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Journal Articles

Bruton Tyrosine Kinase Inhibitor Rilzabrutinib Reduces Vaso-Occlusion and Markers of Inflammation and Adhesion in Transgenic Mice with Sickle Cell Disease

Ahmed Daak, David R. Light, Fuad Abdulla, Chunsheng Chen, Julia Nguyen, Conglin Ruan, Michael Storek, Dimitry Ofengeim, Alexandra Hicks, Michelle Lee, Vincent Mikol, Gregory M. Vercellotti, John D. Belcher
Journal: Blood
Blood (2024) 144 (Supplement 1): 2482.
https://doi.org/10.1182/blood-2024-200182
Published: 2024
Journal Articles

Inhibition of MRP1 Induces Fetal Hemoglobin through NRF2 Activation to Protect Human Erythroid Cells from Sickling

Yannis Hara, Emily Kawabata, Viktor T. Lemgart, Paola G. Bronson, Alexandra Hicks, Sriram Krishnamoorthy, Nicholas Watkins, Robert Peters, David J. Roberts, Emanuele Di Angelantonio, John Danesh, William Astle, Dirk S. Paul, Samuel Lessard, Adam S. Butterworth
Journal: Blood
Blood (2022) 140 (Supplement 1): 952–953.
https://doi.org/10.1182/blood-2022-168169
Published: 2022
Journal Articles

SGK1 Inhibition Induces Fetal Hemoglobin in Erythroid Cells

Yannis Hara, Mark Stottlemyer, Kim Alving, Nis Halland, Alexandra Hicks, David R. Light
Journal: Blood
Blood (2021) 138 (Supplement 1): 963.
https://doi.org/10.1182/blood-2021-146071
Published: 2021
Journal Articles

Heme-Regulated eIF2α Kinase (HRI) Inhibition Decreases PKR Activation in HUDEP2 Cells

Yannis Hara, Dipti Gupta, Courtney Mercadante, Kim Alving, Yukio Nakamura, Sriram Krishnamoorthy, Alexandra Hicks, Melanie Demers
Journal: Blood
Blood (2021) 138 (Supplement 1): 2035.
https://doi.org/10.1182/blood-2021-144679
Published: 2021
Journal Articles

Genetic Silencing of KEAP1 Induces NRF2 Mediated Oxidative Stress Pathway in Human Erythroid Cells

Dipti Gupta, Samuel Lessard, PhD, Shujia Dai, Yukio Nakamura, MD PhD, Alexandra Hicks, PhD, Thomas K Harris, PhD, Sriram Krishnamoorthy, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-139730
Published: 2020
Journal Articles

Catalytic Activity of Heme-Regulated eIF2 Alpha Kinase (HRI) Regulates Fetal Hemoglobin

Dipti Gupta, Yannis Hara, PhD, Samuel Lessard, PhD, Sarah Sturtevant, BSc, Yukio Nakamura, MD PhD, Sriram Krishnamoorthy, PhD, Melanie Demers, PhD, Alexandra Hicks, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7.
https://doi.org/10.1182/blood-2020-139991
Published: 2020
Journal Articles

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

Melanie Demers, PhD, Sarah Sturtevant, BSc, Kevin Guertin, PhD, Dipti Gupta, Kunal Desai, MS, Benjamin Vieira, BS, Alexandra Hicks, PhD, Ayman Ismail, PhD, Yukio Nakamura, MD PhD, Bronner Goncalves, MD PhD, Giuseppe Di Caprio, PhD, Ethan Schonbrun, PhD, Scott Hansen, BS, Martin K. Safo, PhD, David K. Wood, PhD, John M. Higgins, MD PhD, David R. Light, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2260.
https://doi.org/10.1182/blood-2019-128727
Published: 2019
Journal Articles

Differential Efficacy of Anti-Sickling and Anti-Inflammatory Mechanisms in a Fluorescent Intravital Microscopy Dorsal Skinfold Vaso-Occlusion Model in Sickle Cell Disease Townes Mice

Sarah Sturtevant, BSc, Alejandra Macias-Garcia, PhD, Sriram Krishnamoorthy, PhD, Arjan van der Flier, PhD, Alexandra Hicks, PhD, Melanie Demers, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2264.
https://doi.org/10.1182/blood-2019-128922
Published: 2019
Journal Articles

Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells

Dipti Gupta, Samuel Lessard, PhD, Nancy Moore, Jicheng Duan, PhD, Yukio Nakamura, MD PhD, Feng-Chun Yang, MD PhD, Alexandra Hicks, PhD, David R. Light, PhD, Sriram Krishnamoorthy, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 210.
https://doi.org/10.1182/blood-2019-129479
Published: 2019
Journal Articles

Zinc Finger Nuclease-Mediated Disruption of the BCL11A Erythroid Enhancer Results in Enriched Biallelic Editing, Increased Fetal Hemoglobin, and Reduced Sickling in Erythroid Cells Derived from Sickle Cell Disease Patients

Samuel Lessard, PhD, Pauline Rimmele, PhD, Hui Ling, PhD, Kevin Moran, MSc, Benjamin Vieira, BS, Yi-Dong Lin, PhD, Vu Hong, PhD, Andreas Reik, PhD, Denny Dang, Naoya Uchida, MD, John F. Tisdale, MD, Pablo Rendo, MD, Ahmed Daak, PhD, Alexandra Hicks, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 974.
https://doi.org/10.1182/blood-2019-126048
Published: 2019