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Journal Articles

Cathepsin G Potentiates Biased Signaling through Protease Activated Receptor 4

NaShea Kendrick, Marvin T. Nieman

Blood (2024) 144 (Supplement 1): 3934.

https://doi.org/10.1182/blood-2024-211214

Published: 2024

Journal Articles

Elucidating the Structural Dynamics and Native Modifications of α2-Macroglobulin from Native Platelet Samples By Cryo-EM Coupled with “Build and Retrieve” (BaR) Data Processing

Xu Han, Chih-Chia Su, Zhemin Zhang, Masaru Miyagi, Edward Yu, Marvin T. Nieman

Blood (2024) 144 (Supplement 1): 423.

https://doi.org/10.1182/blood-2024-199705

Published: 2024

Journal Articles

PAR2 biased signaling on the move

Marvin T. Nieman

Blood (2024) 143 (10): 835–836.

https://doi.org/10.1182/blood.2023023489

Published: 2024

Journal Articles

A Mouse Model of the PAR4 Sequence Variant P310L Shows Decreased Platelet Reactivity and Thrombosis

Elizabeth Ann Knauss, Xu Han, Maria Almudena De La Fuente, Wei Li, Norman Luc, Steven Edward McKenzie, Marvin T. Nieman

Blood (2023) 142 (Supplement 1): 3932.

https://doi.org/10.1182/blood-2023-186113

Published: 2023

Journal Articles

Elucidating the Structural Dynamics of Integrin α IIb β 3 from Native Platelet Membranes By Cryo-EM Coupled with Build and Retrieve Data Processing Methodology

Xu Han, Chih-Chia Su, Zhemin Zhang, Meinan Lyu, Edward Yu, Marvin T. Nieman

Blood (2023) 142 (Supplement 1): 2559.

https://doi.org/10.1182/blood-2023-178888

Published: 2023

Journal Articles

Intravenous Nanomedicine for Targeted Delivery of Thrombin to Augment Hemostasis

Anirban Sen Gupta, Aditya Girish, Ketan Jolly, Maria de la Fuente, Xu Han, Marvin T. Nieman, Arielle Recchione

Blood (2021) 138 (Supplement 1): 1029.

https://doi.org/10.1182/blood-2021-153708

Published: 2021

Journal Articles

PAR4 activation involves extracellular loop 3 and transmembrane residue Thr153

Xu Han, Lukas Hofmann, Maria de la Fuente, Nathan Alexander, Krzysztof Palczewski, the INVENT Consortium, Marvin T. Nieman

Blood (2020) 136 (19): 2217–2228.

https://doi.org/10.1182/blood.2019004634

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Modulation of Thrombin-Induced Platelet Activation By Defibrotide

Kristin N. Maher, MD PhD, Xu Han, BS, MS, Keith B. Neeves, PhD, Marvin T. Nieman, PhD, Jorge Di Paola, MD

Blood (2019) 134 (Supplement_1): 3614.

https://doi.org/10.1182/blood-2019-125945

Published: 2019

Journal Articles

RAPid signaling in platelets

Marvin T. Nieman

Blood (2018) 132 (18): 1864–1865.

https://doi.org/10.1182/blood-2018-09-872093

Published: 2018

Journal Articles

Analysis of a Naturally Occurring PAR4 Variant By Hydrogen/Deuterium Exchange Reveals Its Structural Rearrangement upon Activation By Thrombin and the Molecular Basis for Altered Reactivity

Xu Han, BS, MS, Lukas Hofmann, PhD, Maria de la Fuente, BS, Tivadar Orban, PhD, Nathan Alexander, PhD, Krzysztof Palczewski, PhD, Marvin T Nieman, PhD

Blood (2017) 130 (Supplement 1): 453.

https://doi.org/10.1182/blood.V130.Suppl_1.453.453

Published: 2017

Journal Articles

Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth

James V. Michael, Jeremy G. T. Wurtzel, Guang Fen Mao, A. Koneti Rao, Mikhail A. Kolpakov, Abdelkarim Sabri, Nicholas E. Hoffman, Sudarsan Rajan, Dhanendra Tomar, Muniswamy Madesh, Marvin T. Nieman, Johnny Yu, Leonard C. Edelstein, Jesse W. Rowley, Andrew S. Weyrich, Lawrence E. Goldfinger

Blood (2017) 130 (5): 567–580.

https://doi.org/10.1182/blood-2016-11-751099

Published: 2017

Includes: Supplemental data

Journal Articles

Protease-activated receptors in hemostasis

Marvin T. Nieman

Blood (2016) 128 (2): 169–177.

https://doi.org/10.1182/blood-2015-11-636472

Published: 2016

Journal Articles

Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets

Jesse W. Rowley, Stéphane Chappaz, Aurélie Corduan, Mark M. W. Chong, Robert Campbell, Amanda Khoury, Bhanu Kanth Manne, Jeremy G. T. Wurtzel, James V. Michael, Lawrence E. Goldfinger, Michele M. Mumaw, Marvin T. Nieman, Benjamin T. Kile, Patrick Provost, Andrew S. Weyrich

Blood (2016) 127 (14): 1743–1751.

https://doi.org/10.1182/blood-2015-07-661371

Published: 2016

Includes: Supplemental data

Journal Articles

Thrombin Induces Protease Activated Receptor (PAR)-3/-4 Interaction in Human Podocytes

Sharma Ruchika, MD, Amanda P Waller, PhD, Shipra Agrawal, PhD, Berend H Isermann, MD, William E Smoyer, MD, Marvin T Nieman, PhD, Bryce A. Kerlin, MD

Blood (2015) 126 (23): 3488.

https://doi.org/10.1182/blood.V126.23.3488.3488

Published: 2015

Journal Articles

Cadherin-6 Forms a Functional Adhesion Complex with Alpha-Catenin and Beta-Catenin in Platelets and Is Required for Platelet Aggregation and Thrombus Formation

Michele Mumaw, PhD, Maria de la Fuente, BS, Carolyn Aldana, BS, BA, Wei Li, MD, Marvin T Nieman, PhD

Blood (2015) 126 (23): 2232.

https://doi.org/10.1182/blood.V126.23.2232.2232

Published: 2015

Journal Articles

PARtitioning protease signaling

Marvin T. Nieman

Blood (2015) 125 (12): 1853–1855.

https://doi.org/10.1182/blood-2015-01-623835

Published: 2015

Journal Articles

Thrombin Induces Apoptosis in Human and Rat Podocytes in a Protease Activated Receptor (PAR)-Dependent Manner

Ruchika Sharma, MD, Amanda P Waller, PhD, Adam Guess, Shipra Agrawal, PhD, Berend Isermann, William E. Smoyer, MD, Marvin T. Nieman, PhD, Bryce A. Kerlin, MD

Blood (2014) 124 (21): 2808.

https://doi.org/10.1182/blood.V124.21.2808.2808

Published: 2014

Journal Articles

Endogenous Thrombin Potential is Directly Correlated with Proteinuria Severity in Both Nephrotic Syndrome Patients and an Animal Model of Nephrotic Syndrome

Amanda P Waller, PhD, Marvin T. Nieman, PhD, William E. Smoyer, MD, Bryce A. Kerlin, MD

Blood (2014) 124 (21): 4243.

https://doi.org/10.1182/blood.V124.21.4243.4243

Published: 2014

Journal Articles

Analysis of Protease Activated Receptor 4 (PAR4) By Histidine Hydrogen Deuterium Exchange

Marvin T. Nieman, PhD, Maria de la Fuente, Masaru Miyagi, PhD

Blood (2014) 124 (21): 4166.

https://doi.org/10.1182/blood.V124.21.4166.4166

Published: 2014

Journal Articles

Identification of a Racially Dimorphic Variant in the Human Platelet PAR4 Thrombin Receptor Altering Platelet Function and Pharmacologic Inhibition

Leonard C. Edelstein, PhD, Lukas M Simon, Cory R Lindsay, PhD, Xiango Kong, MD, Raul Teruel Montoya, PhD, Benjamin E Tourdot, PhD, Edward Chen, PhD, Lin Ma, Shaun R Coughlin, PhD, Marvin T. Nieman, PhD, Michael Holinstat, PhD, Chad Shaw, PhD, Paul F Bray, MD

Blood (2014) 124 (21): 1434.

https://doi.org/10.1182/blood.V124.21.1434.1434

Published: 2014

NARROW

Cathepsin G Potentiates Biased Signaling through Protease Activated Receptor 4

Elucidating the Structural Dynamics and Native Modifications of α2-Macroglobulin from Native Platelet Samples By Cryo-EM Coupled with “Build and Retrieve” (BaR) Data Processing

PAR2 biased signaling on the move

A Mouse Model of the PAR4 Sequence Variant P310L Shows Decreased Platelet Reactivity and Thrombosis

Elucidating the Structural Dynamics of Integrin α IIb β 3 from Native Platelet Membranes By Cryo-EM Coupled with Build and Retrieve Data Processing Methodology

Intravenous Nanomedicine for Targeted Delivery of Thrombin to Augment Hemostasis

PAR4 activation involves extracellular loop 3 and transmembrane residue Thr153

Modulation of Thrombin-Induced Platelet Activation By Defibrotide

RAPid signaling in platelets

Analysis of a Naturally Occurring PAR4 Variant By Hydrogen/Deuterium Exchange Reveals Its Structural Rearrangement upon Activation By Thrombin and the Molecular Basis for Altered Reactivity

Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth

Protease-activated receptors in hemostasis

Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets

Thrombin Induces Protease Activated Receptor (PAR)-3/-4 Interaction in Human Podocytes

Cadherin-6 Forms a Functional Adhesion Complex with Alpha-Catenin and Beta-Catenin in Platelets and Is Required for Platelet Aggregation and Thrombus Formation

PARtitioning protease signaling

Thrombin Induces Apoptosis in Human and Rat Podocytes in a Protease Activated Receptor (PAR)-Dependent Manner

Endogenous Thrombin Potential is Directly Correlated with Proteinuria Severity in Both Nephrotic Syndrome Patients and an Animal Model of Nephrotic Syndrome

Analysis of Protease Activated Receptor 4 (PAR4) By Histidine Hydrogen Deuterium Exchange

Identification of a Racially Dimorphic Variant in the Human Platelet PAR4 Thrombin Receptor Altering Platelet Function and Pharmacologic Inhibition

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American Society of Hematology

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American Society of Hematology

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