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Volume 97, Issue 8

April 15 2001

In this Issue

INSIDE BLOOD
EDITORIALS
PLENARY PAPERS
CHEMOKINES
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

If it's Tuesday, this must be a Belgian chemokine

Barrett J. Rollins

View Articletitled, If it's Tuesday, this must be a Belgian chemokine

Point mutations in the FLT3 gene in AML

James D. Griffin

View Articletitled, Point mutations in the FLT3 gene in AML

A time to live, a time to die

Paul Martin

View Articletitled, A time to live, a time to die

G-CSF: early benefits but late risks?

J. H. Frederik Falkenburg

View Articletitled, G-CSF: early benefits but late risks?

EDITORIALS

Access to the biomedical literature: a stand against coercion

Kenneth Kaushansky

View Articletitled, Access to the biomedical literature: a stand against coercion

PLENARY PAPERS

Identification of a blood-derived chemoattractant for neutrophils and lymphocytes as a novel CC chemokine, Regakine-1

Sofie Struyf,Paul Proost,Jean-Pierre Lenaerts,Griet Stoops,Anja Wuyts,Jo Van Damme

View Articletitled, Identification of a blood-derived chemoattractant for neutrophils and lymphocytes as a novel CC chemokine, Regakine-1

CHEMOKINES

The C-class chemokine lymphotactin costimulates the apoptosis of human CD4⁺ T cells

Chantal Cerdan,Elisabeth Devilard,Luc Xerri,Daniel Olive

View Articletitled, The C-class chemokine lymphotactin costimulates the apoptosis of human CD4+ T cells

GENE THERAPY

βMinor-globin messenger RNA accumulation in reticulocytes governs improved erythropoiesis in β thalassemic mice after erythropoietin complementary DNA electrotransfer in muscles

Selda Samakoglu,Elena Fattori,Stefania Lamartina,Carlo Toniatti,Daniel Stockholm,Jean Michel Heard,Delphine Bohl

View Articletitled, βMinor-globin messenger RNA accumulation in reticulocytes governs improved erythropoiesis in β thalassemic mice after erythropoietin complementary DNA electrotransfer in muscles

Systemic circulation of poly(l-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: differential circulation in mice and rats and the implications for human gene therapy

Christopher M. Ward,Martin L. Read,Leonard W. Seymour

View Articletitled, Systemic circulation of poly(l-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: differential circulation in mice and rats and the implications for human gene therapy

HEMATOPOIESIS

A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation

Dwayne L. Barber,Bryan K. Beattie,Jacqueline M. Mason,Melody H.-H. Nguyen,Monique Yoakim,Benjamin G. Neel,Alan D. D'Andrea,David A. Frank

View Articletitled, A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation

Asymmetrical segregation of chromosomes with a normal metaphase/anaphase checkpoint in polyploid megakaryocytes

Lydia Roy,Philippe Coullin,Natacha Vitrat,Raymond Hellio,Najet Debili,Jasminder Weinstein,Alain Bernheim,William Vainchenker

View Articletitled, Asymmetrical segregation of chromosomes with a normal metaphase/anaphase checkpoint in polyploid megakaryocytes

Core-binding factor β (CBFβ), but not CBFβ–smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFβ-deficient embryonic stem cells

Janelle D. Miller,Terryl Stacy,P. Paul Liu,Nancy A. Speck

View Articletitled, Core-binding factor β (CBFβ), but not CBFβ–smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFβ-deficient embryonic stem cells

Resolution of pluripotential intermediates in murine hematopoietic differentiation by global complementary DNA amplification from single cells: confirmation of assignments by expression profiling of cytokine receptor transcripts

Filio Billia,Mary Barbara,Jon McEwen,Maryanne Trevisan,Norman N. Iscove

View Articletitled, Resolution of pluripotential intermediates in murine hematopoietic differentiation by global complementary DNA amplification from single cells: confirmation of assignments by expression profiling of cytokine receptor transcripts

Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor–induced proliferation but not differentiation of immature thymocytes

Sébastien Trop,Paulo De Sepulveda,Juan Carlos Zúñiga-Pflücker,Robert Rottapel

View Articletitled, Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor–induced proliferation but not differentiation of immature thymocytes

Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle

Douglas E. Wright,Samuel H. Cheshier,Amy J. Wagers,Troy D. Randall,Julie L. Christensen,Irving L. Weissman

View Articletitled, Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle

Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo

Christian Buske,Michaela Feuring-Buske,Jennifer Antonchuk,Patricia Rosten,Donna E. Hogge,Connie J. Eaves,R. Keith Humphries

View Articletitled, Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo

Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches

Susan K. Nilsson,Hayley M. Johnston,Judi A. Coverdale

View Articletitled, Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches

Lineage switch induced by overexpression of Ets family transcription factor PU.1 in murine erythroleukemia cells

Toshiyuki Yamada,Masaaki Abe,Toshinori Higashi,Hitomi Yamamoto,Fumiko Kihara-Negishi,Takuya Sakurai,Toshikazu Shirai,Tsuneyuki Oikawa

View Articletitled, Lineage switch induced by overexpression of Ets family transcription factor PU.1 in murine erythroleukemia cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Prothrombin protects factor Xa in the prothrombinase complex from inhibition by the heparin-antithrombin complex

Alireza R. Rezaie

View Articletitled, Prothrombin protects factor Xa in the prothrombinase complex from inhibition by the heparin-antithrombin complex

Antiplatelet agents in tissue factor–induced blood coagulation

Saulius Butenas,Kevin M. Cawthern,Cornelis van't Veer,Maria E. DiLorenzo,Jennifer B. Lock,Kenneth G. Mann

View Articletitled, Antiplatelet agents in tissue factor–induced blood coagulation

Growth factor–induced angiogenesis in vivo requires specific cleavage of fibrillar type I collagen

Marco Seandel,Katharina Noack-Kunnmann,Dan Zhu,Ronald T. Aimes,James P. Quigley

View Articletitled, Growth factor–induced angiogenesis in vivo requires specific cleavage of fibrillar type I collagen

Echicetin, a GPIb-binding snake C-type lectin from Echis carinatus, also contains a binding site for IgMκ responsible for platelet agglutination in plasma and inducing signal transduction

Alexei Navdaev,Dagmar Dörmann,Jeannine M. Clemetson,Kenneth J. Clemetson

View Articletitled, Echicetin, a GPIb-binding snake C-type lectin from Echis carinatus, also contains a binding site for IgMκ responsible for platelet agglutination in plasma and inducing signal transduction

Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells

Fakhri Mahdi,Zia Shariat-Madar,Robert F. Todd, III,Carlos D. Figueroa,Alvin H. Schmaier

View Articletitled, Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells

IMMUNOBIOLOGY

Inhibition of antigen-receptor signaling by Platelet Endothelial Cell Adhesion Molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56^lck

Debra K. Newman,Christin Hamilton,Peter J. Newman

View Articletitled, Inhibition of antigen-receptor signaling by Platelet Endothelial Cell Adhesion Molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56lck

Stat5a regulates T helper cell differentiation by several distinct mechanisms

Shin-ichiro Kagami,Hiroshi Nakajima,Akira Suto,Koichi Hirose,Kotaro Suzuki,Sumiyo Morita,Ikunoshin Kato,Yasushi Saito,Toshio Kitamura,Itsuo Iwamoto

View Articletitled, Stat5a regulates T helper cell differentiation by several distinct mechanisms

Primary human herpesvirus 8 infection generates a broadly specific CD8⁺ T-cell response to viral lytic cycle proteins

Qiong J. Wang,Frank J. Jenkins,Lisa P. Jacobson,Lawrence A. Kingsley,Richard D. Day,Zhi-Wei Zhang,Yuan-Xiang Meng,Philip E. Pellet,Konstantin G. Kousoulas,Abolghasem Baghian,Charles R. Rinaldo, Jr

View Articletitled, Primary human herpesvirus 8 infection generates a broadly specific CD8+ T-cell response to viral lytic cycle proteins

Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma–associated herpesvirus

J. Paul Zoeteweij,Ashlee V. Moses,Andrea S. Rinderknecht,David A. Davis,Willem W. Overwijk,Robert Yarchoan,Jan M. Orenstein,Andrew Blauvelt

View Articletitled, Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma–associated herpesvirus

Apolipoprotein A-I inhibits the production of interleukin-1β and tumor necrosis factor-α by blocking contact-mediated activation of monocytes by T lymphocytes

Nevila Hyka,Jean-Michel Dayer,Christine Modoux,Tadahiko Kohno,Carl K. Edwards, III,Pascale Roux-Lombard,Danielle Burger

View Articletitled, Apolipoprotein A-I inhibits the production of interleukin-1β and tumor necrosis factor-α by blocking contact-mediated activation of monocytes by T lymphocytes

Regulation of nuclear factor of activated T cells by phosphotyrosyl-specific phosphatase activity: a positive effect on HIV-1 long terminal repeat–driven transcription and a possible implication of SHP-1

Jean-François Fortin,Benoit Barbeau,Gilles A. Robichaud,Marie-Ève Paré,Anne-Marie Lemieux,Michel J. Tremblay

View Articletitled, Regulation of nuclear factor of activated T cells by phosphotyrosyl-specific phosphatase activity: a positive effect on HIV-1 long terminal repeat–driven transcription and a possible implication of SHP-1

NEOPLASIA

Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type

Volkhard Seitz,Michael Hummel,Ioannis Anagnostopoulos,Harald Stein

View Articletitled, Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type

A model of human p210^bcr/ABL-mediated chronic myelogenous leukemia by transduction of primary normal human CD34⁺ cells with a BCR/ABL-containing retroviral vector

Robert C. Zhao,Yuehua Jiang,Catherine M. Verfaillie

View Articletitled, A model of human p210bcr/ABL-mediated chronic myelogenous leukemia by transduction of primary normal human CD34+ cells with a BCR/ABL-containing retroviral vector

The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells

Zhihua Li,Yuan Xiao Zhu,Elizabeth E. Plowright,P. Leif Bergsagel,Marta Chesi,Bruce Patterson,Teresa S. Hawley,Robert G. Hawley,A. Keith Stewart

View Articletitled, The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells

The combination of chemotherapy and systemic immunotherapy with soluble B7–immunoglobulin G leads to cure of murine leukemia and lymphoma and demonstration of tumor-specific memory responses

Kathlene Runyon,Kwang Lee,Krystyna Zuberek,Mary Collins,John P. Leonard,Kyriaki Dunussi-Joannopoulos

View Articletitled, The combination of chemotherapy and systemic immunotherapy with soluble B7–immunoglobulin G leads to cure of murine leukemia and lymphoma and demonstration of tumor-specific memory responses

Novel vitamin D₃ analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D₃, that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells

Jun-ichi Hisatake,James O'Kelly,Milan R. Uskokovic,Shigeru Tomoyasu,H. Phillip Koeffler

View Articletitled, Novel vitamin D3 analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D3, that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

Yukiya Yamamoto,Hitoshi Kiyoi,Yasuyuki Nakano,Ritsuro Suzuki,Yoshihisa Kodera,Shuichi Miyawaki,Norio Asou,Kazutaka Kuriyama,Fumiharu Yagasaki,Chihiro Shimazaki,Hideki Akiyama,Kenji Saito,Miki Nishimura,Toshiko Motoji,Katsuji Shinagawa,Akihiro Takeshita,Hidehiko Saito,Ryuzo Ueda,Ryuzo Ohno,Tomoki Naoe

View Articletitled, Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

ARG tyrosine kinase activity is inhibited by STI571

Keiko Okuda,Ellen Weisberg,D. Gary Gilliland,James D. Griffin

View Articletitled, ARG tyrosine kinase activity is inhibited by STI571

Myeloblastin is an Myb target gene: mechanisms of regulation in myeloid leukemia cells growth-arrested by retinoic acid

Pierre G. Lutz,Anne Houzel-Charavel,Christel Moog-Lutz,Yvon E. Cayre

View Articletitled, Myeloblastin is an Myb target gene: mechanisms of regulation in myeloid leukemia cells growth-arrested by retinoic acid

PHAGOCYTES

RNA expression patterns change dramatically in human neutrophils exposed to bacteria

Yerramilli V. B. K. Subrahmanyam,Shigeru Yamaga,Yatindra Prashar,Helen H. Lee,Nancy P. Hoe,Yuval Kluger,Mark Gerstein,Jon D. Goguen,Peter E. Newburger,Sherman M. Weissman

View Articletitled, RNA expression patterns change dramatically in human neutrophils exposed to bacteria

Activation and priming of neutrophil nicotinamide adenine dinucleotide phosphate oxidase and phospholipase A₂ are dissociated by inhibitors of the kinases p42^ERK2and p38^SAPK and by methyl arachidonyl fluorophosphonate, the dual inhibitor of cytosolic and calcium-independent phospholipase A₂

Elahe Mollapour,David C. Linch,Pamela J. Roberts

View Articletitled, Activation and priming of neutrophil nicotinamide adenine dinucleotide phosphate oxidase and phospholipase A2 are dissociated by inhibitors of the kinases p42ERK2and p38SAPK and by methyl arachidonyl fluorophosphonate, the dual inhibitor of cytosolic and calcium-independent phospholipase A2

Mac-1 (CD11b/CD18) is essential for Fc receptor–mediated neutrophil cytotoxicity and immunologic synapse formation

Annemiek B. van Spriel,Jeanette H. W. Leusen,Marjolein van Egmond,Henry B. P. M. Dijkman,Karel J. M. Assmann,Tanya N. Mayadas,Jan G. J. van de Winkel

View Articletitled, Mac-1 (CD11b/CD18) is essential for Fc receptor–mediated neutrophil cytotoxicity and immunologic synapse formation

Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes

Oliver Werz,Jenny Klemm,Bengt Samuelsson,Olof Rådmark

View Articletitled, Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes

RED CELLS

Coexpression of band 3 mutants and Rh polypeptides: differential effects of band 3 on the expression of the Rh complex containing D polypeptide and the Rh complex containing CcEe polypeptide

Roland Beckmann,Jonathan S. Smythe,David J. Anstee,Michael J. A. Tanner

View Articletitled, Coexpression of band 3 mutants and Rh polypeptides: differential effects of band 3 on the expression of the Rh complex containing D polypeptide and the Rh complex containing CcEe polypeptide

TRANSPLANTATION

Protection from lethal murine graft-versus-host disease without compromise of alloengraftment using transgenic donor T cells expressing a thymidine kinase suicide gene

William R. Drobyski,Herbert C. Morse, III,William H. Burns,James T. Casper,Gordon Sandford

View Articletitled, Protection from lethal murine graft-versus-host disease without compromise of alloengraftment using transgenic donor T cells expressing a thymidine kinase suicide gene

Postgrafting administration of granulocyte colony-stimulating factor impairs functional immune recovery in recipients of human leukocyte antigen haplotype–mismatched hematopoietic transplants

Isabella Volpi,Katia Perruccio,Antonella Tosti,Marusca Capanni,Loredana Ruggeri,Sabrina Posati,Franco Aversa,Antonio Tabilio,Luigina Romani,Massimo F. Martelli,Andrea Velardi

View Articletitled, Postgrafting administration of granulocyte colony-stimulating factor impairs functional immune recovery in recipients of human leukocyte antigen haplotype–mismatched hematopoietic transplants

BRIEF REPORTS

A high bone marrow plasma cell labeling index in stable plateau–phase multiple myeloma is a marker for early disease progression and death: Presented in abstract form at the 36th Annual Meeting of the American Society of Clinical Oncology, New Orleans, Louisiana, May 20-23, 2000.
Clinical Trials & Observations Brief Report

David P. Steensma,Morie A. Gertz,Philip R. Greipp,Robert A. Kyle,Martha Q. Lacy,John A. Lust,Janice R. Offord,Matthew F. Plevak,Terry M. Therneau,Thomas E. Witzig

View Articletitled, A high bone marrow plasma cell labeling index in stable plateau–phase multiple myeloma is a marker for early disease progression and death: Presented in abstract form at the 36th Annual Meeting of the American Society of Clinical Oncology, New Orleans, Louisiana, May 20-23, 2000.

CORRESPONDENCE

Disappearance of chromosomal abnormalities and recovery of hematopoiesis after immunosuppressive therapy for hypoplastic refractory anemia with excess of blasts

Kenji Tamayose,Koichi Sugimoto,Miki Ando,Kazuo Oshimi

View Articletitled, Disappearance of chromosomal abnormalities and recovery of hematopoiesis after immunosuppressive therapy for hypoplastic refractory anemia with excess of blasts

Discrepancy between phenotype and genotype on screening for factor V Leiden after transplantation

Jane Parker,Antonio Pagliuca,Taya Kitiyakara,Malcolm Whitehead,Nigel Heaton,John O'Grady,Roopen Arya

View Articletitled, Discrepancy between phenotype and genotype on screening for factor V Leiden after transplantation

Serum viral interleukin-6 in AIDS-related multicentric Castleman disease

Yoshiyasu Aoki,Giovanna Tosato,Terry W. Fonville,Stefania Pittaluga

View Articletitled, Serum viral interleukin-6 in AIDS-related multicentric Castleman disease

Development of a myeloproliferative disorder in a patient with monoclonal gammopathy of undetermined significance secreting immunoglobulin of the M class and treated with thalidomide and anti-CD20 monoclonal antibody

Maria-Christina Kyrtsonis,Styliani I. Kokoris,Flora N. Kontopidou,Marina P. Siakantaris,Christos Kittas,Gerassimos A. Pangalis

View Articletitled, Development of a myeloproliferative disorder in a patient with monoclonal gammopathy of undetermined significance secreting immunoglobulin of the M class and treated with thalidomide and anti-CD20 monoclonal antibody

Expression of CD10 by human T cells that undergo apoptosis both in vitro and in vivo

Giovanna Cutrona,Manlio Ferrarini

View Articletitled, Expression of CD10 by human T cells that undergo apoptosis both in vitro and in vivo

Angiogenesis is increased in B-cell chronic lymphocytic leukemia

LoAnn Peterson,Ameet R. Kini,Neil Kay

View Articletitled, Angiogenesis is increased in B-cell chronic lymphocytic leukemia

Cationic peptides from leukocytes might kill bacteria by activating their autolytic enzymes causing bacteriolysis: why are publications proposing this concept never acknowledged?

Isaac Ginsburg

View Articletitled, Cationic peptides from leukocytes might kill bacteria by activating their autolytic enzymes causing bacteriolysis: why are publications proposing this concept never acknowledged?

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