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Issue Archive

Volume 125, Issue 5
January 29 2015
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
There’s no such fool like an immunosenescent fool
Clinical Trials & Observations
Markus G. Seidel
View Articletitled, There’s no such fool like an immunosenescent fool
INSIDE BLOOD COMMENTARY
Dissecting complement blockade for clinic use
Clinical Trials & Observations
Antonio M. Risitano
View Articletitled, Dissecting complement blockade for clinic use
INSIDE BLOOD COMMENTARY
The off-target effects of nonspecific NK cells
Clinical Trials & Observations
Dean A. Lee
View Articletitled, The off-target effects of nonspecific NK cells
INSIDE BLOOD COMMENTARY
Blind men and an elephant
Shaji Kumar
View Articletitled, Blind men and an elephant
INSIDE BLOOD COMMENTARY
Proplatelets slip slidin’ away
Alexandra Mazharian,Yotis A. Senis
View Articletitled, Proplatelets slip slidin’ away
INSIDE BLOOD COMMENTARY
Inherited thrombocytopenias: the beat goes on
A. Koneti Rao,Natthapol Songdej
View Articletitled, Inherited thrombocytopenias: the beat goes on
INSIDE BLOOD COMMENTARY
PI3Kβ inhibition: all that glitters is not gold
Mauro Torti
View Articletitled, PI3Kβ inhibition: all that glitters is not gold

PLENARY PAPER

CLINICAL TRIALS AND OBSERVATIONS
Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency
Clinical Trials & Observations
Polina Stepensky,Anne Rensing-Ehl,Ruth Gather,Shoshana Revel-Vilk,Ute Fischer,Schafiq Nabhani,Fabian Beier,Tim H. Brümmendorf,Sebastian Fuchs,Simon Zenke,Elke Firat,Vered Molho Pessach,Arndt Borkhardt,Mirzokhid Rakhmanov,Bärbel Keller,Klaus Warnatz,Hermann Eibel,Gabriele Niedermann,Orly Elpeleg,Stephan Ehl
View Articletitled, Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency
Supplemental data

BLOOD SPOTLIGHT

Fcγ-receptor–mediated trogocytosis impacts mAb-based therapies: historical precedence and recent developments
Ronald P. Taylor,Margaret A. Lindorfer
View Articletitled, Fcγ-receptor–mediated trogocytosis impacts mAb-based therapies: historical precedence and recent developments

HOW I TREAT

How I treat the older patient with acute myeloid leukemia
Clinical Trials & Observations
Gert Ossenkoppele,Bob Löwenberg
View Articletitled, How I treat the older patient with acute myeloid leukemia

CLINICAL TRIALS AND OBSERVATIONS

Assessing complement blockade in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab
Clinical Trials & Observations
Régis Peffault de Latour,Véronique Fremeaux-Bacchi,Raphaël Porcher,Aliénor Xhaard,Jérémie Rosain,Diana Cadena Castaneda,Paula Vieira-Martins,Stéphane Roncelin,Paula Rodriguez-Otero,Aurélie Plessier,Flore Sicre de Fontbrune,Sarah Abbes,Marie Robin,Gérard Socié
View Articletitled, Assessing complement blockade in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab
Supplemental data
Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following T-cell–depleted stem cell transplantation
Clinical Trials & Observations
Nirali N. Shah,Kristin Baird,Cynthia P. Delbrook,Thomas A. Fleisher,Mark E. Kohler,Shakuntala Rampertaap,Kimberly Lemberg,Carolyn K. Hurley,David E. Kleiner,Melinda S. Merchant,Stefania Pittaluga,Marianna Sabatino,David F. Stroncek,Alan S. Wayne,Hua Zhang,Terry J. Fry,Crystal L. Mackall
View Articletitled, Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following T-cell–depleted stem cell transplantation

HEMATOPOIESIS AND STEM CELLS

Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders
Arun Balakumaran,Prasun J. Mishra,Edyta Pawelczyk,Sayuri Yoshizawa,Brian J. Sworder,Natasha Cherman,Sergei A. Kuznetsov,Paolo Bianco,Neelam Giri,Sharon A. Savage,Glenn Merlino,Bogdan Dumitriu,Cynthia E. Dunbar,Neal S. Young,Blanche P. Alter,Pamela G. Robey
View Articletitled, Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders
Supplemental data

IMMUNOBIOLOGY

A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis
Jacob T. Jackson,Chayanica Nasa,Wei Shi,Nicholas D. Huntington,Clifford W. Bogue,Warren S. Alexander,Matthew P. McCormack
View Articletitled, A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis
Supplemental data
Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans
Brief Report
Sung Won Choi,Erin Gatza,Guoqing Hou,Yaping Sun,Joel Whitfield,Yeohan Song,Katherine Oravecz-Wilson,Isao Tawara,Charles A. Dinarello,Pavan Reddy
View Articletitled, Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans
Supplemental data

LYMPHOID NEOPLASIA

Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS)
Sarah Krause,Christian Pfeiffer,Susanne Strube,Ameera Alsadeq,Henning Fedders,Christian Vokuhl,Sonja Loges,Jonas Waizenegger,Isabel Ben-Batalla,Gunnar Cario,Anja Möricke,Martin Stanulla,Martin Schrappe,Denis M. Schewe
View Articletitled, Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS)
Supplemental data
Coexistent hyperdiploidy does not abrogate poor prognosis in myeloma with adverse cytogenetics and may precede IGH translocations
Charlotte Pawlyn,Lorenzo Melchor,Alex Murison,Christopher P. Wardell,Annamaria Brioli,Eileen M. Boyle,Martin F. Kaiser,Brian A. Walker,Dil B. Begum,Nasrin B. Dahir,Paula Proszek,Walter M. Gregory,Mark T. Drayson,Graham H. Jackson,Fiona M. Ross,Faith E. Davies,Gareth J. Morgan
View Articletitled, Coexistent hyperdiploidy does not abrogate poor prognosis in myeloma with adverse cytogenetics and may precede <em>IGH</em> translocations
Supplemental data
Integrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
Florencia Cayrol,María Celeste Díaz Flaqué,Tharu Fernando,Shao Ning Yang,Helena Andrea Sterle,Marcela Bolontrade,Mariana Amorós,Blanca Isse,Ricardo Norberto Farías,Haelee Ahn,Ye F. Tian,Fabrizio Tabbò,Ankur Singh,Giorgio Inghirami,Leandro Cerchietti,Graciela Alicia Cremaschi
View Articletitled, Integrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
Supplemental data
Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity
Brief Report
Ryan H. Newton,Yu Lu,Antonella Papa,Greg H. Whitcher,Youn-Jung Kang,Catherine Yan,Pier Paolo Pandolfi,Laurence A. Turka
View Articletitled, Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity
Supplemental data
Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations
Clinical Trials & Observations Brief Report
Panagiotis Baliakas,Andreas Agathangelidis,Anastasia Hadzidimitriou,Lesley-Ann Sutton,Eva Minga,Athina Tsanousa,Lydia Scarfò,Zadie Davis,Xiao-Jie Yan,Tait Shanafelt,Karla Plevova,Yorick Sandberg,Fie Juhl Vojdeman,Myriam Boudjogra,Tatiana Tzenou,Maria Chatzouli,Charles C. Chu,Silvio Veronese,Anne Gardiner,Larry Mansouri,Karin E. Smedby,Lone Bredo Pedersen,Denis Moreno,Kirsten Van Lom,Véronique Giudicelli,Hana Skuhrova Francova,Florence Nguyen-Khac,Panagiotis Panagiotidis,Gunnar Juliusson,Lefteris Angelis,Achilles Anagnostopoulos,Marie-Paule Lefranc,Monica Facco,Livio Trentin,Mark Catherwood,Marco Montillo,Christian H. Geisler,Anton W. Langerak,Sarka Pospisilova,Nicholas Chiorazzi,David Oscier,Diane F. Jelinek,Nikos Darzentas,Chrysoula Belessi,Frederic Davi,Paolo Ghia,Richard Rosenquist,Kostas Stamatopoulos
View Articletitled, Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations
Supplemental data

PLATELETS AND THROMBOPOIESIS

Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein
Markus Bender,Jonathan N. Thon,Allen J. Ehrlicher,Stephen Wu,Linas Mazutis,Emoke Deschmann,Martha Sola-Visner,Joseph E. Italiano,John H. Hartwig
View Articletitled, Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein
Supplemental data
ACTN1-related thrombocytopenia: identification of novel families for phenotypic characterization
Brief Report
Roberta Bottega,Caterina Marconi,Michela Faleschini,Gabriele Baj,Claudia Cagioni,Alessandro Pecci,Tommaso Pippucci,Ugo Ramenghi,Simonetta Pardini,Loretta Ngu,Carlo Baronci,Shinji Kunishima,Carlo L. Balduini,Marco Seri,Anna Savoia,Patrizia Noris
View Articletitled, <em>ACTN1</em>-related thrombocytopenia: identification of novel families for phenotypic characterization
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait
Emma Jones,Sant-Rayn Pasricha,Angela Allen,Patricia Evans,Chris A. Fisher,Katherine Wray,Anuja Premawardhena,Dyananda Bandara,Ashok Perera,Craig Webster,Pamela Sturges,Nancy F. Olivieri,Timothy St. Pierre,Andrew E. Armitage,John B. Porter,David J. Weatherall,Hal Drakesmith
View Articletitled, Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait
Supplemental data

THROMBOSIS AND HEMOSTASIS

Platelet PI3Kβ and GSK3 regulate thrombus stability at a high shear rate
Pierre-Alexandre Laurent,Sonia Séverin,Béatrice Hechler,Bart Vanhaesebroeck,Bernard Payrastre,Marie-Pierre Gratacap
View Articletitled, Platelet PI3Kβ and GSK3 regulate thrombus stability at a high shear rate
Supplemental data

BLOOD WORK

“Cup-like” blasts in acute myeloid leukemia with FLT3 and NPM1 mutations
Aditi Vidholia,Madhu P. Menon
View Articletitled, “Cup-like” blasts in acute myeloid leukemia with <em>FLT3</em> and <em>NPM1</em> mutations

ERRATA

Irving J, Matheson E, Minto L, et al. Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition. Blood. 2014;124(23):3420-3430.
View Articletitled, Irving J, Matheson E, Minto L, et al. Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition. <em>Blood</em>. 2014;124(23):3420-3430.
Boudreau LH, Duchez A-C, Cloutier N, et al. Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. Blood. 2014;124(14):2173-2183.
View Articletitled, Boudreau LH, Duchez A-C, Cloutier N, et al. Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A<sub>2</sub> to promote inflammation. <em>Blood.</em> 2014;124(14):2173-2183.
  • Cover Image

    Cover Image

    issue cover

    Cytoskeleton disorganization caused by the R46W mutation of α-actinin 1. ACTN1 is a gene recently identified as responsible for a new, autosomal-dominant form of inherited thrombocytopenia, ACTN1-related thrombocytopenia. Expression of the mutant R46W form of α-actinin 1 (green) in human fibroblasts causes complete disorganization of the cytoskeleton with actin (red) no longer organized in filaments, which are instead observed in surrounding untransfected cells. See the article by Bottega et al on page 869.

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