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Journal Articles

Blocking Vascular Niche E-Selectin Dampens AML Stem Cell Regeneration/Survival Potential In Vivo By Inhibiting MAPK/ERK and PI3K/AKT Signalling Pathways

Ingrid G Winkler, PhD, Valerie Barbier, Masters, Joshua Tay, PhD, Jean-Pierre Levesque, PhD, John L. Magnani, PhD, Corrine E Fiveash, BSc(Hons), Johanna D Erbani

Blood (2019) 134 (Supplement_1): 2657.

https://doi.org/10.1182/blood-2019-132212

Published: 2019

Journal Articles

CD162 Is a Key E-Selectin Receptor Promoting Acute Myeloid Leukemia Chemo-Resistance in the Bone Marrow Niche

Johanna D Erbani, Joshua Tay, PhD, Valerie Barbier, Masters, Jean-Pierre Levesque, PhD, John L. Magnani, PhD, Ingrid G Winkler, PhD

Blood (2019) 134 (Supplement_1): 907.

https://doi.org/10.1182/blood-2019-132233

Published: 2019

Journal Articles

Prostaglandin I 2 in the Endosteal Bone Marrow Niche As a Novel Regulator of Hematopoietic Stem Cells

Joshua Tay, PhD, Jean-Pierre Levesque, PhD, Falak Helwani, PhD, Gareth Price, PhD, Bianca Nowlan, Masters, Valerie Barbier, Masters, Ingrid G Winkler, PhD

Blood (2018) 132 (Supplement 1): 2575.

https://doi.org/10.1182/blood-2018-99-115869

Published: 2018

Journal Articles

Vascular E-Selectin Acts As a Gatekeeper Inducing Commitment and Loss of Self-Renewal in HSC Transmigrating through the Marrow Vasculature

Ingrid G Winkler, PhD, Valerie Barbier, Masters, Jessica Lowe, BSc(Hons), Joshua Tay, PhD, John L Magnani, PhD, Paula Marlton, Anthony K Mills, FRACP, FRCPA, MBBS, Andrew Perkins, MBBS, PhD FRCPA, FRACP, Corrine E Fiveash, BSc(Hons), Johanna M Erbani, PhDstudent, Jean-Pierre Levesque, PhD

Blood (2018) 132 (Supplement 1): 4552.

https://doi.org/10.1182/blood-2018-99-120376

Published: 2018

Journal Articles

Vascular E-Selectin Mediates Chemo-Resistance in Acute Myeloid Leukemia Initiating Cells Via Canonical Receptors PSGL-1 (CD162) and Hcell (CD44) and AKT Signaling

Ingrid G Winkler, PhD, Johanna M Erbani, PhDstudent, Valerie Barbier, Masters, Julie M Davies, PhD, Joshua Tay, PhDstudent, Corrine E Fiveash, BSc(Hons), Jessica Lowe, BSc(Hons), Michael Tallack, MDPhD, John L Magnani, PhD, Jean-Pierre Levesque, PhD

Blood (2017) 130 (Supplement 1): 793.

https://doi.org/10.1182/blood.V130.Suppl_1.793.793

Published: 2017

Journal Articles

Vascular E-Selectin Protects Leukemia Cells from Chemotherapy By Directly Activating Pro-Survival NF-Kb Signalling - Therapeutic Blockade of E-Selectin Dampens NF-Kb Activation

Ingrid G Winkler, PhD, Valerie Barbier, Micheal Ward, PhD, Michael Tallack, PhD MD, Jessica Lowe, Julie Davies, Johanna Erbani, John L Magnani, PhD, Jean-Pierre Levesque, PhD

Blood (2016) 128 (22): 2823.

https://doi.org/10.1182/blood.V128.22.2823.2823

Published: 2016

Journal Articles

Mobilization of CD8 + Central Memory T-Cells with Enhanced Reconstitution Potential in Mice By a Combination of G-CSF and GMI-1271-Mediated E-Selectin Blockade

Ingrid G Winkler, PhD, Valerie Barbier, Kristen J Radford, PhD, Julie M Davies, PhD, Jean-Pierre Levesque, PhD, Theodore A.G. Smith, PhD, William E. Fogler, PhD, John L Magnani, PhD

Blood (2015) 126 (23): 512.

https://doi.org/10.1182/blood.V126.23.512.512

Published: 2015

Journal Articles

Mobilisation of Reconstituting HSC Is Boosted By Synergy Between G-CSF and E-Selectin Antagonist GMI-1271.

Ingrid G Winkler, PhD, Valerie Barbier, Andrew C Perkins, MDPhD, John L. Magnani, PhD, Jean-Pierre Levesque, PhD

Blood (2014) 124 (21): 317.

https://doi.org/10.1182/blood.V124.21.317.317

Published: 2014

Journal Articles

Vascular Niche E-Selectin Protects Acute Myeloid Leukaemia Stem Cells from Chemotherapy

Ingrid G Winkler, PhD, Valerie Barbier, Diwakar R Pattabiraman, PhD, Thomas J Gonda, PhD, John L. Magnani, PhD, Jean-Pierre Levesque, PhD

Blood (2014) 124 (21): 620.

https://doi.org/10.1182/blood.V124.21.620.620

Published: 2014

Journal Articles

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes

Diwakar R. Pattabiraman, Crystal McGirr, Konstantin Shakhbazov, Valerie Barbier, Keerthana Krishnan, Pamela Mukhopadhyay, Paula Hawthorne, Ann Trezise, Jianmin Ding, Sean M. Grimmond, Peter Papathanasiou, Warren S. Alexander, Andrew C. Perkins, Jean-Pierre Levesque, Ingrid G. Winkler, Thomas J. Gonda

Blood (2014) 123 (17): 2682–2690.

https://doi.org/10.1182/blood-2012-02-413187

Published: 2014

Includes: Supplemental data

Journal Articles

Administration Of E-Selectin Antagonist GMI-1271 Improves Survival After High-Dose Chemotherapy By Alleviating Mucositis and Accelerating Neutrophil Recovery

Ingrid G Winkler, PhD, Valerie Barbier, Heather L Nutt, Sumaira Z Hasnain, PhD, Jean-Pierre Levesque, PhD, John L. Magnani, PhD, Michael A McGuckin, PhD

Blood (2013) 122 (21): 2266.

https://doi.org/10.1182/blood.V122.21.2266.2266

Published: 2013

Journal Articles

Mobilizing Doses Of G-CSF Stop Medullary Erythropoiesis By Depleting F4/80+ VCAM1+ ER-HR3+ CD169+ Erythroid-Island Macrophages

Rebecca Jacobsen, BSc, Allison R Pettit, PhD, Liza J Raggatt, PhD, Bianca Nowlan, Valerie Barbier, Catherine E Forristal, PhD, Ingrid G Winkler, PhD, Jean-Pierre Levesque, PhD

Blood (2013) 122 (21): 309.

https://doi.org/10.1182/blood.V122.21.309.309

Published: 2013

Journal Articles

Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation

Catherine E. Forristal, Ingrid G. Winkler, Bianca Nowlan, Valerie Barbier, Gail Walkinshaw, Jean-Pierre Levesque

Blood (2013) 121 (5): 759–769.

https://doi.org/10.1182/blood-2012-02-408419

Published: 2013

Includes: Supplemental data

Journal Articles

FG-4497, a Pharmacological Stabilizer of HIF-1α Protein, Synergistically Enhances Hematopoietic Stem Cells (HSC) Mobilization in Response to G-CSF and Plerixafor

Catherine E Forristal, PhD, Bianca Nowlan, Valerie Barbier, Ingrid G Winkler, PhD, Gail Walkinshaw, PhD, Jean-Pierre Levesque, PhD

Blood (2012) 120 (21): 216.

https://doi.org/10.1182/blood.V120.21.216.216

Published: 2012

Journal Articles

Interaction of c-Myb with p300 Is Required for the Induction of Acute Myeloid Leukemia by Human AML Oncogenes, and Represents a Potential Therapeutic Target.

Diwakar R Pattabiraman, PhD, Konstantin Shakhbazov, PhD, Valerie Barbier, Crystal McGirr, BSc (Hons), Keerthana Krishnan, BSc (Hons), Pamela Mukhopadhyay, PhD, Paula Hawthorne, PhD, Ann Trezise, PhD, Sean Grimmond, PhD, Peter Papathanasiou, Andrew C. Perkins, MBBS, PhD, FRACP, FRCPA, Jean-Pierre Levesque, PhD, Warren S. Alexander, Ingrid G Winkler, PhD, Thomas J Gonda, PhD

Blood (2012) 120 (21): 2402.

https://doi.org/10.1182/blood.V120.21.2402.2402

Published: 2012

Journal Articles

Oxygen-Independent Stabilization of the Oxygen-Labile Transcription Factor HIF-1α with Dimethyloxalyl Glycine or FG-4497 Increases Hematopoietic Stem Cell Quiescence In Vivo and Mobilization in Response to G-CSF

Catherine Forristal, PhD, Bianca Nowlan, Valerie Barbier, Domenica McCarthy, Gail Walkinshaw, PhD, Ingrid G Winkler, PhD, Jean-Pierre Levesque, PhD

Blood (2011) 118 (21): 2334.

https://doi.org/10.1182/blood.V118.21.2334.2334

Published: 2011

Journal Articles

Mobilizing Agents G-CSF, Cyclophosphamide or AMD3100 (Plerixafor) Have Distinct Effects on Osteoblasts, Hematopoietic Stem Cell Niches, and B-Lymphopoiesis,

Jean-Pierre Levesque, PhD, Linda J. Bendall, BSc, PhD, Allison R Pettit, PhD, Liza Raggatt, PhD, Rebecca Jacobsen, BSc, Valerie Barbier, Bianca Nowlan, Yi Shen, PhD, Natalie A Sims, PhD, Ingrid G Winkler, PhD

Blood (2011) 118 (21): 4005.

https://doi.org/10.1182/blood.V118.21.4005.4005

Published: 2011

Journal Articles

Impairment of Hematopoietic Stem Cell (HSC) Niche by G-CSF Is Associated with Rapid Mobilization of Serially Reconstituting HSC and Reduced Competitive Repopulation of Mobilized Bone Marrow

Jean-Pierre Levesque, PhD, Valerie Barbier, Bianca Nowlan, Domenica McCarhty, Ingrid G Winkler, PhD

Blood (2011) 118 (21): 1889.

https://doi.org/10.1182/blood.V118.21.1889.1889

Published: 2011

Journal Articles

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

Ingrid G. Winkler, Natalie A. Sims, Allison R. Pettit, Valérie Barbier, Bianca Nowlan, Falak Helwani, Ingrid J. Poulton, Nico van Rooijen, Kylie A. Alexander, Liza J. Raggatt, Jean-Pierre Lévesque

Blood (2010) 116 (23): 4815–4828.

https://doi.org/10.1182/blood-2009-11-253534

Published: 2010

Includes: Supplemental data

Journal Articles

Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches

Ingrid G. Winkler, Valérie Barbier, Robert Wadley, Andrew C. W. Zannettino, Sharon Williams, Jean-Pierre Lévesque

Blood (2010) 116 (3): 375–385.

https://doi.org/10.1182/blood-2009-07-233437

Published: 2010

Includes: Supplemental data

NARROW

Blocking Vascular Niche E-Selectin Dampens AML Stem Cell Regeneration/Survival Potential In Vivo By Inhibiting MAPK/ERK and PI3K/AKT Signalling Pathways

CD162 Is a Key E-Selectin Receptor Promoting Acute Myeloid Leukemia Chemo-Resistance in the Bone Marrow Niche

Prostaglandin I 2 in the Endosteal Bone Marrow Niche As a Novel Regulator of Hematopoietic Stem Cells

Vascular E-Selectin Acts As a Gatekeeper Inducing Commitment and Loss of Self-Renewal in HSC Transmigrating through the Marrow Vasculature

Vascular E-Selectin Mediates Chemo-Resistance in Acute Myeloid Leukemia Initiating Cells Via Canonical Receptors PSGL-1 (CD162) and Hcell (CD44) and AKT Signaling

Vascular E-Selectin Protects Leukemia Cells from Chemotherapy By Directly Activating Pro-Survival NF-Kb Signalling - Therapeutic Blockade of E-Selectin Dampens NF-Kb Activation

Mobilization of CD8 + Central Memory T-Cells with Enhanced Reconstitution Potential in Mice By a Combination of G-CSF and GMI-1271-Mediated E-Selectin Blockade

Mobilisation of Reconstituting HSC Is Boosted By Synergy Between G-CSF and E-Selectin Antagonist GMI-1271.

Vascular Niche E-Selectin Protects Acute Myeloid Leukaemia Stem Cells from Chemotherapy

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes

Administration Of E-Selectin Antagonist GMI-1271 Improves Survival After High-Dose Chemotherapy By Alleviating Mucositis and Accelerating Neutrophil Recovery

Mobilizing Doses Of G-CSF Stop Medullary Erythropoiesis By Depleting F4/80+ VCAM1+ ER-HR3+ CD169+ Erythroid-Island Macrophages

Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation

FG-4497, a Pharmacological Stabilizer of HIF-1α Protein, Synergistically Enhances Hematopoietic Stem Cells (HSC) Mobilization in Response to G-CSF and Plerixafor

Interaction of c-Myb with p300 Is Required for the Induction of Acute Myeloid Leukemia by Human AML Oncogenes, and Represents a Potential Therapeutic Target.

Oxygen-Independent Stabilization of the Oxygen-Labile Transcription Factor HIF-1α with Dimethyloxalyl Glycine or FG-4497 Increases Hematopoietic Stem Cell Quiescence In Vivo and Mobilization in Response to G-CSF

Mobilizing Agents G-CSF, Cyclophosphamide or AMD3100 (Plerixafor) Have Distinct Effects on Osteoblasts, Hematopoietic Stem Cell Niches, and B-Lymphopoiesis,

Impairment of Hematopoietic Stem Cell (HSC) Niche by G-CSF Is Associated with Rapid Mobilization of Serially Reconstituting HSC and Reduced Competitive Repopulation of Mobilized Bone Marrow

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches

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