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Siok-Bian Ng
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Journal Articles

Machine Learning Classification of Spatial Patterns of Malignant Cells Reveals Implications in Prognosis and Tumor Microenvironment Composition in Lymphoma

Shruti Sridhar, Michal Marek Hoppe, Patrick Jaynes, Gayatri Kumar, Siddham Jasoria, Ziwei Meng, Yanfen Peng, Sanjay De Mel, Limei Poon, Esther Hian Li Chan, Wee-Joo Chng, Soo Yong Tan, Susan Swee-Shan Hue, Siok-Bian Ng, Chandramouli Nagarajan, Nicholas Francis Grigoropoulos, Shaoying Li, Joseph D. Khoury, Pedro Farinha, Anja Mottok, David W. Scott, Xiaofei Ye, Qiang Pan-Hammarström, Vaibhav Rajan, Kasthuri Kannan, Anand Devaprasath D. Jeyasekharan
Journal: Blood
Blood (2024) 144 (Supplement 1): 3602.
https://doi.org/10.1182/blood-2024-209372
Published: 2024
Journal Articles

Proliferative CD8 T-Cells: A Novel Immune Microenvironmental Determinant of Outcomes in Multiple Myeloma with Translocation (4;14)

Sanjay De Mel, Jonathan Scolnick, Chern Han Yong, Stacy Li Wen Xu, Xiaojing Huo, Cinnie Soekojo, Fang Fang Song, Melissa G Ooi, Phyu The, Radhika Sharma, Yanfen Peng, Sabrina Toh, Siok-Bian Ng, Anand Devaprasath Jeyasekharan, Joe Yeong, Li Yen Chong, Chi Ching Lim, Felicia Wee, Jinmiao Chen, Lim Soon Wong, Jun Siong Low, Wee-Joo Chng
Journal: Blood
Blood (2024) 144 (Supplement 1): 1950.
https://doi.org/10.1182/blood-2024-198769
Published: 2024
Journal Articles

Frequent Copy Gains of Viral LMP-1 Confers Radiosensitivity in Natural-Killer/T Cell Lymphoma

Jing Quan Lim, Dachuan Huang, Kelila Xin Ye Chai, Phyu The, Kerry May Huifen Lim, Wendy Lee, Liang Wei Wang, Nur Ayuni Muhammad Taib, Beng Hooi Phang, Wee-Joo Chng, Olaf Rötzschke, Jason Yongsheng Chan, Soon Thye Lim, Jin-Xin BEI, Siok-Bian Ng, Choon Kiat Ong
Journal: Blood
Blood (2024) 144 (Supplement 1): 2963.
https://doi.org/10.1182/blood-2024-192976
Published: 2024
Journal Articles

Spatial-Resolved Transcriptomics Reveals Immune Landscape Variations in Primary Central Nervous System Lymphoma (PCNSL) and Diffuse Large B-Cell Lymphoma (DLBCL)

Min Liu, Liang Hong, Shruti Sridhar, Patrick Jaynes, Chartsiam Tipgomut, Limei Poon, Sanjay De Mel, Joanne Shu Xian Lee, Jayalakshmi, Siok-Bian Ng, Char Loo Tan, Wee-Joo Chng, Anand Devaprasath D. Jeyasekharan
Journal: Blood
Blood (2024) 144 (Supplement 1): 3004.
https://doi.org/10.1182/blood-2024-209497
Published: 2024
Journal Articles

Natural killer cell memory precedes HLH in monozygotic twins discordant for chronic active Epstein-Barr virus disease

Chrissie K. Lim, Youjia Zhong, Richard Hopkins, Wei-Xiang Sin, Bijin Veonice Au, Sriram Narayanan, Chiung-Hui Huang, Colin Y. C. Lee, Ming Liang Oon, Avisha Chowdhury, Benjamin Wong, Frances Yeap, Mariflor Villegas, Julien Pompon, Patricia P. L. Ng, Siok-Bian Ng, Thuan Chong Quah, Poh-Lin Tan, Keh-Chuang Chin, John E. Connolly
Journal: Blood
Blood (2023) 141 (17): 2151–2155.
https://doi.org/10.1182/blood.2022018309
Published: 2023
Includes: Supplemental data
Journal Articles

Clinical Application of an Ex-Vivo Platform to Guide the Choice of Drug Combinations in Relapsed/Refractory Lymphoma; A Prospective Study

Sanjay De Mel, Jasmine Goh, Masturah Rashid, Michal Hoppe, Xi Yun Zhang, Patrick Jaynes, Esther KY Ng, Nur Atiqa Diana Binte Rahmat, Xin Liu, Michelle Poon, Hian Li Esther Chan, Joanne Lee, Yen-Lin Chee, Liang Piu Koh, Lip Kun Tan, Teck Guan Soh, Yi Ching Yuen, Hoi Yin Loi, Siok Bian Ng, Xueying Goh, Daryl Tan, Daryl Ming Zhe Cheah, Wan Lu Pang, Dachuan Huang, Nagavalli Somasundaram, Tiffany Tang, Jason Yongsheng Chan, Soon Thye Lim, Choon Kiat Ong, Wee Joo Chng, Edward KH Chow, Anand Jeyasekharan
Journal: Blood
Blood (2021) 138 (Supplement 1): 720.
https://doi.org/10.1182/blood-2021-149331
Published: 2021
Journal Articles

Ambiguous Diagnosis of Nodal T-Cell Lymphomas with T-Follicular Helper (TFH) Phenotype and Hodgkin Lymphoma - a Multicenter Pilot Study

Esther Wei Yin Chang, Grace Fangmin Tan, Si Ting Goh, Talia Li Yin Lim, Shin Yeu Ong, Chandramouli Nagarajan, Nicholas Francis Grigoropoulos, Sanjay De Mel, Michelle Poon, Anand Devaprasath Jeyasekharan, Jianbang Chiang, Ya Hwee Tan, Valerie Yang, Eileen Yi Ling Poon, Nagavalli Somasundaram, Mohamad Farid, Miriam Tao, Chee Leong Cheng, Leonard Hwan Cheong Tan, Siok Bian Ng, Soo Yong Tan, Daryl Ming Zhe Cheah, Dachuan Huang, Jing Quan Lim, Soon Thye Lim, Choon Kiat Ong, Jason Yongsheng Chan
Journal: Blood
Blood (2021) 138 (Supplement 1): 1403.
https://doi.org/10.1182/blood-2021-149358
Published: 2021
Journal Articles

A composite single-nucleotide polymorphism prediction signature for extranodal natural killer/T-cell lymphoma

Clinical Trials & Observations
Xiao-Peng Tian, Shu-Yun Ma, Ken H. Young, Choon Kiat Ong, Yan-Hui Liu, Zhi-Hua Li, Qiong-Li Zhai, Hui-Qiang Huang, Tong-Yu Lin, Zhi-Ming Li, Zhong-Jun Xia, Li-Ye Zhong, Hui-Lan Rao, Mei Li, Jun Cai, Yu-Chen Zhang, Fen Zhang, Ning Su, Peng-Fei Li, Feng Zhu, Zijun Y. Xu-Monette, Esther Kam Yin Wong, Jeslin Chian Hung Ha, Lay Poh Khoo, Le Ai, Run-Fen Cheng, Jing Quan Lim, Sanjay de Mel, Siok-Bian Ng, Soon Thye Lim, Qing-Qing Cai
Journal: Blood
Blood (2021) 138 (6): 452–463.
https://doi.org/10.1182/blood.2020010637
Published: 2021
Includes: Supplemental data
Journal Articles

Super-Enhancer-Driven TOX2 Mediates Oncogenesis in Natural Killer/T Cell Lymphoma

Jianbiao Zhou, MDPhD, Sabrina Hui Min Toh, BSc, Kalpnaa Balan, BSc, Tze King Tan, PhD, Yunlu Jia, MD, Jing Quan Lim, PhD, Choon Kiat Ong, PhDBSc, Soon Thye Lim, MBBS, MRCP, Tuan Zea Tan, Siok-Bian Ng, Takaomi Sanda, MD PhD, Wee-Joo Chng, MBBS, PhD FRCPath, FRCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 17.
https://doi.org/10.1182/blood-2020-136244
Published: 2020
Journal Articles

MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/T-cell lymphoma

Boheng Li, Junli Yan, The Phyu, Shuangyi Fan, Tae-Hoon Chung, Nurulhuda Mustafa, Baohong Lin, Lingzhi Wang, Pieter Johan Adam Eichhorn, Boon-Cher Goh, Siok-Bian Ng, Dennis Kappei, Wee-Joo Chng
Journal: Blood
Blood (2019) 134 (23): 2046–2058.
https://doi.org/10.1182/blood.2019000381
Published: 2019
Includes: Supplemental data
Journal Articles

Overexpressed Melk Promotes the Stability of EZH2 through Phosphorylation in Natural Killer/T Cell Lymphoma (NKTL)

Boheng Li, PhD, Dennis Kappei, PhD, Junli Yan, PhD, Pieter Eichhorn, PhD, Siok Bian Ng, FRCPA, Wee Joo Chng, MB ChB, PhD FRCP(UK), FRCPath, FAMS
Journal: Blood
Blood (2018) 132 (Supplement 1): 2858.
https://doi.org/10.1182/blood-2018-99-110758
Published: 2018
Journal Articles

Aberrant hyperediting of the myeloma transcriptome by ADAR1 confers oncogenicity and is a marker of poor prognosis

Phaik Ju Teoh, Omer An, Tae-Hoon Chung, Jing Yuan Chooi, Sabrina H. M. Toh, Shuangyi Fan, Wilson Wang, Bryan T. H. Koh, Melissa J. Fullwood, Melissa G. Ooi, Sanjay de Mel, Cinnie Y. Soekojo, Leilei Chen, Siok Bian Ng, Henry Yang, Wee Joo Chng
Journal: Blood
Blood (2018) 132 (12): 1304–1317.
https://doi.org/10.1182/blood-2018-02-832576
Published: 2018
Includes: Supplemental data
Journal Articles

Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma

Tammy Linlin Song, Maarja-Liisa Nairismägi, Yurike Laurensia, Jing-Quan Lim, Jing Tan, Zhi-Mei Li, Wan-Lu Pang, Atish Kizhakeyil, Giovani-Claresta Wijaya, Da-Chuan Huang, Sanjanaa Nagarajan, Burton Kuan-Hui Chia, Daryl Cheah, Yan-Hui Liu, Fen Zhang, Hui-Lan Rao, Tiffany Tang, Esther Kam-Yin Wong, Jin-Xin Bei, Jabed Iqbal, Nicholas-Francis Grigoropoulos, Siok-Bian Ng, Wee-Joo Chng, Bin-Tean Teh, Soo-Yong Tan, Navin Kumar Verma, Hao Fan, Soon-Thye Lim, Choon-Kiat Ong
Journal: Blood
Blood (2018) 132 (11): 1146–1158.
https://doi.org/10.1182/blood-2018-01-829424
Published: 2018
Includes: Supplemental data
Journal Articles

Quantitative Analysis of Multiplexed Immunofluorescence in T-Cell Lymphoma

Sanjay de Mel, BSc( Hons) BM (Hons) MRCP(UK) FRCPath, Shou- Nian Choo, Shuangyi Fan, Hoang Mai Phuong, Michal Hoppe, Wee Joo Chng, MB ChB, MRCP, PhD, Anand Jeyasekharan, Siok Bian Ng
Journal: Blood
Blood (2017) 130 (Supplement 1): 2800.
https://doi.org/10.1182/blood.V130.Suppl_1.2800.2800
Published: 2017
Journal Articles

MAPKAP1 (Sin1), a Key Component of the MTORC2 Complex, Confers Resistance to Sorafenib and Correlates with Adverse Clinical Outcomes in Acute Myeloid Leukemia

Joseph David Khoury, MD, Ioanna Xagoraris, MD, Nikolaos Tsesmetzis, MSc., Ida Hed Hed Myrberg, PhD, Thale Kristin Olsen, Siok Bian Ng, Wee-Joo Chng, MBBS, PhD FRCPath, FRCP, Benedict Yan, Chin Hin Ng, MD MRCP, Michael Andreeff, MD PhD, L. Jeffrey Medeiros, MD, Hagop M. Kantarjian, MD, Herold Nikolas, MD PhD, Dan Grander, MD PhD, George Rassidakis, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3964.
https://doi.org/10.1182/blood.V130.Suppl_1.3964.3964
Published: 2017
Journal Articles

EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma

Junli Yan, Boheng Li, Baohong Lin, Pei Tsung Lee, Tae-Hoon Chung, Joy Tan, Chonglei Bi, Xue Ting Lee, Viknesvaran Selvarajan, Siok-Bian Ng, Henry Yang, Qiang Yu, Wee-Joo Chng
Journal: Blood
Blood (2016) 128 (7): 948–958.
https://doi.org/10.1182/blood-2016-01-690701
Published: 2016
Includes: Supplemental data
Journal Articles

Prognostic Significance Of rs6773853 Susceptibility Locus In B-Cell Non-Hodgkin’s Lymphoma

Joycelyn Jie Xin Lee, MBBS, Glorijoy Shi En Tan, MBBS, Chee Hian Tan, MBBS, Summer Pan, Chiea Chuen Khor, Jianjun Liu, Jia Nee Foo, Soo Yong Tan, MBBS, MRCPath, Siok Bian Ng, Miriam Tao, MBBS, MRCP, Soon Thye Lim, MBBS, MRCP, Tiffany Tang, MBBS, MRCP
Journal: Blood
Blood (2013) 122 (21): 4249.
https://doi.org/10.1182/blood.V122.21.4249.4249
Published: 2013
Journal Articles

EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity

Junli Yan, Siok-Bian Ng, Jim Liang-Seah Tay, Baohong Lin, Tze Loong Koh, Joy Tan, Viknesvaran Selvarajan, Shaw-Cheng Liu, Chonglei Bi, Shi Wang, Shoa-Nian Choo, Norio Shimizu, Gaofeng Huang, Qiang Yu, Wee-Joo Chng
Journal: Blood
Blood (2013) 121 (22): 4512–4520.
https://doi.org/10.1182/blood-2012-08-450494
Published: 2013
Includes: Supplemental data
Journal Articles

ATM-dependent spontaneous regression of early Eμ- myc –induced murine B-cell leukemia depends on natural killer and T cells

J. Ludovic Croxford, Melissa Li Fang Tang, Meng Fei Pan, Caleb Weihao Huang, Neha Kamran, Cindy Meow Ling Phua, Wee Joo Chng, Siok Bian Ng, David H. Raulet, Stephan Gasser
Journal: Blood
Blood (2013) 121 (13): 2512–2521.
https://doi.org/10.1182/blood-2012-08-449025
Published: 2013
Includes: Supplemental data
Journal Articles

EZH2 Is Aberrantly Expressed and Plays a Pro-Proliferative Role Independent of Its Methyltransferase Activity in Natural Killer/T-Cell Lymphoma

Wee-Joo Chng, Assoc/Prof, Junli Yan, PhD, Siok-Bian NG, Jim Tay, Ph.D., Baohong Lin, BSc, Tze-Loong Koh, B.sc., Joy Tan, BSc, Viknesvaran Selvarajan, Shaw-Cheng Liu, B.sc., Chonglei Bi, B.sc., Gaofeng Huang, PhD, Qiang Yu, Ph.D.
Journal: Blood
Blood (2012) 120 (21): 3498.
https://doi.org/10.1182/blood.V120.21.3498.3498
Published: 2012