Johnny Mahlangu,for the A-LONG Investigators,Jerry S. Powell,for the A-LONG Investigators,Margaret V. Ragni,for the A-LONG Investigators,Pratima Chowdary,for the A-LONG Investigators,Neil C. Josephson,for the A-LONG Investigators,Ingrid Pabinger,for the A-LONG Investigators,Hideji Hanabusa,for the A-LONG Investigators,Naresh Gupta,for the A-LONG Investigators,Roshni Kulkarni,for the A-LONG Investigators,Patrick Fogarty,for the A-LONG Investigators,David Perry,for the A-LONG Investigators,Amy Shapiro,for the A-LONG Investigators,K. John Pasi,for the A-LONG Investigators,Shashikant Apte,for the A-LONG Investigators,Ivan Nestorov,for the A-LONG Investigators,Haiyan Jiang,for the A-LONG Investigators,Shuanglian Li,for the A-LONG Investigators,Srividya Neelakantan,for the A-LONG Investigators,Lynda M. Cristiano,for the A-LONG Investigators,Jaya Goyal,for the A-LONG Investigators,Jurg M. Sommer,for the A-LONG Investigators,Jennifer A. Dumont,for the A-LONG Investigators,Nigel Dodd,for the A-LONG Investigators,Karen Nugent,for the A-LONG Investigators,Gloria Vigliani,for the A-LONG Investigators,Alvin Luk,for the A-LONG Investigators,Aoife Brennan,for the A-LONG Investigators,Glenn F. Pierce,for the A-LONG Investigators

View Articletitled, Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A

Supplemental data

HOW I TREAT

How I treat unexplained refractory iron deficiency anemia

Chaim Hershko,Clara Camaschella

View Articletitled, How I treat unexplained refractory iron deficiency anemia

CLINICAL TRIALS AND OBSERVATIONS

Early assessment of minimal residual disease identifies patients at very high relapse risk in NPM-ALK–positive anaplastic large-cell lymphoma
Clinical Trials & Observations Brief Report

Christine Damm-Welk,Lara Mussolin,Martin Zimmermann,Marta Pillon,Wolfram Klapper,Ilske Oschlies,Emanuele S. G. d’Amore,Alfred Reiter,Wilhelm Woessmann,Angelo Rosolen

View Articletitled, Early assessment of minimal residual disease identifies patients at very high relapse risk in NPM-ALK–positive anaplastic large-cell lymphoma

Supplemental data

LYMPHOID NEOPLASIA

Monoclonal gammopathy of undetermined significance and risk of lymphoid and myeloid malignancies: 728 cases followed up to 30 years in Sweden
CME

Ingemar Turesson,Stephanie A. Kovalchik,Ruth M. Pfeiffer,Sigurdur Y. Kristinsson,Lynn R. Goldin,Mark T. Drayson,Ola Landgren

View Articletitled, Monoclonal gammopathy of undetermined significance and risk of lymphoid and myeloid malignancies: 728 cases followed up to 30 years in Sweden

Supplemental data

An animal model of adult T-cell leukemia: humanized mice with HTLV-1–specific immunity

Kenta Tezuka,Runze Xun,Mami Tei,Takaharu Ueno,Masakazu Tanaka,Norihiro Takenouchi,Jun-ichi Fujisawa

View Articletitled, An animal model of adult T-cell leukemia: humanized mice with HTLV-1–specific immunity

Supplemental data

MYELOID NEOPLASIA

CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell–engaging antibody AMG 330

Christina Krupka,Peter Kufer,Roman Kischel,Gerhard Zugmaier,Jan Bögeholz,Thomas Köhnke,Felix S. Lichtenegger,Stephanie Schneider,Klaus H. Metzeler,Michael Fiegl,Karsten Spiekermann,Patrick A. Baeuerle,Wolfgang Hiddemann,Gert Riethmüller,Marion Subklewe

View Articletitled, CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell–engaging antibody AMG 330

Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish

A. A. Roger Thompson,Philip M. Elks,Helen M. Marriott,Suttida Eamsamarng,Kathryn R. Higgins,Amy Lewis,Lynne Williams,Selina Parmar,Gary Shaw,Emmet E. McGrath,Federico Formenti,Fredericus J. Van Eeden,Vuokko L. Kinnula,Christopher W. Pugh,Ian Sabroe,David H. Dockrell,Edwin R. Chilvers,Peter A. Robbins,Melanie J. Percy,M. Celeste Simon,Randall S. Johnson,Stephen A. Renshaw,Moira K. B. Whyte,Sarah R. Walmsley

View Articletitled, Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish

Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

John D. Belcher,Chunsheng Chen,Julia Nguyen,Liming Milbauer,Fuad Abdulla,Abdu I. Alayash,Ann Smith,Karl A. Nath,Robert P. Hebbel,Gregory M. Vercellotti

View Articletitled, Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

Supplemental data

RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling
Brief Report

Katarina Kapralova,Lucie Lanikova,Felipe Lorenzo,Jihyun Song,Monika Horvathova,Vladimir Divoky,Josef T. Prchal

View Articletitled, RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling

THROMBOSIS AND HEMOSTASIS

Platelet gene therapy corrects the hemophilic phenotype in immunocompromised hemophilia A mice transplanted with genetically manipulated human cord blood stem cells

Qizhen Shi,Erin L. Kuether,Yingyu Chen,Jocelyn A. Schroeder,Scot A. Fahs,Robert R. Montgomery

View Articletitled, Platelet gene therapy corrects the hemophilic phenotype in immunocompromised hemophilia A mice transplanted with genetically manipulated human cord blood stem cells

Supplemental data

Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH-APS observational study

Sylvie Bouvier,Éva Cochery-Nouvellon,Géraldine Lavigne-Lissalde,Érick Mercier,Tess Marchetti,Jean-Pierre Balducchi,Pierre Marès,Jean-Christophe Gris

View Articletitled, Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH-APS observational study

Comparative incidence of pregnancy outcomes in thrombophilia-positive women from the NOH-APS observational study

Sylvie Bouvier,Éva Cochery-Nouvellon,Géraldine Lavigne-Lissalde,Érick Mercier,Pascale Fabbro-Peray,Jean-Pierre Balducchi,Pierre Marès,Jean-Christophe Gris

View Articletitled, Comparative incidence of pregnancy outcomes in thrombophilia-positive women from the NOH-APS observational study

TRANSFUSION MEDICINE

Allogeneic platelet transfusions prevent murine T-cell–mediated immune thrombocytopenia

Li Guo,Lei Yang,Edwin R. Speck,Rukhsana Aslam,Michael Kim,Christopher G. J. McKenzie,Alan H. Lazarus,Heyu Ni,Ming Hou,John Freedman,John W. Semple

View Articletitled, Allogeneic platelet transfusions prevent murine T-cell–mediated immune thrombocytopenia

Supplemental data

TRANSPLANTATION

Small molecule Me6TREN mobilizes hematopoietic stem/progenitor cells by activating MMP-9 expression and disrupting SDF-1/CXCR4 axis

Jing Zhang,Xiangliang Ren,Wei Shi,Sihan Wang,Haixu Chen,Bowen Zhang,Zhidong Wang,Yong Zhou,Lin Chen,Rui Zhang,Yang Lv,Junnian Zhou,Xue Nan,Lijuan He,Wen Yue,Yanhua Li,Xuetao Pei

View Articletitled, Small molecule Me6TREN mobilizes hematopoietic stem/progenitor cells by activating MMP-9 expression and disrupting SDF-1/CXCR4 axis

Supplemental data

VASCULAR BIOLOGY

G protein–dependent basal and evoked endothelial cell vWF secretion

Luiza Rusu,Alexandra Andreeva,David J. Visintine,Kyungho Kim,Stephen M. Vogel,Aleksandra Stojanovic-Terpo,Olga Chernaya,Guoquan Liu,Farnaz R. Bakhshi,Sandra L. Haberichter,Hiroko Iwanari,Osamu Kusano-Arai,Nobuchika Suzuki,Takao Hamakubo,Tohru Kozasa,Jaehyung Cho,Xiaoping Du,Richard D. Minshall

View Articletitled, G protein–dependent basal and evoked endothelial cell vWF secretion

Supplemental data

CORRESPONDENCE

Patient-reported outcomes for the myelodysplastic syndromes: a new MDS-specific measure of quality of life
Clinical Trials & Observations

Gregory A. Abel,Robert Klaassen,Stephanie J. Lee,Nancy L. Young,Laura Cannella,David P. Steensma,Fabio Efficace

View Articletitled, Patient-reported outcomes for the myelodysplastic syndromes: a new MDS-specific measure of quality of life

A highly specific blood test for vCJD

Graham S. Jackson,Jesse Burk-Rafel,Julie A. Edgeworth,Anita Sicilia,Sabah Abdilahi,Justine Korteweg,Jonathan Mackey,Claire Thomas,Guosu Wang,Simon Mead,John Collinge

View Articletitled, A highly specific blood test for vCJD

Application of CIBMTR risk score to NIH chronic GVHD at individual centers

Yoshihiro Inamoto,Dennis D. Kim,Barry E. Storer,Joon Ho Moon,Jeffrey H. Lipton,John Kuruvilla,Paul J. Martin,Mary E. D. Flowers

View Articletitled, Application of CIBMTR risk score to NIH chronic GVHD at individual centers

ERRATA

Gorska MM, Alam R. A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia. Blood. 2012;119(6):1399-1406.

View Articletitled, Gorska MM, Alam R. A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia. Blood. 2012;119(6):1399-1406.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

MGUS and risk of progression
CME

View Articletitled, MGUS and risk of progression

Cover Image

Cover Image

Confocal image of von Willebrand factor (vWF), immunostaining (green), and DAPI nuclear staining (blue) in endothelial-cell Weibel-Palade bodies (WPBs) (Zeiss LSM510: 63× 1.2 NA objective; 405/488 nm ex lasers; 2048 × 2048 pixel image size; and pinhole set to achieve 1 Airy unit). The authors describe the role of Ga12 and Gaq/11 in RhoA- and Ca²⁺/a-SNAP–dependent mobilization and fusion of WPBs. They demonstrate that direct interaction of Gα12 with α-SNAP serves as a catalyst for basal and evoked vWF secretion. See the article by Rusu et al on page 442.
Front Matter
Table of Contents
Back Matter
Advertising
Editorial Board

All Issues

Advertisement intended for health care professionals

Email alerts

First Edition Alert

Latest Issue Alert

Latest
Most Read
Most Cited

Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B-cell Lymphoma

High-throughput drug screening identifies SMAC mimetics as enhancers of NK cell cytotoxicity in chronic myeloid leukemia

Donor Regulatory T-Cell Therapy to Prevent Graft-Versus-Host Disease

Epcoritamab plus GemOx in transplant-ineligible relapsed/refractory DLBCL: results from the EPCORE NHL-2 trial

Doubling down on GPRC5D in multiple myeloma

Advertisement intended for health care professionals

Issue Archive

Table of Contents

INSIDE BLOOD

A longer acting rFVIII, safe and effective Clinical Trials & Observations

BLOOD WORK

PLENARY PAPER

Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A Clinical Trials & Observations

HOW I TREAT

CLINICAL TRIALS AND OBSERVATIONS

Early assessment of minimal residual disease identifies patients at very high relapse risk in NPM-ALK–positive anaplastic large-cell lymphoma Clinical Trials & Observations Brief Report

LYMPHOID NEOPLASIA

Monoclonal gammopathy of undetermined significance and risk of lymphoid and myeloid malignancies: 728 cases followed up to 30 years in Sweden CME

MYELOID NEOPLASIA

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

RED CELLS, IRON, AND ERYTHROPOIESIS

RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling Brief Report

THROMBOSIS AND HEMOSTASIS

TRANSFUSION MEDICINE

TRANSPLANTATION

VASCULAR BIOLOGY

CORRESPONDENCE

Patient-reported outcomes for the myelodysplastic syndromes: a new MDS-specific measure of quality of life Clinical Trials & Observations

ERRATA

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

MGUS and risk of progression CME

Cover Image

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

A longer acting rFVIII, safe and effective
Clinical Trials & Observations

Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A
Clinical Trials & Observations

Early assessment of minimal residual disease identifies patients at very high relapse risk in NPM-ALK–positive anaplastic large-cell lymphoma
Clinical Trials & Observations Brief Report

Monoclonal gammopathy of undetermined significance and risk of lymphoid and myeloid malignancies: 728 cases followed up to 30 years in Sweden
CME

RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling
Brief Report

Patient-reported outcomes for the myelodysplastic syndromes: a new MDS-specific measure of quality of life
Clinical Trials & Observations

MGUS and risk of progression
CME