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Hepatocytes contain high levels of heme, an iron-containing porphyrin that is required for the activity of many drug-metabolizing enzymes. Heme synthesis occurs within mitochondria where iron is transported into mitochondria by 2 homologous transporters termed mitoferrin 1 and mitoferrin 2. Mice with a targeted gene deletion in hepatocyte mitoferrin 1 show no phenotype under standard conditions. In contrast, hepatocyte-specific deletion of mitoferrin 1 leads to liver fibrosis in mice fed aminolevulinic acid, a porphyrin precursor. This image is a picture of liver centered on a periportal area, stained with trichrome showing collagen deposition in blue, bile duct proliferation, and chronic inflammation. The brown pigment suggests protoporphyrin IX accumulation and cholestasis within bile ducts. See the article by Troadec et al on page 5494.