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Issue Archive

Volume 125, Issue 22
May 28 2015
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
microRNA represses macromolecule
Tilo Grosser
View Articletitled, microRNA represses macromolecule
INSIDE BLOOD COMMENTARY
Fitness deficits in long-term ALL survivors
Clinical Trials & Observations
Richard J. Simpson
View Articletitled, Fitness deficits in long-term ALL survivors
INSIDE BLOOD COMMENTARY
Chronic lymphocytic leukemia and the Warburg effect
Carol Moreno
View Articletitled, Chronic lymphocytic leukemia and the Warburg effect
INSIDE BLOOD COMMENTARY
ATRA and ATO team up against NPM1
Steven Grant
View Articletitled, ATRA and ATO team up against NPM1
INSIDE BLOOD COMMENTARY
Lupus anticoagulant, thrombosis, and death
Reyhan Diz-Küçükkaya
View Articletitled, Lupus anticoagulant, thrombosis, and death
INSIDE BLOOD COMMENTARY
The first specific antiplatelet antidote
David Erlinge
View Articletitled, The first specific antiplatelet antidote
INSIDE BLOOD COMMENTARY
A party of three: iNKT cells in GVHD prevention
Annkristin Heine,Peter Brossart
View Articletitled, A party of three: iNKT cells in GVHD prevention

PLENARY PAPER

THROMBOSIS AND HEMOSTASIS
Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor
Yaozu Xiang,Jijun Cheng,Dandan Wang,Xiaoyue Hu,Yi Xie,Jeremiah Stitham,Gourg Atteya,Jing Du,Wai Ho Tang,Seung Hee Lee,Kristen Leslie,Geralyn Spollett,Zejian Liu,Erica Herzog,Raimund I. Herzog,Jun Lu,Kathleen A. Martin,John Hwa
View Articletitled, Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor
Supplemental data

BLOOD SPOTLIGHT

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms
Olli Silvennoinen,Stevan R. Hubbard
View Articletitled, Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

REVIEW ARTICLE

Immune checkpoint blockade in hematologic malignancies
Clinical Trials & Observations
Philippe Armand
View Articletitled, Immune checkpoint blockade in hematologic malignancies

HOW I TREAT

How I treat and manage strokes in sickle cell disease
Clinical Trials & Observations
Adetola A. Kassim,Najibah A. Galadanci,Sumit Pruthi,Michael R. DeBaun
View Articletitled, How I treat and manage strokes in sickle cell disease

CLINICAL TRIALS AND OBSERVATIONS

Energy balance and fitness in adult survivors of childhood acute lymphoblastic leukemia
Clinical Trials & Observations
Kirsten K. Ness,James P. DeLany,Sue C. Kaste,Daniel A. Mulrooney,Ching-Hon Pui,Wassim Chemaitilly,Robyn E. Karlage,Jennifer Q. Lanctot,Carrie R. Howell,Lu Lu,Deo Kumar Srivastava,Leslie L. Robison,Melissa M. Hudson
View Articletitled, Energy balance and fitness in adult survivors of childhood acute lymphoblastic leukemia
Supplemental data

LYMPHOID NEOPLASIA

Central nervous system acute lymphoblastic leukemia: role of natural killer cells
Liron Frishman-Levy,Avishai Shemesh,Allan Bar-Sinai,Chao Ma,Zhenya Ni,Shahar Frenkel,Vera Muench,Hilke Bruckmueller,Christian Vokuhl,Klaus-Michael Debatin,Cornelia Eckert,Martin Stanulla,Martin Schrappe,Kerry S. Campbell,Ron Loewenthal,Denis M. Schewe,Jacob Hochman,Lueder H. Meyer,Dan Kaufman,Gunnar Cario,Angel Porgador,Shai Izraeli
View Articletitled, Central nervous system acute lymphoblastic leukemia: role of natural killer cells
Supplemental data
Stromal cell–mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling
Brief Report
Regina Jitschin,Martina Braun,Mirjeta Qorraj,Domenica Saul,Katarina Le Blanc,Thorsten Zenz,Dimitrios Mougiakakos
View Articletitled, Stromal cell–mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling
Supplemental data

MYELOID NEOPLASIA

Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2
Takeshi Ueda,Akiko Nagamachi,Keiyo Takubo,Norimasa Yamasaki,Hirotaka Matsui,Akinori Kanai,Yuichiro Nakata,Kenichiro Ikeda,Takaaki Konuma,Hideaki Oda,Linda Wolff,Zen-ichiro Honda,Xudong Wu,Kristian Helin,Atsushi Iwama,Toshio Suda,Toshiya Inaba,Hiroaki Honda
View Articletitled, Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2
Supplemental data
Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells
Clinical Trials & Observations
Hiba El Hajj,Zeina Dassouki,Caroline Berthier,Emmanuel Raffoux,Lionel Ades,Olivier Legrand,Rita Hleihel,Umut Sahin,Nadim Tawil,Ala Salameh,Kazem Zibara,Nadine Darwiche,Mohamad Mohty,Hervé Dombret,Pierre Fenaux,Hugues de Thé,Ali Bazarbachi
View Articletitled, Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells
Supplemental data
Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells
Maria Paola Martelli,Ilaria Gionfriddo,Federica Mezzasoma,Francesca Milano,Sara Pierangeli,Floriana Mulas,Roberta Pacini,Alessia Tabarrini,Valentina Pettirossi,Roberta Rossi,Calogero Vetro,Lorenzo Brunetti,Paolo Sportoletti,Enrico Tiacci,Francesco Di Raimondo,Brunangelo Falini
View Articletitled, Arsenic trioxide and all-<em>trans</em> retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in <em>NPM1</em>-mutated AML cells
Supplemental data
Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor–expressing T cells
Rachel C. Lynn,Mathilde Poussin,Anna Kalota,Yang Feng,Philip S. Low,Dimiter S. Dimitrov,Daniel J. Powell, Jr
View Articletitled, Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor–expressing T cells
Supplemental data

THROMBOSIS AND HEMOSTASIS

Increased mortality in patients with the lupus anticoagulant: the Vienna Lupus Anticoagulant and Thrombosis Study (LATS)
Clinical Trials & Observations
Johanna Gebhart,Florian Posch,Silvia Koder,Thomas Perkmann,Peter Quehenberger,Claudia Zoghlami,Cihan Ay,Ingrid Pabinger
View Articletitled, Increased mortality in patients with the lupus anticoagulant: the Vienna Lupus Anticoagulant and Thrombosis Study (LATS)
Structural and functional characterization of a specific antidote for ticagrelor
Andrew Buchanan,Philip Newton,Susanne Pehrsson,Tord Inghardt,Thomas Antonsson,Peder Svensson,Tove Sjögren,Linda Öster,Annika Janefeldt,Ann-Sofie Sandinge,Feenagh Keyes,Mark Austin,Jennifer Spooner,Peter Gennemark,Mark Penney,Garnet Howells,Tristan Vaughan,Sven Nylander
View Articletitled, Structural and functional characterization of a specific antidote for ticagrelor
Supplemental data

TRANSPLANTATION

Third-party CD4+ invariant natural killer T cells protect from murine GVHD lethality
Dominik Schneidawind,Jeanette Baker,Antonio Pierini,Corina Buechele,Richard H. Luong,Everett H. Meyer,Robert S. Negrin
View Articletitled, Third-party CD4<sup>+</sup> invariant natural killer T cells protect from murine GVHD lethality
Supplemental data
IgH-V(D)J NGS-MRD measurement pre- and early post-allotransplant defines very low- and very high-risk ALL patients
Clinical Trials & Observations
Michael A. Pulsipher,Chris Carlson,Bryan Langholz,Donna A. Wall,Kirk R. Schultz,Nancy Bunin,Ilan Kirsch,Julie M. Gastier-Foster,Michael Borowitz,Cindy Desmarais,David Williamson,Michael Kalos,Stephan A. Grupp
View Articletitled, IgH-V(D)J NGS-MRD measurement pre- and early post-allotransplant defines very low- and very high-risk ALL patients
Supplemental data

VASCULAR BIOLOGY

Content delivery to newly forming Weibel-Palade bodies is facilitated by multiple connections with the Golgi apparatus
Marjon J. Mourik,Frank G. A. Faas,Hans Zimmermann,Jan Voorberg,Abraham J. Koster,Jeroen Eikenboom
View Articletitled, Content delivery to newly forming Weibel-Palade bodies is facilitated by multiple connections with the Golgi apparatus
Supplemental data

BLOOD WORK

High-density genomic analysis reveals basis of spherocytosis in myelodysplastic syndrome
Yarden S. Fraiman,Alison R. Moliterno
View Articletitled, High-density genomic analysis reveals basis of spherocytosis in myelodysplastic syndrome
  • Cover Image

    Cover Image

    issue cover

    A three-dimensional rendering of a forming Weibel-Palade body (green) that is connected to the Golgi apparatus (yellow) via various connections. Weibel-Palade bodies are formed by vascular endothelial cells and are filled with large quantities of von Willebrand factor. The multiple connections between forming Weibel-Palade bodies and the Golgi apparatus were discovered by performing correlative light and electron microscopy and electron tomography on green fluorescent protein–labeled Weibel-Palade bodies. The connections seem to facilitate content delivery to newly forming Weibel-Palade bodies. See the article by Mourik et al on page 3509.

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EVIDENCE meta-analysis: evaluating minimal residual disease as an intermediate clinical endpoint for multiple myeloma
Increased risk of venous thromboembolism in young and middle-aged individuals with hereditary angioedema: a family study
Data mining for second malignancies after CAR-T
Outcomes of younger patients with mantle-cell lymphoma experiencing late relapse (>24 months): the LATE-POD study
Mutational profile of previously treated chronic lymphocytic leukemia patients progressing on acalabrutinib or ibrutinib

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