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Journal Articles

Heme-Regulated eIF2α Kinase (HRI) Inhibition Decreases PKR Activation in HUDEP2 Cells

Yannis Hara, Dipti Gupta, Courtney Mercadante, Kim Alving, Yukio Nakamura, Sriram Krishnamoorthy, Alexandra Hicks, Melanie Demers
Journal: Blood
Blood (2021) 138 (Supplement 1): 2035.
https://doi.org/10.1182/blood-2021-144679
Published: 2021
Journal Articles

Catalytic Activity of Heme-Regulated eIF2 Alpha Kinase (HRI) Regulates Fetal Hemoglobin

Dipti Gupta, Yannis Hara, PhD, Samuel Lessard, PhD, Sarah Sturtevant, BSc, Yukio Nakamura, MD PhD, Sriram Krishnamoorthy, PhD, Melanie Demers, PhD, Alexandra Hicks, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7.
https://doi.org/10.1182/blood-2020-139991
Published: 2020
Journal Articles

Characterization of a Genetically Engineered HUDEP2 Cell Line Harboring a Sickle Cell Disease Mutation As a Potential Research Tool for Preclinical Sickle Cell Disease Drug Discovery

Dipti Gupta, Sarah Sturtevant, BSc, Benjamin Vieira, BS, Yukio Nakamura, MD PhD, Sriram Krishnamoorthy, PhD, Melanie Demers, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3559.
https://doi.org/10.1182/blood-2019-127330
Published: 2019
Journal Articles

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

Melanie Demers, PhD, Sarah Sturtevant, BSc, Kevin Guertin, PhD, Dipti Gupta, Kunal Desai, MS, Benjamin Vieira, BS, Alexandra Hicks, PhD, Ayman Ismail, PhD, Yukio Nakamura, MD PhD, Bronner Goncalves, MD PhD, Giuseppe Di Caprio, PhD, Ethan Schonbrun, PhD, Scott Hansen, BS, Martin K. Safo, PhD, David K. Wood, PhD, John M. Higgins, MD PhD, David R. Light, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2260.
https://doi.org/10.1182/blood-2019-128727
Published: 2019
Journal Articles

Differential Efficacy of Anti-Sickling and Anti-Inflammatory Mechanisms in a Fluorescent Intravital Microscopy Dorsal Skinfold Vaso-Occlusion Model in Sickle Cell Disease Townes Mice

Sarah Sturtevant, BSc, Alejandra Macias-Garcia, PhD, Sriram Krishnamoorthy, PhD, Arjan van der Flier, PhD, Alexandra Hicks, PhD, Melanie Demers, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2264.
https://doi.org/10.1182/blood-2019-128922
Published: 2019
Journal Articles

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

Kimberly Martinod, Tobias A. Fuchs, Naamah L. Zitomersky, Siu Ling Wong, Melanie Demers, Maureen Gallant, Yanming Wang, Denisa D. Wagner
Journal: Blood
Blood (2015) 125 (12): 1948–1956.
https://doi.org/10.1182/blood-2014-07-587709
Published: 2015
Includes: Supplemental data
Journal Articles

The F-BAR Protein PACSIN2 Regulates Platelet Intracellular Membrane Architecture and in Vivo Hemostatic Functions

Terese Jönsson, Fred G Pluthero, Antonija Jurak Begonja, Jan Kormann, Mélanie Demers, Denisa D Wagner, Markus Plomann, John H Hartwig, Walter H Kahr, Hervé Falet
Journal: Blood
Blood (2014) 124 (21): 4154.
https://doi.org/10.1182/blood.V124.21.4154.4154
Published: 2014
Journal Articles

Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice

Daniel Duerschmied, Georgette L. Suidan, Melanie Demers, Nadine Herr, Carla Carbo, Alexander Brill, Stephen M. Cifuni, Maximilian Mauler, Sanja Cicko, Michael Bader, Marco Idzko, Christoph Bode, Denisa D. Wagner
Journal: Blood
Blood (2013) 121 (6): 1008–1015.
https://doi.org/10.1182/blood-2012-06-437392
Published: 2013
Includes: Supplemental data
Journal Articles

Platelets Protect Tumors from Hemorrhage Induced by Stroma-Infiltrating Leukocytes

Benoit H Ho-Tin-Noe, Carla Carbo, Melanie Demers, Stephen M Cifuni, Tobias Goerge, Denisa D. Wagner, PhD
Journal: Blood
Blood (2008) 112 (11): 3916.
https://doi.org/10.1182/blood.V112.11.3916.3916
Published: 2008