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Issue Archive

Volume 121, Issue 6
February 7 2013
Issue Cover

Table of Contents

Inside Blood

HEMATOPOIESIS & STEM CELLS
Osteocytes link bone maintenance to blood homeostasis
Daniel C. Link
View Articletitled, Osteocytes link bone maintenance to blood homeostasis
IMMUNOBIOLOGY
Arenaviruses bite the “dust”
Ricardo M. Gómez,Mirta Schattner
View Articletitled, Arenaviruses bite the “dust”
MYELOID NEOPLASIA
CUX1 in leukemia: dosage matters
Jacqueline Boultwood
View Articletitled, CUX1 in leukemia: dosage matters
PHAGOCYTES, GRANULOCYTES, & MYELOPOIESIS
miR-142 keeps CD4+ DCs in balance
Gabrielle T. Belz
View Articletitled, miR-142 keeps CD4<sup>+</sup> DCs in balance
PHAGOCYTES, GRANULOCYTES, & MYELOPOIESIS
Poikiloderma with neutropenia: beginning at the end
Philip J. Mason,Monica Bessler
View Articletitled, Poikiloderma with neutropenia: beginning at the end

Blood Work

On a WHIM
Charles M. van Slambrouck,Sandeep Gurbuxani
View Articletitled, On a WHIM

Plenary Paper

TRANSPLANTATION
Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes
Clinical Trials & Observations
Rebecca A. Marsh,Kanchan Rao,Prakash Satwani,Kai Lehmberg,Ingo Müller,Dandan Li,Mi-Ok Kim,Alain Fischer,Sylvain Latour,Petr Sedlacek,Vincent Barlogis,Kazuko Hamamoto,Hirokazu Kanegane,Sam Milanovich,David A. Margolis,David Dimmock,James Casper,Dorothea N. Douglas,Persis J. Amrolia,Paul Veys,Ashish R. Kumar,Michael B. Jordan,Jack J. Bleesing,Alexandra H. Filipovich
View Articletitled, Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes

Perspectives

Improving overall survival and overcoming adverse prognosis in the treatment of cytogenetically high-risk multiple myeloma
Clinical Trials & Observations
P. Leif Bergsagel,María-Victoria Mateos,Norma C. Gutierrez,S. Vincent Rajkumar,Jesús F. San Miguel
View Articletitled, Improving overall survival and overcoming adverse prognosis in the treatment of cytogenetically high-risk multiple myeloma

Blood Spotlight

Carfilzomib
K. Martin Kortuem,A. Keith Stewart
View Articletitled, Carfilzomib

Clinical Trials and Observations

Genome-wide study of methotrexate clearance replicates SLCO1B1
Clinical Trials & Observations
Laura B. Ramsey,John C. Panetta,Colton Smith,Wenjian Yang,Yiping Fan,Naomi J. Winick,Paul L. Martin,Cheng Cheng,Meenakshi Devidas,Ching-Hon Pui,William E. Evans,Stephen P. Hunger,Mignon Loh,Mary V. Relling
View Articletitled, Genome-wide study of methotrexate clearance replicates <em>SLCO1B1</em>
Supplemental data

Hematopoiesis and Stem Cells

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells
Mark Y. Chiang,Olga Shestova,Lanwei Xu,Jon C. Aster,Warren S. Pear
View Articletitled, Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells
Supplemental data
LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance
Sung-Uk Lee,Manami Maeda,Yuichi Ishikawa,Sierra Min Li,Anne Wilson,Adrian M. Jubb,Nagisa Sakurai,Lihong Weng,Emma Fiorini,Freddy Radtke,Minhong Yan,H. Robson MacDonald,Ching-Cheng Chen,Takahiro Maeda
View Articletitled, LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance
Supplemental data
Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling
Keertik Fulzele,Daniela S. Krause,Cristina Panaroni,Vaibhav Saini,Kevin J. Barry,Xiaolong Liu,Sutada Lotinun,Roland Baron,Lynda Bonewald,Jian Q. Feng,Min Chen,Lee S. Weinstein,Joy Y. Wu,Henry M. Kronenberg,David T. Scadden,Paola Divieti Pajevic
View Articletitled, Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling
Supplemental data

Immunobiology

Platelets support a protective immune response to LCMV by preventing splenic necrosis
Gilbert David Loria,Pablo A. Romagnoli,Nelson B. Moseley,Alexandra Rucavado,John D. Altman
View Articletitled, Platelets support a protective immune response to LCMV by preventing splenic necrosis
Early and nonreversible decrease of CD161++/MAIT cells in HIV infection
Cormac Cosgrove,James E. Ussher,Andri Rauch,Kathleen Gärtner,Ayako Kurioka,Michael H. Hühn,Krista Adelmann,Yu-Hoi Kang,Joannah R. Fergusson,Peter Simmonds,Philip Goulder,Ted H. Hansen,Julie Fox,Huldrych F. Günthard,Nina Khanna,Fiona Powrie,Alan Steel,Brian Gazzard,Rodney E. Phillips,John Frater,Holm Uhlig,Paul Klenerman
View Articletitled, Early and nonreversible decrease of CD161<sup>++</sup>/MAIT cells in HIV infection
Supplemental data

Lymphoid Neoplasia

PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells
Hiromichi Yuki,Shikiko Ueno,Hiro Tatetsu,Hiroaki Niiro,Tadafumi Iino,Shinya Endo,Yawara Kawano,Yoshihiro Komohara,Motohiro Takeya,Hiroyuki Hata,Seiji Okada,Toshiki Watanabe,Koichi Akashi,Hiroaki Mitsuya,Yutaka Okuno
View Articletitled, PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells
Supplemental data
Impact of oxygen concentration on growth of mesenchymal stromal cells from the marrow of patients with chronic lymphocytic leukemia
Brief Report
Jessie-F. Fecteau,Davorka Messmer,Suping Zhang,Bing Cui,Liguang Chen,Thomas J. Kipps
View Articletitled, Impact of oxygen concentration on growth of mesenchymal stromal cells from the marrow of patients with chronic lymphocytic leukemia
Supplemental data

Myeloid Neoplasia

CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia
Megan E. McNerney,Christopher D. Brown,Xiaoyue Wang,Elizabeth T. Bartom,Subhradip Karmakar,Chaitanya Bandlamudi,Shan Yu,Jinkyung Ko,Barry P. Sandall,Thomas Stricker,John Anastasi,Robert L. Grossman,John M. Cunningham,Michelle M. Le Beau,Kevin P. White
View Articletitled, <em>CUX1</em> is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Macrophage microvesicles induce macrophage differentiation and miR-223 transfer
Noura Ismail,Yijie Wang,Duaa Dakhlallah,Leni Moldovan,Kitty Agarwal,Kara Batte,Prexy Shah,Jon Wisler,Tim D. Eubank,Susheela Tridandapani,Michael E. Paulaitis,Melissa G. Piper,Clay B. Marsh
View Articletitled, Macrophage microvesicles induce macrophage differentiation and <em>miR-223</em> transfer
Supplemental data
Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro and in a neutropenic mouse model
Wanjing Ding,Hiroyuki Shimada,Lin Li,Rahul Mittal,Xiaokun Zhang,Koichi Shudo,Qiaojun He,Nemani V. Prasadarao,Lingtao Wu
View Articletitled, Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro and in a neutropenic mouse model
Supplemental data
Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice
Daniel Duerschmied,Georgette L. Suidan,Melanie Demers,Nadine Herr,Carla Carbo,Alexander Brill,Stephen M. Cifuni,Maximilian Mauler,Sanja Cicko,Michael Bader,Marco Idzko,Christoph Bode,Denisa D. Wagner
View Articletitled, Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice
Supplemental data
Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis
Alexander Mildner,Elik Chapnik,Ohad Manor,Simon Yona,Ki-Wook Kim,Tegest Aychek,Diana Varol,Gilad Beck,Zohar Barnett Itzhaki,Ester Feldmesser,Ido Amit,Eran Hornstein,Steffen Jung
View Articletitled, Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis
Supplemental data
Aberrant 3′ oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia
Christine Hilcenko,Paul J. Simpson,Andrew J. Finch,Frank R. Bowler,Mark J. Churcher,Li Jin,Len C. Packman,Adam Shlien,Peter Campbell,Michael Kirwan,Inderjeet Dokal,Alan J. Warren
View Articletitled, Aberrant 3′ oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia
Supplemental data

Red Cells, Iron, and Erythropoiesis

Ontogeny of erythroid gene expression
e-blood
Paul D. Kingsley,Emily Greenfest-Allen,Jenna M. Frame,Timothy P. Bushnell,Jeffrey Malik,Kathleen E. McGrath,Christian J. Stoeckert,James Palis
View Articletitled, Ontogeny of erythroid gene expression
Supplemental data

Thrombosis and Hemostasis

Distinct characteristics of antibody responses against factor VIII in healthy individuals and in different cohorts of hemophilia A patients
Shawn F. J. Whelan,Christoph J. Hofbauer,Frank M. Horling,Peter Allacher,Martin J. Wolfsegger,Johannes Oldenburg,Christoph Male,Jerzy Windyga,Andreas Tiede,Hans Peter Schwarz,Friedrich Scheiflinger,Birgit M. Reipert
View Articletitled, Distinct characteristics of antibody responses against factor VIII in healthy individuals and in different cohorts of hemophilia A patients
Supplemental data

Transplantation

Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy
Miranda A. Coleman,Jennifer A. Bridge,Steven W. Lane,Chantelle M. Dixon,Geoffrey R. Hill,James W. Wells,Ranjeny Thomas,Raymond J. Steptoe
View Articletitled, Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy
New autoimmune diseases after cord blood transplantation: a retrospective study of EUROCORD and the Autoimmune Disease Working Party of the European Group for Blood and Marrow Transplantation
Thomas Daikeler,Myriam Labopin,Annalisa Ruggeri,Alessandro Crotta,Mario Abinun,Ayad Ahmed Hussein,Kristina Carlson,Jérôme Cornillon,Jose L. Diez-Martin,Virginie Gandemer,Maura Faraci,Caroline Lindemans,Anne O'Meara,Valerie Mialou,Marleen Renard,Petr Sedlacek,Anne Sirvent,Gérard Socié,Federica Sora,Stefania Varotto,Jaime Sanz,Jan Voswinkel,Ajay Vora,M. Akif Yesilipek,Andree-Laure Herr,Eliane Gluckman,Dominique Farge,Vanderson Rocha
View Articletitled, New autoimmune diseases after cord blood transplantation: a retrospective study of EUROCORD and the Autoimmune Disease Working Party of the European Group for Blood and Marrow Transplantation
Supplemental data
  • Cover Image

    Cover Image

    issue cover

    Haploinsufficiency of the CUX1 homologue (cut) leads to hematopoietic overgrowth and formation of melanotic pseudo-tumors in Drosophila melanogaster. Larvae (right) and pupae (left) develop abnormal black masses (outlined by red squares) upon cut knockdown. Punctate GFP+ hemocytes can be appreciated in the larval stage. CUX1 is frequently deleted in high-risk acute myeloid leukemia and haploinsufficient levels lead to increased growth of human hematopoietic cells, demonstrating the conservation of CUX1/cut from invertebrates to humans. Figure illustration was designed by Dimitri Novikov. See the article by McNerney et al on page 975.

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