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Journal Articles

A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT, Ameliorate Disease in Autoimmune Models, Potently Kill Human Immune Cells from Normal Donors and MS Patients, and Achieve Immune Depletion in Non-Human Primates (NHP)

Geoff O Gillard, Jennifer L Proctor, BS, Melissa L. Brooks, BS, Tahirih L Lamothe, BS, Sharon L. Hyzy, MS, Oliver Mikse, Sean McDonough, Rahul Palchaudhuri, PhD, Anjali Bhat, MS, Ganapathy N. Sarma, PhD, Prashant Bhattarai, Pranoti Sawant, MS, Bradley R Pearse, PhD, Charlotte F. Mcdonough, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD

Blood (2019) 134 (Supplement_1): 3208.

https://doi.org/10.1182/blood-2019-130752

Published: 2019

Journal Articles

Homeostatic Reconstitution of CD4+ Regulatory and Conventional T Cell Subsets in Adult Patients after Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Ana Cristina Alho, MD, Kim T Haesook, PhD, Carol G Reynolds, PhD, Marie J Chammas, BSc, Sean McDonough, MS, Suzan Lazo-Kallanian, John Daley, PhD, Sarah Nikiforow, MD PhD, Corey S Cutler, MD MPH, John Koreth, MBBS, DPhil, Vincent T Ho, MD, Philippe Armand, MD PhD, Robert J. Soiffer, MD, Joseph H Antin, MD, Jerome Ritz, MD

Blood (2014) 124 (21): 2496.

https://doi.org/10.1182/blood.V124.21.2496.2496

Published: 2014

Journal Articles

Low-Dose IL-2 Induces Bcl2 Expression and Resistance To Apoptosis In CD4 Regulatory T Cells

Kazuyuki Murase, MD, PhD, Yutaka Kawano, MD, PhD, Jeremy Ryan, SM, Ken-ichi Matsuoka, MD, PhD, Gregory Bascug, BS, Sean McDonough, MS, Robert W Smith, BS, Kristen Cowens, Suzan Lazo-Kallanian, John Daley, PhD, John Koreth, MBBS, DPhil, Robert J. Soiffer, MD, Anthony Letai, MD, PhD, Jerome Ritz, MD

Blood (2013) 122 (21): 3475.

https://doi.org/10.1182/blood.V122.21.3475.3475

Published: 2013

Journal Articles

Reconstitution Of EBV-Specific Immunity In Adult Recipients Of Double Cord Blood Transplantation Depends On SCF and IL-7 Levels and Maintenance Of a Diverse TCR Repertoire

Ioannis Politikos, MD, Haesook Kim, PhD, Sarah Nikiforow, MD, PhD, Anoma Nellore, MD, Lequn Li, MD, PhD, Sean McDonough, Robert J. Soiffer, MD, Joseph H. Antin, MD, Karen K. Ballen, MD, Corey S. Cutler, MD, MPH, FRCPC, Jerome Ritz, MD, Vassiliki A. Boussiotis, MD, PhD

Blood (2013) 122 (21): 3302.

https://doi.org/10.1182/blood.V122.21.3302.3302

Published: 2013

Journal Articles

Immune Reconstitution and Preliminary Safety Analysis Of 9 Patients Treated With Somatic Gene Therapy For X-Linked Severe Combined Immunodeficiency (SCID-X1) With a Self-Inactivating Gammaretroviral Vector

Blood (2013) 122 (21): 715.

https://doi.org/10.1182/blood.V122.21.715.715

Published: 2013

Journal Articles

Rituximab prophylaxis prevents corticosteroid-requiring chronic GVHD after allogeneic peripheral blood stem cell transplantation: results of a phase 2 trial

Corey Cutler, Haesook T. Kim, Bhavjot Bindra, Stefanie Sarantopoulos, Vincent T. Ho, Yi-Bin Chen, Jacalyn Rosenblatt, Sean McDonough, Phandee Watanaboonyongcharoen, Philippe Armand, John Koreth, Brett Glotzbecker, Edwin Alyea, Bruce R. Blazar, Robert J. Soiffer, Jerome Ritz, Joseph H. Antin

Blood (2013) 122 (8): 1510–1517.

https://doi.org/10.1182/blood-2013-04-495895

Published: 2013

Journal Articles

Differential Plasma Cytokine Levels in Patients with and without Chronic Graft-Versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation

Caron A. Jacobson, MD, Joshua Geary, Haesook T Kim, PhD, Sean McDonough, MS, Carol G Reynolds, PhD, Maria I. Herrera, MD, PhD, John Koreth, MBBS, DPhil, Corey Cutler, MD, MPH, FRCPC, Vincent T Ho, MD, Edwin P Alyea, III, MD, Philippe Armand, MD, PhD, Robert J. Soiffer, MD, Joseph H. Antin, MD, Jerome Ritz, MD

Blood (2012) 120 (21): 4476.

https://doi.org/10.1182/blood.V120.21.4476.4476

Published: 2012

Journal Articles

Differential Effects of TCR Stimulation and IL-2 On Apoptotic Pathways in CD4 Regulatory T Cells Compared to Conventional CD4 T Cells and CD8 T Cells

Kazuyuki Murase, MD, PhD, Yutaka Kawano, MD, PhD, Jeremy Ryan, Ken-ichi Matsuoka, MD, PhD, Gregory Bascug, BS, Sean McDonough, MS, Robert W Smith, BS, Suzan Lazo-Kallanian, John Daley, PhD, Matthew S. Davids, MD, Anthony G. Letai, MD, PhD, Jerome Ritz, MD

Blood (2012) 120 (21): 3280.

https://doi.org/10.1182/blood.V120.21.3280.3280

Published: 2012

Journal Articles

Apoptotic Pathways of Human Regulatory T Cells in Chronic Graft Versus Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Kazuyuki Murase, MD, PhD, Yutaka Kawano, MD, PhD, Jeremy Ryan, Ken-ichi Matsuoka, MD, PhD, Gregory Bascug, BS, Sean McDonough, MS, Robert W Smith, BS, Suzan Lazo-Kallanian, John Daley, PhD, John Koreth, MBBS, DPhil, Robert J. Soiffer, MD, Anthony G. Letai, MD, PhD, Jerome Ritz, MD

Blood (2012) 120 (21): 225.

https://doi.org/10.1182/blood.V120.21.225.225

Published: 2012

Journal Articles

Prostaglandin E 2 (PGE 2 ) Alters the Molecular and Functional Properties of Umbilical Cord Blood T Cells Via Modulating Wnt/β-Catenin Signaling

Lequn Li, MD, PhD, Anoma Nellore, MD, Sean McDonough, Ioannis Politikos, MD, Haesook Kim, PhD, Sarah Nikiforow, MD, PhD, Joseph H. Antin, MD, Karen K. Ballen, MD, Corey Cutler, MD, MPH, FRCPC, Jerome Ritz, MD, Vassiliki A. Boussiotis, MD, PhD

Blood (2012) 120 (21): 226.

https://doi.org/10.1182/blood.V120.21.226.226

Published: 2012

Journal Articles

BK Virus Reactivation After Double Umbilical Cord Blood Transplantation in Adults Correlates with Tregs and Delayed Reconstitution of CD4 + and CD8 + T Effector Cells

Gowri Satyanarayana, MD, Sarah Hammond, MD, Haesook T Kim, PhD, Sean McDonough, MS, Julia Brown, PhD, Ioannis Politikos, MD, Lequn Li, MD, PhD, Raphael Viscidi, MD, Thomas Broge, Igor Koralnik, MD, Corey Cutler, MD, MPH, FRCPC, Karen K. Ballen, MD, Joseph H. Antin, MD, Francisco M Marty, MD, Jerome Ritz, MD, C Sabrina Tan, MD, Vassiliki A. Boussiotis, MD, PhD

Blood (2012) 120 (21): 4174.

https://doi.org/10.1182/blood.V120.21.4174.4174

Published: 2012

Journal Articles

Recovery of Thymic Epithelial Cells and T Cell Immune Reconstitution After Cord Blood Transplantation in Adults Depends On Angiogenesis and Neovascularization

Ioannis Politikos, MD, Haesook Kim, PhD, Julia Brown, PhD, Sean McDonough, Lequn Li, MD, PhD, Corey Cutler, MD, MPH, FRCPC, Joseph H. Antin, MD, Karen K. Ballen, MD, Jerome Ritz, MD, Vassiliki A. Boussiotis, MD, PhD

Blood (2012) 120 (21): 4175.

https://doi.org/10.1182/blood.V120.21.4175.4175

Published: 2012

Journal Articles

A Phase I Study of Alemtuzumab Dosing for Steroid-Refractory Chronic Graft-Versus-Host Disease

Sarah Nikiforow, MD, PhD, Haesook T Kim, PhD, Bhavjot Bindra, Sean McDonough, MS, Brett Glotzbecker, MD, Philippe Armand, MD, PhD, John Koreth, MBBS, DPhil, Vincent T Ho, MD, Edwin P Alyea, III, MD, Jerome Ritz, MD, Robert J. Soiffer, MD, Joseph H. Antin, MD, Corey Cutler, MD, MPH, FRCPC

Blood (2012) 120 (21): 744.

https://doi.org/10.1182/blood.V120.21.744.744

Published: 2012

Journal Articles

Expression of CD30 in patients with acute graft-versus-host disease

Yi-Bin Chen, Sean McDonough, Robert Hasserjian, Heidi Chen, Erin Coughlin, Christina Illiano, In Sun Park, Madan Jagasia, Thomas R. Spitzer, Corey S. Cutler, Robert J. Soiffer, Jerome Ritz

Blood (2012) 120 (3): 691–696.

https://doi.org/10.1182/blood-2012-03-415422

Published: 2012

Journal Articles

Immune Reconstitution After Cord Blood Transplantation in Adults Depends on Activity of Thymic Epithelial Cells and Vascular Endothelial Elements,

Julia Brown, PhD, Haesook T Kim, PhD, Corey Cutler, MD, MPH, FRCPC, Sean McDonough, Edwin Alyea, MD, Vincent Ho, MD, Eyal C. Attar, MD, Bimalangshu R. Dey, MD, Steven L. McAfee, MD, Thomas Spitzer, MD, Robert J Soiffer, MD, Jerome Ritz, MD, Joseph H Antin, MD, Karen K. Ballen, MD, Vassiliki A Boussiotis, MD, PhD

Blood (2011) 118 (21): 4075.

https://doi.org/10.1182/blood.V118.21.4075.4075

Published: 2011

Journal Articles

Patterns of B Cell Activating Factor (BAFF) Levels, B Cell Recovery, and BAFF/B Cell Ratios Correlate with the Development of Chronic Graft-Versus-Host Disease (cGVHD) Following Hematopoietic Stem Cell Transplantation (HSCT)

Caron A. Jacobson, MD, Haesook T Kim, PhD, Stefanie Sarantopoulos, MD, PhD, Lixian Sun, MS, Sean McDonough, MS, Carol G Reynolds, PhD, Maria I. Herrera, MD, PhD, John Koreth, MBBS, DPhil, Corey S. Cutler, MD, MPH, FRCPC, Vincent T Ho, MD, Edwin P Alyea, III, MD, Philippe Armand, MD, PhD, Robert J. Soiffer, MD, Joseph H. Antin, MD, Jerome Ritz, MD

Blood (2011) 118 (21): 3036.

https://doi.org/10.1182/blood.V118.21.3036.3036

Published: 2011

Journal Articles

Low telomerase activity in CD4 + regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation

Yutaka Kawano, Haesook T. Kim, Ken-ichi Matsuoka, Gregory Bascug, Sean McDonough, Vincent T. Ho, Corey Cutler, John Koreth, Edwin P. Alyea, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz

Blood (2011) 118 (18): 5021–5030.

https://doi.org/10.1182/blood-2011-06-362137

Published: 2011

Journal Articles

Effects of Daily Low Dose IL-2 Therapy on Homeostatic Regulation of CD4+Foxp3+ Regulatory T Cells In Patients with Chronic Graft-Versus-Host Disease

Ken-ichi Matsuoka, MD, PhD, John Koreth, MBBS, DPhil, Haesook T. Kim, PhD, O. Gregory Bascug, Sean McDonough, MS, Joseph H. Antin, MD, Robert Soiffer, MD, Jerome Ritz, MD

Blood (2010) 116 (21): 895.

https://doi.org/10.1182/blood.V116.21.895.895

Published: 2010

Journal Articles

A Phase I Study of Escalated Dose Subcutaneous Alemtuzumab Given Weekly with Rituximab In Relapsed CLL/SLL.

Jennifer R Brown, MD, PhD, Bradley Messmer, Lillian Werner, Evgeny Mikler, David C. Fisher, MD, Ann LaCasce, MD, MSc, Philippe Armand, MD, PhD, Eric D Jacobsen, MD, Virginia Dalton, Bethany Tesar, Stacey M Fernandes, Sean McDonough, MS, Jerome Ritz, MD, Laura Z Rassenti, PhD, Thomas J. Kipps, MD, PhD, Donna Neuberg, ScD, Arnold S. Freedman, MD

Blood (2010) 116 (21): 1381.

https://doi.org/10.1182/blood.V116.21.1381.1381

Published: 2010

Journal Articles

Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis

Blood (2010) 115 (20): 4111–4119.

https://doi.org/10.1182/blood-2009-09-244145

Published: 2010

Includes: Supplemental data

NARROW

A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT, Ameliorate Disease in Autoimmune Models, Potently Kill Human Immune Cells from Normal Donors and MS Patients, and Achieve Immune Depletion in Non-Human Primates (NHP)

Homeostatic Reconstitution of CD4+ Regulatory and Conventional T Cell Subsets in Adult Patients after Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Low-Dose IL-2 Induces Bcl2 Expression and Resistance To Apoptosis In CD4 Regulatory T Cells

Reconstitution Of EBV-Specific Immunity In Adult Recipients Of Double Cord Blood Transplantation Depends On SCF and IL-7 Levels and Maintenance Of a Diverse TCR Repertoire

Immune Reconstitution and Preliminary Safety Analysis Of 9 Patients Treated With Somatic Gene Therapy For X-Linked Severe Combined Immunodeficiency (SCID-X1) With a Self-Inactivating Gammaretroviral Vector

Rituximab prophylaxis prevents corticosteroid-requiring chronic GVHD after allogeneic peripheral blood stem cell transplantation: results of a phase 2 trial

Differential Plasma Cytokine Levels in Patients with and without Chronic Graft-Versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation

Differential Effects of TCR Stimulation and IL-2 On Apoptotic Pathways in CD4 Regulatory T Cells Compared to Conventional CD4 T Cells and CD8 T Cells

Apoptotic Pathways of Human Regulatory T Cells in Chronic Graft Versus Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

Prostaglandin E 2 (PGE 2 ) Alters the Molecular and Functional Properties of Umbilical Cord Blood T Cells Via Modulating Wnt/β-Catenin Signaling

BK Virus Reactivation After Double Umbilical Cord Blood Transplantation in Adults Correlates with Tregs and Delayed Reconstitution of CD4 + and CD8 + T Effector Cells

Recovery of Thymic Epithelial Cells and T Cell Immune Reconstitution After Cord Blood Transplantation in Adults Depends On Angiogenesis and Neovascularization

A Phase I Study of Alemtuzumab Dosing for Steroid-Refractory Chronic Graft-Versus-Host Disease

Expression of CD30 in patients with acute graft-versus-host disease

Immune Reconstitution After Cord Blood Transplantation in Adults Depends on Activity of Thymic Epithelial Cells and Vascular Endothelial Elements,

Patterns of B Cell Activating Factor (BAFF) Levels, B Cell Recovery, and BAFF/B Cell Ratios Correlate with the Development of Chronic Graft-Versus-Host Disease (cGVHD) Following Hematopoietic Stem Cell Transplantation (HSCT)

Low telomerase activity in CD4 + regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation

Effects of Daily Low Dose IL-2 Therapy on Homeostatic Regulation of CD4+Foxp3+ Regulatory T Cells In Patients with Chronic Graft-Versus-Host Disease

A Phase I Study of Escalated Dose Subcutaneous Alemtuzumab Given Weekly with Rituximab In Relapsed CLL/SLL.

Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis

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American Society of Hematology

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American Society of Hematology

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