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Journal Articles

Frequency and epitope specificity of anti–factor VIII C1 domain antibodies in acquired and congenital hemophilia A

Joerg Kahle, Aleksander Orlowski, Diana Stichel, John F. Healey, Ernest T. Parker, Marc Jacquemin, Manuela Krause, Andreas Tiede, Dirk Schwabe, Pete Lollar, Christoph Königs

Blood (2017) 130 (6): 808–816.

https://doi.org/10.1182/blood-2016-11-751347

Published: 2017

Includes: Supplemental data

Journal Articles

Frequency and Epitope Specificity of Anti-Factor VIII C1 Domain Antibodies in Acquired and Hereditary Hemophilia Inhibitor Patient Plasma

Joerg Kahle, PhD, Aleksander Orlowski, Anja Schmidt, PhD, Kerstin Brettschneider, Thomas Klingebiel, MD, John F Healey, BS, Ernest T Parker, BA, John (Pete) S Lollar, MD, Marc Jacquemin, MD, Manuela Krause, MD, Andreas Tiede, MD PhD, Dirk Schwabe, MD, Christoph Königs, MD PhD

Blood (2015) 126 (23): 3491.

https://doi.org/10.1182/blood.V126.23.3491.3491

Published: 2015

Journal Articles

Free hemoglobin: a boost to platelet thrombi

Marc Jacquemin, Kathelijne Peerlinck

Blood (2015) 126 (20): 2262–2263.

https://doi.org/10.1182/blood-2015-09-667642

Published: 2015

Journal Articles

Factor VIII inhibitor: affinity is the clue

Marc Jacquemin, Kathelijne Peerlinck

Blood (2015) 125 (7): 1056–1058.

https://doi.org/10.1182/blood-2014-12-618991

Published: 2015

Journal Articles

Response: Extended analysis of microarray data does not contradict preplasmablast phenotype of human CD20 + CD27 + CD43 + cells

Kris Covens, Bert Verbinnen, Marc Jacquemin, Xavier Bossuyt

Blood (2013) 122 (22): 3693–3694.

https://doi.org/10.1182/blood-2013-09-528091

Published: 2013

Journal Articles

Characterization of proposed human B-1 cells reveals pre-plasmablast phenotype

Kris Covens, Bert Verbinnen, Nick Geukens, Isabelle Meyts, Frans Schuit, Leentje Van Lommel, Marc Jacquemin, Xavier Bossuyt

Blood (2013) 121 (26): 5176–5183.

https://doi.org/10.1182/blood-2012-12-471953

Published: 2013

Journal Articles

A membrane-interactive surface on the factor VIII C1 domain cooperates with the C2 domain for cofactor function

Junhong Lü, Steven W. Pipe, Hongzhi Miao, Marc Jacquemin, Gary E. Gilbert

Blood (2011) 117 (11): 3181–3189.

https://doi.org/10.1182/blood-2010-08-301663

Published: 2011

Journal Articles

Activation of human endothelial cells from specific vascular beds induces the release of a FVIII storage pool

Tina Shahani, Renaud Lavend'homme, Aernout Luttun, Jean-Marie Saint-Remy, Kathelijne Peerlinck, Marc Jacquemin

Blood (2010) 115 (23): 4902–4909.

https://doi.org/10.1182/blood-2009-07-232546

Published: 2010

Includes: Supplemental data

Journal Articles

Membrane-Interactive Amino Acids in the Factor VIII C1 Domain Are Cooperative with C2 Domain Epitopes for Membrane Binding and Cofactor Function.

Junhong Lu, Ph.D., Steven W. Pipe, MD, Hongzhi Miao, Marc Jacquemin, Ph.D., Gary E. Gilbert, MD

Blood (2009) 114 (22): 848.

https://doi.org/10.1182/blood.V114.22.848.848

Published: 2009

Journal Articles

Six Amino Acid Residues in a 1200 Å 2 Interface Mediate Binding of Factor VIII to An IgG4 Inhibitory Antibody.

Jasper C. Lin, Ph.D., Jason T. Schuman, Ph.D., Shelley M. Nakaya, Vasudha Kaushik, Marc Jacquemin, Ph.D., Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2008) 112 (11): 3380.

https://doi.org/10.1182/blood.V112.11.3380.3380

Published: 2008

Journal Articles

Phase I Clinical Trial of a Novel, Long-Acting Antithrombotic Drug: A Human Monoclonal Antibody Partially Inhibiting FVIII Activity.

Peter Verhamme, MD, PhD, Steve Pakola, MD, Marc Jacquemin, MD, PhD, Jean Marie Saint-Remy, MD, PhD, Jean Marie Stassen, PhD, Desire Collen, MD, PhD, Rikke Riisbro, MD, PhD, Thomas Jensen, MD, PhD, Steven Glazer, MD

Blood (2007) 110 (11): 312.

https://doi.org/10.1182/blood.V110.11.312.312

Published: 2007

Journal Articles

VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors

Suryasarathi Dasgupta, Yohann Repessé, Jagadeesh Bayry, Ana-Maria Navarrete, Bharath Wootla, Sandrine Delignat, Theano Irinopoulou, Caroline Kamaté, Jean-Marie Saint-Remy, Marc Jacquemin, Peter J. Lenting, Annie Borel-Derlon, Srinivas V. Kaveri, Sébastien Lacroix-Desmazes

Blood (2006) 109 (2): 610–612.

https://doi.org/10.1182/blood-2006-05-022756

Published: 2006

Includes: Supplemental data

Journal Articles

FVIII production by human lung microvascular endothelial cells

Marc Jacquemin, Arne Neyrinck, Maria Iris Hermanns, Renaud Lavend'homme, Filip Rega, Jean-Marie Saint-Remy, Kathelijne Peerlinck, Dirk Van Raemdonck, Charles James Kirkpatrick

Blood (2006) 108 (2): 515–517.

https://doi.org/10.1182/blood-2005-11-4571

Published: 2006

Journal Articles

Antibody to C1 Domain of Factor VIII Alters Interaction of Factor Xase Complex with Factor X.

Gary E. Gilbert, M.D., Anu Bhimavarapu, Patricia Price, Marc Jacquemin, M.D., Ph.D.

Blood (2004) 104 (11): 1738.

https://doi.org/10.1182/blood.V104.11.1738.1738

Published: 2004

Journal Articles

Deletion of alanine 2201 in the FVIII C2 domain results in mild hemophilia A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development

Roseline d'Oiron, Jean-Maurice Lavergne, Renaud Lavend'homme, Abdellah Benhida, Jean-Claude Bordet, Claude Negrier, Kathelijne Peerlinck, Jos Vermylen, Jean-Marie Saint-Remy, Marc Jacquemin

Blood (2004) 103 (1): 155–157.

https://doi.org/10.1182/blood-2003-04-1321

Published: 2004

Journal Articles

CD4 + T-cell clones specific for wild-type factor VIII: a molecular mechanism responsible for a higher incidence of inhibitor formation in mild/moderate hemophilia A

Marc Jacquemin, Valérie Vantomme, Cécile Buhot, Renaud Lavend'homme, Wivine Burny, Nathalie Demotte, Pascal Chaux, Kathelijne Peerlinck, Jos Vermylen, Bernard Maillere, Pierre van der Bruggen, Jean-Marie Saint-Remy

Blood (2003) 101 (4): 1351–1358.

https://doi.org/10.1182/blood-2002-05-1369

Published: 2003

Journal Articles

Antithrombotic effects of controlled inhibition of factor VIII with a partially inhibitory human monoclonal antibody in a murine vena cava thrombosis model

Inderjit Singh, Alberto Smith, Beatrijs Vanzieleghem, Désiré Collen, Kevin Burnand, Jean-Marie Saint-Remy, Marc Jacquemin

Blood (2002) 99 (9): 3235–3240.

https://doi.org/10.1182/blood.V99.9.3235

Published: 2002

Journal Articles

Structure of a factor VIII C2 domain–immunoglobulin G4κ Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII

Paul Clint Spiegel, Jr, Marc Jacquemin, Jean-Marie R. Saint-Remy, Barry L. Stoddard, Kathleen P. Pratt

Blood (2001) 98 (1): 13–19.

https://doi.org/10.1182/blood.V98.1.13

Published: 2001

Journal Articles

A novel cause of mild/moderate hemophilia A: mutations scattered in the factor VIII C1 domain reduce factor VIII binding to von Willebrand factor

Marc Jacquemin, Renaud Lavend'homme, Abdellah Benhida, Beatrijs Vanzieleghem, Roseline d'Oiron, Jean-Maurice Lavergne, Hans H. Brackmann, Rainer Schwaab, Thierry VandenDriessche, Marinee K. L. Chuah, Marc Hoylaerts, Jean Guy G. Gilles, Kathelijne Peerlinck, Jos Vermylen, Jean-Marie R. Saint-Remy

Blood (2000) 96 (3): 958–965.

https://doi.org/10.1182/blood.V96.3.958

Published: 2000

Journal Articles

A human antibody directed to the factor VIII C1 domain inhibits factor VIII cofactor activity and binding to von Willebrand factor

Marc Jacquemin, Abdellah Benhida, Kathelijne Peerlinck, Benoı̂t Desqueper, Luc Vander Elst, Renaud Lavend'homme, Roseline d'Oiron, Rainer Schwaab, Marleen Bakkus, Kris Thielemans, Jean-Guy Gilles, Jos Vermylen, Jean-Marie Saint-Remy

Blood (2000) 95 (1): 156–163.

https://doi.org/10.1182/blood.V95.1.156

Published: 2000

NARROW

Frequency and epitope specificity of anti–factor VIII C1 domain antibodies in acquired and congenital hemophilia A

Frequency and Epitope Specificity of Anti-Factor VIII C1 Domain Antibodies in Acquired and Hereditary Hemophilia Inhibitor Patient Plasma

Free hemoglobin: a boost to platelet thrombi

Factor VIII inhibitor: affinity is the clue

Response: Extended analysis of microarray data does not contradict preplasmablast phenotype of human CD20 + CD27 + CD43 + cells

Characterization of proposed human B-1 cells reveals pre-plasmablast phenotype

A membrane-interactive surface on the factor VIII C1 domain cooperates with the C2 domain for cofactor function

Activation of human endothelial cells from specific vascular beds induces the release of a FVIII storage pool

Membrane-Interactive Amino Acids in the Factor VIII C1 Domain Are Cooperative with C2 Domain Epitopes for Membrane Binding and Cofactor Function.

Six Amino Acid Residues in a 1200 Å 2 Interface Mediate Binding of Factor VIII to An IgG4 Inhibitory Antibody.

Phase I Clinical Trial of a Novel, Long-Acting Antithrombotic Drug: A Human Monoclonal Antibody Partially Inhibiting FVIII Activity.

VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors

FVIII production by human lung microvascular endothelial cells

Antibody to C1 Domain of Factor VIII Alters Interaction of Factor Xase Complex with Factor X.

Deletion of alanine 2201 in the FVIII C2 domain results in mild hemophilia A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development

CD4 + T-cell clones specific for wild-type factor VIII: a molecular mechanism responsible for a higher incidence of inhibitor formation in mild/moderate hemophilia A

Antithrombotic effects of controlled inhibition of factor VIII with a partially inhibitory human monoclonal antibody in a murine vena cava thrombosis model

Structure of a factor VIII C2 domain–immunoglobulin G4κ Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII

A novel cause of mild/moderate hemophilia A: mutations scattered in the factor VIII C1 domain reduce factor VIII binding to von Willebrand factor

A human antibody directed to the factor VIII C1 domain inhibits factor VIII cofactor activity and binding to von Willebrand factor

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American Society of Hematology

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ASH Publications

American Society of Hematology

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