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Issue Archive

Volume 122, Issue 20
November 14 2013
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS
A new twist to the GATA switch
Sjaak Philipsen
View Articletitled, A new twist to the GATA switch
IMMUNOBIOLOGY
Risky business: target choice in adoptive cell therapy
Richard A. Morgan
View Articletitled, Risky business: target choice in adoptive cell therapy
IMMUNOBIOLOGY
The C3a receptor, caspase-1, and release of IL-1β
Charles A. Dinarello
View Articletitled, The C3a receptor, caspase-1, and release of IL-1β
INSIDE BLOOD
Shedding light on UVR and Hodgkin lymphoma
Lindsay M. Morton,D. Michal Freedman
View Articletitled, Shedding light on UVR and Hodgkin lymphoma
INSIDE BLOOD
In the spotlight: a novel CD37 antibody-drug conjugate
M. Lia Palomba,Anas Younes
View Articletitled, In the spotlight: a novel CD37 antibody-drug conjugate
MYELOID NEOPLASIA
Asparaginase unveils glutamine-addicted AML
Ismael Samudio,Marina Konopleva
View Articletitled, Asparaginase unveils glutamine-addicted AML
PLATELETS & THROMBOPOIESIS
Dengue platelets meet Sir Arthur Conan Doyle
Paul F. Bray
View Articletitled, Dengue platelets meet Sir Arthur Conan Doyle

BLOOD WORK

Hemophagocytosis and complex marrow karyotype in metastatic adenocarcinoma
Richard Cheung Yiu,Lai-Ching Lau
View Articletitled, Hemophagocytosis and complex marrow karyotype in metastatic adenocarcinoma
Opana-ER used the wrong way: intravenous abuse leading to microangiopathic hemolysis and a TTP-like syndrome
Ali Imran Amjad,Rahul A. Parikh
View Articletitled, Opana-ER used the wrong way: intravenous abuse leading to microangiopathic hemolysis and a TTP-like syndrome

PLENARY PAPER

Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation
Eugenio D. Hottz,Juliana F. Lopes,Carla Freitas,Rogério Valls-de-Souza,Marcus F. Oliveira,Marcelo T. Bozza,Andrea T. Da Poian,Andrew S. Weyrich,Guy A. Zimmerman,Fernando A. Bozza,Patricia T. Bozza
View Articletitled, Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation
Supplemental data

REVIEW ARTICLE

Inflammation, obesity, and thrombosis
Fahumiya Samad,Wolfram Ruf
View Articletitled, Inflammation, obesity, and thrombosis

REVIEW SERIES

Genetic sequence analysis of inherited bleeding diseases
Flora Peyvandi,Tom Kunicki,David Lillicrap
View Articletitled, Genetic sequence analysis of inherited bleeding diseases

CLINICAL TRIALS AND OBSERVATIONS

A phase 2 trial of azacitidine and gemtuzumab ozogamicin therapy in older patients with acute myeloid leukemia
Clinical Trials & Observations
Sucha Nand,Megan Othus,John E. Godwin,Cheryl L. Willman,Thomas H. Norwood,Dianna S. Howard,Steven E. Coutre,Harry P. Erba,Frederick R. Appelbaum
View Articletitled, A phase 2 trial of azacitidine and gemtuzumab ozogamicin therapy in older patients with acute myeloid leukemia

HEMATOPOIESIS AND STEM CELLS

Exome sequencing reveals a thrombopoietin ligand mutation in a Micronesian family with autosomal recessive aplastic anemia
Majed J. Dasouki,Syed K. Rafi,Adam J. Olm-Shipman,Nathan R. Wilson,Sunil Abhyankar,Brigitte Ganter,L. Mike Furness,Jianwen Fang,Rodrigo T. Calado,Irfan Saadi
View Articletitled, Exome sequencing reveals a thrombopoietin ligand mutation in a Micronesian family with autosomal recessive aplastic anemia
Supplemental data
The Gata1 5′ region harbors distinct cis-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCs
Jun Takai,Takashi Moriguchi,Mikiko Suzuki,Lei Yu,Kinuko Ohneda,Masayuki Yamamoto
View Articletitled, The <em>Gata1</em> 5′ region harbors distinct <em>cis</em>-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCs
Supplemental data

IMMUNOBIOLOGY

CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma
Monica Casucci,Benedetta Nicolis di Robilant,Laura Falcone,Barbara Camisa,Margherita Norelli,Pietro Genovese,Bernhard Gentner,Fabiana Gullotta,Maurilio Ponzoni,Massimo Bernardi,Magda Marcatti,Aurore Saudemont,Claudio Bordignon,Barbara Savoldo,Fabio Ciceri,Luigi Naldini,Gianpietro Dotti,Chiara Bonini,Attilio Bondanza
View Articletitled, CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma
Supplemental data
C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation
Elham Asgari,Gaelle Le Friec,Hidekazu Yamamoto,Esperanza Perucha,Steven S. Sacks,Jörg Köhl,H. Terence Cook,Claudia Kemper
View Articletitled, C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation
Supplemental data
Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab
Josée Golay,Fabio Da Roit,Luca Bologna,Claudia Ferrara,Jeanette H. Leusen,Alessandro Rambaldi,Christian Klein,Martino Introna
View Articletitled, Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab
Supplemental data

LYMPHOID NEOPLASIA

Exposure to UV radiation and risk of Hodgkin lymphoma: a pooled analysis
Alain Monnereau,Sally L. Glaser,Clayton W. Schupp,Karin Ekström Smedby,Silvia de Sanjosé,Eleanor Kane,Mads Melbye,Lenka Forétova,Marc Maynadié,Anthony Staines,Nikolaus Becker,Alexandra Nieters,Paul Brennan,Paolo Boffetta,Pierluigi Cocco,Ingrid Glimelius,Jacqueline Clavel,Henrik Hjalgrim,Ellen T. Chang
View Articletitled, Exposure to UV radiation and risk of Hodgkin lymphoma: a pooled analysis
A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies
Jutta Deckert,Peter U. Park,Sharon Chicklas,Yong Yi,Min Li,Katharine C. Lai,Michele F. Mayo,Christina N. Carrigan,Hans K. Erickson,Jan Pinkas,Robert J. Lutz,Thomas Chittenden,John M. Lambert
View Articletitled, A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies
Comprehensive analysis of PTEN status in Sézary syndrome
Cristina Cristofoletti,Maria Cristina Picchio,Cristina Lazzeri,Valeria Tocco,Elena Pagani,Antonella Bresin,Barbara Mancini,Francesca Passarelli,Antonio Facchiano,Enrico Scala,Giuseppe Alfonso Lombardo,Maria Cantonetti,Elisabetta Caprini,Giandomenico Russo,Maria Grazia Narducci
View Articletitled, Comprehensive analysis of PTEN status in Sézary syndrome
Supplemental data

MYELOID NEOPLASIA

Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia
Lise Willems,Nathalie Jacque,Arnaud Jacquel,Nathalie Neveux,Thiago Trovati Maciel,Mireille Lambert,Alain Schmitt,Laury Poulain,Alexa S. Green,Madalina Uzunov,Olivier Kosmider,Isabelle Radford-Weiss,Ivan Cruz Moura,Patrick Auberger,Norbert Ifrah,Valérie Bardet,Nicolas Chapuis,Catherine Lacombe,Patrick Mayeux,Jérôme Tamburini,Didier Bouscary
View Articletitled, Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia
Supplemental data

PLATELETS AND THROMBOPOIESIS

cAMP signaling regulates platelet myosin light chain (MLC) phosphorylation and shape change through targeting the RhoA-Rho kinase-MLC phosphatase signaling pathway
Ahmed Aburima,Katie S. Wraith,Zaher Raslan,Robert Law,Simbarashe Magwenzi,Khalid M. Naseem
View Articletitled, cAMP signaling regulates platelet myosin light chain (MLC) phosphorylation and shape change through targeting the RhoA-Rho kinase-MLC phosphatase signaling pathway
Supplemental data
  • Cover Image

    Cover Image

    issue cover

    Immunofluorescence histology of a biopsy sample from a kidney undergoing T-cell–mediated rejection after transplantation. Depicted is the increase in IL-17 production by kidney epithelial cells (green) during the inflammatory rejection reaction and the infiltration of high numbers of tissue-destructive CD4+ IL-17-producing (red and yellow/orange) effector T cells. Nuclei are stained blue with 4′-6-diamidino-2-phenylindole (DAPI). See the article by Asgari et al on page 3473.

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