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α-Ketoglutarate promotes amino acid depletion and suppresses B-cell lymphoma growth and development

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Carine Jaafar, Purushoth Ethiraj, Zhijun Qiu, An-Ping Lin, Pedro Simonis Seabra Martins Ferrari, Ricardo Aguiar
Journal: Blood
Blood blood.2024028069.
https://doi.org/10.1182/blood.2024028069
Published: 2025
Includes: Supplemental data
Journal Articles

Perturbation of Intermediary Metabolism Inhibits Glycolysis, Oxidative Phosphorylation, Amino Acid Synthesis and Prevents Lymphoma Development in Mice

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Purushoth Ethiraj, Carine Jaafar, An-Ping Lin, Zhijun Qiu, Ricardo Aguiar
Journal: Blood
Blood (2022) 140 (Supplement 1): 1694–1695.
https://doi.org/10.1182/blood-2022-160395
Published: 2022
Journal Articles

Alpha-Ketoglutarate Suppresses MYC and mTORC1 and Displays Anti-Lymphoma Activity

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Carine Jaafar, Purushoth Ethiraj, Zhijun Qiu, An-Ping Lin, Ricardo Aguiar
Journal: Blood
Blood (2022) 140 (Supplement 1): 2046–2047.
https://doi.org/10.1182/blood-2022-160374
Published: 2022
Journal Articles

A MYC Driven and Metabolite Executed Axis Controls the Subcellular Localization and Activity of TET DNA Hydroxylases and RNA Demethylases in B Cell Lymphomas

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Zhijun Qiu, PhD, An-Ping Lin, MD, Shoulei Jiang, PhD, Binu Sasi, PhD, Patricia Dahia, MD PhD, Siyuan Zheng, PhD, Ricardo Aguiar, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 114.
https://doi.org/10.1182/blood-2019-123101
Published: 2019
Journal Articles

Cyclic-AMP Is an Actionable Novel Regulator of PD-L1 Expression in Untransformed Lymphocytes and Diffuse Large B Cell Lymphomas

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Binu Sasi, PhD, Zhijun Qiu, PhD, Shoulei Jiang, PhD, An-Ping Lin, MD, Ricardo Aguiar, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3962.
https://doi.org/10.1182/blood-2019-123155
Published: 2019
Journal Articles

Mitochondrial Metabolism and RNA Methylation in DLBCL

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Sara Elkashef, PhD, An-Ping Lin, MD, Lilly Chiou, Jamie Myers, MSc, ZhiJun Qiu, PhD, Ricardo C.T. Aguiar, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2732.
https://doi.org/10.1182/blood.V130.Suppl_1.2732.2732
Published: 2017
Journal Articles

Synergism Between PDE4 and PI3Kδ Inhibitors in DLBCL: Improved Clinical Activity with the Potential for Lower Toxicity

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Jeffrey Cooney, Long Wang, MD, An-Ping Lin, MD, Daifeng Jiang, PhD, Avvaru Suhasini, PhD, Ricardo C Aguiar, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2938.
https://doi.org/10.1182/blood.V128.22.2938.2938
Published: 2016
Journal Articles

A Phosphodiesterase 4B-Mediated Interplay Between Tumor Cells and the Microenvironment Regulates Angiogenesis in B Cell Lymphoma

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Avvaru Suhasini, Long Wang, Kenneth Holder, An-Ping Lin, Sang-Woo Kim, Harshita Bhatnagar, August Moritz, Ricardo C Aguiar, MD PhD
Journal: Blood
Blood (2015) 126 (23): 463.
https://doi.org/10.1182/blood.V126.23.463.463
Published: 2015
Journal Articles

Heightened DNA Damage Response and p53 Activation In MiR-155 Null Cells Are Context Specific and Aid Dependent

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Hakim Bouamar, PhD, Long Wang, MD, Manoela Ortega, PhD, An-Ping Lin, MD, Daifeng Jiang, PhD, Ricardo Aguiar, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2279.
https://doi.org/10.1182/blood.V122.21.2279.2279
Published: 2013
Journal Articles

A capture-sequencing strategy identifies IRF8 , EBF1, and APRIL as novel IGH fusion partners in B-cell lymphoma

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Hakim Bouamar, Saman Abbas, An-Ping Lin, Long Wang, Daifeng Jiang, Kenneth N. Holder, Marsha C. Kinney, Scott Hunicke-Smith, Ricardo C. T. Aguiar
Journal: Blood
Blood (2013) 122 (5): 726–733.
https://doi.org/10.1182/blood-2013-04-495804
Published: 2013
Includes: Supplemental data