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Issue Archive

Volume 123, Issue 17
April 24 2014
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Deep sequencing blood transcriptomes
Alistair R. R. Forrest
View Articletitled, Deep sequencing blood transcriptomes
INSIDE BLOOD COMMENTARY
Dangerous power: mitochondria in CLL cells
Li Jia,John G. Gribben
View Articletitled, Dangerous power: mitochondria in CLL cells
INSIDE BLOOD COMMENTARY
Podosomes are disrupted in PAPA syndrome
Isabelle Maridonneau-Parini
View Articletitled, Podosomes are disrupted in PAPA syndrome
INSIDE BLOOD COMMENTARY
Eliminate dark side from antiplatelet therapy
Yoshiaki Tomiyama
View Articletitled, Eliminate dark side from antiplatelet therapy
INSIDE BLOOD COMMENTARY
Decrypting C2 inhibitors
Jan Voorberg,Henriët Meems
View Articletitled, Decrypting C2 inhibitors

BLOOD WORK

Aggressive bone marrow metastatic medullary thyroid carcinoma
Jean-Francois Lesesve,François Plénat
View Articletitled, Aggressive bone marrow metastatic medullary thyroid carcinoma

REVIEW ARTICLE

Multiple roles of the coagulation protease cascade during virus infection
Silvio Antoniak,Nigel Mackman
View Articletitled, Multiple roles of the coagulation protease cascade during virus infection
Pressing the right buttons: signaling in lymphangiogenesis
Sanja Coso,Esther Bovay,Tatiana V. Petrova
View Articletitled, Pressing the right buttons: signaling in lymphangiogenesis

REVIEW SERIES

Antibody-modified T cells: CARs take the front seat for hematologic malignancies
Marcela V. Maus,Stephan A. Grupp,David L. Porter,Carl H. June
View Articletitled, Antibody-modified T cells: CARs take the front seat for hematologic malignancies
Supplemental data

HOW I TREAT

How I treat the peripheral T-cell lymphomas
Alison J. Moskowitz,Matthew A. Lunning,Steven M. Horwitz
View Articletitled, How I treat the peripheral T-cell lymphomas

CLINICAL TRIALS AND OBSERVATIONS

Atypical chronic myeloid leukemia is clinically distinct from unclassifiable myelodysplastic/myeloproliferative neoplasms
Clinical Trials & Observations
Sa A. Wang,Robert P. Hasserjian,Patricia S. Fox,Heesun J. Rogers,Julia T. Geyer,Devon Chabot-Richards,Elizabeth Weinzierl,Joseph Hatem,Jesse Jaso,Rashmi Kanagal-Shamanna,Francesco C. Stingo,Keyur P. Patel,Meenakshi Mehrotra,Carlos Bueso-Ramos,Ken H. Young,Courtney D. Dinardo,Srdan Verstovsek,Ramon V. Tiu,Adam Bagg,Eric D. Hsi,Daniel A. Arber,Kathryn Foucar,Raja Luthra,Attilio Orazi
View Articletitled, Atypical chronic myeloid leukemia is clinically distinct from unclassifiable myelodysplastic/myeloproliferative neoplasms
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf
Verena Labi,Claudia Woess,Selma Tuzlak,Miriam Erlacher,Philippe Bouillet,Andreas Strasser,Alexandar Tzankov,Andreas Villunger
View Articletitled, Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf
Supplemental data
High-throughput transcription profiling identifies putative epigenetic regulators of hematopoiesis
e-blood
Punit Prasad,for the FANTOM consortium,Michelle Rönnerblad,for the FANTOM consortium,Erik Arner,for the FANTOM consortium,Masayoshi Itoh,for the FANTOM consortium,Hideya Kawaji,for the FANTOM consortium,Timo Lassmann,for the FANTOM consortium,Carsten O. Daub,for the FANTOM consortium,Alistair R. R. Forrest,for the FANTOM consortium,Andreas Lennartsson,for the FANTOM consortium,Karl Ekwall,for the FANTOM consortium
View Articletitled, High-throughput transcription profiling identifies putative epigenetic regulators of hematopoiesis
Supplemental data

IMMUNOBIOLOGY

Redefinition of the human mast cell transcriptome by deep-CAGE sequencing
e-blood
Efthymios Motakis,for the FANTOM consortium,Sven Guhl,for the FANTOM consortium,Yuri Ishizu,for the FANTOM consortium,Masayoshi Itoh,for the FANTOM consortium,Hideya Kawaji,for the FANTOM consortium,Michiel de Hoon,for the FANTOM consortium,Timo Lassmann,for the FANTOM consortium,Piero Carninci,for the FANTOM consortium,Yoshihide Hayashizaki,for the FANTOM consortium,Torsten Zuberbier,for the FANTOM consortium,Alistair R. R. Forrest,for the FANTOM consortium,Magda Babina,for the FANTOM consortium
View Articletitled, Redefinition of the human mast cell transcriptome by deep-CAGE sequencing
Supplemental data
The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations
e-blood
Christian Schmidl,for the FANTOM consortium,Leo Hansmann,for the FANTOM consortium,Timo Lassmann,for the FANTOM consortium,Piotr J. Balwierz,for the FANTOM consortium,Hideya Kawaji,for the FANTOM consortium,Masayoshi Itoh,for the FANTOM consortium,Jun Kawai,for the FANTOM consortium,Sayaka Nagao-Sato,for the FANTOM consortium,Harukazu Suzuki,for the FANTOM consortium,Reinhard Andreesen,for the FANTOM consortium,Yoshihide Hayashizaki,for the FANTOM consortium,Alistair R. R. Forrest,for the FANTOM consortium,Piero Carninci,for the FANTOM consortium,Petra Hoffmann,for the FANTOM consortium,Matthias Edinger,for the FANTOM consortium,Michael Rehli,for the FANTOM consortium
View Articletitled, The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations
Supplemental data

LYMPHOID NEOPLASIA

Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia
Regina Jitschin,Andreas D. Hofmann,Heiko Bruns,Andreas Gießl,Juliane Bricks,Jana Berger,Domenica Saul,Michael J. Eckart,Andreas Mackensen,Dimitrios Mougiakakos
View Articletitled, Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia
Supplemental data
MYD88-independent growth and survival effects of Sp1 transactivation in Waldenström macroglobulinemia
Mariateresa Fulciniti,Nicola Amodio,Rajya Lakshmi Bandi,Mansa Munshi,Guang Yang,Lian Xu,Zachary Hunter,Pierfrancesco Tassone,Kenneth C. Anderson,Steven P. Treon,Nikhil C. Munshi
View Articletitled, MYD88-independent growth and survival effects of Sp1 transactivation in Waldenström macroglobulinemia

MYELOID NEOPLASIA

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes
Diwakar R. Pattabiraman,Crystal McGirr,Konstantin Shakhbazov,Valerie Barbier,Keerthana Krishnan,Pamela Mukhopadhyay,Paula Hawthorne,Ann Trezise,Jianmin Ding,Sean M. Grimmond,Peter Papathanasiou,Warren S. Alexander,Andrew C. Perkins,Jean-Pierre Levesque,Ingrid G. Winkler,Thomas J. Gonda
View Articletitled, Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes
Supplemental data
Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance
Rodrigo Jacamo,Ye Chen,Zhiqiang Wang,Wencai Ma,Min Zhang,Erika L. Spaeth,Ying Wang,Venkata L. Battula,Po Yee Mak,Katharina Schallmoser,Peter Ruvolo,Wendy D. Schober,Elizabeth J. Shpall,Martin H. Nguyen,Dirk Strunk,Carlos E. Bueso-Ramos,Sergej Konoplev,R. Eric Davis,Marina Konopleva,Michael Andreeff
View Articletitled, Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages
Taylor W. Starnes,David A. Bennin,Xinyu Bing,Jens C. Eickhoff,Daniel C. Grahf,Jason M. Bellak,Christine M. Seroogy,Polly J. Ferguson,Anna Huttenlocher
View Articletitled, The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages
Supplemental data
Analysis of the DNA methylome and transcriptome in granulopoiesis reveals timed changes and dynamic enhancer methylation
e-blood
Michelle Rönnerblad,for the FANTOM consortium,Robin Andersson,for the FANTOM consortium,Tor Olofsson,for the FANTOM consortium,Iyadh Douagi,for the FANTOM consortium,Mohsen Karimi,for the FANTOM consortium,Sören Lehmann,for the FANTOM consortium,Ilka Hoof,for the FANTOM consortium,Michiel de Hoon,for the FANTOM consortium,Masayoshi Itoh,for the FANTOM consortium,Sayaka Nagao-Sato,for the FANTOM consortium,Hideya Kawaji,for the FANTOM consortium,Timo Lassmann,for the FANTOM consortium,Piero Carninci,for the FANTOM consortium,Yoshihide Hayashizaki,for the FANTOM consortium,Alistair R. R. Forrest,for the FANTOM consortium,Albin Sandelin,for the FANTOM consortium,Karl Ekwall,for the FANTOM consortium,Erik Arner,for the FANTOM consortium,Andreas Lennartsson,for the FANTOM consortium
View Articletitled, Analysis of the DNA methylome and transcriptome in granulopoiesis reveals timed changes and dynamic enhancer methylation
Supplemental data
Transcription and enhancer profiling in human monocyte subsets
e-blood
Christian Schmidl,for the FANTOM consortium,Kathrin Renner,for the FANTOM consortium,Katrin Peter,for the FANTOM consortium,Ruediger Eder,for the FANTOM consortium,Timo Lassmann,for the FANTOM consortium,Piotr J. Balwierz,for the FANTOM consortium,Masayoshi Itoh,for the FANTOM consortium,Sayaka Nagao-Sato,for the FANTOM consortium,Hideya Kawaji,for the FANTOM consortium,Piero Carninci,for the FANTOM consortium,Harukazu Suzuki,for the FANTOM consortium,Yoshihide Hayashizaki,for the FANTOM consortium,Reinhard Andreesen,for the FANTOM consortium,David A. Hume,for the FANTOM consortium,Petra Hoffmann,for the FANTOM consortium,Alistair R. R. Forrest,for the FANTOM consortium,Marina P. Kreutz,for the FANTOM consortium,Matthias Edinger,for the FANTOM consortium,Michael Rehli,for the FANTOM consortium
View Articletitled, Transcription and enhancer profiling in human monocyte subsets
Supplemental data

PLATELETS AND THROMBOPOIESIS

Platelet adhesion involves a novel interaction between vimentin and von Willebrand factor under high shear stress
Qi Da,Molly Behymer,Juliana I. Correa,K. Vinod Vijayan,Miguel A. Cruz
View Articletitled, Platelet adhesion involves a novel interaction between vimentin and von Willebrand factor under high shear stress
Supplemental data
A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding
Lucia Stefanini,Feng Ye,Adam K. Snider,Kasra Sarabakhsh,Raymond Piatt,David S. Paul,Wolfgang Bergmeier,Brian G. Petrich
View Articletitled, A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding
Supplemental data

THROMBOSIS AND HEMOSTASIS

High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance
Phuong-Cac T. Nguyen,Kenneth B. Lewis,Ruth A. Ettinger,Jason T. Schuman,Jasper C. Lin,John F. Healey,Shannon L. Meeks,Pete Lollar,Kathleen P. Pratt
View Articletitled, High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance
Supplemental data

CORRESPONDENCE

Rituximab maintenance obviates the poor prognosis associated with circulating lymphoma cells in patients with follicular lymphoma
Clinical Trials & Observations
Clémentine Sarkozy,John Francis Seymour,Christophe Ferme,Dolores Caballero,Hervé Ghesquieres,Sirpa Leppa,Richard Delarue,Lars Moller Pedersen,Christiane Mounier,Maria Gomes Da Silva,Catherine Chassagne-Clement,Marie Maerevoet,Gilles Salles
View Articletitled, Rituximab maintenance obviates the poor prognosis associated with circulating lymphoma cells in patients with follicular lymphoma
PLZF staining identifies peripheral T-cell lymphomas derived from innate-like T-cells with TRAV1-2-TRAJ33 TCR-α rearrangement
Stephanie McGregor,Anant Shah,Gordana Raca,M. Kamran Mirza,Sonali M. Smith,John Anastasi,James W. Vardiman,Elizabeth Hyjek,Sandeep Gurbuxani
View Articletitled, PLZF staining identifies peripheral T-cell lymphomas derived from innate-like T-cells with TRAV1-2-TRAJ33 TCR-α rearrangement
Somatic mutations in calreticulin can be found in pedigrees with familial predisposition to myeloproliferative neoplasms
Pontus Lundberg,Ronny Nienhold,Achille Ambrosetti,Francisco Cervantes,Manuel M. Pérez-Encinas,Radek C. Skoda
View Articletitled, Somatic mutations in calreticulin can be found in pedigrees with familial predisposition to myeloproliferative neoplasms
Physical activity limits pulmonary endothelial activation in sickle cell SAD mice
Emeline Aufradet,Aymeric Douillard,Emmanuelle Charrin,Aymen Romdhani,Genevieve De Souza,Amine Bessaad,Camille Faes,Vanessa Bourgeaux,Erica N. Chirico,Emmanuelle Canet-Soulas,Vincent Pialoux,Cyril Martin
View Articletitled, Physical activity limits pulmonary endothelial activation in sickle cell SAD mice
  • Cover Image

    Cover Image

    issue cover

    A macrophage from a patient with pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome forms characteristic, filopodia-like projections. These projections were associated with increased extracellular matrix and correlated with increased WASp activity. Images were acquired of these monocyte-derived macrophages after they had been differentiated for 7 days, plated on Oregon Green 488-conjugated gelatin (not shown) for 24 hours, and stained with rhodamine phalloidin (magenta). See the article by Starnes et al on page 2703.

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