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Volume 118, Issue 18
November 3 2011
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS
Time to put the CAR-T before the horse
Caron A. Jacobson,Jerome Ritz
View Articletitled, Time to put the CAR-T before the horse
INSIDE BLOOD
Lymphoma spread? Target CD47-SIRPα!
Marcel Spaargaren
View Articletitled, Lymphoma spread? Target CD47-SIRPα!
PHAGOCYTES & GRANULOCYTES
Released on a WHIM
George A. Diaz
View Articletitled, Released on a WHIM
TRANSPLANTATION
Th1 and Th17 join forces for acute GVHD
Takanori Teshima
View Articletitled, Th1 and Th17 join forces for acute GVHD
VASCULAR BIOLOGY
Ang2, the instigator of inflammation
Honsoul Kim,Gou Young Koh
View Articletitled, Ang2, the instigator of inflammation

Blood Work

Polycythemia vera with pancytopenia and red cell fragmentation
Cyrus C. Hsia,Anargyros Xenocostas
View Articletitled, Polycythemia vera with pancytopenia and red cell fragmentation

Plenary Paper

PLENARY PAPER
Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide
Yuan Xiao Zhu,Esteban Braggio,Chang-Xin Shi,Laura A. Bruins,Jessica E. Schmidt,Scott Van Wier,Xiu-Bao Chang,Chad C. Bjorklund,Rafael Fonseca,P. Leif Bergsagel,Robert Z. Orlowski,A. Keith Stewart
View Articletitled, Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide
Supplemental data

Perspectives

Is heparin a placental anticoagulant in high-risk pregnancies?
John C. P. Kingdom,Sascha Drewlo
View Articletitled, Is heparin a placental anticoagulant in high-risk pregnancies?

Review Article

The role of the annexin A2 heterotetramer in vascular fibrinolysis
Patricia A. Madureira,Alexi P. Surette,Kyle D. Phipps,Michael A. S. Taboski,Victoria A. Miller,David M. Waisman
View Articletitled, The role of the annexin A2 heterotetramer in vascular fibrinolysis

Clinical Trials and Observations

A survey of 90 patients with autoimmune lymphoproliferative syndrome related to TNFRSF6 mutation
Clinical Trials & Observations
Bénédicte Neven,Aude Magerus-Chatinet,Benoit Florkin,Delphine Gobert,Olivier Lambotte,Lien De Somer,Nina Lanzarotti,Marie-Claude Stolzenberg,Brigitte Bader-Meunier,Nathalie Aladjidi,Christophe Chantrain,Yves Bertrand,Eric Jeziorski,Guy Leverger,Gérard Michel,Felipe Suarez,Eric Oksenhendler,Olivier Hermine,Stéphane Blanche,Capucine Picard,Alain Fischer,Frédéric Rieux-Laucat
View Articletitled, A survey of 90 patients with autoimmune lymphoproliferative syndrome related to <em>TNFRSF6</em> mutation
Addition of rituximab to chemotherapy alone as first-line therapy improves overall survival in elderly patients with mantle cell lymphoma
Clinical Trials & Observations
Robert Griffiths,Joseph Mikhael,Michelle Gleeson,Mark Danese,Martin Dreyling
View Articletitled, Addition of rituximab to chemotherapy alone as first-line therapy improves overall survival in elderly patients with mantle cell lymphoma
Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas
Clinical Trials & Observations
Thomas E. Witzig,Hui Tang,Ivana N. M. Micallef,Stephen M. Ansell,Brian K. Link,David J. Inwards,Luis F. Porrata,Patrick B. Johnston,Joseph P. Colgan,Svetomir N. Markovic,Grzegorz S. Nowakowski,Carrie A. Thompson,Cristine Allmer,Matthew J. Maurer,Mamta Gupta,George Weiner,Ray Hohl,Paul J. Kurtin,Husheng Ding,David Loegering,Paula Schneider,Kevin Peterson,Thomas M. Habermann,Scott H. Kaufmann
View Articletitled, Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas

Gene Therapy

Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
Clinical Trials & Observations
Renier J. Brentjens,Isabelle Rivière,Jae H. Park,Marco L. Davila,Xiuyan Wang,Jolanta Stefanski,Clare Taylor,Raymond Yeh,Shirley Bartido,Oriana Borquez-Ojeda,Malgorzata Olszewska,Yvette Bernal,Hollie Pegram,Mark Przybylowski,Daniel Hollyman,Yelena Usachenko,Domenick Pirraglia,James Hosey,Elmer Santos,Elizabeth Halton,Peter Maslak,David Scheinberg,Joseph Jurcic,Mark Heaney,Glenn Heller,Mark Frattini,Michel Sadelain
View Articletitled, Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
Supplemental data

Hematopoiesis and Stem Cells

Bone marrow dendritic cell progenitors sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes
Michael A. Schmid,Hitoshi Takizawa,Dior R. Baumjohann,Yasuyuki Saito,Markus G. Manz
View Articletitled, Bone marrow dendritic cell progenitors sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes
Supplemental data

Immunobiology

HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation
Damjan S. Nikolic,Martin Lehmann,Richard Felts,Eduardo Garcia,Fabien P. Blanchet,Sriram Subramaniam,Vincent Piguet
View Articletitled, HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation
Supplemental data
A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens
Helene Pere,Yves Montier,Jagadeesh Bayry,Francoise Quintin-Colonna,Nathalie Merillon,Estelle Dransart,Cecile Badoual,Alain Gey,Patrice Ravel,Elie Marcheteau,Frederic Batteux,Federico Sandoval,Olivier Adotevi,Christopher Chiu,Sylvie Garcia,Corinne Tanchot,Yu-Chun Lone,Luis Carlos Ferreira,Brad H. Nelson,Douglas Hanahan,Wolf Herman Fridman,Ludger Johannes,Eric Tartour
View Articletitled, A CCR4 antagonist combined with vaccines induces antigen-specific CD8<sup>+</sup> T cells and tumor immunity against self antigens
Supplemental data
Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking
Katia Mayol,Vincent Biajoux,Jacqueline Marvel,Karl Balabanian,Thierry Walzer
View Articletitled, Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking
Supplemental data

Lymphoid Neoplasia

Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation
Husheng Ding,Jennifer Hackbarth,Paula A. Schneider,Kevin L. Peterson,X. Wei Meng,Haiming Dai,Thomas E. Witzig,Scott H. Kaufmann
View Articletitled, Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation
Supplemental data
Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy
Mark P. Chao,Chad Tang,Russell K. Pachynski,Robert Chin,Ravindra Majeti,Irving L. Weissman
View Articletitled, Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy
Supplemental data
Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (FcμR) in patients with chronic lymphocytic leukemia
Fu Jun Li,Yoshiki Kubagawa,Matthew K. McCollum,Landon Wilson,Tomoko Motohashi,Luigi F. Bertoli,James C. Barton,Stephen Barnes,Randall S. Davis,Hiromi Kubagawa
View Articletitled, Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (FcμR) in patients with chronic lymphocytic leukemia
Supplemental data
ETV6-RUNX1 promotes survival of early B lineage progenitor cells via a dysregulated erythropoietin receptor
Veronica Torrano,Julia Procter,Penny Cardus,Mel Greaves,Anthony M. Ford
View Articletitled, ETV6-RUNX1 promotes survival of early B lineage progenitor cells via a dysregulated erythropoietin receptor
Supplemental data
Dysregulated microRNAs affect pathways and targets of biologic relevance in nasal-type natural killer/T-cell lymphoma
Siok-Bian Ng,Junli Yan,Gaofeng Huang,Viknesvaran Selvarajan,Jim Liang-Seah Tay,Baohong Lin,Chonglei Bi,Joy Tan,Yok-Lam Kwong,Norio Shimizu,Katsuyuki Aozasa,Wee-Joo Chng
View Articletitled, Dysregulated microRNAs affect pathways and targets of biologic relevance in nasal-type natural killer/T-cell lymphoma
Supplemental data
Alteration of BIRC3 and multiple other NF-κB pathway genes in splenic marginal zone lymphoma
Brief Report
Davide Rossi,Silvia Deaglio,David Dominguez-Sola,Silvia Rasi,Tiziana Vaisitti,Claudio Agostinelli,Valeria Spina,Alessio Bruscaggin,Sara Monti,Michaela Cerri,Stefania Cresta,Marco Fangazio,Luca Arcaini,Marco Lucioni,Roberto Marasca,Catherine Thieblemont,Daniela Capello,Fabio Facchetti,Ivo Kwee,Stefano A. Pileri,Robin Foà,Francesco Bertoni,Riccardo Dalla-Favera,Laura Pasqualucci,Gianluca Gaidano
View Articletitled, Alteration of <em>BIRC3</em> and multiple other NF-κB pathway genes in splenic marginal zone lymphoma
Supplemental data

Myeloid Neoplasia

Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice
Li Li,Emily Bailey,Sarah Greenblatt,David Huso,Donald Small
View Articletitled, Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice

Phagocytes, Granulocytes, and Myelopoiesis

Digestive vacuoles of Plasmodium falciparum are selectively phagocytosed by and impair killing function of polymorphonuclear leukocytes
Prasad Dasari,Karina Reiss,Klaus Lingelbach,Stefan Baumeister,Ralph Lucius,Rachanee Udomsangpetch,Sebastian Chakrit Bhakdi,Sucharit Bhakdi
View Articletitled, Digestive vacuoles of <em>Plasmodium falciparum</em> are selectively phagocytosed by and impair killing function of polymorphonuclear leukocytes
The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome
Clinical Trials & Observations
David H. McDermott,Qian Liu,Jean Ulrick,Nana Kwatemaa,Sandra Anaya-O'Brien,Scott R. Penzak,Joao Oliveira Filho,Debra A. Long Priel,Corin Kelly,Mary Garofalo,Patricia Littel,Martha M. Marquesen,Diane Hilligoss,Rosamma DeCastro,Thomas A. Fleisher,Douglas B. Kuhns,Harry L. Malech,Philip M. Murphy
View Articletitled, The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome
Supplemental data
The CXCR4 antagonist plerixafor is a potential therapy for myelokathexis, WHIM syndrome
Brief Report
David C. Dale,Audrey Anna Bolyard,Merideth L. Kelley,Ernest C. Westrup,Vahagn Makaryan,Andrew Aprikyan,Brent Wood,Frank J. Hsu
View Articletitled, The CXCR4 antagonist plerixafor is a potential therapy for myelokathexis, WHIM syndrome

Red Cells, Iron, and Erythropoiesis

Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake
Jovana Serbanovic-Canic,Ana Cvejic,Nicole Soranzo,Derek L. Stemple,Willem H. Ouwehand,Kathleen Freson
View Articletitled, Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake
Supplemental data
Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats
Igor Theurl,Andrea Schroll,Thomas Sonnweber,Manfred Nairz,Milan Theurl,Wolfgang Willenbacher,Kathrin Eller,Dominik Wolf,Markus Seifert,Chia Chi Sun,Jodie L. Babitt,Charles C. Hong,Tracey Menhall,Patrick Gearing,Herbert Y. Lin,Guenter Weiss
View Articletitled, Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats
Supplemental data
Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia
Clinical Trials & Observations
Russell E. Ware,Jenny M. Despotovic,Nicole A. Mortier,Jonathan M. Flanagan,Jin He,Matthew P. Smeltzer,Amy C. Kimble,Banu Aygun,Song Wu,Thad Howard,Alex Sparreboom
View Articletitled, Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia
Supplemental data

Thrombosis and Hemostasis

Heparin and warfarin anticoagulation intensity as predictors of recurrence after deep vein thrombosis or pulmonary embolism: a population-based cohort study
Clinical Trials & Observations
John A. Heit,Brian D. Lahr,Tanya M. Petterson,Kent R. Bailey,Aneel A. Ashrani,L. Joseph Melton, III
View Articletitled, Heparin and warfarin anticoagulation intensity as predictors of recurrence after deep vein thrombosis or pulmonary embolism: a population-based cohort study
Supplemental data

Transplantation

Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice
Yu Yu,Dapeng Wang,Chen Liu,Kane Kaosaard,Kenrick Semple,Claudio Anasetti,Xue-Zhong Yu
View Articletitled, Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice
Supplemental data
Low telomerase activity in CD4+ regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation
Yutaka Kawano,Haesook T. Kim,Ken-ichi Matsuoka,Gregory Bascug,Sean McDonough,Vincent T. Ho,Corey Cutler,John Koreth,Edwin P. Alyea,Joseph H. Antin,Robert J. Soiffer,Jerome Ritz
View Articletitled, Low telomerase activity in CD4<sup>+</sup> regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation
Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model
A. Mario Marcondes,Xiang Li,Laura Tabellini,Matthias Bartenstein,Julia Kabacka,George E. Sale,John A. Hansen,Charles A. Dinarello,H. Joachim Deeg
View Articletitled, Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model

Vascular Biology

Critical role for Syk in responses to vascular injury
Patrick Andre,Toshifumi Morooka,Derek Sim,Keith Abe,Clifford Lowell,Nisha Nanda,Suzanne Delaney,Gail Siu,Yibing Yan,Stan Hollenbach,Anjali Pandey,Huiyun Gao,Yunmei Wang,Kohsuke Nakajima,Sahil A. Parikh,Can Shi,David Phillips,Whyte Owen,Uma Sinha,Daniel I. Simon
View Articletitled, Critical role for Syk in responses to vascular injury
Supplemental data
BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium
Thomas Helbing,René Rothweiler,Elena Ketterer,Lena Goetz,Jennifer Heinke,Sebastian Grundmann,Daniel Duerschmied,Cam Patterson,Christoph Bode,Martin Moser
View Articletitled, BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium
Supplemental data
Angiopoietin-2 promotes myeloid cell infiltration in a β2-integrin–dependent manner
Alexander Scholz,Victoria Lang,Reinhard Henschler,Marcus Czabanka,Peter Vajkoczy,Emmanouil Chavakis,Janina Drynski,Patrick N. Harter,Michel Mittelbronn,Daniel J. Dumont,Karl H. Plate,Yvonne Reiss
View Articletitled, Angiopoietin-2 promotes myeloid cell infiltration in a β<sub>2</sub>-integrin–dependent manner
Supplemental data

Errata

Cappellini MD, Bejaoui M, Agaoglu L, et al. Iron chelation with deferasirox in adult and pediatric patients with thalassemia major: efficacy and safety during 5 years' follow-up. Blood. 2011;118(4):884–893.
View Articletitled, Cappellini MD, Bejaoui M, Agaoglu L, et al. Iron chelation with deferasirox in adult and pediatric patients with thalassemia major: efficacy and safety during 5 years' follow-up. <em>Blood</em>. 2011;118(4):<span class="related-article">884–893</span>.
Booth C, Gilmour KC, Veys P, et al. X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease. Blood. 2011;117(1):53–62.
View Articletitled, Booth C, Gilmour KC, Veys P, et al. X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease. <em>Blood</em>. 2011;117(1):<span class="related-article">53–62</span>.
Gregori S, Tomasoni D, Pacciani V, et al. Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10–dependent ILT4/HLA-G pathway. Blood. 2010;116(6):935–944.
View Articletitled, Gregori S, Tomasoni D, Pacciani V, et al. Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10–dependent ILT4/HLA-G pathway. <em>Blood</em>. 2010;116(6):<span class="related-article">935–944</span>.
Gomes AL, Carvalho T, Serpa J, Torre C, Dias S. Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF-1:CXCR4 axis. Blood. 2010;115(19):3886–3894.
View Articletitled, Gomes AL, Carvalho T, Serpa J, Torre C, Dias S. Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF-1:CXCR4 axis. <em>Blood</em>. 2010;115(19):<span class="related-article">3886–3894</span>.
  • Cover Image

    Cover Image

    issue cover

    Diagrammatic representation of the trophoblast surface covering floating villi within the human placenta. Cytotrophoblast cells (green) at bottom left divide asymmetrically to fuse (top) into the outer syncytiotrophoblast layer that is in direct contact with maternal blood and acts as an anticoagulant surface under normal circumstances. This outer layer may degenerate, resulting in local thrombosis and infarction (yellow) in pathologic high-risk pregnancies (bottom right). Credit: Kenneth Xavier Probst, Sascha Drewlo, and John Kingdom. See the article by Kingdom and Drewlo, page 4780.

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Cardiac complete response in AL amyloidosis has similar survival to matched general population
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Heme induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice
Interleukin-1 mediated hyperinflammation in XIAP-deficiency is associated with defective autophagy.
NOVEL THERAPEUTIC APPROACHES IN THALASSEMIAS, SICKLE CELL DISEASE AND OTHER RED CELL DISORDERS

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