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Volume 116, Issue 6
August 12 2010
Issue Cover

Table of Contents

Inside Blood

INSIDE BLOOD
CLL 17p deletion: more than ‘miR’ly p53?
Thorsten Zenz,Stephan Stilgenbauer
View Articletitled, CLL 17p deletion: more than ‘miR’ly p53?
CLINICAL TRIALS
The substrate is down: is the IV out?
Jeff Szer
View Articletitled, The substrate is down: is the IV out?
INSIDE BLOOD
Discovery of Hippo in MCL
Rebecca Auer
View Articletitled, Discovery of Hippo in MCL
MYELOID NEOPLASIA
Another Lnk to STAT activation
Kevin D. Bunting
View Articletitled, Another Lnk to STAT activation
PLATELETS & THROMBOPOIESIS
A Munc in the platelet granule works
Michael S. Marks
View Articletitled, A Munc in the platelet granule works

Editorial

Enhancing research in regenerative medicine
David A. Williams,Armand Keating
View Articletitled, Enhancing research in regenerative medicine
Supplemental data

Plenary Paper

PLATELETS AND THROMBOPOIESIS
Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis
Qiansheng Ren,Christian Wimmer,Michael C. Chicka,Shaojing Ye,Yi Ren,Frederick M. Hughson,Sidney W. Whiteheart
View Articletitled, Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis
Supplemental data

Perspectives

Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences
Ton Lisman,Robert J. Porte
View Articletitled, Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences

Clinical Trials and Observations

Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia
Clinical Trials & Observations
Kumudha Balakrishnan,Dushyant Verma,Susan O'Brien,John Michael Kilpatrick,Yuling Chen,Brenita F. Tyler,Susan Bickel,Shanta Bantia,Michael J. Keating,Hagop Kantarjian,Varsha Gandhi,Farhad Ravandi
View Articletitled, Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia

Gene therapy

A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells
Sheng Zhou,Disha Mody,Suk See DeRavin,Julia Hauer,Taihe Lu,Zhijun Ma,Salima Hacein-Bey Abina,John T. Gray,Michael R. Greene,Marina Cavazzana-Calvo,Harry L. Malech,Brian P. Sorrentino
View Articletitled, A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells
Supplemental data

Hematopoiesis and Stem Cells

Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells
Enid Yi Ni Lam,Christopher J. Hall,Philip S. Crosier,Kathryn E. Crosier,Maria Vega Flores
View Articletitled, Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells
Supplemental data

Immunobiology

Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing
Rémy T. Boscacci,Friederike Pfeiffer,Kathrin Gollmer,Ana Isabel Checa Sevilla,Ana Maria Martin,Silvia Fernandez Soriano,Daniela Natale,Sarah Henrickson,Ulrich H. von Andrian,Yoshinori Fukui,Mario Mellado,Urban Deutsch,Britta Engelhardt,Jens V. Stein
View Articletitled, Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing
Supplemental data
Long-lasting antitumor protection by anti-CD20 antibody through cellular immune response
Riad Abès,Emmanuelle Gélizé,Wolf Herman Fridman,Jean-Luc Teillaud
View Articletitled, Long-lasting antitumor protection by anti-CD20 antibody through cellular immune response
Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10–dependent ILT4/HLA-G pathway
Silvia Gregori,Daniela Tomasoni,Valentina Pacciani,Miriam Scirpoli,Manuela Battaglia,Chiara Francesca Magnani,Ehud Hauben,Maria-Grazia Roncarolo
View Articletitled, Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10–dependent ILT4/HLA-G pathway
Supplemental data

Lymphoid Neoplasia

microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival
Simona Rossi,Masayoshi Shimizu,Elisa Barbarotto,Milena S. Nicoloso,Federica Dimitri,Deepa Sampath,Muller Fabbri,Susan Lerner,Lynn L. Barron,Laura Z. Rassenti,Li Jiang,Lianchun Xiao,Jianhua Hu,Paola Secchiero,Giorgio Zauli,Stefano Volinia,Massimo Negrini,William Wierda,Thomas J. Kipps,William Plunkett,Kevin R. Coombes,Lynne V. Abruzzo,Michael J. Keating,George A. Calin
View Articletitled, microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a <em>miR-21</em> score that stratifies early survival
Supplemental data
Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling
Elena M. Hartmann,Elias Campo,George Wright,Georg Lenz,Itziar Salaverria,Pedro Jares,Wenming Xiao,Rita M. Braziel,Lisa M. Rimsza,Wing-Chung Chan,Dennis D. Weisenburger,Jan Delabie,Elaine S. Jaffe,Randy D. Gascoyne,Sandeep S. Dave,Hans-Konrad Mueller-Hermelink,Louis M. Staudt,German Ott,Sílvia Beà,Andreas Rosenwald
View Articletitled, Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling
Supplemental data
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)
Kinuko Hirose,Takeshi Inukai,Jiro Kikuchi,Yusuke Furukawa,Tomokatsu Ikawa,Hiroshi Kawamoto,S. Helen Oram,Berthold Göttgens,Nobutaka Kiyokawa,Yoshitaka Miyagawa,Hajime Okita,Koshi Akahane,Xiaochun Zhang,Itaru Kuroda,Hiroko Honna,Keiko Kagami,Kumiko Goi,Hidemitsu Kurosawa,A. Thomas Look,Hirotaka Matsui,Toshiya Inaba,Kanji Sugita
View Articletitled, Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)
Supplemental data

Myeloid Neoplasia

A novel prognostic model in elderly patients with acute myeloid leukemia: results of 909 patients entered into the prospective AML96 trial
Clinical Trials & Observations
Christoph Röllig,Christian Thiede,Martin Gramatzki,Walter Aulitzky,Heinrich Bodenstein,Martin Bornhäuser,Uwe Platzbecker,Reingard Stuhlmann,Ulrich Schuler,Silke Soucek,Michael Kramer,Brigitte Mohr,Uta Oelschlaegel,Friedrich Stölzel,Malte von Bonin,Martin Wermke,Hannes Wandt,Gerhard Ehninger,Markus Schaich,for the Study Alliance Leukemia
View Articletitled, A novel prognostic model in elderly patients with acute myeloid leukemia: results of 909 patients entered into the prospective AML96 trial
Myeloid-specific inactivation of p15Ink4b results in monocytosis and predisposition to myeloid leukemia
Juraj Bies,Marek Sramko,Joanna Fares,Michael Rosu-Myles,Steven Zhang,Richard Koller,Linda Wolff
View Articletitled, Myeloid-specific inactivation of <em>p15Ink4b</em> results in monocytosis and predisposition to myeloid leukemia
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

A phase 2 study of eliglustat tartrate (Genz-112638), an oral substrate reduction therapy for Gaucher disease type 1
Clinical Trials & Observations
Elena Lukina,Nora Watman,Elsa Avila Arreguin,Maryam Banikazemi,Marta Dragosky,Marcelo Iastrebner,Hanna Rosenbaum,Mici Phillips,Gregory M. Pastores,Daniel I. Rosenthal,Mathilde Kaper,Tejdip Singh,Ana Cristina Puga,Peter L. Bonate,M. Judith Peterschmitt
View Articletitled, A phase 2 study of eliglustat tartrate (Genz-112638), an oral substrate reduction therapy for Gaucher disease type 1

Platelets and Thrombopoiesis

Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
Brief Report
Stephen T. Oh,Erin F. Simonds,Carol Jones,Matthew B. Hale,Yury Goltsev,Kenneth D. Gibbs, Jr,Jason D. Merker,James L. Zehnder,Garry P. Nolan,Jason Gotlib
View Articletitled, Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
Supplemental data

Thrombosis and Hemostasis

Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis
Robert Silasi-Mansat,Hua Zhu,Narcis I. Popescu,Glenn Peer,Georgia Sfyroera,Paola Magotti,Lacramioara Ivanciu,Cristina Lupu,Tom E. Mollnes,Fletcher B. Taylor,Gary Kinasewitz,John D. Lambris,Florea Lupu
View Articletitled, Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of <em>Escherichia coli</em> sepsis
Supplemental data

Vascular Biology

Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure
Narcis I. Popescu,Cristina Lupu,Florea Lupu
View Articletitled, Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure
Supplemental data

Correspondence

Population-based analyses in adult acute lymphoblastic leukemia
Gunnar Juliusson,Karin Karlsson,Helen Hallböök
View Articletitled, Population-based analyses in adult acute lymphoblastic leukemia
Response: Age- and sex-adjusted incidence rates of adults with acute lymphoblastic leukemia (ALL) in the northern part of England
Anthony V. Moorman,Lucy Chilton,Jennifer Wilkinson,Hannah M. Ensor,Nick Bown,Stephen J. Proctor
View Articletitled, Response: Age- and sex-adjusted incidence rates of adults with acute lymphoblastic leukemia (ALL) in the northern part of England
Independently acquired biallelic JAK2 mutations are present in a minority of patients with essential thrombocythemia
Philip A. Beer,Christina A. Ortmann,Peter J. Campbell,Anthony R. Green
View Articletitled, Independently acquired biallelic <em>JAK2</em> mutations are present in a minority of patients with essential thrombocythemia
Poor outcome after reintroduction of imatinib in patients with chronic myeloid leukemia who interrupt therapy on account of pregnancy without having achieved an optimal response
Aya Kuwabara,Anna Babb,Amr Ibrahim,Dragana Milojkovic,Jane Apperley,Marco Bua,Alistair Reid,Letizia Foroni,Katayoun Rezvani,John Goldman,David Marin
View Articletitled, Poor outcome after reintroduction of imatinib in patients with chronic myeloid leukemia who interrupt therapy on account of pregnancy without having achieved an optimal response

Errata

Moorman AV, Chilton L, Wilkinson J, Ensor HM, Bown N, Proctor SJ. A population-based cytogenetic study of adults with acute lymphoblastic leukemia. Blood. 2010;115(2):206–214.
View Articletitled, Moorman AV, Chilton L, Wilkinson J, Ensor HM, Bown N, Proctor SJ. A population-based cytogenetic study of adults with acute lymphoblastic leukemia. <em>Blood</em>. 2010;115(2):<span class="related-article">206–214</span>.
Falini B, Macijewski K, Weiss T, et al. Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1). Blood. 2010;115(18):3776–3786.
View Articletitled, Falini B, Macijewski K, Weiss T, et al. Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (<em>NPM1</em>). <em>Blood</em>. 2010;115(18):<span class="related-article">3776–3786</span>.
Mahadeo KM, Cole PD. Successful treatment using omacetaxine for a patient with CML and BCR-ABL2 35INS [letter]. Blood. 2010;115(18):3852.
View Articletitled, Mahadeo KM, Cole PD. Successful treatment using omacetaxine for a patient with CML and BCR-ABL2 35INS [letter]. <em>Blood</em>. 2010;115(18):<span class="related-article">3852</span>.
  • Cover Image

    Cover Image

    issue cover

    Visualization of T-cell extravasation into lymphoid tissue. The image shows an immunofluorescent section of transmigrated T cells (red) entering a mouse peripheral lymph node through high endothelial venules (HEVs; pink) shortly after adoptive transfer. Transferred cells are in close proximity to the laminin-positive basement membrane (blue) surrounding HEVs. The observed perivascular entrapment of transferred T cells is consistent with a transient decrease in T-cell motility shortly after transmigration as observed via dynamic twophoton microscopy imaging. See the article by Boscacci et al on page 915.

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