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Journal Articles

Convergent Evolution Towards CD38 Biallelic Loss Is a Recurrent Mechanism of Resistance to Anti-CD38 Antibodies in Multiple Myeloma

Blood (2024) 144 (Supplement 1): 592.

https://doi.org/10.1182/blood-2024-201056

Published: 2024

Journal Articles

Mutant Idh1 Blocks Neutrophil Maturation By Repressing Myeloid Progenitor Programs

Blood (2024) 144 (Supplement 1): 1341.

https://doi.org/10.1182/blood-2024-210352

Published: 2024

Journal Articles

Tumor Reactive T Cells Reside in the Bone Marrow and Are Associated with Clinical Response to Hematological Malignancies

Blood (2023) 142 (Supplement 1): 4074.

https://doi.org/10.1182/blood-2023-189779

Published: 2023

Journal Articles

Somatic Mutational Landscape of Hereditary Hematopoietic Malignancies Associated with Germline Variants in RUNX1 , GATA2 and DDX41

Anna L. Brown, Claire Homan, Michael W. Drazer, Kai Yu, David Lawrence, Jinghua Feng, Luis Arriola-Martinez, Matthew Pozsgai, Kelsey McNeely, Thuong Ha, Parvathy Venugopal, Peer Arts, Sarah King-Smith, Jesse JC Cheah, Mark Armstrong, Csaba Bödör, Paul Wang, Alan B. Cantor, Mario Cazzola, Erin Degelman, Courtney D. DiNardo, Nicolas Duployez, Remi Favier, Stefan Fröhling, Ana Rio-Machin, Jeffery M. Klco, Alwin Krämer, Mineo Kurokawa, Joanne Lee, Luca Malcovati, Neil V Morgan, Georges Natsoulis, Carolyn Owen, Keyur P. Patel, Claude Preudhomme, Hana Raslova, Hugh Young Rienhoff, Jr., Tim Ripperger, Rachael Schulte, Kiran Tawana, Elvira Deolinda Rodrigues Pereira Velloso, Benedict Yan, Raman Sood, Amy Hsu, Steven M. Holland, Kerry Phillips, Nicola Poplawski, Milena Babic, Erika M Kwon Kim, Andrew H. Wei, Cecily Forsyth, Helen Mar Fan, Ian D Lewis, Julian Cooney, Rachel Susman, Lucy C Fox, Piers Blombery, Deepak Singhal, Devendra Hiwase, Andreas W Schreiber, Christopher N Hahn, Hamish S Scott, Paul P. Liu, Lucy A. Godley

Blood (2022) 140 (Supplement 1): 4030–4033.

https://doi.org/10.1182/blood-2022-167600

Published: 2022

Journal Articles

Discovery of Tumor Reactive T Cell Receptors in Newly Diagnosed Multiple Myeloma

Blood (2022) 140 (Supplement 1): 604–605.

https://doi.org/10.1182/blood-2022-169721

Published: 2022

Journal Articles

Multi-Omics Profiling of JMML HSPCs Reveals Onco-Fetal Reprogramming and Identifies Novel Prognostic Biomarkers and Therapeutic Targets in High-Risk JMML

Blood (2022) 140 (Supplement 1): 8729–8730.

https://doi.org/10.1182/blood-2022-162224

Published: 2022

Journal Articles

Recurrent Germline Variant in the Cohesin Complex Gene RAD21 Predisposes Children to Lymphoblastic Leukemia and Lymphoma

Blood (2021) 138 (Supplement 1): 3358.

https://doi.org/10.1182/blood-2021-150284

Published: 2021

Journal Articles

Development of a Data Portal for Aggregation and Analysis of Genomics Data in Familial Platelet Disorder with Predisposition to Myeloid Malignancy - the RUNX1.DB

Anna L. Brown, PhD BSc, Mark Armstrong, MSc, David Lawrence, Paul Wang, Peer Arts, PhD, Nicolas Duployez, PharmD, PhD, Jane Churpek, MD, Kiran Tawana, MD, Erin Degelman, MSc, BSc, Georges Natsoulis, PhD, Monica L. Guzman, PhD, Mrinal M. Patnaik, MD MBBS, Akiko Shimamura, MD PhD, Alan B. Cantor, MD PhD, Tim Ripperger, MD PhD, Brigitte Schlegelberger, MD PhD, Doris Steinemann, PhD, Courtney D. DiNardo, MD MSc, Cristina Mecucci, MD PhD, Elvira DRP Velloso, MD PhD, Fabio PS Santos, MD, Marcela CA Silva, Uma Borate, MD, Shannon K. McWeeney, PhD, Grzegorz Nalepa, MD PhD, Susanne Ragg, MD PhD, Erika Mijin Kwon, PhD, Anupriya Agarwal, PhD, Stephen Langabeer, PhD, Jeffery M. Klco, MD PhD, Jun J. Yang, PhD, Cecily Forsyth, FRACP, FRCPA, MBBS, Sally Mapp, MD PhD, Helen Mar Fan, MD, Lesley Rawlings, PhD, Rachel Susman, Sue Morgan, FRACP, FRCPA, MBBS, Andrew H Wei, MBBS,PhD, Inderjeet Dokal, MD, Tom Vulliamy, Devendra K Hiwase, MBBS, MD FRACP, FRCPA, PhD, Deepak Singhal, MBBS, MD FRACP, FRCPA, Susan Branford, PhD, Elli Papaemmanuil, PhD, Jean Soulier, MDPhD, Stefan Fröhling, MD, Alwin Kramer, MD, Guy Sauvageau, MD PhD, Neil Morgan, Carolyn Owen, Csaba Bödör, PhD, Jude Fitzgibbon, Hugh Y. Rienhoff, Jr., MD, Mineo Kurokawa, MD PhD, Lucy Godley, MD PhD, Claude Preudhomme, Paul P Liu, MD PhD, Nicola Poplawski, MD, Christopher N. Hahn, PhD, Hamish S. Scott, PhD

Blood (2018) 132 (Supplement 1): 5241.

https://doi.org/10.1182/blood-2018-99-118017

Published: 2018

Journal Articles

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

Blood (2018) 132 (14): 1526–1534.

https://doi.org/10.1182/blood-2018-05-852566

Published: 2018

Includes: Supplemental data

Journal Articles

Branched Chain Amino Acid Catabolism Restricts Alpha-Ketoglutarate Levels Resembling IDH mut -Driven DNA Hypermethylation in AML Stem Cells

Blood (2017) 130 (Supplement 1): 472.

https://doi.org/10.1182/blood.V130.Suppl_1.472.472

Published: 2017

Journal Articles

The RET Receptor Tyrosine Kinase Promotes Acute Myeloid Leukemia through Protection of FLT3-ITD Mutants from Autophagic Degradation

Saskia Rudat, MSc, Anja Pfaus, MSc, Claudia Bühler, MD, Sophie Rabe, MSc, Lars Bullinger, MD, Stefan Gröschel, MD, Stephen M. Sykes, PhD, Michael D. Milsom, PhD, Jana M. Ellegast, MD, Stefan Fröhling, MD, Claudia Scholl, MD

Blood (2016) 128 (22): 2849.

https://doi.org/10.1182/blood.V128.22.2849.2849

Published: 2016

Journal Articles

CDK4/6 Inhibitor Palbociclib for Treatment of KMT2A -Rearranged Acute Myeloid Leukemia: Interim Analysis of the AMLSG 23-14 Trial

Stefan Fröhling, MD, Mridul Agrawal, MD, Nikolaus Jahn, MD, Lars R. Fransecky, MD, Claudia D. Baldus, MD, Ralph Wäsch, MD, Michael Lübbert, MD, Gina Walter, PhD, Patrizia Jensen, Claudia Scholl, MD, Marianne Habdank, Konstanze Döhner, Hartmut Döhner, MD, Richard F. Schlenk, MD

Blood (2016) 128 (22): 1608.

https://doi.org/10.1182/blood.V128.22.1608.1608

Published: 2016

Journal Articles

Expanded Phenotypic and Genetic Heterogeneity in the Clinical Spectrum of FPD-AML: Lymphoid Malignancies and Skin Disorders Are Common Features in Carriers of Germline RUNX1 Mutations

Anna L Brown, PhD, Christopher N Hahn, PhD, Catherine Carmichael, Ella Wilkins, Milena Babic, BMPharBio (Hons), Chan-Eng Chong, PhD, Xiao-Chun Li, Joelle Michaud, Ping Cannon, Nicola Poplawski, MBChB, DipPaed, FRACP, MD, Meryl Altree, Kerry Phillips, Louise Jaensch, Miriam Fine, Andreas W Schreiber, PhD, Jinghua Feng, PhD, Lesley Rawlings, PhD, Cassandra Vakulin, Carolyn Butcher, Richard D'Andrea, PhD, Ian D Lewis, MBBS, PhD FRACP, FRCPA, Nigel Patton, Cecily Forsyth, MBBS, FRACP, FRCPA, Sally Mapp, PhD MD, Helen Mar Fan, Rachel Susman, Sue Morgan, FRACP, FRCPA, MBBS, Julian Cooney, MD, Mark S Currie, MD, Uday R. Popat, MD, Kenneth Bradstock, MBBS, PhD, April D. Sorrell, MD, Carolyn J. Owen, MD MDes(UK), FRCPC, Marshall S Horwitz, MD PhD, Devendra Hiwase, MBBS, FRACP, FRCPA, MD PhD, Alwin Krämer, MD, Stefan Fröhling, MD, Lucy A Godley, MD PhD, Jane E Churpek, MD, Hamish S Scott, BSc, PhD FFSc (RCPA), FAHMS

Blood (2016) 128 (22): 1212.

https://doi.org/10.1182/blood.V128.22.1212.1212

Published: 2016

Journal Articles

Palbociclib treatment of FLT3 -ITD + AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6

Iris Z. Uras, Gina J. Walter, Ruth Scheicher, Florian Bellutti, Michaela Prchal-Murphy, Anca S. Tigan, Peter Valent, Florian H. Heidel, Stefan Kubicek, Claudia Scholl, Stefan Fröhling, Veronika Sexl

Blood (2016) 127 (23): 2890–2902.

https://doi.org/10.1182/blood-2015-11-683581

Published: 2016

Includes: Supplemental data

Journal Articles

C-Jun Regulates ER Stress Signaling to Promote Chemotherapy Resistance in Acute Myeloid Leukemia

Chun Zhou, PhD, Daniela Di Marcantonio, PhD, Esteban Martinez, Nehal Solanki-Patel, Suraj Peri, PhD, Claudia Scholl, Stefan Fröhling, David L. Wiest, PhD, Stephen Matthew Sykes, PhD

Blood (2015) 126 (23): 2464.

https://doi.org/10.1182/blood.V126.23.2464.2464

Published: 2015

Journal Articles

Cdx2 Cooperates with Flt3-ITD to Induce Acute Myeloid Leukaemia in Mice

Therese Vu, BSc, Claudia Bruedigam, Axia Song, Solene Guignes, Rebecca Austin, Sebastien Jacquelin, Alistair Chalk, Carl Walkley, PhD BPharm, Claudia Scholl, Stefan Fröhling, MD, Steven W. Lane, MD

Blood (2015) 126 (23): 557.

https://doi.org/10.1182/blood.V126.23.557.557

Published: 2015

Journal Articles

Pkc Epsilon Regulates Mitochondrial Redox Biology to Support the Differentiation Blockade in Acute Myeloid Leukemia

Daniela Di Marcantonio, PhD, Jessica Vadaketh, Esteban Martinez, Prisco Mirandola, PhD, Giuliana Gobbi, PhD, Michael D. Milsom, PhD, Claudia Scholl, Stefan Fröhling, Marco Vitale, MD, Stephen Matthew Sykes, PhD

Blood (2015) 126 (23): 444.

https://doi.org/10.1182/blood.V126.23.444.444

Published: 2015

Journal Articles

Foxos Suppress Lipid Peroxidation to Promote AML Progression and Chemotherapy Resistance

Turan Aghayev, Chun Zhou, PhD, Alyssa Klein, Esteban Martinez, Claudia Scholl, Stefan Fröhling, Stephen Matthew Sykes, PhD

Blood (2015) 126 (23): 1861.

https://doi.org/10.1182/blood.V126.23.1861.1861

Published: 2015

Journal Articles

Cooperative Activity of BRAF F595L and Mutant HRAS in Histiocytic Sarcoma Provides New Insights into Oncogenic BRAF Signaling

Maximilian Kordes, Michael Röring, Christoph Heining, Sandra Braun, Barbara Hutter, Daniela Richter, Christina Geörg, Claudia Scholl, Wilfried Roth, Andreas Rosenwald, MD, Eva Geissinger, Christof von Kalle, Dirk Jäger, Benedikt Brors, Wilko Weichert, Carsten Grüllich, Hanno Glimm, Tilman Brummer, PhD, Stefan Fröhling

Blood (2015) 126 (23): 1631.

https://doi.org/10.1182/blood.V126.23.1631.1631

Published: 2015

Journal Articles

Recurrent CDKN1B (p27) mutations in hairy cell leukemia

Blood (2015) 126 (8): 1005–1008.

https://doi.org/10.1182/blood-2015-04-643361

Published: 2015

Includes: Supplemental data

NARROW

Convergent Evolution Towards CD38 Biallelic Loss Is a Recurrent Mechanism of Resistance to Anti-CD38 Antibodies in Multiple Myeloma

Mutant Idh1 Blocks Neutrophil Maturation By Repressing Myeloid Progenitor Programs

Tumor Reactive T Cells Reside in the Bone Marrow and Are Associated with Clinical Response to Hematological Malignancies

Somatic Mutational Landscape of Hereditary Hematopoietic Malignancies Associated with Germline Variants in RUNX1 , GATA2 and DDX41

Discovery of Tumor Reactive T Cell Receptors in Newly Diagnosed Multiple Myeloma

Multi-Omics Profiling of JMML HSPCs Reveals Onco-Fetal Reprogramming and Identifies Novel Prognostic Biomarkers and Therapeutic Targets in High-Risk JMML

Recurrent Germline Variant in the Cohesin Complex Gene RAD21 Predisposes Children to Lymphoblastic Leukemia and Lymphoma

Development of a Data Portal for Aggregation and Analysis of Genomics Data in Familial Platelet Disorder with Predisposition to Myeloid Malignancy - the RUNX1.DB

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

Branched Chain Amino Acid Catabolism Restricts Alpha-Ketoglutarate Levels Resembling IDH mut -Driven DNA Hypermethylation in AML Stem Cells

The RET Receptor Tyrosine Kinase Promotes Acute Myeloid Leukemia through Protection of FLT3-ITD Mutants from Autophagic Degradation

CDK4/6 Inhibitor Palbociclib for Treatment of KMT2A -Rearranged Acute Myeloid Leukemia: Interim Analysis of the AMLSG 23-14 Trial

Expanded Phenotypic and Genetic Heterogeneity in the Clinical Spectrum of FPD-AML: Lymphoid Malignancies and Skin Disorders Are Common Features in Carriers of Germline RUNX1 Mutations

Palbociclib treatment of FLT3 -ITD + AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6

C-Jun Regulates ER Stress Signaling to Promote Chemotherapy Resistance in Acute Myeloid Leukemia

Cdx2 Cooperates with Flt3-ITD to Induce Acute Myeloid Leukaemia in Mice

Pkc Epsilon Regulates Mitochondrial Redox Biology to Support the Differentiation Blockade in Acute Myeloid Leukemia

Foxos Suppress Lipid Peroxidation to Promote AML Progression and Chemotherapy Resistance

Cooperative Activity of BRAF F595L and Mutant HRAS in Histiocytic Sarcoma Provides New Insights into Oncogenic BRAF Signaling

Recurrent CDKN1B (p27) mutations in hairy cell leukemia

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American Society of Hematology

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