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Issue Archive

Volume 121, Issue 22
May 30 2013
Issue Cover

Table of Contents

Inside Blood

INSIDE BLOOD
TP53 and outcome in DLBCL: not only the coding region
Fabrice Jardin,Bertrand Coiffier
View Articletitled, TP53 and outcome in DLBCL: not only the coding region
INSIDE BLOOD
A new era for Waldenstrom macroglobulinemia: MYD88 L265P
Steven P. Treon,Zachary R. Hunter
View Articletitled, A new era for Waldenstrom macroglobulinemia: MYD88 L265P

Blood Work

Concomitant microfilaria and malaria infection
Arwa Z. Al-Riyami,Murtadha Al-Khabori
View Articletitled, Concomitant microfilaria and malaria infection

Blood Forum

The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices of cancer drugs: from the perspective of a large group of CML experts
Experts in Chronic Myeloid Leukemia
View Articletitled, The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices of cancer drugs: from the perspective of a large group of CML experts
Supplemental data

Blood Spotlight

How I diagnose acute pulmonary embolism
Menno V. Huisman,Frederikus A. Klok
View Articletitled, How I diagnose acute pulmonary embolism

Review Article

Progress toward inducing immunologic tolerance to factor VIII
David W. Scott,Kathleen P. Pratt,Carol H. Miao
View Articletitled, Progress toward inducing immunologic tolerance to factor VIII

Clinical Trials and Observations

Bleeding manifestations and management of children with persistent and chronic immune thrombocytopenia: data from the Intercontinental Cooperative ITP Study Group (ICIS)
Clinical Trials & Observations
Cindy E. Neunert,George R. Buchanan,Paul Imbach,Paula H. B. Bolton-Maggs,Carolyn M. Bennett,Ellis Neufeld,Sara K. Vesely,Leah Adix,Victor S. Blanchette,Thomas Kühne,for the Intercontinental Cooperative ITP Study Group Registry II Participants
View Articletitled, Bleeding manifestations and management of children with persistent and chronic immune thrombocytopenia: data from the Intercontinental Cooperative ITP Study Group (ICIS)

Hematopoiesis and Stem Cells

CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age
Christos Gekas,Thomas Graf
View Articletitled, CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age
Supplemental data

Immunobiology

MicroRNA-17∼92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections
Arif A. Khan,Laura A. Penny,Yevgeniy Yuzefpolskiy,Surojit Sarkar,Vandana Kalia
View Articletitled, MicroRNA-17∼92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections
Supplemental data
IL-7/anti–IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R
Christopher E. Martin,Ester M. M. van Leeuwen,Se Jin Im,Derry C. Roopenian,Young-Chul Sung,Charles D. Surh
View Articletitled, IL-7/anti–IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R
Supplemental data

Lymphoid Neoplasia

Tumor cells in multiple myeloma patients inhibit myeloma-reactive T cells through carcinoembryonic antigen-related cell adhesion molecule-6
Mathias Witzens-Harig,Dirk Hose,Simone Jünger,Christina Pfirschke,Nisit Khandelwal,Ludmila Umansky,Anja Seckinger,Heinke Conrad,Bettina Brackertz,Thierry Rème,Brigitte Gueckel,Tobias Meißner,Michael Hundemer,Anthony D. Ho,Jean-Francois Rossi,Kai Neben,Helga Bernhard,Hartmut Goldschmidt,Bernard Klein,Philipp Beckhove
View Articletitled, Tumor cells in multiple myeloma patients inhibit myeloma-reactive T cells through carcinoembryonic antigen-related cell adhesion molecule-6
Supplemental data
MYD88 L265P mutation in Waldenstrom macroglobulinemia
Stéphanie Poulain,Christophe Roumier,Audrey Decambron,Aline Renneville,Charles Herbaux,Elisabeth Bertrand,Sabine Tricot,Agnès Daudignon,Sylvie Galiègue-Zouitina,Valerie Soenen,Olivier Theisen,Nathalie Grardel,Olivier Nibourel,Catherine Roche-Lestienne,Bruno Quesnel,Patrick Duthilleul,Claude Preudhomme,Xavier Leleu
View Articletitled, MYD88 L265P mutation in Waldenstrom macroglobulinemia
EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity
Junli Yan,Siok-Bian Ng,Jim Liang-Seah Tay,Baohong Lin,Tze Loong Koh,Joy Tan,Viknesvaran Selvarajan,Shaw-Cheng Liu,Chonglei Bi,Shi Wang,Shoa-Nian Choo,Norio Shimizu,Gaofeng Huang,Qiang Yu,Wee-Joo Chng
View Articletitled, EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity
Supplemental data
Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL
Anna Vardi,Antonis Dagklis,Lydia Scarfò,Diane Jelinek,Darren Newton,Fiona Bennett,Julia Almeida,Arancha Rodriguez-Caballero,Sallie Allgood,Mark Lanasa,Agostino Cortelezzi,Ester Orlandi,Silvio Veronese,Marco Montillo,Andy Rawstron,Tait Shanafelt,Alberto Orfao,Kostas Stamatopoulos,Paolo Ghia
View Articletitled, Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL
Supplemental data
Single nucleotide variation in the TP53 3′ untranslated region in diffuse large B-cell lymphoma treated with rituximab-CHOP: a report from the International DLBCL Rituximab-CHOP Consortium Program
Yong Li,Michael W. Gordon,Zijun Y. Xu-Monette,Carlo Visco,Alexander Tzankov,Dehui Zou,Lugui Qiu,Santiago Montes-Moreno,Karen Dybkaer,Attilio Orazi,Youli Zu,Govind Bhagat,Kristy L. Richards,Eric D. Hsi,William W. L. Choi,J. Han van Krieken,Qin Huang,Weiyun Ai,Maurilio Ponzoni,Andrés J. M. Ferreri,Jane N. Winter,Ronald S. Go,Miguel A. Piris,Michael B. Møller,Lin Wu,Michael Wang,Kenneth S. Ramos,L. Jeffrey Medeiros,Ken H. Young
View Articletitled, Single nucleotide variation in the <em>TP53</em> 3′ untranslated region in diffuse large B-cell lymphoma treated with rituximab-CHOP: a report from the International DLBCL Rituximab-CHOP Consortium Program
Supplemental data
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia
Hanna L. M. Rajala,Samuli Eldfors,Heikki Kuusanmäki,Arjan J. van Adrichem,Thomas Olson,Sonja Lagström,Emma I. Andersson,Andres Jerez,Michael J. Clemente,Yiyi Yan,Dan Zhang,Andy Awwad,Pekka Ellonen,Olli Kallioniemi,Krister Wennerberg,Kimmo Porkka,Jaroslaw P. Maciejewski,Thomas P. Loughran, Jr,Caroline Heckman,Satu Mustjoki
View Articletitled, Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia
Supplemental data
BCL6 breaks occur at different AID sequence motifs in Ig–BCL6 and non-Ig–BCL6 rearrangements
Brief Report
Zhengfei Lu,Albert G. Tsai,Takashi Akasaka,Hitoshi Ohno,Yanwen Jiang,Ari M. Melnick,Harvey A. Greisman,Michael R. Lieber
View Articletitled, <em>BCL6</em> breaks occur at different AID sequence motifs in Ig–BCL6 and non-Ig–BCL6 rearrangements
Supplemental data

Platelets and Thrombopoiesis

The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi
Mehran Ghasemzadeh,Zane S. Kaplan,Imala Alwis,Simone M. Schoenwaelder,Katrina J. Ashworth,Erik Westein,Ehteramolsadat Hosseini,Hatem H. Salem,Robyn Slattery,Shaun R. McColl,Michael J. Hickey,Zaverio M. Ruggeri,Yuping Yuan,Shaun P. Jackson
View Articletitled, The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi
Supplemental data
IκB kinase phosphorylation of SNAP-23 controls platelet secretion
Zubair A. Karim,Jinchao Zhang,Meenakshi Banerjee,Michael C. Chicka,Rania Al Hawas,Tara R. Hamilton,Paul A. Roche,Sidney W. Whiteheart
View Articletitled, IκB kinase phosphorylation of SNAP-23 controls platelet secretion
Supplemental data

Red Cells, Iron, and Erythropoiesis

Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation
LiQi Li,Johannes Freudenberg,Kairong Cui,Ryan Dale,Sang-Hyun Song,Ann Dean,Keji Zhao,Raja Jothi,Paul E. Love
View Articletitled, Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation
Supplemental data
Massively parallel sequencing, aCGH, and RNA-Seq technologies provide a comprehensive molecular diagnosis of Fanconi anemia
e-blood
Settara C. Chandrasekharappa,Francis P. Lach,Danielle C. Kimble,Aparna Kamat,Jamie K. Teer,Frank X. Donovan,Elizabeth Flynn,Shurjo K. Sen,Supawat Thongthip,Erica Sanborn,Agata Smogorzewska,Arleen D. Auerbach,Elaine A. Ostrander,and NISC Comparative Sequencing Program5
View Articletitled, Massively parallel sequencing, aCGH, and RNA-Seq technologies provide a comprehensive molecular diagnosis of Fanconi anemia
Supplemental data

Thrombosis and Hemostasis

LIM kinase-1 selectively promotes glycoprotein Ib-IX–mediated TXA2 synthesis, platelet activation, and thrombosis
Brian Estevez,Aleksandra Stojanovic-Terpo,M. Keegan Delaney,Kelly A. O’Brien,Michael C. Berndt,Changgeng Ruan,Xiaoping Du
View Articletitled, LIM kinase-1 selectively promotes glycoprotein Ib-IX–mediated TXA<sub>2</sub> synthesis, platelet activation, and thrombosis

Transplantation

Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice
Amar Nijagal,Chris Derderian,Tom Le,Erin Jarvis,Linda Nguyen,Qizhi Tang,Tippi C. MacKenzie
View Articletitled, Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice
Supplemental data
Multiple mismatches at the low expression HLA loci DP, DQ, and DRB3/4/5 associate with adverse outcomes in hematopoietic stem cell transplantation
Marcelo A. Fernández-Viña,John P. Klein,Michael Haagenson,Stephen R. Spellman,Claudio Anasetti,Harriet Noreen,Lee Ann Baxter-Lowe,Pedro Cano,Neal Flomenberg,Dennis L. Confer,Mary M. Horowitz,Machteld Oudshoorn,Effie W. Petersdorf,Michelle Setterholm,Richard Champlin,Stephanie J. Lee,Marcos de Lima
View Articletitled, Multiple mismatches at the low expression HLA loci DP, DQ, and DRB3/4/5 associate with adverse outcomes in hematopoietic stem cell transplantation
Supplemental data
All Issues

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Relating NF-κB regulation to MPN pathogenesis
The elusive endothelial iron transporter
AAV delivers as a lingering guest, not an invader
PCM1::JAK2 myeloproliferative neoplasm suggested by bone marrow histopathological features
Fostamatinib effectiveness and safety for immune thrombocytopenia in clinical practice.

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