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Issue Archive

Volume 113, Issue 15
April 9 2009
Issue Cover

Table of Contents

INSIDE BLOOD

INSIDE BLOOD
Going retro on lymphoma
Alexander L. Dent
View Articletitled, Going retro on lymphoma
CLINICAL TRIALS
Thalidomide/dexamethasone in myeloma: a double-edged sword
Pieter Sonneveld
View Articletitled, Thalidomide/dexamethasone in myeloma: a double-edged sword
PLATELETS & THROMBOPOIESIS
Pinning a tail on platelet thrombi
Joel S. Bennett
View Articletitled, Pinning a tail on platelet thrombi

PLENARY PAPERS

A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo
Leandro C. Cerchietti,Shao Ning Yang,Rita Shaknovich,Katerina Hatzi,Jose M. Polo,Amy Chadburn,Steven F. Dowdy,Ari Melnick
View Articletitled, A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo
Supplemental data

PERSPECTIVE

Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention
Eleftherios C. Vamvakas,Morris A. Blajchman
View Articletitled, Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention

REVIEW ARTICLES

Dendritic cell homeostasis
Miriam Merad,Markus G. Manz
View Articletitled, Dendritic cell homeostasis
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Results of high-dose imatinib mesylate in intermediate Sokal risk chronic myeloid leukemia patients in early chronic phase: a phase 2 trial of the GIMEMA CML Working Party
Clinical Trials & Observations
Fausto Castagnetti,Francesca Palandri,Marilina Amabile,Nicoletta Testoni,Simona Luatti,Simona Soverini,Ilaria Iacobucci,Massimo Breccia,Giovanna Rege Cambrin,Fabio Stagno,Giorgina Specchia,Piero Galieni,Franco Iuliano,Fabrizio Pane,Giuseppe Saglio,Giuliana Alimena,Giovanni Martinelli,Michele Baccarani,Gianantonio Rosti,for the GIMEMA CML Working Party
View Articletitled, Results of high-dose imatinib mesylate in intermediate Sokal risk chronic myeloid leukemia patients in early chronic phase: a phase 2 trial of the GIMEMA CML Working Party
Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myeloma
Clinical Trials & Observations
Heinz Ludwig,Roman Hajek,Elena Tóthová,Johannes Drach,Zdenek Adam,Boris Labar,Miklós Egyed,Ivan Spicka,Heinz Gisslinger,Richard Greil,Ingrid Kuhn,Niklas Zojer,Axel Hinke
View Articletitled, Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myeloma

GENE THERAPY

The F12-Vif derivative Chim3 inhibits HIV-1 replication in CD4+ T lymphocytes and CD34+-derived macrophages by blocking HIV-1 DNA integration
Simona Porcellini,Luca Alberici,Francesco Gubinelli,Rossella Lupo,Clelia Olgiati,Gian-Paolo Rizzardi,Chiara Bovolenta
View Articletitled, The F12-Vif derivative Chim3 inhibits HIV-1 replication in CD4<sup>+</sup> T lymphocytes and CD34<sup>+</sup>-derived macrophages by blocking HIV-1 DNA integration
Supplemental data

HEMATOPOIESIS AND STEM CELLS

FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells
Natalija Buza-Vidas,Min Cheng,Sara Duarte,Hojjatollah Nozad Charoudeh,Sten Eirik W. Jacobsen,Ewa Sitnicka
View Articletitled, FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis
Christos Gekas,Katrin E. Rhodes,Laurraine M. Gereige,Hildur Helgadottir,Roberto Ferrari,Siavash K. Kurdistani,Encarnación Montecino-Rodriguez,Rhonda Bassel-Duby,Eric Olson,Andrei V. Krivtsov,Scott Armstrong,Stuart H. Orkin,Matteo Pellegrini,Hanna K. A. Mikkola
View Articletitled, Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis
Supplemental data
Skewing of X-inactivation ratios in blood cells of aging women is confirmed by independent methodologies
Brief Report
Lambert Busque,Yves Paquette,Sylvie Provost,Denis-Claude Roy,Ross L. Levine,Luigina Mollica,D. Gary Gilliland
View Articletitled, Skewing of X-inactivation ratios in blood cells of aging women is confirmed by independent methodologies

IMMUNOBIOLOGY

CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance
Josef Kurtz,Forum Raval,Casey Vallot,Jayden Der,Megan Sykes
View Articletitled, CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance
C1q enhances IFN-γ production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells
Paramita Baruah,Ingrid E. Dumitriu,Talat H. Malik,H. Terence Cook,Julian Dyson,Diane Scott,Elizabeth Simpson,Marina Botto
View Articletitled, C1q enhances IFN-γ production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells
Supplemental data
EpCAM, a human tumor-associated antigen promotes Th2 development and tumor immune evasion
Alexandra Ziegler,Regina Heidenreich,Heidi Braumüller,Hartwig Wolburg,Susanne Weidemann,Ralph Mocikat,Martin Röcken
View Articletitled, EpCAM, a human tumor-associated antigen promotes Th2 development and tumor immune evasion
Supplemental data
ATM-ATR–dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype
Alessandra Soriani,Alessandra Zingoni,Cristina Cerboni,Maria Luisa Iannitto,Maria Rosaria Ricciardi,Valentina Di Gialleonardo,Marco Cippitelli,Cinzia Fionda,Maria Teresa Petrucci,Anna Guarini,Robin Foà,Angela Santoni
View Articletitled, ATM-ATR–dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype
Supplemental data
Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase–dependent induction of Socs-3
Roberta Caruso,Carmine Stolfi,Massimiliano Sarra,Angelamaria Rizzo,Massimo C. Fantini,Francesco Pallone,Thomas T. MacDonald,Giovanni Monteleone
View Articletitled, Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase–dependent induction of Socs-3
Supplemental data
Viperin is required for optimal Th2 responses and T-cell receptor–mediated activation of NF-κB and AP-1
Lian-Qun Qiu,Peter Cresswell,Keh-Chuang Chin
View Articletitled, Viperin is required for optimal Th2 responses and T-cell receptor–mediated activation of NF-κB and AP-1
Supplemental data
Incomplete T-cell receptor–β peptides target the mitochondrion and induce apoptosis
Nir Shani,Hila Rubin-Lifshitz,Yifat Peretz-Cohen,Ketty Shkolnik,Vera Shinder,Michal Cohen-Sfady,Yaron Shav-Tal,Mira Barda-Saad,Dov Zipori
View Articletitled, Incomplete T-cell receptor–β peptides target the mitochondrion and induce apoptosis
Supplemental data
Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress–induced cell death
Brief Report
Dimitrios Mougiakakos,C. Christian Johansson,Rolf Kiessling
View Articletitled, Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress–induced cell death
Supplemental data

LYMPHOID NEOPLASIA

T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy
Roch Houot,Ronald Levy
View Articletitled, T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy
Transformation of follicular lymphoma to diffuse large B-cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution from the follicular lymphoma clone
Brief Report
Emanuela Carlotti,David Wrench,Janet Matthews,Sameena Iqbal,Andrew Davies,Andrew Norton,Jason Hart,Raymond Lai,Silvia Montoto,John G. Gribben,T. Andrew Lister,Jude Fitzgibbon
View Articletitled, Transformation of follicular lymphoma to diffuse large B-cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution from the follicular lymphoma clone
Supplemental data

MYELOID NEOPLASIA

Structure of the AML1-ETO eTAFH domain–HEB peptide complex and its contribution to AML1-ETO activity
Sangho Park,Wei Chen,Tomasz Cierpicki,Marco Tonelli,Xiongwei Cai,Nancy A. Speck,John H. Bushweller
View Articletitled, Structure of the AML1-ETO eTAFH domain–HEB peptide complex and its contribution to AML1-ETO activity
Supplemental data
Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality
Dirk Schmidt-Arras,Sylvia-Annette Böhmer,Sina Koch,Jörg P. Müller,Lutz Blei,Hauke Cornils,Reinhard Bauer,Sridhar Korasikha,Christian Thiede,Frank-D. Böhmer
View Articletitled, Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality
Supplemental data

PLATELETS AND THROMBOPOIESIS

Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis
Lurong Lian,Yanfeng Wang,Matthew Flick,John Choi,Edward W. Scott,Jay Degen,Mark A. Lemmon,Charles S. Abrams
View Articletitled, Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis
Antithrombotic effects of targeting αIIbβ3 signaling in platelets
Ararat J. Ablooglu,Jian Kang,Brian G. Petrich,Mark H. Ginsberg,Sanford J. Shattil
View Articletitled, Antithrombotic effects of targeting αIIbβ3 signaling in platelets
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli
Hua Huang,Marco Constante,Antonio Layoun,Manuela M. Santos
View Articletitled, Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli

THROMBOSIS AND HEMOSTASIS

Deficiency of von Willebrand factor protects mice from ischemic stroke
Brief Report
Christoph Kleinschnitz,Simon F. De Meyer,Tobias Schwarz,Madeleine Austinat,Karen Vanhoorelbeke,Bernhard Nieswandt,Hans Deckmyn,Guido Stoll
View Articletitled, Deficiency of von Willebrand factor protects mice from ischemic stroke
Supplemental data

TRANSFUSION MEDICINE

Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National Marrow Donor Program
Michael A. Pulsipher,Pintip Chitphakdithai,John P. Miller,Brent R. Logan,Roberta J. King,J. Douglas Rizzo,Susan F. Leitman,Paolo Anderlini,Michael D. Haagenson,Seira Kurian,John P. Klein,Mary M. Horowitz,Dennis L. Confer
View Articletitled, Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National Marrow Donor Program

TRANSPLANTATION

Paradoxical effects of IFN-γ in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury
Hui Wang,Wannee Asavaroengchai,Beow Yong Yeap,Min-Guang Wang,Shumei Wang,Megan Sykes,Yong-Guang Yang
View Articletitled, Paradoxical effects of IFN-γ in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury
Supplemental data
Increased T-bet+ cytotoxic effectors and type I interferon–mediated processes in chronic graft-versus-host disease of the oral mucosa
Matin M. Imanguli,William D. Swaim,Stacy C. League,Ronald E. Gress,Steven Z. Pavletic,Frances T. Hakim
View Articletitled, Increased T-bet<sup>+</sup> cytotoxic effectors and type I interferon–mediated processes in chronic graft-versus-host disease of the oral mucosa
Supplemental data

VASCULAR BIOLOGY

Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade
Shinsuke Yamanda,Satoru Ebihara,Masanori Asada,Tatsuma Okazaki,Kaijun Niu,Takae Ebihara,Akemi Koyanagi,Noriko Yamaguchi,Hideo Yagita,Hiroyuki Arai
View Articletitled, Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade
C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function
Fleur Bossi,Lucia Rizzi,Roberta Bulla,Alessandra Debeus,Claudio Tripodo,Paola Picotti,Elena Betto,Paolo Macor,Carlo Pucillo,Reinhard Würzner,Francesco Tedesco
View Articletitled, C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function
Supplemental data
All Issues

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Relating NF-κB regulation to MPN pathogenesis
The elusive endothelial iron transporter
AAV delivers as a lingering guest, not an invader
PCM1::JAK2 myeloproliferative neoplasm suggested by bone marrow histopathological features
Fostamatinib effectiveness and safety for immune thrombocytopenia in clinical practice.

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