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Can CRd be a standard for refractory myeloma?
Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
EZH2 mutations are frequent and represent an early event in follicular lymphoma
Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients
High-resolution HLA matching in hematopoietic stem cell transplantation: a retrospective collaborative analysis
Issue Archive
October 31 2013
Table of Contents
INSIDE BLOOD
CLINICAL TRIALS & OBSERVATIONS
Can CRd be a standard for refractory myeloma?
Clinical Trials & Observations
BLOOD WORK
PLENARY PAPER
Hydroa vacciniforme-like lymphoma: a chronic EBV+ lymphoproliferative disorder with risk to develop a systemic lymphoma
Leticia Quintanilla-Martinez,Cecilia Ridaura,Florian Nagl,Marimar Sáez-de-Ocariz,Carola Durán-McKinster,Ramon Ruiz-Maldonado,Georgia Alderete,Peter Grube,Carmen Lome-Maldonado,Irina Bonzheim,Falko Fend
BLOOD FORUM
BLOOD SPOTLIGHT
CLINICAL TRIALS AND OBSERVATIONS
Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
Clinical Trials & Observations
Michael Wang,Tom Martin,William Bensinger,Melissa Alsina,David S. Siegel,Edward Kavalerchik,Mei Huang,Robert Z. Orlowski,Ruben Niesvizky
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY
T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia
Armen Mardiros,Cedric Dos Santos,Tinisha McDonald,Christine E. Brown,Xiuli Wang,L. Elizabeth Budde,Lauren Hoffman,Brenda Aguilar,Wen-Chung Chang,William Bretzlaff,Brenda Chang,Mahesh Jonnalagadda,Renate Starr,Julie R. Ostberg,Michael C. Jensen,Ravi Bhatia,Stephen J. Forman
LYMPHOID NEOPLASIA
EZH2 mutations are frequent and represent an early event in follicular lymphoma
Brief Report
Csaba Bödör,Vera Grossmann,Nikolay Popov,Jessica Okosun,Ciarán O’Riain,King Tan,Jacek Marzec,Shamzah Araf,Jun Wang,Abigail M. Lee,Andrew Clear,Silvia Montoto,Janet Matthews,Sameena Iqbal,Hajnalka Rajnai,Andreas Rosenwald,German Ott,Elias Campo,Lisa M. Rimsza,Erlend B. Smeland,Wing C. Chan,Rita M. Braziel,Louis M. Staudt,George Wright,T. Andrew Lister,Olivier Elemento,Robert Hills,John G. Gribben,Claude Chelala,András Matolcsy,Alexander Kohlmann,Torsten Haferlach,Randy D. Gascoyne,Jude Fitzgibbon
MYELOID NEOPLASIA
BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders
Frederik Damm,Virginie Chesnais,Yasunobu Nagata,Kenichi Yoshida,Laurianne Scourzic,Yusuke Okuno,Raphael Itzykson,Masashi Sanada,Yuichi Shiraishi,Véronique Gelsi-Boyer,Aline Renneville,Satoru Miyano,Hiraku Mori,Lee-Yung Shih,Sophie Park,François Dreyfus,Agnes Guerci-Bresler,Eric Solary,Christian Rose,Stéphane Cheze,Thomas Prébet,Norbert Vey,Marion Legentil,Yannis Duffourd,Stéphane de Botton,Claude Preudhomme,Daniel Birnbaum,Olivier A. Bernard,Seishi Ogawa,Michaela Fontenay,Olivier Kosmider
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOISIS
Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients
Clinical Trials & Observations
Brief Report
Asuka Hira,Hiromasa Yabe,Kenichi Yoshida,Yusuke Okuno,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Satoru Miyano,Jun Nakamura,Seiji Kojima,Seishi Ogawa,Keitaro Matsuo,Minoru Takata,Miharu Yabe
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
High-resolution HLA matching in hematopoietic stem cell transplantation: a retrospective collaborative analysis
Clinical Trials & Observations
Daniel Fürst,Carlheinz Müller,Vladan Vucinic,Donald Bunjes,Wolfgang Herr,Martin Gramatzki,Rainer Schwerdtfeger,Renate Arnold,Hermann Einsele,Gerald Wulf,Michael Pfreundschuh,Bertram Glass,Hubert Schrezenmeier,Klaus Schwarz,Joannis Mytilineos
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Cover Image
Cover Image
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In proplatelet-forming megakaryocytes lacking the small Rho GTPases Rac1 and Cdc42, tubulin is organized in thick bundles, which only partially colocalize with actin. Additionally, tubulin is virtually absent in most proplatelet tips, providing a possible explanation for the observed macrothrombocytopenia in the absence of Rac1 and Cdc42. The image shows fetal liver cell-derived megakaryocytes that were stained with an anti-tubulin antibody (green), phalloidin (red), and DAPI (blue). See the article by Pleines et al on page 3178.
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