis D. Kim,Barry E. Storer,Joon Ho Moon,Jeffrey H. Lipton,John Kuruvilla,Paul J. Martin,Mary E. D. Flowers
View Articletitled, Application of CIBMTR risk score to NIH chronic GVHD at individual centers

ERRATA

Gorska MM, Alam R. A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia. Blood. 2012;119(6):1399-1406.
View Articletitled, Gorska MM, Alam R. A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia. <em>Blood</em>. 2012;119(6):<span class="related-article">1399-1406</span>.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

MGUS and risk of progression
CME
View Articletitled, MGUS and risk of progression
  • Cover Image

    Cover Image

    issue cover

    Confocal image of von Willebrand factor (vWF), immunostaining (green), and DAPI nuclear staining (blue) in endothelial-cell Weibel-Palade bodies (WPBs) (Zeiss LSM510: 63× 1.2 NA objective; 405/488 nm ex lasers; 2048 × 2048 pixel image size; and pinhole set to achieve 1 Airy unit). The authors describe the role of Ga12 and Gaq/11 in RhoA- and Ca2+/a-SNAP–dependent mobilization and fusion of WPBs. They demonstrate that direct interaction of Gα12 with α-SNAP serves as a catalyst for basal and evoked vWF secretion. See the article by Rusu et al on page 442.

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