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Issue Archive

Volume 125, Issue 12
March 19 2015
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Mogamulizumab: 2 birds, 1 stone
Clinical Trials & Observations
Ryan A. Wilcox
View Articletitled, Mogamulizumab: 2 birds, 1 stone
INSIDE BLOOD COMMENTARY
DNA methylation in lymphoma: an opportunity?
Stephen M. Ansell
View Articletitled, DNA methylation in lymphoma: an opportunity?
INSIDE BLOOD COMMENTARY
Speaking a common language in MDS/MPNs
David P. Steensma
View Articletitled, Speaking a common language in MDS/MPNs
INSIDE BLOOD COMMENTARY
ADAMTS13, lucky to have a hydrophobic pocket
X. Long Zheng
View Articletitled, ADAMTS13, lucky to have a hydrophobic pocket
INSIDE BLOOD COMMENTARY
PARtitioning protease signaling
Marvin T. Nieman
View Articletitled, PARtitioning protease signaling
INSIDE BLOOD COMMENTARY
You’ve got to be kindlin!
Scott I. Simon
View Articletitled, You’ve got to be kindlin!

PERSPECTIVES

An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults
Clinical Trials & Observations
Michael R. Savona,Luca Malcovati,Rami Komrokji,Ramon V. Tiu,Tariq I. Mughal,Attilio Orazi,Jean-Jacques Kiladjian,Eric Padron,Eric Solary,Raoul Tibes,Raphael Itzykson,Mario Cazzola,Ruben Mesa,Jaroslaw Maciejewski,Pierre Fenaux,Guillermo Garcia-Manero,Aaron Gerds,Guillermo Sanz,Charlotte M. Niemeyer,Francisco Cervantes,Ulrich Germing,Nicholas C. P. Cross,Alan F. List,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group,on behalf of the MDS/MPN International Working Group
View Articletitled, An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults

BLOOD FORUM

Value of innovation in hematologic malignancies: a systematic review of published cost-effectiveness analyses
Clinical Trials & Observations
Cayla J. Saret,Aaron N. Winn,Gunjan Shah,Susan K. Parsons,Pei-Jung Lin,Joshua T. Cohen,Peter J. Neumann
View Articletitled, Value of innovation in hematologic malignancies: a systematic review of published cost-effectiveness analyses
Supplemental data

REVIEW ARTICLE

Genetics of multiple myeloma: another heterogeneity level?
Clinical Trials & Observations
Jill Corre,Nikhil Munshi,Hervé Avet-Loiseau
View Articletitled, Genetics of multiple myeloma: another heterogeneity level?

HOW I TREAT

How I treat incidental pulmonary embolism
CME
Casey O’Connell
View Articletitled, How I treat incidental pulmonary embolism

CLINICAL TRIALS AND OBSERVATIONS

Phase 1/2 study of mogamulizumab, a defucosylated anti-CCR4 antibody, in previously treated patients with cutaneous T-cell lymphoma
Clinical Trials & Observations
Madeleine Duvic,Lauren C. Pinter-Brown,Francine M. Foss,Lubomir Sokol,Jeffrey L. Jorgensen,Pramoda Challagundla,Karen M. Dwyer,Xiaoping Zhang,Michael R. Kurman,Rocco Ballerini,Li Liu,Youn H. Kim
View Articletitled, Phase 1/2 study of mogamulizumab, a defucosylated anti-CCR4 antibody, in previously treated patients with cutaneous T-cell lymphoma

HEMATOPOIESIS AND STEM CELLS

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2
Sarah A. Kinkel,Roman Galeev,Christoffer Flensburg,Andrew Keniry,Kelsey Breslin,Omer Gilan,Stanley Lee,Joy Liu,Kelan Chen,Linden J. Gearing,Darcy L. Moore,Warren S. Alexander,Mark Dawson,Ian J. Majewski,Alicia Oshlack,Jonas Larsson,Marnie E. Blewitt
View Articletitled, Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2
Supplemental data

IMMUNOBIOLOGY

Antigenic modulation limits the effector cell mechanisms employed by type I anti-CD20 monoclonal antibodies
Thomas R. W. Tipton,Ali Roghanian,Robert J. Oldham,Matthew J. Carter,Kerry L. Cox,C. Ian Mockridge,Ruth R. French,Lekh N. Dahal,Patrick J. Duriez,Philip G. Hargreaves,Mark S. Cragg,Stephen A. Beers
View Articletitled, Antigenic modulation limits the effector cell mechanisms employed by type I anti-CD20 monoclonal antibodies
Supplemental data

LYMPHOID NEOPLASIA

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development
Bilal N. Sheikh,Stanley C. W. Lee,Farrah El-Saafin,Hannah K. Vanyai,Yifang Hu,Swee Heng Milon Pang,Stephanie Grabow,Andreas Strasser,Stephen L. Nutt,Warren S. Alexander,Gordon K. Smyth,Anne K. Voss,Tim Thomas
View Articletitled, MOZ regulates B-cell progenitors and, consequently, <em>Moz</em> haploinsufficiency dramatically retards MYC-induced lymphoma development
Supplemental data
DNA methylation profiling identifies two splenic marginal zone lymphoma subgroups with different clinical and genetic features
Alberto J. Arribas,Andrea Rinaldi,Afua A. Mensah,Ivo Kwee,Luciano Cascione,Eloy F. Robles,Jose A. Martinez-Climent,David Oscier,Luca Arcaini,Luca Baldini,Roberto Marasca,Catherine Thieblemont,Josette Briere,Francesco Forconi,Alberto Zamò,Massimiliano Bonifacio,Manuela Mollejo,Fabio Facchetti,Stephan Dirnhofer,Maurilio Ponzoni,Govind Bhagat,Miguel A. Piris,Gianluca Gaidano,Emanuele Zucca,Davide Rossi,Francesco Bertoni
View Articletitled, DNA methylation profiling identifies two splenic marginal zone lymphoma subgroups with different clinical and genetic features
Supplemental data
Minimal residual disease in myeloma by flow cytometry: independent prediction of survival benefit per log reduction
Clinical Trials & Observations Brief Report
Andy C. Rawstron,Walter M. Gregory,Ruth M. de Tute,Faith E. Davies,Sue E. Bell,Mark T. Drayson,Gordon Cook,Graham H. Jackson,Gareth J. Morgan,J. Anthony Child,Roger G. Owen
View Articletitled, Minimal residual disease in myeloma by flow cytometry: independent prediction of survival benefit per log reduction
Supplemental data

MYELOID NEOPLASIA

FLT3-ITD and TLR9 use Bruton tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation
Thomas Oellerich,Sebastian Mohr,Jasmin Corso,Julia Beck,Carmen Döbele,Helene Braun,Anjali Cremer,Silvia Münch,Johannes Wicht,Mark F. Oellerich,Gesine Bug,Hanibal Bohnenberger,Christina Perske,Ekkehard Schütz,Henning Urlaub,Hubert Serve
View Articletitled, FLT3-ITD and TLR9 use Bruton tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock
Kimberly Martinod,Tobias A. Fuchs,Naamah L. Zitomersky,Siu Ling Wong,Melanie Demers,Maureen Gallant,Yanming Wang,Denisa D. Wagner
View Articletitled, PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock
Supplemental data

PLATELETS AND THROMBOPOIESIS

Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function
Marjolein Meinders,Divine I. Kulu,Harmen J. G. van de Werken,Mark Hoogenboezem,Hans Janssen,Rutger W. W. Brouwer,Wilfred F. J. van Ijcken,Erik-Jan Rijkers,Jeroen A. A. Demmers,Imme Krüger,Timo K. van den Berg,Guntram Suske,Laura Gutiérrez,Sjaak Philipsen
View Articletitled, Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function
Supplemental data

THROMBOSIS AND HEMOSTASIS

The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis
Rens de Groot,David A. Lane,James T. B. Crawley
View Articletitled, The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis
Supplemental data
Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar
Omozuanvbo Aisiku,Christian G. Peters,Karen De Ceunynck,Chandra C. Ghosh,James R. Dilks,Susanna F. Fustolo-Gunnink,Mingdong Huang,Chris Dockendorff,Samir M. Parikh,Robert Flaumenhaft
View Articletitled, Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar
Supplemental data

TRANSPLANTATION

Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT
Clinical Trials & Observations
Judith Feucht,Kathrin Opherk,Peter Lang,Simone Kayser,Lena Hartl,Wolfgang Bethge,Susanne Matthes-Martin,Peter Bader,Michael H. Albert,Britta Maecker-Kolhoff,Johann Greil,Hermann Einsele,Paul-Gerhardt Schlegel,Friedhelm R. Schuster,Bernhard Kremens,Claudia Rossig,Bernd Gruhn,Rupert Handgretinger,Tobias Feuchtinger
View Articletitled, Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT
Supplemental data

VASCULAR BIOLOGY

Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor
Zhongji Liao,Hisashi Kato,Manjula Pandey,Joseph M. Cantor,Ararat J. Ablooglu,Mark H. Ginsberg,Sanford J. Shattil
View Articletitled, Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor
Supplemental data

BLOOD WORK

Ependymal cells in cerebrospinal fluid: a traumatic occurrence
Paul Yeh,David A. Westerman
View Articletitled, Ependymal cells in cerebrospinal fluid: a traumatic occurrence

ERRATA

Markel G, Mussaffi H, Ling K-L, et al. The mechanisms controlling NK cell autoreactivity in TAP2-deficient patients. Blood. 2004;103(5):1770-1778.
View Articletitled, Markel G, Mussaffi H, Ling K-L, et al. The mechanisms controlling NK cell autoreactivity in TAP2-deficient patients. <em>Blood</em>. 2004;103(5):1770-1778.
Nair N, Rincon MY, Evens H, et al. Computationally designed liver-specific transcriptional modules and hyperactive factor IX improve hepatic gene therapy. Blood. 2014;123(20):3195-3199.
View Articletitled, Nair N, Rincon MY, Evens H, et al. Computationally designed liver-specific transcriptional modules and hyperactive factor IX improve hepatic gene therapy. <em>Blood</em>. 2014;123(20):3195-3199.
Slupsky JR. Enhancing BCR signals at the cell membrane. Blood. 2015;125(4):586-587.
View Articletitled, Slupsky JR. Enhancing BCR signals at the cell membrane. <em>Blood.</em> 2015;125(4):586-587.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Incidental pulmonary embolism
CME
View Articletitled, Incidental pulmonary embolism
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