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Caroline Heckman
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Journal Articles

Stratification of Multiple Myeloma Patients Based on Ex Vivo Drug Sensitivity and Identification of New Treatments for Patients with High-Risk Relapsed/Refractory Disease

Muntasir Mamun Majumder, MSc,MPharm, Raija Silvennoinen, MD, Pekka Anttila, MD, David Tamborero, PhD, Samuli Eldfors, MSc, Juha Lievonen, MD, Riikka J Karjalainen, Heikki Kuusanmäki, MSc, Alun Parsons, Minna Suvela, Kimmo Porkka, MD PhD, Caroline Heckman
Journal: Blood
Blood (2015) 126 (23): 3006.
https://doi.org/10.1182/blood.V126.23.3006.3006
Published: 2015
Journal Articles

JAK1/2 and BCL2 Inhibitors Synergize to Counter-Act Bone Marrow Stromal Cell-Induced Protection of AML

Riikka Karjalalainen, Tea Pemovska, Muntasir Mamun Majumder, Bhagwan Yadav, Jing Tang, Mika Kontro, Bjørn Gjertsen, MD PhD, Alun Parsons, Minna Suvela, Kimmo Porkka, Tero Aittokallio, Olli Kallioniemi, Krister Wennerberg, Jonathan Knowles, Caroline Heckman
Journal: Blood
Blood (2015) 126 (23): 867.
https://doi.org/10.1182/blood.V126.23.867.867
Published: 2015
Journal Articles

Landscape of Mutations in Relapsed Acute Myeloid Leukemia

Samuli Eldfors, MSc, Mika Kontro, MD, Kimmo Porkka, MD PhD, Olli Kallioniemi, MD PhD, Caroline Heckman, PhD
Journal: Blood
Blood (2014) 124 (21): 2367.
https://doi.org/10.1182/blood.V124.21.2367.2367
Published: 2014
Journal Articles

Primary T-Prolymphocytic Leukemia (T-PLL) Cells Are Sensitive To BCL-2 and HDAC Inhibitors: Results From High-Throughput Ex Vivo Drug Testing

Emma I Andersson, MSc, Tea Pemovska, MSc, Samuli Eldfors, MSc, Anneli Lauhio, MD, Paavo Pietarinen, MSc, Edgar Faber, MD, PhD, Olli Kallioniemi, MD, PhD, Krister Wennerberg, PhD, Caroline Heckman, PhD, Kimmo Porkka, MD, PhD, Satu Mustjoki, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3828.
https://doi.org/10.1182/blood.V122.21.3828.3828
Published: 2013
Journal Articles

Novel Activating STAT5B Mutations As Drivers Of T-ALL

Mika Kontro, MD, Heikki Kuusanmäki, MSc, Samuli Eldfors, MSc, Tea Pemovska, MSc, Hanna L M Rajala, MD, Henrik Edgren, PhD, Pekka Ellonen, MSc, Sonja Lagström, MSc, Tuija Lundán, PhD, Olli Kallioniemi, MD, PhD, Satu Mustjoki, MD, PhD, Kimmo Porkka, MD, PhD, Caroline Heckman, PhD
Journal: Blood
Blood (2013) 122 (21): 3863.
https://doi.org/10.1182/blood.V122.21.3863.3863
Published: 2013
Journal Articles

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

Hanna L. M. Rajala, Samuli Eldfors, Heikki Kuusanmäki, Arjan J. van Adrichem, Thomas Olson, Sonja Lagström, Emma I. Andersson, Andres Jerez, Michael J. Clemente, Yiyi Yan, Dan Zhang, Andy Awwad, Pekka Ellonen, Olli Kallioniemi, Krister Wennerberg, Kimmo Porkka, Jaroslaw P. Maciejewski, Thomas P. Loughran, Jr, Caroline Heckman, Satu Mustjoki
Journal: Blood
Blood (2013) 121 (22): 4541–4550.
https://doi.org/10.1182/blood-2012-12-474577
Published: 2013
Includes: Supplemental data
Journal Articles

Somatic PTPRT and ANGPT2 Mutations in Large Granulocyte Leukemia

Emma I Andersson, MSc, Samuli Eldfors, MSc, Hanna L M Koskela, MD, Pekka Ellonen, MSc, Thomas Olson, BSc, Andres Jerez, MD, PhD, Michael J. Clemente, Olli Kallioniemi, MD, PhD, Kimmo Porkka, MD, PhD, Thomas P. Loughran, Jr., M.D., Jaroslaw P. Maciejewski, MD, PhD, Caroline Heckman, PhD, Satu Mustjoki, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1302.
https://doi.org/10.1182/blood.V120.21.1302.1302
Published: 2012
Journal Articles

Development of a Cancer Pharmacopeia-Wide Ex-Vivo Drug Sensitivity and Resistance Testing (DSRT) Platform: Identification of MEK and mTOR As Patient-Specific Molecular Drivers of Adult AML and Potent Therapeutic Combinations with Dasatinib

Mika Kontro, MD, Caroline Heckman, PhD, Evgeny Kulesskiy, MSc, Tea Pemovska, MSc, Maxim Bespalov, PhD, Samuli Eldfors, MSc, Elonen Erkki, MD, PhD, Riikka Karjalainen, MSc, Jonathan Knowles, PhD, Disha Malani, MSc, Muntasir Mamun Majumder, MSc, John Patrick Mpindi, MSc, PhD, Astrid Murumägi, PhD, Satu Mustjoki, MD, PhD, Laura Turunen, MSc, Maija Wolf, PhD, Kimmo Porkka, MD, PhD, Krister Wennerberg, PhD, Olli Kallioniemi, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 2487.
https://doi.org/10.1182/blood.V118.21.2487.2487
Published: 2011
Journal Articles

Recurrent Missense Mutations in the STAT3 Gene in LGL Leukemia Provide Insights to Pathogenetic Mechanisms and Suggest Potential Diagnostic and Therapeutic Applications

Hanna Koskela, MD, Samuli Eldfors, MSc, Henrikki Almusa, MSc, Emma Andersson, Pekka Ellonen, BSc, Henrik Edgren, MSc, Pirjo Koistinen, MD, PhD, Taru Kuittinen, MD, PhD, Kati Penttinen, Jonathan Knowles, PhD, Janna Saarela, MD, PhD, Olli Kallioniemi, MD, PhD, Krister Wennerberg, PhD, Kimmo Porkka, MD, PhD, Caroline Heckman, PhD, Satu Mustjoki, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 936.
https://doi.org/10.1182/blood.V118.21.936.936
Published: 2011
Journal Articles

Phosphoprotein Profiling Predicts Response to Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukemia Patients

Sari E Jalkanen, MSc, Anna-Maria Lahesmaa-Korpinen, MSc, Caroline Heckman, PhD, Ville Rantanen, MSc, Kimmo Porkka, MD, PhD, Sampsa Hautaniemi, PhD, Satu Mustjoki, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 4427.
https://doi.org/10.1182/blood.V118.21.4427.4427
Published: 2011