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Journal Articles

Factor VIII forges its own path

Kathleen P. Pratt

Blood (2023) 142 (3): 217–219.

https://doi.org/10.1182/blood.2023021021

Published: 2023

Journal Articles

FVIII Protein Is Not Detectable in Human PBMCs or Livers from Dogs with an Intron-22 Inversion Mutation: Implications for FVIII Immunogenicity and Tolerance

Devi Gunasekera, MBBS, Pooja Vir, PhD, Ahmad Faisal Karim, PhD, Margaret V. Ragni, MD MPH, Elizabeth P. Merricks, PhD, Timothy C. Nichols, MD, Kathleen P. Pratt, PhD

Blood (2019) 134 (Supplement_1): 630.

https://doi.org/10.1182/blood-2019-124880

Published: 2019

Journal Articles

Higher Incidence of Neutralizing Anti-FVIII Antibodies (Inhibitors) in Black and Hispanic American Hemophilia A Patients Enrolled in the My Life, Our Future Programme

Kathleen P. Pratt, PhD

Blood (2019) 134 (Supplement_1): 901.

https://doi.org/10.1182/blood-2019-127412

Published: 2019

Journal Articles

Elispots and Ex Vivo Expansion of FVIII-Specific T-Cell Clones Confirm Specificity of CD4 + T-Cell Responses to Self-FVIII in Healthy Non-Hemophilic Blood Donors

Ahmad Faisal Karim, PhD, Pooja Vir, PhD, Devi Gunasekera, MBBS, Allen I. Stering, MD, Kenneth Lieuw, MD PhD, Kathleen P. Pratt, PhD

Blood (2019) 134 (Supplement_1): 2413.

https://doi.org/10.1182/blood-2019-124803

Published: 2019

Journal Articles

Neutralizing and Non-Neutralizing Anti-FVIII Antibodies in Black and White Hemophilia A Subjects: A Natural History Profile

Kathleen P. Pratt, PhD, Devi Gunasekera, MBBS, Pooja Vir, PhD, Robert Peters, Siyuan Tan, PhD, Glenn Pierce, MD PhD, Cara Olsen, PhD, Saulius Butenas, PhD, Kenneth G. Mann, PhD

Blood (2019) 134 (Supplement_1): 1131.

https://doi.org/10.1182/blood-2019-124743

Published: 2019

Journal Articles

Hemophilia A Inhibitor Subjects Show Unique PBMC Gene Expression Profiles That Include up-Regulated Innate Immune Modulators

Ahmad Faisal Karim, PhD, Anthony R. Soltis, PhD, Nadia P Ewing, MD, Clifton L. Dalgard, PhD, Matthew D. Wilkerson, PhD, Kathleen P. Pratt, PhD

Blood (2019) 134 (Supplement_1): 160.

https://doi.org/10.1182/blood-2019-124855

Published: 2019

Journal Articles

Marginal immunogenicity of factor VIII

Kathleen P. Pratt

Blood (2017) 130 (23): 2450–2451.

https://doi.org/10.1182/blood-2017-10-811109

Published: 2017

Journal Articles

FVIII Proteins with a Modified Immunodominant T-Cell Epitope Exhibit Reduced Immunogenicity and Normal Procoagulant Activity

Ruth A. Ettinger, PhD, Joseph A. Liberman, PhD, Devi Gunasekera, BSSM, Eddie A. James, PhD, Arthur R. Thompson, MD PhD, Kathleen P. Pratt, PhD

Blood (2017) 130 (Supplement 1): 179.

https://doi.org/10.1182/blood.V130.Suppl_1.179.179

Published: 2017

Journal Articles

An Accurate, Simple, and Inexpensive Assay to Diagnose F8 Gene Inversion Mutations in Hemophilia a Patients and Carriers

Debargh Kumar Dutta, PhD, Gourgopal Roy, PhD, Devi Gunasekera, MBBS, Margaret V. Ragni, MD, Kathleen P. Pratt, PhD

Blood (2016) 128 (22): 2580.

https://doi.org/10.1182/blood.V128.22.2580.2580

Published: 2016

Journal Articles

T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire

Ruth A. Ettinger, Pedro Paz, Eddie A. James, Devi Gunasekera, Fred Aswad, Arthur R. Thompson, Dana C. Matthews, Kathleen P. Pratt

Blood (2016) 128 (16): 2043–2054.

https://doi.org/10.1182/blood-2015-11-682468

Published: 2016

Includes: Supplemental data

Journal Articles

Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A

Steven W. Pipe, Robert R. Montgomery, Kathleen P. Pratt, Peter J. Lenting, David Lillicrap

Blood (2016) 128 (16): 2007–2016.

https://doi.org/10.1182/blood-2016-04-713289

Published: 2016

Journal Articles

Neither Factor VIII Nor the Putative F8B Protein Is Detectable in Human Peripheral Blood Mononuclear Cells

Devi Gunasekera, MBBS, Kenneth B. Lewis, PhD, Alexis A. Thompson, MD, Ronald R, Louie, MD, David W. Scott, PhD, Kathleen P. Pratt, PhD

Blood (2015) 126 (23): 3507.

https://doi.org/10.1182/blood.V126.23.3507.3507

Published: 2015

Journal Articles

PBMCs from Hemophilia a Subjects with and without an Inhibitor Show Robust Cytokine Secretion in Response to Factor VIII C2 Domain Epitopes

Devi Gunasekera, MBBS, Debargh Kumar Dutta, PhD, Eddie A. James, PhD, Margaret V Ragni, Kathleen P. Pratt, PhD

Blood (2015) 126 (23): 2291.

https://doi.org/10.1182/blood.V126.23.2291.2291

Published: 2015

Journal Articles

fVIII binds platelets + fibrin: no PS!

Kathleen P. Pratt

Blood (2015) 126 (10): 1158–1159.

https://doi.org/10.1182/blood-2015-07-657924

Published: 2015

Journal Articles

Factor VIII gene variants and inhibitor risk in African American hemophilia A patients

Devi Gunasekera, Ruth A. Ettinger, Shelley Nakaya Fletcher, Eddie A. James, Maochang Liu, John C. Barrett, Janice Withycombe, Dana C. Matthews, Melinda S. Epstein, Richard J. Hughes, Kathleen P. Pratt

Blood (2015) 126 (7): 895–904.

https://doi.org/10.1182/blood-2014-09-599365

Published: 2015

Includes: Supplemental data

Journal Articles

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

Yong Chan Kim, Ai-Hong Zhang, Yan Su, Sadiye Amcaoglu Rieder, Robert J. Rossi, Ruth A. Ettinger, Kathleen P. Pratt, Ethan M. Shevach, David W. Scott

Blood (2015) 125 (7): 1107–1115.

https://doi.org/10.1182/blood-2014-04-566786

Published: 2015

Includes: Supplemental data

Journal Articles

Engineered Antigen-Specific Human Regulatory T Cells Suppress Both FVIII-Specific T- and B-Cell Responses

Yong Chan Kim, PhD, Aihong Zhang, PhD, Kathleen P. Pratt, PhD, Ethan Shevach, MD, David William Scott, PhD

Blood (2014) 124 (21): 239.

https://doi.org/10.1182/blood.V124.21.239.239

Published: 2014

Journal Articles

Factor VIII Gene Variants and Inhibitor Risk in African American Hemophilia a Patients

Devi Gunasekera, MD, Ruth A. Ettinger, PhD, Shelley Nakaya Fletcher, B.S., Eddie A. James, PhD, Maochang Liu, PhD, John C. Barrett, MD, Janice Withycombe, PhD, R.N., M.N., C.C.R.P., Dana C. Matthews, MD, Melinda S. Epstein, PhD, Richard J. Hughes, PhD, Kathleen P. Pratt, PhD

Blood (2014) 124 (21): 235.

https://doi.org/10.1182/blood.V124.21.235.235

Published: 2014

Journal Articles

Screening for Potential HLA-DRB1-Restricted T-Cell Epitopes in Factor VIII Using Peptide Microarrays

Debargh Dutta, PhD, Maochang Liu, PhD, Devi Gunasekera, MD, Kenneth B. Lewis, PhD, Eddie A. James, PhD, Kathleen P. Pratt, PhD

Blood (2014) 124 (21): 1506.

https://doi.org/10.1182/blood.V124.21.1506.1506

Published: 2014

Journal Articles

Engineered FVIII-Specific Human T-Effector Cells: Can the T-Cell Receptor Modulate CD4 + T-Helper Phenotypes or Is It Just a “Switch”?

Patrick Adair, Yong Chan Kim, PhD, Kathleen P. Pratt, PhD, David W Scott, PhD

Blood (2014) 124 (21): 1417.

https://doi.org/10.1182/blood.V124.21.1417.1417

Published: 2014

NARROW

Factor VIII forges its own path

FVIII Protein Is Not Detectable in Human PBMCs or Livers from Dogs with an Intron-22 Inversion Mutation: Implications for FVIII Immunogenicity and Tolerance

Higher Incidence of Neutralizing Anti-FVIII Antibodies (Inhibitors) in Black and Hispanic American Hemophilia A Patients Enrolled in the My Life, Our Future Programme

Elispots and Ex Vivo Expansion of FVIII-Specific T-Cell Clones Confirm Specificity of CD4 + T-Cell Responses to Self-FVIII in Healthy Non-Hemophilic Blood Donors

Neutralizing and Non-Neutralizing Anti-FVIII Antibodies in Black and White Hemophilia A Subjects: A Natural History Profile

Hemophilia A Inhibitor Subjects Show Unique PBMC Gene Expression Profiles That Include up-Regulated Innate Immune Modulators

Marginal immunogenicity of factor VIII

FVIII Proteins with a Modified Immunodominant T-Cell Epitope Exhibit Reduced Immunogenicity and Normal Procoagulant Activity

An Accurate, Simple, and Inexpensive Assay to Diagnose F8 Gene Inversion Mutations in Hemophilia a Patients and Carriers

T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire

Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A

Neither Factor VIII Nor the Putative F8B Protein Is Detectable in Human Peripheral Blood Mononuclear Cells

PBMCs from Hemophilia a Subjects with and without an Inhibitor Show Robust Cytokine Secretion in Response to Factor VIII C2 Domain Epitopes

fVIII binds platelets + fibrin: no PS!

Factor VIII gene variants and inhibitor risk in African American hemophilia A patients

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

Engineered Antigen-Specific Human Regulatory T Cells Suppress Both FVIII-Specific T- and B-Cell Responses

Factor VIII Gene Variants and Inhibitor Risk in African American Hemophilia a Patients

Screening for Potential HLA-DRB1-Restricted T-Cell Epitopes in Factor VIII Using Peptide Microarrays

Engineered FVIII-Specific Human T-Effector Cells: Can the T-Cell Receptor Modulate CD4 + T-Helper Phenotypes or Is It Just a “Switch”?

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American Society of Hematology

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American Society of Hematology

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