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Journal Articles

Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain

Emily R. Legan, Yi Liu, Nicholas A. Arce, Ernest T. Parker, Pete Lollar, X. Frank Zhang, Renhao Li

Blood (2023) 141 (10): 1221–1232.

https://doi.org/10.1182/blood.2022017239

Published: 2023

Includes: Supplemental data

Journal Articles

Marginal Zone B Cells Facilitate CD4 T Cell Proliferation in Response to Factor VIII in Mice with Hemophilia Α

Patricia E Zerra, James W. McCoy, Seema R Patel, Ernest T. Parker, Wallace H. Baldwin, John Healey, Shannon L. Meeks, Sean R. Stowell

Blood (2022) 140 (Supplement 1): 2703–2704.

https://doi.org/10.1182/blood-2022-167501

Published: 2022

Journal Articles

The Immune Response to Murine Factor VIII in Single Exon Deletion and Total Gene Deletion Murine Models of Hemophilia a

Seema R Patel, PhD, Wallace H. Baldwin, Courtney Cox, MSc, John Healey, BS, Ernest T. Parker, Glaivy Batsuli, MD, Shannon L. Meeks, MD

Blood (2019) 134 (Supplement_1): 1109.

https://doi.org/10.1182/blood-2019-130890

Published: 2019

Journal Articles

The 3.2 Angstrom Crystal Structure of a Bioengineered Factor VIII Construct Illustrates Two Conformations of the C2 Domain

Ian W Smith, MS, Anne d'Aquino, BS, Ernest T. Parker, Christopher B Doering, PhD, Paul C Spiegel, Jr., PhD

Blood (2018) 132 (Supplement 1): 21.

https://doi.org/10.1182/blood-2018-99-119083

Published: 2018

Journal Articles

Mapping the Masked Region of the A1 Domain in Full-Length VWF

Wei Deng, PhD, Ernest T. Parker, BA, John S. Lollar, MD, Renhao Li, PhD

Blood (2017) 130 (Supplement 1): 3599.

https://doi.org/10.1182/blood.V130.Suppl_1.3599.3599

Published: 2017

Journal Articles

Frequency and epitope specificity of anti–factor VIII C1 domain antibodies in acquired and congenital hemophilia A

Joerg Kahle, Aleksander Orlowski, Diana Stichel, John F. Healey, Ernest T. Parker, Marc Jacquemin, Manuela Krause, Andreas Tiede, Dirk Schwabe, Pete Lollar, Christoph Königs

Blood (2017) 130 (6): 808–816.

https://doi.org/10.1182/blood-2016-11-751347

Published: 2017

Includes: Supplemental data

Journal Articles

Characterization of Factor VIII Immune Complexes By Analytical Ultracentrifugation

Pete Lollar, MD, Ernest T. Parker, John F. Healey, Christopher B. Doering, PhD

Blood (2016) 128 (22): 3787.

https://doi.org/10.1182/blood.V128.22.3787.3787

Published: 2016

Journal Articles

Factor VIII C2 Domain Epitopes Recognized By Classical and Non-Classical Anti-C2 Domain Monoclonal Antibodies Help Mediate FVIII Uptake By Dendritic Cells

Glaivy Batsuli, MD, Wallace Hunter Baldwin, BS, John F Healey, BS, Ernest T Parker, BS, Courtney Cox, MSc, Pete Lollar, MD, Shannon L. Meeks, MD

Blood (2016) 128 (22): 3762.

https://doi.org/10.1182/blood.V128.22.3762.3762

Published: 2016

Journal Articles

High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors

Glaivy Batsuli, Wei Deng, John F. Healey, Ernest T. Parker, W. Hunter Baldwin, Courtney Cox, Brenda Nguyen, Joerg Kahle, Christoph Königs, Renhao Li, Pete Lollar, Shannon L. Meeks

Blood (2016) 128 (16): 2055–2067.

https://doi.org/10.1182/blood-2016-02-701805

Published: 2016

Includes: Supplemental data

Journal Articles

A subset of high-titer anti–factor VIII A2 domain antibodies is responsive to treatment with factor VIII

Joshua Eubanks, W. Hunter Baldwin, Rebecca Markovitz, Ernest T. Parker, Courtney Cox, Christine L. Kempton, Shannon L. Meeks

Blood (2016) 127 (16): 2028–2034.

https://doi.org/10.1182/blood-2015-09-670034

Published: 2016

Journal Articles

Bioengineering Coagulation Factor VIII through Ancestral Protein Reconstruction

Philip Zakas, BS, Kristopher Knight, Ernest T Parker, BA, H. Trent Spencer, PhD, Eric Gaucher, PhD, Christopher B Doering, PhD

Blood (2015) 126 (23): 123.

https://doi.org/10.1182/blood.V126.23.123.123

Published: 2015

Journal Articles

Frequency and Epitope Specificity of Anti-Factor VIII C1 Domain Antibodies in Acquired and Hereditary Hemophilia Inhibitor Patient Plasma

Joerg Kahle, PhD, Aleksander Orlowski, Anja Schmidt, PhD, Kerstin Brettschneider, Thomas Klingebiel, MD, John F Healey, BS, Ernest T Parker, BA, John (Pete) S Lollar, MD, Marc Jacquemin, MD, Manuela Krause, MD, Andreas Tiede, MD PhD, Dirk Schwabe, MD, Christoph Königs, MD PhD

Blood (2015) 126 (23): 3491.

https://doi.org/10.1182/blood.V126.23.3491.3491

Published: 2015

Journal Articles

Decreasing the Humoral Response to Factor VIII By Targeted Deletion of Factor VIII - Specific B Cells

Rebecca C. Markovitz, John F. Healey, W. Hunter Baldwin, Ernest T. Parker, Shannon L. Meeks, Pete Lollar

Blood (2014) 124 (21): 238.

https://doi.org/10.1182/blood.V124.21.238.238

Published: 2014

Journal Articles

Anti-Factor VIII A2 Epitopes In a Murine Bleeding Model

Joshua Eubanks, B.A., Wallace Hunter Baldwin, B.S., Rebecca Markovitz, B.A., Ernest T Parker, B.A., Shannon L. Meeks, MD

Blood (2013) 122 (21): 1100.

https://doi.org/10.1182/blood.V122.21.1100.1100

Published: 2013

Journal Articles

Anti-FVIII Autoantibodies Share Similar Characteristics In Acquired Hemophilia A Patients With and Without An Associated Disease

Joerg Kahle, PhD, Christoph Königs, MD, PhD, Anja Naumann, Thomas Klingebiel, MD, John F Healey, Ernest T Parker, B.A., Pete Lollar, MD, Dirk Schwabe, MD, Manuela Krause, MD

Blood (2013) 122 (21): 1110.

https://doi.org/10.1182/blood.V122.21.1110.1110

Published: 2013

Journal Articles

The diversity of the immune response to the A2 domain of human factor VIII

Rebecca C. Markovitz, John F. Healey, Ernest T. Parker, Shannon L. Meeks, Pete Lollar

Blood (2013) 121 (14): 2785–2795.

https://doi.org/10.1182/blood-2012-09-456582

Published: 2013

Includes: Supplemental data

Journal Articles

A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function

Shannon L. Meeks, Courtney L. Cox, John F. Healey, Ernest T. Parker, Bhavya S. Doshi, Bagirath Gangadharan, Rachel T. Barrow, Pete Lollar

Blood (2012) 120 (12): 2512–2520.

https://doi.org/10.1182/blood-2012-02-412361

Published: 2012

Includes: Supplemental data

Journal Articles

The Structural and Functional Diversity of the Humoral Immune Response to the A2 Domain of Human Factor VIII

Rebecca Markovitz, John (Pete) S. Lollar, III, M.D., John F. Healey, B.S., Ernest T Parker, B.A., Shannon Meeks, M.D.

Blood (2011) 118 (21): 2247.

https://doi.org/10.1182/blood.V118.21.2247.2247

Published: 2011

Journal Articles

Factor VIII Structure, Not Activity, Is the Primary Determinant of Immunogenicity in Hemophilia A and Combined Hemophilia A/Von Willebrand Disease Mice

Shannon L. Meeks, MD, Courtney Cox, M.S., John F. Healey, B.S., Ernest T Parker, B.A., Bagirath Gangadharan, MS, Rachel T. Barrow, BS, John (Pete) S. Lollar, III, M.D.

Blood (2011) 118 (21): 1187.

https://doi.org/10.1182/blood.V118.21.1187.1187

Published: 2011

Journal Articles

Factor VIII A3 domain substitution N1922S results in hemophilia A due to domain-specific misfolding and hyposecretion of functional protein

Ryan J. Summers, Shannon L. Meeks, John F. Healey, Harrison C. Brown, Ernest T. Parker, Christine L. Kempton, Christopher B. Doering, Pete Lollar

Blood (2011) 117 (11): 3190–3198.

https://doi.org/10.1182/blood-2010-09-307074

Published: 2011

Includes: Supplemental data

NARROW

Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain

Marginal Zone B Cells Facilitate CD4 T Cell Proliferation in Response to Factor VIII in Mice with Hemophilia Α

The Immune Response to Murine Factor VIII in Single Exon Deletion and Total Gene Deletion Murine Models of Hemophilia a

The 3.2 Angstrom Crystal Structure of a Bioengineered Factor VIII Construct Illustrates Two Conformations of the C2 Domain

Mapping the Masked Region of the A1 Domain in Full-Length VWF

Frequency and epitope specificity of anti–factor VIII C1 domain antibodies in acquired and congenital hemophilia A

Characterization of Factor VIII Immune Complexes By Analytical Ultracentrifugation

Factor VIII C2 Domain Epitopes Recognized By Classical and Non-Classical Anti-C2 Domain Monoclonal Antibodies Help Mediate FVIII Uptake By Dendritic Cells

High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors

A subset of high-titer anti–factor VIII A2 domain antibodies is responsive to treatment with factor VIII

Bioengineering Coagulation Factor VIII through Ancestral Protein Reconstruction

Frequency and Epitope Specificity of Anti-Factor VIII C1 Domain Antibodies in Acquired and Hereditary Hemophilia Inhibitor Patient Plasma

Decreasing the Humoral Response to Factor VIII By Targeted Deletion of Factor VIII - Specific B Cells

Anti-Factor VIII A2 Epitopes In a Murine Bleeding Model

Anti-FVIII Autoantibodies Share Similar Characteristics In Acquired Hemophilia A Patients With and Without An Associated Disease

The diversity of the immune response to the A2 domain of human factor VIII

A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function

The Structural and Functional Diversity of the Humoral Immune Response to the A2 Domain of Human Factor VIII

Factor VIII Structure, Not Activity, Is the Primary Determinant of Immunogenicity in Hemophilia A and Combined Hemophilia A/Von Willebrand Disease Mice

Factor VIII A3 domain substitution N1922S results in hemophilia A due to domain-specific misfolding and hyposecretion of functional protein

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American Society of Hematology

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American Society of Hematology

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