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Issue Archive

Volume 120, Issue 15
October 11 2012
Issue Cover

Table of Contents

Inside Blood

PLATELETS & THROMBOPOIESIS
Platelet protein shake as playmaker
Paola E. van der Meijden,Johan W. Heemskerk
View Articletitled, Platelet protein shake as playmaker
INSIDE BLOOD
LGL: a disease rediscovered
J. Joseph Melenhorst
View Articletitled, LGL: a disease rediscovered
MYELOID NEOPLASIA
Live and let (MPN cells) die!
Bruno Cassinat,Jean-Jacques Kiladjian
View Articletitled, Live and let (MPN cells) die!
MYELOID NEOPLASIA
GR SNP helps transform myelofibrosis
Farhad Ravandi
View Articletitled, GR SNP helps transform myelofibrosis

Blood Work

Cerebrospinal fluid plasmacytosis
Cyrus C. Hsia,Alan Gob
View Articletitled, Cerebrospinal fluid plasmacytosis
Histoplasmosis-induced pancytopenia
Cyrus C. Hsia,Alejandro Lazo-Langner
View Articletitled, Histoplasmosis-induced pancytopenia

Plenary Paper

Red Cells, Iron, and Erythropoiesis
Methemoglobinemia and ascorbate deficiency in hemoglobin E β thalassemia: metabolic and clinical implications
Angela Allen,Christopher Fisher,Anuja Premawardhena,Dayananda Bandara,Ashok Perera,Stephen Allen,Timothy St Pierre,Nancy Olivieri,David Weatherall
View Articletitled, Methemoglobinemia and ascorbate deficiency in hemoglobin E β thalassemia: metabolic and clinical implications

Review Article

Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders
Daniel E. Bauer,Sophia C. Kamran,Stuart H. Orkin
View Articletitled, Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders

How I Treat

How I treat anticoagulated patients undergoing an elective procedure or surgery
Alex C. Spyropoulos,James D. Douketis
View Articletitled, How I treat anticoagulated patients undergoing an elective procedure or surgery

Clinical Trials and Observations

A novel hierarchical prognostic model of AML solely based on molecular mutations
Clinical Trials & Observations
Vera Grossmann,Susanne Schnittger,Alexander Kohlmann,Christiane Eder,Andreas Roller,Frank Dicker,Christoph Schmid,Clemens-Martin Wendtner,Peter Staib,Hubert Serve,Karl-Anton Kreuzer,Wolfgang Kern,Torsten Haferlach,Claudia Haferlach
View Articletitled, A novel hierarchical prognostic model of AML solely based on molecular mutations
Supplemental data
The clinical implication of SRSF2 mutation in patients with myelodysplastic syndrome and its stability during disease evolution
Clinical Trials & Observations
Shang-Ju Wu,Yuan-Yeh Kuo,Hsin-An Hou,Li-Yu Li,Mei-Hsuan Tseng,Chi-Fei Huang,Fen-Yu Lee,Ming-Chih Liu,Chia-Wen Liu,Chien-Ting Lin,Chien-Yuan Chen,Wen-Chien Chou,Ming Yao,Shang-Yi Huang,Bor-Sheng Ko,Jih-Luh Tang,Woei Tsay,Hwei-Fang Tien
View Articletitled, The clinical implication of <em>SRSF2</em> mutation in patients with myelodysplastic syndrome and its stability during disease evolution
Supplemental data

Hematopoiesis and Stem Cells

Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function
Laura G. Schuettpelz,Priya K. Gopalan,Felipe O. Giuste,Molly P. Romine,Ronald van Os,Daniel C. Link
View Articletitled, Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function
Supplemental data
Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita
Fabian Beier,Miguel Foronda,Paula Martinez,Maria A. Blasco
View Articletitled, Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita
Supplemental data

Immunobiology

Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity
Sabina Sangaletti,Claudio Tripodo,Claudia Chiodoni,Carla Guarnotta,Barbara Cappetti,Patrizia Casalini,Silvia Piconese,Mariella Parenza,Cristiana Guiducci,Caterina Vitali,Mario P. Colombo
View Articletitled, Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity
Supplemental data
NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma
Stephen R. Mattarollo,Alison C. West,Kim Steegh,Helene Duret,Christophe Paget,Ben Martin,Geoffrey M. Matthews,Jake Shortt,Marta Chesi,P. Leif Bergsagel,Michael Bots,Johannes Zuber,Scott W. Lowe,Ricky W. Johnstone,Mark J. Smyth
View Articletitled, NKT cell adjuvant-based tumor vaccine for treatment of <em>myc</em> oncogene-driven mouse B-cell lymphoma
Supplemental data
Elevated serum soluble CD40 ligand in cancer patients may play an immunosuppressive role
Jianping Huang,Caroline Jochems,Tara Talaie,Austin Anderson,Alessandra Jales,Kwong Y. Tsang,Ravi A. Madan,James L. Gulley,Jeffrey Schlom
View Articletitled, Elevated serum soluble CD40 ligand in cancer patients may play an immunosuppressive role

Lymphoid Neoplasia

SMILE for natural killer/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group
Clinical Trials & Observations
Yok-Lam Kwong,Won Seog Kim,Soon Thye Lim,Seok Jin Kim,Tiffany Tang,Eric Tse,Anskar Y. H. Leung,Chor-Sang Chim
View Articletitled, SMILE for natural killer/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group
Supplemental data
HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk
Kevin Y. Urayama,Anand P. Chokkalingam,Catherine Metayer,Xiaomei Ma,Steve Selvin,Lisa F. Barcellos,Joseph L. Wiemels,John K. Wiencke,Malcolm Taylor,Paul Brennan,Gary V. Dahl,Priscilla Moonsamy,Henry A. Erlich,Elizabeth Trachtenberg,Patricia A. Buffler
View Articletitled, <em>HLA-DP</em> genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia
Andres Jerez,Michael J. Clemente,Hideki Makishima,Hanna Koskela,Francis LeBlanc,Kwok Peng Ng,Thomas Olson,Bartlomiej Przychodzen,Manuel Afable,Ines Gomez-Segui,Kathryn Guinta,Lisa Durkin,Eric D. Hsi,Kathy McGraw,Dan Zhang,Marcin W. Wlodarski,Kimmo Porkka,Mikkael A. Sekeres,Alan List,Satu Mustjoki,Thomas P. Loughran,Jaroslaw P. Maciejewski
View Articletitled, STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia
Supplemental data

Myeloid Neoplasia

Chromatin accessibility, p300, and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemia
Sadia Saeed,Colin Logie,Kees-Jan Francoijs,Gianmaria Frigè,Mauro Romanenghi,Fiona G. Nielsen,Lianne Raats,Maryam Shahhoseini,Martijn Huynen,Lucia Altucci,Saverio Minucci,Joost H. A. Martens,Hendrik G. Stunnenberg
View Articletitled, Chromatin accessibility, p300, and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemia
Supplemental data
Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia
Allen B. Williams,Li Li,Bao Nguyen,Patrick Brown,Mark Levis,Donald Small
View Articletitled, Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia
SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)
Manja Meggendorfer,Andreas Roller,Torsten Haferlach,Christiane Eder,Frank Dicker,Vera Grossmann,Alexander Kohlmann,Tamara Alpermann,Kenichi Yoshida,Seishi Ogawa,H. Phillip Koeffler,Wolfgang Kern,Claudia Haferlach,Susanne Schnittger
View Articletitled, <em>SRSF2</em> mutations in 275 cases with chronic myelomonocytic leukemia (CMML)
Supplemental data
Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13–driven mouse model
Haiming Xu,Silvia Menendez,Brigitte Schlegelberger,Narae Bae,Peter D. Aplan,Gudrun Göhring,Tony R. Deblasio,Stephen D. Nimer
View Articletitled, Loss of p53 accelerates the complications of myelodysplastic syndrome in a <em>NUP98-HOXD13</em>–driven mouse model
Supplemental data
Combination treatment in vitro with Nutlin, a small-molecule antagonist of MDM2, and pegylated interferon-α 2a specifically targets JAK2V617F-positive polycythemia vera cells
Min Lu,Xiaoli Wang,Yan Li,Joseph Tripodi,Goar Mosoyan,John Mascarenhas,Marina Kremyanskaya,Vesna Najfeld,Ronald Hoffman
View Articletitled, Combination treatment in vitro with Nutlin, a small-molecule antagonist of MDM2, and pegylated interferon-α 2a specifically targets JAK2V617F-positive polycythemia vera cells
A3669G polymorphism of glucocorticoid receptor is a susceptibility allele for primary myelofibrosis and contributes to phenotypic diversity and blast transformation
Valentina Poletto,Vittorio Rosti,Laura Villani,Paolo Catarsi,Adriana Carolei,Rita Campanelli,Margherita Massa,Myriam Martinetti,Gianluca Viarengo,Alberto Malovini,Anna Rita Migliaccio,Giovanni Barosi
View Articletitled, A3669G polymorphism of glucocorticoid receptor is a susceptibility allele for primary myelofibrosis and contributes to phenotypic diversity and blast transformation

Phagocytes, Granulocytes, and Myelopoiesis

HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo
Brief Report
Andreas Weigert,Benjamin Weichand,Divya Sekar,Weixiao Sha,Christina Hahn,Javier Mora,Stephanie Ley,Silke Essler,Nathalie Dehne,Bernhard Brüne
View Articletitled, HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo
Supplemental data
Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α
Alison M. McInturff,Mark J. Cody,Elizabeth A. Elliott,Jared W. Glenn,Jesse W. Rowley,Matthew T. Rondina,Christian C. Yost
View Articletitled, Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α
Supplemental data
PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts
Violeta Chitu,Viorel Nacu,Julia F. Charles,William M. Henne,Harvey T. McMahon,Sayan Nandi,Halley Ketchum,Renee Harris,Mary C. Nakamura,E. Richard Stanley
View Articletitled, PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts
Supplemental data
Interphase Chromosome Flow-FISH
e-blood
Keyvan Keyvanfar,Jason Weed,Prashanth Swamy,Sachiko Kajigaya,Rodrigo T. Calado,Neal S. Young
View Articletitled, Interphase Chromosome Flow-FISH
Supplemental data
Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators
e-blood
Jesmond Dalli,Charles N. Serhan
View Articletitled, Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators
Supplemental data

Platelets and Thrombopoiesis

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways
e-blood
Julia M. Burkhart,Marc Vaudel,Stepan Gambaryan,Sonja Radau,Ulrich Walter,Lennart Martens,Jörg Geiger,Albert Sickmann,René P. Zahedi
View Articletitled, The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways
Supplemental data

Red Cells, Iron, and Erythropoiesis

Erythrocyte density in sickle cell syndromes is associated with specific clinical manifestations and hemolysis
Pablo Bartolucci,Carlo Brugnara,Armando Teixeira-Pinto,Serge Pissard,Kamran Moradkhani,Hélène Jouault,Frederic Galacteros
View Articletitled, Erythrocyte density in sickle cell syndromes is associated with specific clinical manifestations and hemolysis

Transplantation

Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjögren syndrome
Clinical Trials & Observations
Junji Xu,Dandan Wang,Dayong Liu,Zhipeng Fan,Huayong Zhang,Ousheng Liu,Gang Ding,Runtao Gao,Chunmei Zhang,Yaozhong Ding,Jonathan S. Bromberg,Wanjun Chen,Lingyun Sun,Songlin Wang
View Articletitled, Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjögren syndrome
Supplemental data

Vascular Biology

Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages
Huanhuan He,Jingying Xu,Carmen M. Warren,Dan Duan,Xinmin Li,Lily Wu,M. Luisa Iruela-Arispe
View Articletitled, Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages
Supplemental data
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