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Issue Archive

Volume 119, Issue 18
May 3 2012
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS
Off-targeting oft-targeted CD20 in cHL
Leo I. Gordon,Richard Longnecker
View Articletitled, Off-targeting oft-targeted CD20 in cHL
GENE THERAPY
The power and pitfalls of IL-12
Sid P. Kerkar,Nicholas P. Restifo
View Articletitled, The power and pitfalls of IL-12
PLATELETS & THROMBOPOIESIS
Death-defying apoptotic caspases in thrombopoiesis
Alan B. Cantor
View Articletitled, Death-defying apoptotic caspases in thrombopoiesis

Blood Work

Platelet satellitism as a cause of spurious thrombocytopenia
Ravi K. Bobba,Donald C. Doll
View Articletitled, Platelet satellitism as a cause of spurious thrombocytopenia

Perspectives

Risk categories and refractory CLL in the era of chemoimmunotherapy
Thorsten Zenz,John G. Gribben,Michael Hallek,Hartmut Döhner,Michael J. Keating,Stephan Stilgenbauer
View Articletitled, Risk categories and refractory CLL in the era of chemoimmunotherapy

How I treat

How we choose factor VIII to treat hemophilia
Pier Mannuccio Mannucci,Maria Elisa Mancuso,Elena Santagostino
View Articletitled, How we choose factor VIII to treat hemophilia

Clinical Trials and Observations

Identification of an active, well-tolerated dose of pralatrexate in patients with relapsed or refractory cutaneous T-cell lymphoma
Clinical Trials & Observations
Steven M. Horwitz,Youn H. Kim,Francine Foss,Jasmine M. Zain,Patricia L. Myskowski,Mary Jo Lechowicz,David C. Fisher,Andrei R. Shustov,Nancy L. Bartlett,Maria L. Delioukina,Tony Koutsoukos,Michael E. Saunders,Owen A. O'Connor,Madeleine Duvic
View Articletitled, Identification of an active, well-tolerated dose of pralatrexate in patients with relapsed or refractory cutaneous T-cell lymphoma
Phase 2 study of rituximab plus ABVD in patients with newly diagnosed classical Hodgkin lymphoma
Clinical Trials & Observations
Anas Younes,Yasuhiro Oki,Peter McLaughlin,Amanda R. Copeland,Andre Goy,Barbara Pro,Lei Feng,Ying Yuan,Hubert H. Chuang,Homer A. Macapinlac,Fredrick Hagemeister,Jorge Romaguera,Felipe Samaniego,Michelle A. Fanale,Bouthaina Shbib Dabaja,Maria A. Rodriguez,Nam Dang,Larry W. Kwak,Sattva S. Neelapu,Luis E. Fayad
View Articletitled, Phase 2 study of rituximab plus ABVD in patients with newly diagnosed classical Hodgkin lymphoma
Supplemental data
Phase 2 study of rituximab-ABVD in classical Hodgkin lymphoma
Brief Report
Yvette L. Kasamon,Heather A. Jacene,Christopher D. Gocke,Lode J. Swinnen,Douglas E. Gladstone,Brandy Perkins,Brian K. Link,Leslie L. Popplewell,Thomas M. Habermann,Joseph M. Herman,William H. Matsui,Richard J. Jones,Richard F. Ambinder
View Articletitled, Phase 2 study of rituximab-ABVD in classical Hodgkin lymphoma
BCR-ABL1 doubling times more reliably assess the dynamics of CML relapse compared with the BCR-ABL1 fold rise: implications for monitoring and management
Clinical Trials & Observations
Susan Branford,David T. Yeung,Jodi A. Prime,Soo-Young Choi,Ju-hee Bang,Jin Eok Park,Dong-Wook Kim,David M. Ross,Timothy P. Hughes
View Articletitled, <em>BCR-ABL1</em> doubling times more reliably assess the dynamics of CML relapse compared with the <em>BCR-ABL1</em> fold rise: implications for monitoring and management
Supplemental data

Gene Therapy

Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
Hollie J. Pegram,James C. Lee,Erik G. Hayman,Gavin H. Imperato,Thomas F. Tedder,Michel Sadelain,Renier J. Brentjens
View Articletitled, Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
Supplemental data

Hematopoiesis and Stem Cells

The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters
Wei Du,Reena Rani,Jared Sipple,Jonathan Schick,Kasiani C. Myers,Parinda Mehta,Paul R. Andreassen,Stella M. Davies,Qishen Pang
View Articletitled, The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters
Supplemental data
Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells
Katharina Ross,Anna K. Sedello,Gabriele Putz Todd,Maciej Paszkowski-Rogacz,Alexander W. Bird,Li Ding,Tatyana Grinenko,Kira Behrens,Nina Hubner,Matthias Mann,Claudia Waskow,Carol Stocking,Frank Buchholz
View Articletitled, Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells
Supplemental data
Salidroside stimulates DNA repair enzyme Parp-1 activity in mouse HSC maintenance
Xue Li,Jared Sipple,Qishen Pang,Wei Du
View Articletitled, Salidroside stimulates DNA repair enzyme Parp-1 activity in mouse HSC maintenance
Supplemental data

Immunobiology

The Ets-1 transcription factor is required for Stat1-mediated T-bet expression and IgG2a class switching in mouse B cells
Hai Vu Nguyen,Enguerran Mouly,Karine Chemin,Romain Luinaud,Raymonde Despres,Jean-Paul Fermand,Bertrand Arnulf,Jean-Christophe Bories
View Articletitled, The Ets-1 transcription factor is required for Stat1-mediated T-bet expression and IgG2a class switching in mouse B cells
Supplemental data
A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function
Lubka T. Roumenina,Marie Frimat,Elizabeth C. Miller,Francois Provot,Marie-Agnes Dragon-Durey,Pauline Bordereau,Sylvain Bigot,Christophe Hue,Simon C. Satchell,Peter W. Mathieson,Christiane Mousson,Christian Noel,Catherine Sautes-Fridman,Lise Halbwachs-Mecarelli,John P. Atkinson,Arnaud Lionet,Veronique Fremeaux-Bacchi
View Articletitled, A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function
Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection
Shokrollah Elahi,Toshiro Niki,Mitsuomi Hirashima,Helen Horton
View Articletitled, Galectin-9 binding to Tim-3 renders activated human CD4<sup>+</sup> T cells less susceptible to HIV-1 infection
Supplemental data

Lymphoid Neoplasia

Expression of XBP1s in bone marrow stromal cells is critical for myeloma cell growth and osteoclast formation
Guoshuang Xu,Kai Liu,Judy Anderson,Kenneth Patrene,Suzanne Lentzsch,G. David Roodman,Hongjiao Ouyang
View Articletitled, Expression of XBP1s in bone marrow stromal cells is critical for myeloma cell growth and osteoclast formation
Supplemental data
Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma
Lina Nygren,Stefanie Baumgartner Wennerholm,Monika Klimkowska,Birger Christensson,Eva Kimby,Birgitta Sander
View Articletitled, Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma
Leukemia-initiating cells of patient-derived acute lymphoblastic leukemia xenografts are sensitive toward TRAIL
Brief Report
Catarina Castro Alves,Nadia Terziyska,Michaela Grunert,Sibylle Gündisch,Ulrike Graubner,Leticia Quintanilla-Martinez,Irmela Jeremias
View Articletitled, Leukemia-initiating cells of patient-derived acute lymphoblastic leukemia xenografts are sensitive toward TRAIL
Supplemental data

Myeloid Neoplasia

Cotargeting signaling pathways driving survival and cell cycle circumvents resistance to Kit inhibitors in leukemia
Dorothée Buet,Isabelle Gallais,Evelyne Lauret,Nicole Denis,Bérangère Lombard,François Guillonneau,Olivier Kosmider,Damarys Loew,Isabelle Dusanter-Fourt,Christel Guillouf,Patrick Mayeux,Françoise Moreau-Gachelin
View Articletitled, Cotargeting signaling pathways driving survival and cell cycle circumvents resistance to Kit inhibitors in leukemia
Supplemental data
5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS-demethylation and FAS re-expression, and synergism with FAS-ligand
Viviane Ghanim,Harald Herrmann,Gerwin Heller,Barbara Peter,Emir Hadzijusufovic,Katharina Blatt,Karina Schuch,Sabine Cerny-Reiterer,Irina Mirkina,Heidrun Karlic,Winfried F. Pickl,Sabine Zöchbauer-Müller,Peter Valent
View Articletitled, 5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of <em>FAS-</em>demethylation and FAS re-expression, and synergism with FAS-ligand
Supplemental data
Rac2-MRC-cIII–generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors
Margaret Nieborowska-Skorska,Piotr K. Kopinski,Regina Ray,Grazyna Hoser,Danielle Ngaba,Sylwia Flis,Kimberly Cramer,Mamatha M. Reddy,Mateusz Koptyra,Tyrone Penserga,Eliza Glodkowska-Mrowka,Elisabeth Bolton,Tessa L. Holyoake,Connie J. Eaves,Sabine Cerny-Reiterer,Peter Valent,Andreas Hochhaus,Timothy P. Hughes,Heiko van der Kuip,Martin Sattler,Wieslaw Wiktor-Jedrzejczak,Christine Richardson,Adrienne Dorrance,Tomasz Stoklosa,David A. Williams,Tomasz Skorski
View Articletitled, Rac2-MRC-cIII–generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors
Supplemental data
Mitochondrial myopathy caused by arsenic trioxide therapy
Brief Report
Andoni Echaniz-Laguna,Aurélien Benoilid,Stéphane Vinzio,Luc-Matthieu Fornecker,Béatrice Lannes,Jean-Pierre Goullé,Frank Broly,Bénédicte Mousson de Camaret
View Articletitled, Mitochondrial myopathy caused by arsenic trioxide therapy
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation
Craig T. Lefort,Jan Rossaint,Markus Moser,Brian G. Petrich,Alexander Zarbock,Susan J. Monkley,David R. Critchley,Mark H. Ginsberg,Reinhard Fässler,Klaus Ley
View Articletitled, Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation
Supplemental data

Platelets and Thrombopoiesis

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function
Michael J. White,Simone M. Schoenwaelder,Emma C. Josefsson,Kate E. Jarman,Katya J. Henley,Chloé James,Marlyse A. Debrincat,Shaun P. Jackson,David C. S. Huang,Benjamin T. Kile
View Articletitled, Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function
Supplemental data

Red Cells, Iron, and Erythropoiesis

The DEAH-box helicase RHAU is an essential gene and critical for mouse hematopoiesis
Janice Ching Lai,Svetlana Ponti,Dejing Pan,Hubertus Kohler,Radek C. Skoda,Patrick Matthias,Yoshikuni Nagamine
View Articletitled, The DEAH-box helicase <em>RHAU</em> is an essential gene and critical for mouse hematopoiesis
Supplemental data

Thrombosis and Hemostasis

Digestive vacuole of Plasmodium falciparum released during erythrocyte rupture dually activates complement and coagulation
Prasad Dasari,Sophia D. Heber,Maike Beisele,Michael Torzewski,Kurt Reifenberg,Carolin Orning,Anja Fries,Anna-Lena Zapf,Stefan Baumeister,Klaus Lingelbach,Rachanee Udomsangpetch,Sebastian Chakrit Bhakdi,Karina Reiss,Sucharit Bhakdi
View Articletitled, Digestive vacuole of <em>Plasmodium falciparum</em> released during erythrocyte rupture dually activates complement and coagulation
Supplemental data
Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels
Mohammad Al-Tamimi,Chee Wee Tan,Jianlin Qiao,Gabrielle J. Pennings,Ashkan Javadzadegan,Andy S. C. Yong,Jane F. Arthur,Amanda K. Davis,Jing Jing,Fi-Tjen Mu,Justin R. Hamilton,Shaun P. Jackson,Andreas Ludwig,Michael C. Berndt,Christopher M. Ward,Leonard Kritharides,Robert K. Andrews,Elizabeth E. Gardiner
View Articletitled, Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels

Vascular Biology

Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome)
Zhihui Xie,Chandra C. Ghosh,Roshni Patel,Shoko Iwaki,Donna Gaskins,Celeste Nelson,Nina Jones,Philip R. Greipp,Samir M. Parikh,Kirk M. Druey
View Articletitled, Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome)
Supplemental data

Correspondence

Is targeting of CD47-SIRPα enough for treating hematopoietic malignancy?
Xi Wen Zhao,Taco W. Kuijpers,Timo K. van den Berg
View Articletitled, Is targeting of CD47-SIRPα enough for treating hematopoietic malignancy?
Response: mechanisms of targeting CD47-SIRPα in hematologic malignancies
Mark P. Chao,Ravindra Majeti,Irving Weissman
View Articletitled, Response: mechanisms of targeting CD47-SIRPα in hematologic malignancies
Improved classification of MLL-AF9–positive acute myeloid leukemia patients based on BRE and EVI1 expression
Sylvie M. Noordermeer,Davide Monteferrario,Mathijs A. Sanders,Lars Bullinger,Joop H. Jansen,Bert A. van der Reijden
View Articletitled, Improved classification of <em>MLL-AF9</em>–positive acute myeloid leukemia patients based on <em>BRE</em> and <em>EVI1</em> expression
Supplemental data
Bcl-xL–inhibitory BH3 mimetic ABT-737 depletes platelet calcium stores
Matthew T. Harper,Alastair W. Poole
View Articletitled, Bcl-x<sub>L</sub>–inhibitory BH3 mimetic ABT-737 depletes platelet calcium stores
Platelet tissue factor is not expressed transiently after platelet activation
Beth A. Bouchard,Jolanta Krudysz-Amblo,Saulius Butenas
View Articletitled, Platelet tissue factor is not expressed transiently after platelet activation
Response: functionally active platelets do express tissue factor
Marina Camera,Marta Brambilla,Daniela Boselli,Laura Facchinetti,Paola Canzano,Laura Rossetti,Vincenzo Toschi,Elena Tremoli
View Articletitled, Response: functionally active platelets do express tissue factor
All Issues

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