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Journal Articles

ICT01, an Investigational γ9δ2 T Cell Activator, Added to Azacitidine-Venetoclax Achieves Frequent and Early Complete Remissions in Adults with AML Unfit for Intensive Induction Chemotherapy: Interim Results from the Ongoing Open-Label, Randomized Phase 1 Study Eviction

Abhishek Maiti, Pierre Yves Dumas, Pierre Peterlin, Daniel Morillo, Jose Torregrosa, Paul B. Koller, Maelle Mairesse, Patrick Brune, Emmanuel Valenitn, Aude De Gassart, Katrien Lemmens, Daniel Olive, Naval Daver, Stephan Braun, Sylvain Garciaz
Journal: Blood
Blood (2024) 144 (Supplement 1): 2876.
https://doi.org/10.1182/blood-2024-193493
Published: 2024
Journal Articles

Evaluation of ICT01, a γ9δ2 T Cell-Activating Monoclonal Antibody, Combined with Venetoclax and Azacitidine in 1L AML (EVICTION Study)

Elisabeth Wieduwild, Anne-Charlotte Le Floch, Céline Garulli, Caroline Imbert, Aude De Gassart, Patrick Brune, Katrien Lemmens, Sylvain Garciaz, Abhishek Maiti, Pierre Peterlin, Celine Leparquier, Marina Iche, Norbert Vey, Daniel Olive, Paul Frohna
Journal: Blood
Blood (2023) 142 (Supplement 1): 1552.
https://doi.org/10.1182/blood-2023-189936
Published: 2023
Journal Articles

5-Azacytidine and Venetoclax Combination Boost Vγ9Vδ2 T Cell Effector Functions

Anne-Charlotte Le Floch, Elisabeth Wieduwild, Anne-Sophie Chretien, Florence Orlanducci, Céline Garulli, Sarah Bourass, Caroline Imbert, Aude De Gassart, Norbert Vey, Loui Madakamutil, Daniel Olive
Journal: Blood
Blood (2022) 140 (Supplement 1): 11535–11536.
https://doi.org/10.1182/blood-2022-165161
Published: 2022
Journal Articles

ICOS Is Widely Expressed in Cutaneous T-Cell Lymphoma and Its Targeting Promotes Potent Killing of Malignant Cells

Florent Amatore, Nicolas Ortonne, Marc Lopez, Mathilde Barré, Florence Orlanducci, Remy Castellano, Saskia Ingen-Housz-Oro, Amandine De Croos, Laurent Gorvel, Armelle Goubard, Reda Bouabdallah, Jean Marc Schiano De Colella, Jean-Jacques Grob, Philippe Gaulard, Martine Bagot, Armand Bensussan, Emmanuel Delaporte, Daniel Olive
Journal: Blood
Blood (2021) 138 (Supplement 1): 790.
https://doi.org/10.1182/blood-2021-150677
Published: 2021
Journal Articles

Safety of Anti-NKG2A Blocking Antibody Monalizumab As Maintenance Therapy after Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Study

Raynier Devillier, Sabine Furst, Agnes boyer Chammard, Thomas Pagliardini, Samia Harbi, Valerio Maisano, Angela Granata, Faezeh Legrand, Jihane Pakradouni, jean Marie Boher, Cyril Fauriat, Anne-Sophie Chretien, Christian Chabannon, Norbert Vey, Eric Vivier, Daniel Olive, Didier Blaise
Journal: Blood
Blood (2021) 138 (Supplement 1): 1817.
https://doi.org/10.1182/blood-2021-150730
Published: 2021
Journal Articles

Targeting BTN2A1 By a Unique Activating Mab Improves Vγ9Vδ2 T Cell Cytotoxicity Against Primary Acute Lymphoblastic Blasts

Anne-Charlotte Le Floch, Caroline Imbert, Aude De Gassart, Florence Orlanducci, Aude Le Roy, Laurent Gorvel, Norbert Vey, Antoine Briantais, Nicolas Boucherit, Carla E Cano, Daniel Olive
Journal: Blood
Blood (2021) 138 (Supplement 1): 2302.
https://doi.org/10.1182/blood-2021-152577
Published: 2021
Journal Articles

Chimerized Anti-ICOS 314.8 Monoclonal Antibodies Inhibit Tumor Cells and Regulatory T Cells in Patients with Sézary Syndrome

Florent Amatore, Mathilde Barré, Florence Orlanducci, Marc Lopez, Remy Castellano, Caroline Ram-Wolff, Laurent Gorvel, Armelle Goubard, Caroline Gaudy-Marqueste, Martine Bagot, Armand Bensussan, Emmanuel Delaporte, Daniel Olive
Journal: Blood
Blood (2021) 138 (Supplement 1): 2260.
https://doi.org/10.1182/blood-2021-153345
Published: 2021
Journal Articles

Phase 1 Trial of Prophylactic Donor-Derived IL-2 Activated NK Cell Infusion after Allogeneic Hematopoietic Stem Cell Transplantation from a Matched Sibling Donor

Raynier Devillier, Boris Calmels, Pharm.D., Sophie Guia, Cyril Fauriat, Sabine Furst, Samia Harbi, Angela Granata, MD, Sophie Ugolini, Christian Chabannon, MD PhD, Daniel Olive, MD PhD, Eric Vivier, Didier Blaise, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
https://doi.org/10.1182/blood-2020-140753
Published: 2020
Journal Articles

BTN2A, a New Immune-Checkpoint Targeting Vg9Vd2 T Cell Cytotoxicity

Carla E Cano, PhD, Christine Pasero, Aude De Gassart, René Hoet, Emmanuel Scotet, Erwan Mortier, Agnes Quemeneur, Chirine Rafia, Antoine Briantais, Anne-Charlotte Le Floch, MBBS,MSc, Daniel Olive, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1044.
https://doi.org/10.1182/blood-2019-128658
Published: 2019
Journal Articles

Anti-BTN3A 20.1 Agonist Monoclonal Antibody Enhances Autologous Vγ9Vδ2 T Cells Cytotoxicity Against Primary Acute Myeloid Blasts

Anne-Charlotte Le Floch, MBBS, MSc, Florence Orlanducci, Antoine Briantais, Aude Le Roy, Anne-Sophie Chretien, Norbert Vey, MD PhD, Daniel Olive, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5153.
https://doi.org/10.1182/blood-2019-125541
Published: 2019
Journal Articles

Randomized Phase 2 Trial of Lirilumab (anti-KIR monoclonal antibody, mAb) As Maintenance Treatment in Elderly Patients (pts) with Acute Myeloid Leukemia (AML): Results of the Effikir Trial

Norbert Vey, Pierre-Yves Dumas, MD, Christian Recher, MD PhD, Lauris Gastaud, MD, Bruno Lioure, MD, Claude-Eric Bulabois, MD, Cecile Pautas, Jean-Pierre Marolleau, MD PhD, Stéphane Leprêtre, MD, Emmanuel Raffoux, MD, Xavier Thomas, MD, Yosr Hicheri, Caroline Bonmati, MD, Bruno Quesnel, MD PhD, Philippe Rousselot, Sylvie Castaigne, MD PhD, Eric Jourdan, MD, Jean Valère Malfuson, Gaelle Guillerm, MD, Jean Henri Bouhris, Mario Ojeda, MD, Mathilde Hunault, MD PhD, Norbert Ifrah, MD PhD, Claude Gardin, MD PhD, Andre Delannoy, MD, Lucile Beautier, Carine Paturel, PhD, Pascale Andre, PhD, Robert Zerbib, Claude Preudhomme, PharmD, PhD, Antoine Toubert, MD PhD, Nicolas Dulphy, PhD, Daniel Olive, MD PhD, Arnaud Pigneux, MD, Herve Dombret, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 889.
https://doi.org/10.1182/blood.V130.Suppl_1.889.889
Published: 2017
Journal Articles

Follicular Lymphoma B Cells Generate Functional Regulatory T Cells Via ICOS/ICOSL Pathway and Are Inhibited By Intratumoral Tregs

Daniel Olive, MD, PhD, Suong Khieu LE, PhD, marie-Laure Thibult, Francoise gondois-Rey, Samuel Granjeaud, PhD, Thierry Fest, Azzaoui Imene, Reda Bouabdallah, MD, Florence Broussais, Luc Xerri, Dominique Leroux, Christophe Caux, Christine Caux
Journal: Blood
Blood (2015) 126 (23): 5018.
https://doi.org/10.1182/blood.V126.23.5018.5018
Published: 2015
Journal Articles

Influence of Btk Inhibitors on Antitumor Activity of Natural Killer Cells

Marta Siernicka, MSc, Kamil Bojarczuk, MSc, Malgorzata Bobrowicz, MSc, Michal Dwojak, DMD, Beata Pyrzynska, PhD, Daniel Olive, MD, PhD, Magdalena Winiarska, PhD
Journal: Blood
Blood (2014) 124 (21): 2742.
https://doi.org/10.1182/blood.V124.21.2742.2742
Published: 2014
Journal Articles

Diffuse Large B Cell Lymphoma (DLBCL) infiltrating T Cells Display an Activated and Exhausted Status and Are Inhibited By Ligands of Cosignaling Receptors Including PD-L1, PD-L2 and CD80 Expressed By Most DLBCL in Situ

Daniel Olive, MD, PhD, Kieu Suong Le, Mikael Roussel, MD PhD, Florence Broussais, MD, Imane Azzaoui, PhD, Delphine Rossille, Reda Bouabdallah, MD, Thierry Fest, MD PhD, Luc Xerri, Thierry Lamy, MD PhD, Céline Pangault, PharmD, PhD
Journal: Blood
Blood (2014) 124 (21): 1665.
https://doi.org/10.1182/blood.V124.21.1665.1665
Published: 2014
Journal Articles

Vgamma9Vdelta2 T Cells-Based Immunotherapy Targeting BTN3 Molecules in Acute Myeloid Leukemia

Daniel Olive, MD, PhD, Audrey Benyamine, MD, Aude Le Roy, Rémy Castellano, PhD, Julie Gertner-Dardenne, Norbert Vey, MDPhD
Journal: Blood
Blood (2014) 124 (21): 3726.
https://doi.org/10.1182/blood.V124.21.3726.3726
Published: 2014
Journal Articles

AML drug resistance: c-Myc comes into play

Cyril Fauriat, Daniel Olive
Journal: Blood
Blood (2014) 123 (23): 3528–3530.
https://doi.org/10.1182/blood-2014-04-566711
Published: 2014
Journal Articles

CD8+ /ICOS+ /CXCR5+ Tumor Infiltrating T-CELLS (CD8 fc ) Sharing Functional Similarities With TFH CELLS ARE Present In Classical Hodgkin’S Lymphoma Tissues Displaying A Specific “MIXED NODULARITY” Pattern

Suong Le Thi, M.D., Florence Broussais, Reda Bouabdallah, MD, Françoise gondois-Rey, Luc Xerri, MD, PhD, Daniel Olive, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4233.
https://doi.org/10.1182/blood.V122.21.4233.4233
Published: 2013
Journal Articles

The co-receptor BTLA negatively regulates human Vγ9Vδ2 T-cell proliferation: a potential way of immune escape for lymphoma cells

Julie Gertner-Dardenne, Cyril Fauriat, Florence Orlanducci, Marie-Laure Thibult, Sonia Pastor, Jude Fitzgibbon, Reda Bouabdallah, Luc Xerri, Daniel Olive
Journal: Blood
Blood (2013) 122 (6): 922–931.
https://doi.org/10.1182/blood-2012-11-464685
Published: 2013
Includes: Supplemental data
Journal Articles

HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells

Jonathan Florentin, Besma Aouar, Clélia Dental, Christine Thumann, Guylène Firaguay, Francoise Gondois-Rey, Vassili Soumelis, Thomas F. Baumert, Jacques A. Nunès, Daniel Olive, Ivan Hirsch, Ruzena Stranska
Journal: Blood
Blood (2012) 120 (23): 4544–4551.
https://doi.org/10.1182/blood-2012-02-413286
Published: 2012
Journal Articles

A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission

Clinical Trials & Observations
Norbert Vey, Jean-Henri Bourhis, Nicolas Boissel, Dominique Bordessoule, Thomas Prebet, Aude Charbonnier, Anne Etienne, Pascale Andre, François Romagne, Don Benson, Herve Dombret, Daniel Olive
Journal: Blood
Blood (2012) 120 (22): 4317–4323.
https://doi.org/10.1182/blood-2012-06-437558
Published: 2012
Includes: Supplemental data