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Journal Articles

Frequency and epitope specificity of anti–factor VIII C1 domain antibodies in acquired and congenital hemophilia A

Joerg Kahle, Aleksander Orlowski, Diana Stichel, John F. Healey, Ernest T. Parker, Marc Jacquemin, Manuela Krause, Andreas Tiede, Dirk Schwabe, Pete Lollar, Christoph Königs

Blood (2017) 130 (6): 808–816.

https://doi.org/10.1182/blood-2016-11-751347

Published: 2017

Includes: Supplemental data

Journal Articles

Characterization of Factor VIII Immune Complexes By Analytical Ultracentrifugation

Pete Lollar, MD, Ernest T. Parker, John F. Healey, Christopher B. Doering, PhD

Blood (2016) 128 (22): 3787.

https://doi.org/10.1182/blood.V128.22.3787.3787

Published: 2016

Journal Articles

Factor VIII C2 Domain Epitopes Recognized By Classical and Non-Classical Anti-C2 Domain Monoclonal Antibodies Help Mediate FVIII Uptake By Dendritic Cells

Glaivy Batsuli, MD, Wallace Hunter Baldwin, BS, John F Healey, BS, Ernest T Parker, BS, Courtney Cox, MSc, Pete Lollar, MD, Shannon L. Meeks, MD

Blood (2016) 128 (22): 3762.

https://doi.org/10.1182/blood.V128.22.3762.3762

Published: 2016

Journal Articles

High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors

Glaivy Batsuli, Wei Deng, John F. Healey, Ernest T. Parker, W. Hunter Baldwin, Courtney Cox, Brenda Nguyen, Joerg Kahle, Christoph Königs, Renhao Li, Pete Lollar, Shannon L. Meeks

Blood (2016) 128 (16): 2055–2067.

https://doi.org/10.1182/blood-2016-02-701805

Published: 2016

Includes: Supplemental data

Journal Articles

Frequency and Epitope Specificity of Anti-Factor VIII C1 Domain Antibodies in Acquired and Hereditary Hemophilia Inhibitor Patient Plasma

Joerg Kahle, PhD, Aleksander Orlowski, Anja Schmidt, PhD, Kerstin Brettschneider, Thomas Klingebiel, MD, John F Healey, BS, Ernest T Parker, BA, John (Pete) S Lollar, MD, Marc Jacquemin, MD, Manuela Krause, MD, Andreas Tiede, MD PhD, Dirk Schwabe, MD, Christoph Königs, MD PhD

Blood (2015) 126 (23): 3491.

https://doi.org/10.1182/blood.V126.23.3491.3491

Published: 2015

Journal Articles

Anti-Factor VIII C1 Domain Antibodies Are Present in the Plasmas of Patients with Hemophilia and Inhibitors

Glaivy Batsuli, MD, Courtney Cox, M.S., John F. Healey, B.S., Pete Lollar, MD, Shannon L Meeks, MD

Blood (2014) 124 (21): 1482.

https://doi.org/10.1182/blood.V124.21.1482.1482

Published: 2014

Journal Articles

Decreasing the Humoral Response to Factor VIII By Targeted Deletion of Factor VIII - Specific B Cells

Rebecca C. Markovitz, John F. Healey, W. Hunter Baldwin, Ernest T. Parker, Shannon L. Meeks, Pete Lollar

Blood (2014) 124 (21): 238.

https://doi.org/10.1182/blood.V124.21.238.238

Published: 2014

Journal Articles

High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance

Phuong-Cac T. Nguyen, Kenneth B. Lewis, Ruth A. Ettinger, Jason T. Schuman, Jasper C. Lin, John F. Healey, Shannon L. Meeks, Pete Lollar, Kathleen P. Pratt

Blood (2014) 123 (17): 2732–2739.

https://doi.org/10.1182/blood-2013-09-527275

Published: 2014

Includes: Supplemental data

Journal Articles

Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes

Justin D. Walter, Rachel A. Werther, Caileen M. Brison, Rebecca K. Cragerud, John F. Healey, Shannon L. Meeks, Pete Lollar, P. Clint Spiegel, Jr

Blood (2013) 122 (26): 4270–4278.

https://doi.org/10.1182/blood-2013-08-519124

Published: 2013

Includes: Supplemental data

Journal Articles

Structural Studies Of The Factor VIII C2 Domain In a Ternary Complex With Two Inhibitory Antibodies Reveals Classical and Non-Classical Epitopes

Justin D Walter, M.S., Rachel A Werther, M.S., Caileen M Brison, B.S., John F. Healey, B.S., Shannon L. Meeks, MD, John (Pete) S. Lollar, III, MD, P. Clint Spiegel, Jr., Ph.D.

Blood (2013) 122 (21): 2358.

https://doi.org/10.1182/blood.V122.21.2358.2358

Published: 2013

Journal Articles

Anti-FVIII Autoantibodies Share Similar Characteristics In Acquired Hemophilia A Patients With and Without An Associated Disease

Joerg Kahle, PhD, Christoph Königs, MD, PhD, Anja Naumann, Thomas Klingebiel, MD, John F Healey, Ernest T Parker, B.A., Pete Lollar, MD, Dirk Schwabe, MD, Manuela Krause, MD

Blood (2013) 122 (21): 1110.

https://doi.org/10.1182/blood.V122.21.1110.1110

Published: 2013

Journal Articles

Cooperative Binding Of Anti-Factor VIII Inhibitors and Induced Conformational Change Detected By Hydrogen-Deuterium Exchange Mass Spectrometry

Shannon L. Meeks, MD, Alexander M. Sevy, B.S., John F. Healey, B.S., Wei Deng, Ph.D., P. Clint Spiegel, Ph.D., Renhao Li, PhD

Blood (2013) 122 (21): 1088.

https://doi.org/10.1182/blood.V122.21.1088.1088

Published: 2013

Journal Articles

The diversity of the immune response to the A2 domain of human factor VIII

Rebecca C. Markovitz, John F. Healey, Ernest T. Parker, Shannon L. Meeks, Pete Lollar

Blood (2013) 121 (14): 2785–2795.

https://doi.org/10.1182/blood-2012-09-456582

Published: 2013

Includes: Supplemental data

Journal Articles

A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function

Shannon L. Meeks, Courtney L. Cox, John F. Healey, Ernest T. Parker, Bhavya S. Doshi, Bagirath Gangadharan, Rachel T. Barrow, Pete Lollar

Blood (2012) 120 (12): 2512–2520.

https://doi.org/10.1182/blood-2012-02-412361

Published: 2012

Includes: Supplemental data

Journal Articles

High-Resolution Mapping of B-Cell Epitopes on the Factor VIII C2 Domain Using Surface Plasmon Resonance

Phuong-Cac Nguyen, Ph.D., Kenneth B Lewis, Ph.D., Jason T. Schuman, Ph.D., Shannon L. Meeks, MD, John F. Healey, B.S., Pete Lollar, MD, Kathleen P. Pratt, Ph.D.

Blood (2011) 118 (21): 203.

https://doi.org/10.1182/blood.V118.21.203.203

Published: 2011

Journal Articles

The Structural and Functional Diversity of the Humoral Immune Response to the A2 Domain of Human Factor VIII

Rebecca Markovitz, John (Pete) S. Lollar, III, M.D., John F. Healey, B.S., Ernest T Parker, B.A., Shannon Meeks, M.D.

Blood (2011) 118 (21): 2247.

https://doi.org/10.1182/blood.V118.21.2247.2247

Published: 2011

Journal Articles

Factor VIII Structure, Not Activity, Is the Primary Determinant of Immunogenicity in Hemophilia A and Combined Hemophilia A/Von Willebrand Disease Mice

Shannon L. Meeks, MD, Courtney Cox, M.S., John F. Healey, B.S., Ernest T Parker, B.A., Bagirath Gangadharan, MS, Rachel T. Barrow, BS, John (Pete) S. Lollar, III, M.D.

Blood (2011) 118 (21): 1187.

https://doi.org/10.1182/blood.V118.21.1187.1187

Published: 2011

Journal Articles

Factor VIII A3 domain substitution N1922S results in hemophilia A due to domain-specific misfolding and hyposecretion of functional protein

Ryan J. Summers, Shannon L. Meeks, John F. Healey, Harrison C. Brown, Ernest T. Parker, Christine L. Kempton, Christopher B. Doering, Pete Lollar

Blood (2011) 117 (11): 3190–3198.

https://doi.org/10.1182/blood-2010-09-307074

Published: 2011

Includes: Supplemental data

Journal Articles

The Diversity of the Immune Response to the A2 Domain of Human Factor VIII In a Murine Hemophilia A Model

John F. Healey, B.S., John (Pete) S. Lollar, III, M.D., Ernest T Parker, B.A., Shannon Meeks, M.D.

Blood (2010) 116 (21): 2223.

https://doi.org/10.1182/blood.V116.21.2223.2223

Published: 2010

Journal Articles

N1922S Mutation In the Factor VIII A3 Domain Produces a Rate-Limiting, Domain-Specific Folding Defect Leading to Hyposecretion of a Functional Protein

Ryan J. Summers, B.S., Shannon L. Meeks, MD, John F. Healey, B.S., Harrison C. Brown, BBA, Ernest T Parker, BA, Christopher Doering, PhD, Christine L. Kempton, MD, MSc, John (Pete) S. Lollar, III, MD

Blood (2010) 116 (21): 2209.

https://doi.org/10.1182/blood.V116.21.2209.2209

Published: 2010

NARROW

Frequency and epitope specificity of anti–factor VIII C1 domain antibodies in acquired and congenital hemophilia A

Characterization of Factor VIII Immune Complexes By Analytical Ultracentrifugation

Factor VIII C2 Domain Epitopes Recognized By Classical and Non-Classical Anti-C2 Domain Monoclonal Antibodies Help Mediate FVIII Uptake By Dendritic Cells

High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors

Frequency and Epitope Specificity of Anti-Factor VIII C1 Domain Antibodies in Acquired and Hereditary Hemophilia Inhibitor Patient Plasma

Anti-Factor VIII C1 Domain Antibodies Are Present in the Plasmas of Patients with Hemophilia and Inhibitors

Decreasing the Humoral Response to Factor VIII By Targeted Deletion of Factor VIII - Specific B Cells

High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance

Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes

Structural Studies Of The Factor VIII C2 Domain In a Ternary Complex With Two Inhibitory Antibodies Reveals Classical and Non-Classical Epitopes

Anti-FVIII Autoantibodies Share Similar Characteristics In Acquired Hemophilia A Patients With and Without An Associated Disease

Cooperative Binding Of Anti-Factor VIII Inhibitors and Induced Conformational Change Detected By Hydrogen-Deuterium Exchange Mass Spectrometry

The diversity of the immune response to the A2 domain of human factor VIII

A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function

High-Resolution Mapping of B-Cell Epitopes on the Factor VIII C2 Domain Using Surface Plasmon Resonance

The Structural and Functional Diversity of the Humoral Immune Response to the A2 Domain of Human Factor VIII

Factor VIII Structure, Not Activity, Is the Primary Determinant of Immunogenicity in Hemophilia A and Combined Hemophilia A/Von Willebrand Disease Mice

Factor VIII A3 domain substitution N1922S results in hemophilia A due to domain-specific misfolding and hyposecretion of functional protein

The Diversity of the Immune Response to the A2 Domain of Human Factor VIII In a Murine Hemophilia A Model

N1922S Mutation In the Factor VIII A3 Domain Produces a Rate-Limiting, Domain-Specific Folding Defect Leading to Hyposecretion of a Functional Protein

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American Society of Hematology

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American Society of Hematology

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