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Issue Archive

Volume 122, Issue 5
August 1 2013
Issue Cover

Table of Contents

INSIDE BLOOD

INSIDE BLOOD
Engineering Trojan-horse bacteria to fight cancer
Eshel Ben-Jacob
View Articletitled, Engineering Trojan-horse bacteria to fight cancer
MYELOID NEOPLASIA
Arginase-mediated “field” defects in AML
Guido Marcucci
View Articletitled, Arginase-mediated “field” defects in AML
PHAGOCYTES, GRANULOCYTES, & MYELOPOIESIS
To be, or not to be, an eosinophil: that is the ???
Steven J. Ackerman
View Articletitled, To be, or not to be, an eosinophil: that is the ???
TRANSPLANTATION
A 2-hit model for chronic GVHD
Robertson Parkman
View Articletitled, A 2-hit model for chronic GVHD
VASCULAR BIOLOGY
The endothelial protein C receptor and malaria
Tom van der Poll
View Articletitled, The endothelial protein C receptor and malaria

BLOOD WORK

Beyond the obviousness, searching for ambiguities…
Biswadip Hazarika
View Articletitled, Beyond the obviousness, searching for ambiguities…
Visceral leishmaniasis involving the bone marrow
Mahmoud Hellal,Sumant Kundu
View Articletitled, Visceral leishmaniasis involving the bone marrow

PLENARY PAPER

Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response
Peter Aka,Maria Candida Vila,Amar Jariwala,Francis Nkrumah,Benjamin Emmanuel,Masanori Yagi,Nirianne Marie Q. Palacpac,Maria V. Periago,Janet Neequaye,Christine Kiruthu,Takahiro Tougan,Paul H. Levine,Robert J. Biggar,Ruth M. Pfeiffer,Kishor Bhatia,Toshihiro Horii,Jeffrey M. Bethony,Sam M. Mbulaiteye
View Articletitled, Endemic Burkitt lymphoma is associated with strength and diversity of <em>Plasmodium falciparum</em> malaria stage-specific antigen antibody response
Supplemental data

REVIEW ARTICLE

Alloantibodies in von Willebrand disease
Paula D. James,David Lillicrap,Pier M. Mannucci
View Articletitled, Alloantibodies in von Willebrand disease

CLINICAL TRIALS AND OBSERVATIONS

Measuring the symptom burden associated with the treatment of chronic myeloid leukemia
Clinical Trials & Observations
Loretta A. Williams,Araceli G. Garcia Gonzalez,Patricia Ault,Tito R. Mendoza,Mary L. Sailors,Janet L. Williams,Furong Huang,Aziz Nazha,Hagop M. Kantarjian,Charles S. Cleeland,Jorge E. Cortes
View Articletitled, Measuring the symptom burden associated with the treatment of chronic myeloid leukemia
Pharmacokinetics and safety of a novel recombinant human von Willebrand factor manufactured with a plasma-free method: a prospective clinical trial
Clinical Trials & Observations
Pier Mannuccio Mannucci,Christine Kempton,Carolyn Millar,Edward Romond,Amy Shapiro,Ingvild Birschmann,Margaret V. Ragni,Joan Cox Gill,Thynn Thynn Yee,Robert Klamroth,Wing-Yen Wong,Miranda Chapman,Werner Engl,Peter L. Turecek,Tobias M. Suiter,Bruce M. Ewenstein,and members of the rVWF Ad Hoc Study Group
View Articletitled, Pharmacokinetics and safety of a novel recombinant human von Willebrand factor manufactured with a plasma-free method: a prospective clinical trial
Supplemental data

GENE THERAPY

Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization
Emília Ilona Gaál,Tuomas Tammela,Andrey Anisimov,Serge Marbacher,Petri Honkanen,Georgia Zarkada,Veli-Matti Leppänen,Turgut Tatlisumak,Juha Hernesniemi,Mika Niemelä,Kari Alitalo
View Articletitled, Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization
Supplemental data

IMMUNOBIOLOGY

The CXCR4 mutations in WHIM syndrome impair the stability of the T-cell immunologic synapse
Marinos Kallikourdis,Anna Elisa Trovato,Fabio Anselmi,Adelaida Sarukhan,Giuliana Roselli,Laura Tassone,Raffaele Badolato,Antonella Viola
View Articletitled, The CXCR4 mutations in WHIM syndrome impair the stability of the T-cell immunologic synapse
Supplemental data
CX3CR1 reduces Ly6Chigh-monocyte motility within and release from the bone marrow after chemotherapy in mice
Sébastien Jacquelin,Fabrice Licata,Karim Dorgham,Patricia Hermand,Lucie Poupel,Elodie Guyon,Philippe Deterre,David A. Hume,Christophe Combadière,Alexandre Boissonnas
View Articletitled, CX3CR1 reduces Ly6C<sup>high</sup>-monocyte motility within and release from the bone marrow after chemotherapy in mice
Supplemental data
Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells
Nathalie Fiegler,Sonja Textor,Annette Arnold,Alexander Rölle,Ina Oehme,Kai Breuhahn,Gerhard Moldenhauer,Mathias Witzens-Harig,Adelheid Cerwenka
View Articletitled, Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells
Supplemental data

LYMPHOID NEOPLASIA

β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL
Deepika Kaveri,Philippe Kastner,Doulaye Dembélé,Claus Nerlov,Susan Chan,Peggy Kirstetter
View Articletitled, β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL
Supplemental data
Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas
Paul E. Massa,Aida Paniccia,Ana Monegal,Ario de Marco,Maria Rescigno
View Articletitled, <em>Salmonella</em> engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas
Supplemental data
HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP10
Masahiko Takahashi,Masaya Higuchi,Grace Naswa Makokha,Hideaki Matsuki,Manami Yoshita,Yuetsu Tanaka,Masahiro Fujii
View Articletitled, HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP10
Supplemental data
A capture-sequencing strategy identifies IRF8, EBF1, and APRIL as novel IGH fusion partners in B-cell lymphoma
Hakim Bouamar,Saman Abbas,An-Ping Lin,Long Wang,Daifeng Jiang,Kenneth N. Holder,Marsha C. Kinney,Scott Hunicke-Smith,Ricardo C. T. Aguiar
View Articletitled, A capture-sequencing strategy identifies <em>IRF8</em>, <em>EBF1,</em> and <em>APRIL</em> as novel <em>IGH</em> fusion partners in B-cell lymphoma
Supplemental data
Lenalidomide induces long-lasting responses in elderly patients with chronic lymphocytic leukemia
Brief Report
Paolo Strati,Michael J. Keating,William G. Wierda,Xavier C. Badoux,Steliana Calin,James M. Reuben,Susan O’Brien,Steven M. Kornblau,Hagop M. Kantarjian,Hui Gao,Alessandra Ferrajoli
View Articletitled, Lenalidomide induces long-lasting responses in elderly patients with chronic lymphocytic leukemia

MYELOID NEOPLASIA

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription
Daniel Thomas,Jason A. Powell,Francois Vergez,David H. Segal,Nhu-Y. N. Nguyen,Adele Baker,Tse-Chieh Teh,Emma F. Barry,Jean-Emmanuel Sarry,Erwin M. Lee,Tracy L. Nero,Anissa M. Jabbour,Giovanna Pomilio,Benjamin D. Green,Stéphane Manenti,Stefan P. Glaser,Michael W. Parker,Angel F. Lopez,Paul G. Ekert,Richard B. Lock,David C. S. Huang,Susie K. Nilsson,Christian Récher,Andrew H. Wei,Mark A. Guthridge
View Articletitled, Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription
Supplemental data
Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment
Francis Mussai,Carmela De Santo,Issa Abu-Dayyeh,Sarah Booth,Lynn Quek,Rosanna M. McEwen-Smith,Amrana Qureshi,Francesco Dazzi,Paresh Vyas,Vincenzo Cerundolo
View Articletitled, Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment
Supplemental data
Lineage-inappropriate PAX5 expression in t(8;21) acute myeloid leukemia requires signaling-mediated abrogation of polycomb repression
Debleena Ray,So Yeon Kwon,Hiromi Tagoh,Olaf Heidenreich,Anetta Ptasinska,Constanze Bonifer
View Articletitled, Lineage-inappropriate <em>PAX5</em> expression in t(8;21) acute myeloid leukemia requires signaling-mediated abrogation of polycomb repression
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Matrix metalloproteinases modulate ameboid-like migration of neutrophils through inflamed interstitial tissue
Max Lerchenberger,Bernd Uhl,Konstantin Stark,Gabriele Zuchtriegel,Annekathrin Eckart,Meike Miller,Daniel Puhr-Westerheide,Marc Praetner,Markus Rehberg,Alexander G. Khandoga,Kirsten Lauber,Steffen Massberg,Fritz Krombach,Christoph A. Reichel
View Articletitled, Matrix metalloproteinases modulate ameboid-like migration of neutrophils through inflamed interstitial tissue
Supplemental data
Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice
Alfred D. Doyle,Elizabeth A. Jacobsen,Sergei I. Ochkur,Michael P. McGarry,Kevin G. Shim,David T. C. Nguyen,Cheryl Protheroe,Dana Colbert,Jake Kloeber,Joseph Neely,Kelly P. Shim,Kimberly D. Dyer,Helene F. Rosenberg,James J. Lee,Nancy A. Lee
View Articletitled, Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice
Supplemental data

PLATELETS AND THROMBOPOIESIS

Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P)
Lin Zhang,Nicole Urtz,Florian Gaertner,Kyle R. Legate,Tobias Petzold,Michael Lorenz,Alexandra Mazharian,Steve P. Watson,Steffen Massberg
View Articletitled, Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P)
Supplemental data
Quiescent complement in nonhuman primates during E coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy
Brief Report
Benjamin C. Lee,Chad L. Mayer,Caitlin S. Leibowitz,D. J. Stearns-Kurosawa,Shinichiro Kurosawa
View Articletitled, Quiescent complement in nonhuman primates during <em>E coli</em> Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy

THROMBOSIS AND HEMOSTASIS

Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3
Laurent Burnier,Laurent O. Mosnier
View Articletitled, Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3
Supplemental data
Antiphospholipid antibodies and the risk of recurrence after a first episode of venous thromboembolism: a systematic review
David Garcia,Elie A. Akl,Richard Carr,Clive Kearon
View Articletitled, Antiphospholipid antibodies and the risk of recurrence after a first episode of venous thromboembolism: a systematic review

TRANSPLANTATION

CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease
James M. Coghill,Kenneth A. Fowler,Michelle L. West,LeShara M. Fulton,Hendrik van Deventer,Karen P. McKinnon,Benjamin G. Vincent,Kaifeng Lin,Angela Panoskaltsis-Mortari,Donald N. Cook,Bruce R. Blazar,Jonathan S. Serody
View Articletitled, CC chemokine receptor 8 potentiates donor T<sub>reg</sub> survival and is critical for the prevention of murine graft-versus-host disease
Supplemental data
Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD
Brief Report
Simone Dertschnig,Gretel Nusspaumer,Robert Ivanek,Mathias M. Hauri-Hohl,Georg A. Holländer,Werner Krenger
View Articletitled, Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD
Supplemental data

VASCULAR BIOLOGY

Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children
Christopher A. Moxon,Samuel C. Wassmer,Danny A. Milner, Jr,Ngawina V. Chisala,Terrie E. Taylor,Karl B. Seydel,Malcolm E. Molyneux,Brian Faragher,Charles T. Esmon,Colin Downey,Cheng-Hock Toh,Alister G. Craig,Robert S. Heyderman
View Articletitled, Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children
Supplemental data
All Issues

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