Nicola Gökbuget,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Daniel Stanze,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Joachim Beck,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Helmut Diedrich,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Heinz-August Horst,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Andreas Hüttmann,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Guido Kobbe,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Karl-Anton Kreuzer,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Lothar Leimer,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Albrecht Reichle,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Markus Schaich,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Stefan Schwartz,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Hubert Serve,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Michael Starck,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Matthias Stelljes,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Reingard Stuhlmann,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Andreas Viardot,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Knut Wendelin,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Mathias Freund,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia,Dieter Hoelzer,on behalf of the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia

View Articletitled, Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation

Supplemental data

Hematopoiesis and Stem Cells

Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein

Meghan A. Rego,Frederick W. Kolling, IV,Elizabeth A. Vuono,Maurizio Mauro,Niall G. Howlett

View Articletitled, Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein

Supplemental data

Immunobiology

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells

Bithi Chatterjee,Anna Smed-Sörensen,Lillian Cohn,Cécile Chalouni,Richard Vandlen,Byoung-Chul Lee,Jenifer Widger,Tibor Keler,Lélia Delamarre,Ira Mellman

View Articletitled, Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells

Supplemental data

Human regulatory T cells induce T-lymphocyte senescence

Jian Ye,Xingxu Huang,Eddy C. Hsueh,Qunyuan Zhang,Chunling Ma,Yanping Zhang,Mark A. Varvares,Daniel F. Hoft,Guangyong Peng

View Articletitled, Human regulatory T cells induce T-lymphocyte senescence

Supplemental data

Lymphoid Neoplasia

Mast cells play a protumorigenic role in primary cutaneous lymphoma

Anja Rabenhorst,Max Schlaak,Lukas C. Heukamp,Anja Förster,Sebastian Theurich,Michael von Bergwelt-Baildon,Reinhard Büttner,Peter Kurschat,Cornelia Mauch,Axel Roers,Karin Hartmann

View Articletitled, Mast cells play a protumorigenic role in primary cutaneous lymphoma

Supplemental data

CD86⁺ or HLA-G⁺ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis

Ross Brown,Karieshma Kabani,James Favaloro,Shihong Yang,P. Joy Ho,John Gibson,Phillip Fromm,Hayley Suen,Narelle Woodland,Najah Nassif,Derek Hart,Douglas Joshua

View Articletitled, CD86+ or HLA-G+ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis

Myeloid Neoplasia

High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia
Clinical Trials & Observations

Maaike Luesink,Iris H. I. M. Hollink,Vincent H. J. van der Velden,Ruth H. J. N. Knops,Jan B. M. Boezeman,Valérie de Haas,Jan Trka,Andre Baruchel,Dirk Reinhardt,Bert A. van der Reijden,Marry M. van den Heuvel-Eibrink,C. Michel Zwaan,Joop H. Jansen

View Articletitled, High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia

Supplemental data

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations

Britta Will,Li Zhou,Thomas O. Vogler,Susanna Ben-Neriah,Carolina Schinke,Roni Tamari,Yiting Yu,Tushar D. Bhagat,Sanchari Bhattacharyya,Laura Barreyro,Christoph Heuck,Yonkai Mo,Samir Parekh,Christine McMahon,Andrea Pellagatti,Jacqueline Boultwood,Cristina Montagna,Lewis Silverman,Jaroslaw Maciejewski,John M. Greally,B. Hilda Ye,Alan F. List,Christian Steidl,Ulrich Steidl,Amit Verma

View Articletitled, Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations

Supplemental data

Mechanisms of resistance to high and low linear energy transfer radiation in myeloid leukemia cells

Kurtis J. Haro,Andrew C. Scott,David A. Scheinberg

View Articletitled, Mechanisms of resistance to high and low linear energy transfer radiation in myeloid leukemia cells

Supplemental data

Treatment-influenced associations of PML-RARα mutations, FLT3 mutations, and additional chromosome abnormalities in relapsed acute promyelocytic leukemia

Robert E. Gallagher,Barry K. Moser,Janis Racevskis,Xavier Poiré,Clara D. Bloomfield,Andrew J. Carroll,Rhett P. Ketterling,Diane Roulston,Esther Schachter-Tokarz,Da-cheng Zhou,I-Ming L. Chen,Richard Harvey,Greg Koval,Dorie A. Sher,James H. Feusner,Martin S. Tallman,Richard A. Larson,Bayard L. Powell,Frederick R. Appelbaum,Elisabeth Paietta,Cheryl L. Willman,Wendy Stock

View Articletitled, Treatment-influenced associations of PML-RARα mutations, FLT3 mutations, and additional chromosome abnormalities in relapsed acute promyelocytic leukemia

Supplemental data

High expression of lymphoid enhancer-binding factor-1 (LEF1) is a novel favorable prognostic factor in cytogenetically normal acute myeloid leukemia

Klaus H. Metzeler,Bernhard Heilmeier,Katrin E. Edmaier,Vijay P. S. Rawat,Annika Dufour,Konstanze Döhner,Michaela Feuring-Buske,Jan Braess,Karsten Spiekermann,Thomas Büchner,Maria C. Sauerland,Hartmut Döhner,Wolfgang Hiddemann,Stefan K. Bohlander,Richard F. Schlenk,Lars Bullinger,Christian Buske

View Articletitled, High expression of lymphoid enhancer-binding factor-1 (LEF1) is a novel favorable prognostic factor in cytogenetically normal acute myeloid leukemia

Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Tissue factor–positive neutrophils bind to injured endothelial wall and initiate thrombus formation

Roxane Darbousset,Grace M. Thomas,Soraya Mezouar,Corinne Frère,Rénaté Bonier,Nigel Mackman,Thomas Renné,Françoise Dignat-George,Christophe Dubois,Laurence Panicot-Dubois

View Articletitled, Tissue factor–positive neutrophils bind to injured endothelial wall and initiate thrombus formation

Supplemental data

Platelets and Thrombopoiesis

Thymic retention of CD4⁺CD25⁺FoxP3⁺ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia

Rukhsana Aslam,Yu Hu,Simon Gebremeskel,George B. Segel,Edwin R. Speck,Li Guo,Michael Kim,Heyu Ni,John Freedman,John W. Semple

View Articletitled, Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia

Supplemental data

Transplantation

Early posttransplantation donor-derived invariant natural killer T-cell recovery predicts the occurrence of acute graft-versus-host disease and overall survival
Clinical Trials & Observations

Marie-Thérèse Rubio,Lucia Moreira-Teixeira,Emmanuel Bachy,Marie Bouillié,Pierre Milpied,Tereza Coman,Felipe Suarez,Ambroise Marcais,David Sibon,Agnès Buzyn,Sophie Caillat-Zucman,Marina Cavazzana-Calvo,Bruno Varet,Michel Dy,Olivier Hermine,Maria Leite-de-Moraes

View Articletitled, Early posttransplantation donor-derived invariant natural killer T-cell recovery predicts the occurrence of acute graft-versus-host disease and overall survival

Supplemental data

Errata

Musso T, Calosso L, Zucca M, et al. Human Monocytes Constitutively Express Membrane-Bound, Biologically Active, and Interferon-γ–Upregulated Interleukin-15. Blood. 1999;93(10):3531–3539.

View Articletitled, Musso T, Calosso L, Zucca M, et al. Human Monocytes Constitutively Express Membrane-Bound, Biologically Active, and Interferon-γ–Upregulated Interleukin-15. Blood. 1999;93(10):3531–3539.

Cover Image

Cover Image

Representative immunofluorescence microscopy image of a murine proplatelet-producing megakaryocyte. Trastuzumab is labeled red and is shown having permeated the megakaryocyte plasma membrane. β1-tubulin is labeled green. Microtubule organization and proplatelet production are not affected by trastuzumab. See the article by Thon et al on page 1975.
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Table of Contents

Inside Blood

Blood Work

Plenary Paper

Review Article

How I Treat

Clinical Trials and Observations

Clinical implications of plasma Epstein-Barr virus DNA in early-stage extranodal nasal-type NK/T-cell lymphoma patients receiving primary radiotherapy Clinical Trials & Observations

Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation Clinical Trials & Observations

Hematopoiesis and Stem Cells

Immunobiology

Lymphoid Neoplasia

Myeloid Neoplasia

High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia Clinical Trials & Observations

Phagocytes, Granulocytes, and Myelopoiesis

Platelets and Thrombopoiesis

Transplantation

Early posttransplantation donor-derived invariant natural killer T-cell recovery predicts the occurrence of acute graft-versus-host disease and overall survival Clinical Trials & Observations

Errata

Cover Image

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Clinical implications of plasma Epstein-Barr virus DNA in early-stage extranodal nasal-type NK/T-cell lymphoma patients receiving primary radiotherapy
Clinical Trials & Observations

Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation
Clinical Trials & Observations

High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia
Clinical Trials & Observations

Early posttransplantation donor-derived invariant natural killer T-cell recovery predicts the occurrence of acute graft-versus-host disease and overall survival
Clinical Trials & Observations