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Issue Archive

Volume 120, Issue 3
July 19 2012
Issue Cover

Table of Contents

Inside Blood

PHAGOCYTES & GRANULOCYTES
The wound healing chronicles
Jo A. Van Ginderachter
View Articletitled, The wound healing chronicles
THROMBOSIS & HEMOSTASIS
Predicting individual risk of venous thrombosis
Juan Carlos Souto,José Manuel Soria
View Articletitled, Predicting individual risk of venous thrombosis
THROMBOSIS & HEMOSTASIS
Liberating R169 promotes anticoagulant protein C
Muriel C. Maurer
View Articletitled, Liberating R169 promotes anticoagulant protein C

Blood Work

Acute myeloid leukemia with Charcot-Leyden crystals
Julia S. Manny,Leslie R. Ellis
View Articletitled, Acute myeloid leukemia with Charcot-Leyden crystals

Plenary Paper

TRANSPLANTATION
Transmaternal cell flow leads to antigen-experienced cord blood
Miranda P. Dierselhuis,Els C. Blokland,Jos Pool,Ellen Schrama,Sicco A. Scherjon,Els Goulmy
View Articletitled, Transmaternal cell flow leads to antigen-experienced cord blood

Perspectives

Immunoregulation through extracellular nucleotides
Laura Vitiello,Stefania Gorini,Giuseppe Rosano,Andrea la Sala
View Articletitled, Immunoregulation through extracellular nucleotides

Review Article

Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis
Vijay P. S. Rawat,R. Keith Humphries,Christian Buske
View Articletitled, Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis
Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management
Karina Yazdanbakhsh,Russell E. Ware,France Noizat-Pirenne
View Articletitled, Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management
Supplemental data

How I Treat

How I treat prolymphocytic leukemia
Claire Dearden
View Articletitled, How I treat prolymphocytic leukemia

Clinical Trials and Observations

A phase 1, multicenter, open-label, dose escalation study of elotuzumab in patients with advanced multiple myeloma
Clinical Trials & Observations
Jeffrey A. Zonder,Ann F. Mohrbacher,Seema Singhal,Frits van Rhee,William I. Bensinger,Han Ding,John Fry,Daniel E. H. Afar,Anil K. Singhal
View Articletitled, A phase 1, multicenter, open-label, dose escalation study of elotuzumab in patients with advanced multiple myeloma
Safety and efficacy of brentuximab vedotin for Hodgkin lymphoma recurring after allogeneic stem cell transplantation
Clinical Trials & Observations
Ajay K. Gopal,Radhakrishnan Ramchandren,Owen A. O'Connor,Robert B. Berryman,Ranjana H. Advani,Robert Chen,Scott E. Smith,Maureen Cooper,Achim Rothe,Jeffrey V. Matous,Laurie E. Grove,Jasmine Zain
View Articletitled, Safety and efficacy of brentuximab vedotin for Hodgkin lymphoma recurring after allogeneic stem cell transplantation
Supplemental data
Disease characteristics and clinical outcome in young adults with essential thrombocythemia versus early/prefibrotic primary myelofibrosis
Brief Report
Tiziano Barbui,Jürgen Thiele,Alessandra Carobbio,Francesco Passamonti,Elisa Rumi,Maria Luigia Randi,Irene Bertozzi,Alessandro M. Vannucchi,Heinz Gisslinger,Bettina Gisslinger,Guido Finazzi,Marco Ruggeri,Francesco Rodeghiero,Alessandro Rambaldi,Naseema Gangat,Ayalew Tefferi
View Articletitled, Disease characteristics and clinical outcome in young adults with essential thrombocythemia versus early/prefibrotic primary myelofibrosis
Supplemental data

Immunobiology

Transcytosis of HTLV-1 across a tight human epithelial barrier and infection of subepithelial dendritic cells
Sandra Martin-Latil,Nina F. Gnädig,Adeline Mallet,Marion Desdouits,Florence Guivel-Benhassine,Patricia Jeannin,Marie-Christine Prevost,Olivier Schwartz,Antoine Gessain,Simona Ozden,Pierre-Emmanuel Ceccaldi
View Articletitled, Transcytosis of HTLV-1 across a tight human epithelial barrier and infection of subepithelial dendritic cells
Regulatory dendritic cells program B cells to differentiate into CD19hiFcγIIbhi regulatory B cells through IFN-β and CD40L
Li Qian,Cheng Qian,Yongjian Chen,Yi Bai,Yan Bao,Liwei Lu,Xuetao Cao
View Articletitled, Regulatory dendritic cells program B cells to differentiate into CD19<sup>hi</sup>FcγIIb<sup>hi</sup> regulatory B cells through IFN-β and CD40L
Supplemental data
Impaired natural killer cell self-education and “missing-self” responses in Ly49-deficient mice
Simon Bélanger,Megan M. Tu,Mir Munir Ahmed Rahim,Ahmad B. Mahmoud,Rajen Patel,Lee-Hwa Tai,Angela D. Troke,Brian T. Wilhelm,Josette-Renée Landry,Qinzhang Zhu,Kenneth S. Tung,David H. Raulet,Andrew P. Makrigiannis
View Articletitled, Impaired natural killer cell self-education and “missing-self” responses in Ly49-deficient mice
Supplemental data

Lymphoid Neoplasia

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma
e-blood
Richard W. J. Groen,Willy A. Noort,Reinier A. Raymakers,Henk-Jan Prins,Linda Aalders,Frans M. Hofhuis,Petra Moerer,Jeroen F. van Velzen,Andries C. Bloem,Berris van Kessel,Henk Rozemuller,Ellen van Binsbergen,Arjan Buijs,Huipin Yuan,Joost D. de Bruijn,Michel de Weers,Paul W. H. I. Parren,Jan Jacob Schuringa,Henk M. Lokhorst,Tuna Mutis,Anton C. M. Martens
View Articletitled, Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma
Supplemental data

Myeloid Neoplasia

Cell lineage analysis of acute leukemia relapse uncovers the role of replication-rate heterogeneity and microsatellite instability
Liran I. Shlush,Noa Chapal-Ilani,Rivka Adar,Neta Pery,Yosef Maruvka,Adam Spiro,Roni Shouval,Jacob M. Rowe,Maty Tzukerman,Dani Bercovich,Shai Izraeli,Guido Marcucci,Clara D. Bloomfield,Tsila Zuckerman,Karl Skorecki,Ehud Shapiro
View Articletitled, Cell lineage analysis of acute leukemia relapse uncovers the role of replication-rate heterogeneity and microsatellite instability
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair
Sebastian Willenborg,Tina Lucas,Geert van Loo,Johanna A. Knipper,Thomas Krieg,Ingo Haase,Bent Brachvogel,Matthias Hammerschmidt,Andras Nagy,Napoleone Ferrara,Manolis Pasparakis,Sabine A. Eming
View Articletitled, CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair
Supplemental data

Platelets and Thrombopoiesis

The origin and function of platelet glycosyltransferases
Hans H. Wandall,Viktoria Rumjantseva,Anne Louise Tølbøll Sørensen,Sunita Patel-Hett,Emma C. Josefsson,Eric P. Bennett,Joseph E. Italiano, Jr,Henrik Clausen,John H. Hartwig,Karin M. Hoffmeister
View Articletitled, The origin and function of platelet glycosyltransferases
Supplemental data

Red Cells, Iron, and Erythropoiesis

Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease
Pichika Chantrathammachart,Nigel Mackman,Erica Sparkenbaugh,Jian-Guo Wang,Leslie V. Parise,Daniel Kirchhofer,Nigel S. Key,Rafal Pawlinski
View Articletitled, Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease

Thrombosis and Hemostasis

Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins
Jaehyung Cho,Daniel R. Kennedy,Lin Lin,Mingdong Huang,Glenn Merrill-Skoloff,Barbara C. Furie,Bruce Furie
View Articletitled, Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins
Supplemental data
Multiple SNP testing improves risk prediction of first venous thrombosis
Hugoline G. de Haan,Irene D. Bezemer,Carine J. M. Doggen,Saskia Le Cessie,Pieter H. Reitsma,Andre R. Arellano,Carmen H. Tong,James J. Devlin,Lance A. Bare,Frits R. Rosendaal,Carla Y. Vossen
View Articletitled, Multiple SNP testing improves risk prediction of first venous thrombosis
Supplemental data
Exposure of R169 controls protein C activation and autoactivation
Nicola Pozzi,Sergio Barranco-Medina,Zhiwei Chen,Enrico Di Cera
View Articletitled, Exposure of R169 controls protein C activation and autoactivation
The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis
Wenman Wu,Hongbo Li,Duraiswamy Navaneetham,Zachary W. Reichenbach,Ronald F. Tuma,Peter N. Walsh
View Articletitled, The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis
Monoclonal antibodies against receptor-induced binding sites detect cell-bound plasminogen in blood
Brief Report
Jordi Félez,Mercè Jardí,Pere Fàbregas,Robert J. Parmer,Lindsey A. Miles
View Articletitled, Monoclonal antibodies against receptor-induced binding sites detect cell-bound plasminogen in blood

Transplantation

Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells
Rachelle G. Veenstra,Patricia A. Taylor,Qing Zhou,Angela Panoskaltsis-Mortari,Mitsuomi Hirashima,Ryan Flynn,Derek Liu,Ana C. Anderson,Terry B. Strom,Vijay K. Kuchroo,Bruce R. Blazar
View Articletitled, Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells
Supplemental data
Expression of CD30 in patients with acute graft-versus-host disease
Yi-Bin Chen,Sean McDonough,Robert Hasserjian,Heidi Chen,Erin Coughlin,Christina Illiano,In Sun Park,Madan Jagasia,Thomas R. Spitzer,Corey S. Cutler,Robert J. Soiffer,Jerome Ritz
View Articletitled, Expression of CD30 in patients with acute graft-versus-host disease

Correspondence

Dasatinib may overcome the negative prognostic impact of KIR2DS1 in newly diagnosed patients with chronic myeloid leukemia
Sara Ali,Ruhena Sergeant,Stephen G. O'Brien,Letizia Foroni,Corinne Hedgley,Gareth Gerrard,Dragana Milojkovic,Kate Stringaris,Ahmad Khoder,Abdullah Alsuliman,Maria Gilleece,Ian H. Gabriel,Nichola Cooper,John M. Goldman,Jane F. Apperley,Richard E. Clark,David Marin,Katayoun Rezvani
View Articletitled, Dasatinib may overcome the negative prognostic impact of <em>KIR2DS1</em> in newly diagnosed patients with chronic myeloid leukemia
The α4β7 integrin binds HIV envelope but does not mediate bystander killing of γδ T cells
Haishan Li,C. David Pauza
View Articletitled, The α4β7 integrin binds HIV envelope but does not mediate bystander killing of γδ T cells
Further examination of BAFF SNPs in cGVHD
Matthew Fore,Madan Jagasia,Stefanie Sarantopoulos,Kristy L. Richards
View Articletitled, Further examination of BAFF SNPs in cGVHD
  • Cover Image

    Cover Image

    issue cover

    In Hodgkin lymphoma, malignant CD30+ Hodgkin Reed-Sternberg (HRS) cells typically represent a small fraction (0.1% to 10%) of the nodal infiltrate. The cover image shows the distribution of HRS cells (red) among CD4+ T cells (green) in Hodgkin lymphoma tissue, with counterstained nuclei (blue). HRS cells and CD4+ T cells are detected with murine anti-CD30 and anti-CD4 antibodies, respectively; nuclei are counterstained with hematoxylin. The image was acquired with a Zeiss Axiovert 200M microscope (×40 objective). Immunohistochemical staining was enhanced using the Multispectral Nuance CRI Camera System to apply artificial fluorescent colors. Tissue from National Disease Research Interchange (NDRI), image by Dr M. Jonas, Seattle Genetics Inc. See the article by Gopal et al on page 560.

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