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Journal Articles

FVIII Proteins with a Modified Immunodominant T-Cell Epitope Exhibit Reduced Immunogenicity and Normal Procoagulant Activity

Ruth A. Ettinger, PhD, Joseph A. Liberman, PhD, Devi Gunasekera, BSSM, Eddie A. James, PhD, Arthur R. Thompson, MD PhD, Kathleen P. Pratt, PhD

Blood (2017) 130 (Supplement 1): 179.

https://doi.org/10.1182/blood.V130.Suppl_1.179.179

Published: 2017

Journal Articles

T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire

Ruth A. Ettinger, Pedro Paz, Eddie A. James, Devi Gunasekera, Fred Aswad, Arthur R. Thompson, Dana C. Matthews, Kathleen P. Pratt

Blood (2016) 128 (16): 2043–2054.

https://doi.org/10.1182/blood-2015-11-682468

Published: 2016

Includes: Supplemental data

Journal Articles

Factor VIII Proteins Having a Rationally Modified, Immunodominant T-Cell Epitope Demonstrate Normal Procoagulant Activity, Bind To VWF With High Affinity, and Are Markedly Less Stimulatory To FVIII-Specific Human T Cells

Ruth A. Ettinger, Ph.D., Eddie A. James, Ph.D., Komal Puranik, M.Sc., Arthur R. Thompson, M.D., Ph.D., Dana C. Matthews, M.D., Kathleen P. Pratt, Ph.D.

Blood (2013) 122 (21): 574.

https://doi.org/10.1182/blood.V122.21.574.574

Published: 2013

Journal Articles

F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis

Samantha C. Gouw, H. Marijke van den Berg, Johannes Oldenburg, Jan Astermark, Philip G. de Groot, Maurizio Margaglione, Arthur R. Thompson, Waander van Heerde, Jorien Boekhorst, Connie H. Miller, Saskia le Cessie, Johanna G. van der Bom

Blood (2012) 119 (12): 2922–2934.

https://doi.org/10.1182/blood-2011-09-379453

Published: 2012

Includes: Supplemental data

Journal Articles

Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients

Blood (2012) 119 (3): 666–672.

https://doi.org/10.1182/blood-2011-07-367003

Published: 2012

Includes: Supplemental data

Journal Articles

Factor VIII Mutation and Desmopressin-Responsiveness in 63 Patients with Mild Hemophilia A

Danielle Nance, MD, Shelley Nakaya Fletcher, Doug C Bolgiano, MS, Arthur R. Thompson, MD, PhD, Neil C. Josephson, MD, Barbara A. Konkle, M.D.

Blood (2011) 118 (21): 1203.

https://doi.org/10.1182/blood.V118.21.1203.1203

Published: 2011

Journal Articles

Reduced Immunogenicity of FVIII Peptides by Rational Modifications of An Immunodominant T-Cell Epitope.

Ruth A. Ettinger, Ph.D., Joseph A. Liberman, B.S., Douglas C. Bolgiano, M.S., Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2009) 114 (22): 220.

https://doi.org/10.1182/blood.V114.22.220.220

Published: 2009

Journal Articles

Risk Factors for Inhibitor Development in Mild and Moderate Hemophilia A: A Case-Control Study.

Christine L Kempton, MD, MSc, J. Michael Soucie, Ph.D, Connie H. Miller, PhD, Craig Hooper, PhD, Miguel A. Escobar, MD, Mark T. Reding, MD, Alice J. Cohen, MD, Nigel S. Key, MBChB, Arthur R. Thompson, M.D., Ph.D., Marilyn J. Manco-Johnson, Thomas C. Abshire, MD

Blood (2009) 114 (22): 3184.

https://doi.org/10.1182/blood.V114.22.3184.3184

Published: 2009

Journal Articles

CD4 + FOXP3 + regulatory T cells confer long-term regulation of factor VIII–specific immune responses in plasmid-mediated gene therapy–treated hemophilia mice

Carol H. Miao, Benjamin R. Harmeling, Steven F. Ziegler, Benjamin C. Yen, Troy Torgerson, Liping Chen, Roger J. Yau, Baowei Peng, Arthur R. Thompson, Hans D. Ochs, David J. Rawlings

Blood (2009) 114 (19): 4034–4044.

https://doi.org/10.1182/blood-2009-06-228155

Published: 2009

Includes: Supplemental data

Journal Articles

Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti–factor VIII immune responses

Ruth A. Ettinger, Eddie A. James, William W. Kwok, Arthur R. Thompson, Kathleen P. Pratt

Blood (2009) 114 (7): 1423–1428.

https://doi.org/10.1182/blood-2009-01-200725

Published: 2009

Journal Articles

A FVIII C1 Domain Loop Containing Phe2093 Contributes Affinity to the Binding of Recombinant FVIII C1C2 Proteins to Activated Platelets

Ting-Chang Hsu, Ph.D., Kathleen P. Pratt, Ph.D., Arthur R. Thompson, M.D., Ph.D.

Blood (2008) 112 (11): 3069.

https://doi.org/10.1182/blood.V112.11.3069.3069

Published: 2008

Journal Articles

Six Amino Acid Residues in a 1200 Å 2 Interface Mediate Binding of Factor VIII to An IgG4 Inhibitory Antibody.

Jasper C. Lin, Ph.D., Jason T. Schuman, Ph.D., Shelley M. Nakaya, Vasudha Kaushik, Marc Jacquemin, Ph.D., Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2008) 112 (11): 3380.

https://doi.org/10.1182/blood.V112.11.3380.3380

Published: 2008

Journal Articles

B-Cell Epitope Mapping of Monoclonal Anti-Factor VIII C2 Domain Inhibitors: Identification of Amino Acids That Contribute Significant Antigen-Antibody Binding Affinity.

Jasper C. Lin, Ph.D., Jason T. Schuman, Ph.D., Shannon L. Meeks, M.D., John F. Healey, Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2008) 112 (11): 1211.

https://doi.org/10.1182/blood.V112.11.1211.1211

Published: 2008

Journal Articles

HLA-DRB1*1101-Restricted T Cells from Two Unrelated Mild Hemophilia a Inhibitor Subjects with Missense Genotype R593C Respond to the Same Minimal Epitope.

Eddie A. James, Ph.D., Simon D. van Haren, Ruth A. Ettinger, Ph.D., Arthur R. Thompson, M.D., Ph.D., William W. Kwok, Ph.D., Jan Voorberg, Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2008) 112 (11): 1212.

https://doi.org/10.1182/blood.V112.11.1212.1212

Published: 2008

Journal Articles

Identification of Specific Residues in a Human FVIII T-Cell Epitope That Are Essential for An HLA-DRA-DRB1*0101-Restricted T-Cell Response Associated with Inhibitor Development.

Joseph A. Liberman, Ruth A. Ettinger, Ph.D., Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2008) 112 (11): 3396.

https://doi.org/10.1182/blood.V112.11.3396.3396

Published: 2008

Journal Articles

IL-17 Is Secreted by T-Cell Clones Isolated Following An Initial Peak Inhibitor Response to Factor VIIII, Suggesting Th17 Cells Play a Role in Inhibitor Development

Ruth A. Ettinger, Ph.D., Eddie James, Ph.D., William W. Kwok, Ph.D, Arthur R. Thompson, M.D., Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2008) 112 (11): 244.

https://doi.org/10.1182/blood.V112.11.244.244

Published: 2008

Journal Articles

The factor VIII C1 domain contributes to platelet binding

Ting-Chang Hsu, Kathleen P. Pratt, Arthur R. Thompson

Blood (2008) 111 (1): 200–208.

https://doi.org/10.1182/blood-2007-01-068957

Published: 2008

Includes: Supplemental data

Journal Articles

Epitope Identification and Generation of an Antigen-Specific T-Cell Clone in a Mild Hemophilia A Inhibitor Subject with Missense Genotype R593C.

Eddie A. James, PhD, Simon D. van Haren, Ruth A. Ettinger, Ph.D., Arthur R. Thompson, M.D., Ph.D., William W. Kwok, Ph.D., Jan Voorberg, Ph.D., Kathleen P. Pratt, Ph.D.

Blood (2007) 110 (11): 1159.

https://doi.org/10.1182/blood.V110.11.1159.1159

Published: 2007

Journal Articles

Factor VIII’s C Domains Bind to Platelets.

Ting-Chang Hsu, PhD, Kathleen P. Pratt, PhD, Arthur R. Thompson, MD, PhD

Blood (2006) 108 (11): 1715.

https://doi.org/10.1182/blood.V108.11.1715.1715

Published: 2006

Journal Articles

Potential Spectrum of Missense and Nonsense Factor (F)VIII Gene (F8) Alleles Based on Single Nucleotide Substitutions - How Many Remain To Be Identified?.

Kevin R. Viel, BS, Manana Khachidze, MD, PhD, MPH, Laura Almasy, PhD, Arthur R. Thompson, MD, PhD, Tom E. Howard, MD, PhD

Blood (2006) 108 (11): 4039.

https://doi.org/10.1182/blood.V108.11.4039.4039

Published: 2006

NARROW

FVIII Proteins with a Modified Immunodominant T-Cell Epitope Exhibit Reduced Immunogenicity and Normal Procoagulant Activity

T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire

Factor VIII Proteins Having a Rationally Modified, Immunodominant T-Cell Epitope Demonstrate Normal Procoagulant Activity, Bind To VWF With High Affinity, and Are Markedly Less Stimulatory To FVIII-Specific Human T Cells

F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis

Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients

Factor VIII Mutation and Desmopressin-Responsiveness in 63 Patients with Mild Hemophilia A

Reduced Immunogenicity of FVIII Peptides by Rational Modifications of An Immunodominant T-Cell Epitope.

Risk Factors for Inhibitor Development in Mild and Moderate Hemophilia A: A Case-Control Study.

CD4 + FOXP3 + regulatory T cells confer long-term regulation of factor VIII–specific immune responses in plasmid-mediated gene therapy–treated hemophilia mice

Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti–factor VIII immune responses

A FVIII C1 Domain Loop Containing Phe2093 Contributes Affinity to the Binding of Recombinant FVIII C1C2 Proteins to Activated Platelets

Six Amino Acid Residues in a 1200 Å 2 Interface Mediate Binding of Factor VIII to An IgG4 Inhibitory Antibody.

B-Cell Epitope Mapping of Monoclonal Anti-Factor VIII C2 Domain Inhibitors: Identification of Amino Acids That Contribute Significant Antigen-Antibody Binding Affinity.

HLA-DRB1*1101-Restricted T Cells from Two Unrelated Mild Hemophilia a Inhibitor Subjects with Missense Genotype R593C Respond to the Same Minimal Epitope.

Identification of Specific Residues in a Human FVIII T-Cell Epitope That Are Essential for An HLA-DRA-DRB1*0101-Restricted T-Cell Response Associated with Inhibitor Development.

IL-17 Is Secreted by T-Cell Clones Isolated Following An Initial Peak Inhibitor Response to Factor VIIII, Suggesting Th17 Cells Play a Role in Inhibitor Development

The factor VIII C1 domain contributes to platelet binding

Epitope Identification and Generation of an Antigen-Specific T-Cell Clone in a Mild Hemophilia A Inhibitor Subject with Missense Genotype R593C.

Factor VIII’s C Domains Bind to Platelets.

Potential Spectrum of Missense and Nonsense Factor (F)VIII Gene (F8) Alleles Based on Single Nucleotide Substitutions - How Many Remain To Be Identified?.

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American Society of Hematology

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American Society of Hematology

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