Shimian Zou,for the NHLBI AIDS Blood Session Working Group,Simone Glynn,for the NHLBI AIDS Blood Session Working Group,Daniel Kuritzkes,for the NHLBI AIDS Blood Session Working Group,Monica Shah,for the NHLBI AIDS Blood Session Working Group,Nakela Cook,for the NHLBI AIDS Blood Session Working Group,Nancy Berliner,for the NHLBI AIDS Blood Session Working Group

View Articletitled, Hematopoietic cell transplantation and HIV cure: where we are and what next?

BLOOD SPOTLIGHT

Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation

Dominik Schneidawind,Antonio Pierini,Robert S. Negrin

View Articletitled, Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation

CLINICAL TRIALS AND OBSERVATIONS

Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
Clinical Trials & Observations

Michael Wang,Tom Martin,William Bensinger,Melissa Alsina,David S. Siegel,Edward Kavalerchik,Mei Huang,Robert Z. Orlowski,Ruben Niesvizky

View Articletitled, Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma

Supplemental data

HEMATOPOIESIS AND STEM CELLS

Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice

Alice M. S. Cheung,Long V. Nguyen,Annaick Carles,Philip Beer,Paul H. Miller,David J. H. F. Knapp,Kiran Dhillon,Martin Hirst,Connie J. Eaves

View Articletitled, Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice

Supplemental data

IMMUNOBIOLOGY

T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia

Armen Mardiros,Cedric Dos Santos,Tinisha McDonald,Christine E. Brown,Xiuli Wang,L. Elizabeth Budde,Lauren Hoffman,Brenda Aguilar,Wen-Chung Chang,William Bretzlaff,Brenda Chang,Mahesh Jonnalagadda,Renate Starr,Julie R. Ostberg,Michael C. Jensen,Ravi Bhatia,Stephen J. Forman

View Articletitled, T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia

Supplemental data

Transcriptional regulation of the Ikzf1 locus

Toshimi Yoshida,Esther Landhuis,Marei Dose,Idit Hazan,Jiangwen Zhang,Taku Naito,Audrey F. Jackson,Jeffrey Wu,Elizabeth A. Perotti,Christoph Kaufmann,Fotini Gounari,Bruce A. Morgan,Katia Georgopoulos

View Articletitled, Transcriptional regulation of the Ikzf1 locus

Supplemental data

Neutrophils mediate antibody-induced antitumor effects in mice
Brief Report

Marcello Albanesi,David A. Mancardi,Friederike Jönsson,Bruno Iannascoli,Laurence Fiette,James P. Di Santo,Clifford A. Lowell,Pierre Bruhns

View Articletitled, Neutrophils mediate antibody-induced antitumor effects in mice

Supplemental data

LYMPHOID NEOPLASIA

EZH2 mutations are frequent and represent an early event in follicular lymphoma
Brief Report

Csaba Bödör,Vera Grossmann,Nikolay Popov,Jessica Okosun,Ciarán O’Riain,King Tan,Jacek Marzec,Shamzah Araf,Jun Wang,Abigail M. Lee,Andrew Clear,Silvia Montoto,Janet Matthews,Sameena Iqbal,Hajnalka Rajnai,Andreas Rosenwald,German Ott,Elias Campo,Lisa M. Rimsza,Erlend B. Smeland,Wing C. Chan,Rita M. Braziel,Louis M. Staudt,George Wright,T. Andrew Lister,Olivier Elemento,Robert Hills,John G. Gribben,Claude Chelala,András Matolcsy,Alexander Kohlmann,Torsten Haferlach,Randy D. Gascoyne,Jude Fitzgibbon

View Articletitled, EZH2 mutations are frequent and represent an early event in follicular lymphoma

Supplemental data

MYELOID NEOPLASIA

BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders

Frederik Damm,Virginie Chesnais,Yasunobu Nagata,Kenichi Yoshida,Laurianne Scourzic,Yusuke Okuno,Raphael Itzykson,Masashi Sanada,Yuichi Shiraishi,Véronique Gelsi-Boyer,Aline Renneville,Satoru Miyano,Hiraku Mori,Lee-Yung Shih,Sophie Park,François Dreyfus,Agnes Guerci-Bresler,Eric Solary,Christian Rose,Stéphane Cheze,Thomas Prébet,Norbert Vey,Marion Legentil,Yannis Duffourd,Stéphane de Botton,Claude Preudhomme,Daniel Birnbaum,Olivier A. Bernard,Seishi Ogawa,Michaela Fontenay,Olivier Kosmider

View Articletitled, BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders

Supplemental data

PLATELETS AND THROMBOPOIESIS

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42

Irina Pleines,Sebastian Dütting,Deya Cherpokova,Anita Eckly,Imke Meyer,Martina Morowski,Georg Krohne,Harald Schulze,Christian Gachet,Najet Debili,Cord Brakebusch,Bernhard Nieswandt

View Articletitled, Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42

Supplemental data

Antithrombotic actions of statins involve PECAM-1 signaling

Leonardo A. Moraes,Sakthivel Vaiyapuri,Parvathy Sasikumar,Marfoua S. Ali,Neline Kriek,Tanya Sage,Jonathan M. Gibbins

View Articletitled, Antithrombotic actions of statins involve PECAM-1 signaling

Supplemental data

RED CELLS, IRON, AND ERYTHROPOISIS

FANCA and FANCC modulate TLR and p38 MAPK–dependent expression of IL-1β in macrophages

Michael R. Garbati,Laura E. Hays,Winifred Keeble,Jane E. Yates,R. Keaney Rathbun,Grover C. Bagby

View Articletitled, FANCA and FANCC modulate TLR and p38 MAPK–dependent expression of IL-1β in macrophages

Supplemental data

Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients
Clinical Trials & Observations Brief Report

Asuka Hira,Hiromasa Yabe,Kenichi Yoshida,Yusuke Okuno,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Satoru Miyano,Jun Nakamura,Seiji Kojima,Seishi Ogawa,Keitaro Matsuo,Minoru Takata,Miharu Yabe

View Articletitled, Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients

Supplemental data

THROMBOSIS AND HEMOSTASIS

Protein S levels and the risk of venous thrombosis: results from the MEGA case-control study

Maria Carolina Pintao,Daniel D. Ribeiro,Irene D. Bezemer,Andrea A. Garcia,Marieke C. H. de Visser,Carine J. M. Doggen,Willem M. Lijfering,Pieter H. Reitsma,Frits R. Rosendaal

View Articletitled, Protein S levels and the risk of venous thrombosis: results from the MEGA case-control study

TRANSPLANTATION

High-resolution HLA matching in hematopoietic stem cell transplantation: a retrospective collaborative analysis
Clinical Trials & Observations

Daniel Fürst,Carlheinz Müller,Vladan Vucinic,Donald Bunjes,Wolfgang Herr,Martin Gramatzki,Rainer Schwerdtfeger,Renate Arnold,Hermann Einsele,Gerald Wulf,Michael Pfreundschuh,Bertram Glass,Hubert Schrezenmeier,Klaus Schwarz,Joannis Mytilineos

View Articletitled, High-resolution HLA matching in hematopoietic stem cell transplantation: a retrospective collaborative analysis

Effector T cells require fatty acid metabolism during murine graft-versus-host disease

Craig A. Byersdorfer,Victor Tkachev,Anthony W. Opipari,Stefanie Goodell,Jacob Swanson,Stacy Sandquist,Gary D. Glick,James L. M. Ferrara

View Articletitled, Effector T cells require fatty acid metabolism during murine graft-versus-host disease

Supplemental data

Cover Image

Cover Image

In proplatelet-forming megakaryocytes lacking the small Rho GTPases Rac1 and Cdc42, tubulin is organized in thick bundles, which only partially colocalize with actin. Additionally, tubulin is virtually absent in most proplatelet tips, providing a possible explanation for the observed macrothrombocytopenia in the absence of Rac1 and Cdc42. The image shows fetal liver cell-derived megakaryocytes that were stained with an anti-tubulin antibody (green), phalloidin (red), and DAPI (blue). See the article by Pleines et al on page 3178.
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Table of Contents

INSIDE BLOOD

Can CRd be a standard for refractory myeloma? Clinical Trials & Observations

BLOOD WORK

PLENARY PAPER

BLOOD FORUM

BLOOD SPOTLIGHT

CLINICAL TRIALS AND OBSERVATIONS

Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

IMMUNOBIOLOGY

Neutrophils mediate antibody-induced antitumor effects in mice Brief Report

LYMPHOID NEOPLASIA

EZH2 mutations are frequent and represent an early event in follicular lymphoma Brief Report

MYELOID NEOPLASIA

PLATELETS AND THROMBOPOIESIS

RED CELLS, IRON, AND ERYTHROPOISIS

Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients Clinical Trials & Observations Brief Report

THROMBOSIS AND HEMOSTASIS

TRANSPLANTATION

High-resolution HLA matching in hematopoietic stem cell transplantation: a retrospective collaborative analysis Clinical Trials & Observations

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This Feature Is Available To Subscribers Only

Can CRd be a standard for refractory myeloma?
Clinical Trials & Observations

Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
Clinical Trials & Observations

Neutrophils mediate antibody-induced antitumor effects in mice
Brief Report

EZH2 mutations are frequent and represent an early event in follicular lymphoma
Brief Report

Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients
Clinical Trials & Observations Brief Report

High-resolution HLA matching in hematopoietic stem cell transplantation: a retrospective collaborative analysis
Clinical Trials & Observations