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Issue Archive

Volume 113, Issue 14
April 2 2009
Issue Cover

Table of Contents

INSIDE BLOOD

CLINICAL TRIALS
A Syk inhibitor for sick platelets?
Donna S. Woulfe
View Articletitled, A Syk inhibitor for sick platelets?
PLATELETS & THROMBOPOIESIS
The VWD2B saga continues to Montreal
Paquita Nurden
View Articletitled, The VWD2B saga continues to Montreal
TRANSPLANTATION
Reduced-intensity allogeneic transplantation for myeloma: reality bites
A. Keith Stewart
View Articletitled, Reduced-intensity allogeneic transplantation for myeloma: reality bites

BLOOD WORK

Backache and breast cancer
View Articletitled, Backache and breast cancer

REVIEW ARTICLES

Regulation of macrophage function in tumors: the multifaceted role of NF-κB
Thorsten Hagemann,Subhra K. Biswas,Toby Lawrence,Antonio Sica,Claire E. Lewis
View Articletitled, Regulation of macrophage function in tumors: the multifaceted role of NF-κB

HOW I TREAT

How I treat and monitor viral hepatitis B infection in patients receiving intensive immunosuppressive therapies or undergoing hematopoietic stem cell transplantation
Raymond Liang
View Articletitled, How I treat and monitor viral hepatitis B infection in patients receiving intensive immunosuppressive therapies or undergoing hematopoietic stem cell transplantation

CLINICAL TRIALS AND OBSERVATIONS

Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk
Clinical Trials & Observations
Anna Podolanczuk,Alan H. Lazarus,Andrew R. Crow,Elliot Grossbard,James B. Bussel
View Articletitled, Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk
Supplemental data
Bone marrow angiogenesis magnetic resonance imaging in patients with acute myeloid leukemia: peak enhancement ratio is an independent predictor for overall survival
Clinical Trials & Observations
Tiffany Ting-Fang Shih,Hsin-An Hou,Chieh-Yu Liu,Bang-Bin Chen,Jih-Luh Tang,Hsuan-Yu Chen,Shwu-Yuan Wei,Ming Yao,Shang-Yi Huang,Wen-Chien Chou,Szu-Chun Hsu,Woei Tsay,Chih-Wei Yu,Chao-Yu Hsu,Hwei-Fang Tien,Pan-Chyr Yang
View Articletitled, Bone marrow angiogenesis magnetic resonance imaging in patients with acute myeloid leukemia: peak enhancement ratio is an independent predictor for overall survival
Relevance of the immunoglobulin VH somatic mutation status in patients with chronic lymphocytic leukemia treated with fludarabine, cyclophosphamide, and rituximab (FCR) or related chemoimmunotherapy regimens
Brief Report
Katherine I. Lin,Constantine S. Tam,Michael J. Keating,William G. Wierda,Susan O'Brien,Susan Lerner,Kevin R. Coombes,Ellen Schlette,Alessandra Ferrajoli,Lynn L. Barron,Thomas J. Kipps,Laura Rassenti,Stefan Faderl,Hagop Kantarjian,Lynne V. Abruzzo
View Articletitled, Relevance of the <em>immunoglobulin V<sub>H</sub></em> somatic mutation status in patients with chronic lymphocytic leukemia treated with fludarabine, cyclophosphamide, and rituximab (FCR) or related chemoimmunotherapy regimens

HEMATOPOIESIS AND STEM CELLS

Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
Frédéric Pendino,Eric Nguyen,Inge Jonassen,Bjarte Dysvik,Abdulkader Azouz,Michel Lanotte,Evelyne Ségal-Bendirdjian,Johan R. Lillehaug
View Articletitled, Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
Supplemental data
Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation
Anita Eckly,Catherine Strassel,Monique Freund,Jean-Pierre Cazenave,François Lanza,Christian Gachet,Catherine Léon
View Articletitled, Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted <em>MYH9</em> inactivation
Supplemental data

IMMUNOBIOLOGY

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease
Irah L. King,Travis L. Dickendesher,Benjamin M. Segal
View Articletitled, Circulating Ly-6C<sup>+</sup> myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease
Supplemental data
p85β phosphoinositide 3-kinase regulates CD28 coreceptor function
Isabela Alcázar,Isabel Cortés,Angel Zaballos,Carmen Hernandez,David A. Fruman,Domingo F. Barber,Ana C. Carrera
View Articletitled, p85β phosphoinositide 3-kinase regulates CD28 coreceptor function
Identification of a particular HIV-specific CD8+ T-cell subset with a CD27+ CD45RO−/RA+ phenotype and memory characteristics after initiation of HAART during acute primary HIV infection
Camille Lécuroux,Isabelle Girault,Alejandra Urrutia,Jean-Marc Doisne,Christiane Deveau,Cécile Goujard,Laurence Meyer,Martine Sinet,Alain Venet
View Articletitled, Identification of a particular HIV-specific CD8<sup>+</sup> T-cell subset with a CD27<sup>+</sup> CD45RO<sup>−</sup>/RA<sup>+</sup> phenotype and memory characteristics after initiation of HAART during acute primary HIV infection
Supplemental data
Activin-A attenuates several human natural killer cell functions
Neil C. Robson,Heng Wei,Tristan McAlpine,Naomi Kirkpatrick,Jonathan Cebon,Eugene Maraskovsky
View Articletitled, Activin-A attenuates several human natural killer cell functions
Supplemental data
A critical role for DAP10 and DAP12 in CD8+ T cell–mediated tissue damage in large granular lymphocyte leukemia
Xianghong Chen,Fanqi Bai,Lubomir Sokol,Junmin Zhou,Amy Ren,Jeffrey S. Painter,Jinhong Liu,David A. Sallman,Y. Ann Chen,Jeffrey A. Yoder,Julie Y. Djeu,Thomas P. Loughran,Pearlie K. Epling-Burnette,Sheng Wei
View Articletitled, A critical role for DAP10 and DAP12 in CD8<sup>+</sup> T cell–mediated tissue damage in large granular lymphocyte leukemia
TLR2-dependent eosinophil interactions with mycobacteria: role of α-defensins
Virginie Driss,Fanny Legrand,Emmanuel Hermann,Sylvie Loiseau,Yann Guerardel,Laurent Kremer,Estelle Adam,Gaëtane Woerly,David Dombrowicz,Monique Capron
View Articletitled, TLR2-dependent eosinophil interactions with mycobacteria: role of α-defensins
Supplemental data
The transcription factor c-Myc enhances KIR gene transcription through direct binding to an upstream distal promoter element
Frank Cichocki,Rebecca J. Hanson,Todd Lenvik,Michelle Pitt,Valarie McCullar,Hongchuan Li,Stephen K. Anderson,Jeffrey S. Miller
View Articletitled, The transcription factor c-Myc enhances <em>KIR</em> gene transcription through direct binding to an upstream distal promoter element
Notch signaling is required for proliferation but not for differentiation at a well-defined β-selection checkpoint during human T-cell development
Tom Taghon,Inge Van de Walle,Greet De Smet,Magda De Smedt,Georges Leclercq,Bart Vandekerckhove,Jean Plum
View Articletitled, Notch signaling is required for proliferation but not for differentiation at a well-defined β-selection checkpoint during human T-cell development
Supplemental data
HSV ICP0 recruits USP7 to modulate TLR-mediated innate response
Sandrine Daubeuf,Divyendu Singh,Yaohong Tan,Hongiu Liu,Howard J. Federoff,William J. Bowers,Khaled Tolba
View Articletitled, HSV ICP0 recruits USP7 to modulate TLR-mediated innate response
Supplemental data

LYMPHOID NEOPLASIA

The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies
Aimable Nahimana,Antoine Attinger,Dominique Aubry,Peter Greaney,Christopher Ireson,Annemette V. Thougaard,Jette Tjørnelund,Keith M. Dawson,Marc Dupuis,Michel A. Duchosal
View Articletitled, The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies
Supplemental data
Expression of CD133 on leukemia-initiating cells in childhood ALL
Charlotte V. Cox,Paraskevi Diamanti,Roger S. Evely,Pamela R. Kearns,Allison Blair
View Articletitled, Expression of CD133 on leukemia-initiating cells in childhood ALL
Supplemental data
Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia
Roman Crazzolara,Adam Cisterne,Marilyn Thien,John Hewson,Rana Baraz,Kenneth F. Bradstock,Linda J. Bendall
View Articletitled, Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia
Supplemental data
Pharmacogenetic study in Hodgkin lymphomas reveals the impact of UGT1A1 polymorphisms on patient prognosis
Vincent Ribrag,Serge Koscielny,Olivier Casasnovas,Cecile Cazeneuve,Pauline Brice,Franck Morschhauser,Jean Gabarre,Aspasia Stamatoullas,Gilbert Lenoir,Gilles Salles,on Behalf from the Groupe d'Etude des Lymphomes agressifs group, Laboratoire de Génétique et de recherche translationnelle, and Institut Gustave Roussy
View Articletitled, Pharmacogenetic study in Hodgkin lymphomas reveals the impact of UGT1A1 polymorphisms on patient prognosis

MYELOID NEOPLASIA

Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization
Relja Popovic,Laurie E. Riesbeck,Chinavenmeni S. Velu,Aditya Chaubey,Jiwang Zhang,Nicholas J. Achille,Frank E. Erfurth,Katherine Eaton,Jun Lu,H. Leighton Grimes,Jianjun Chen,Janet D. Rowley,Nancy J. Zeleznik-Le
View Articletitled, Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization
Runx2 induces acute myeloid leukemia in cooperation with Cbfβ-SMMHC in mice
Ya-Huei Kuo,Sayyed K. Zaidi,Svetlana Gornostaeva,Toshihisa Komori,Gary S. Stein,Lucio H. Castilla
View Articletitled, Runx2 induces acute myeloid leukemia in cooperation with Cbfβ-SMMHC in mice

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response
Brief Report
Aaron F. Carlin,Satoshi Uchiyama,Yung-Chi Chang,Amanda L. Lewis,Victor Nizet,Ajit Varki
View Articletitled, Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

PLATELETS AND THROMBOPOIESIS

ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells
Monika J. Stankiewicz,John D. Crispino
View Articletitled, ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells
Supplemental data
The Montreal platelet syndrome kindred has type 2B von Willebrand disease with the VWF V1316M mutation
Brief Report
Shannon C. Jackson,Gary D. Sinclair,Stephanie Cloutier,Zhaoxia Duan,Margaret L. Rand,Man-Chiu Poon
View Articletitled, The Montreal platelet syndrome kindred has type 2B von Willebrand disease with the <em>VWF</em> V1316M mutation

RED CELLS, IRON, AND ERYTHROPOIESIS

Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant
Gerhard Rank,Rosemary Sutton,Vikki Marshall,Rachel J. Lundie,Jacinta Caddy,Tony Romeo,Kate Fernandez,Matthew P. McCormack,Brian M. Cooke,Simon J. Foote,Brendan S. Crabb,David J. Curtis,Douglas J. Hilton,Benjamin T. Kile,Stephen M. Jane
View Articletitled, Novel roles for erythroid <em>Ankyrin-1</em> revealed through an ENU-induced null mouse mutant
Supplemental data
Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis
Miki L. Yamamoto,Tyson A. Clark,Sherry L. Gee,Jeong-Ah Kang,Anthony C. Schweitzer,Amittha Wickrema,John G. Conboy
View Articletitled, Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis
Supplemental data

THROMBOSIS AND HEMOSTASIS

Role of activated protein C and its receptor in inhibition of tumor metastasis
Brief Report
Michael Bezuhly,Robyn Cullen,Charles T. Esmon,Steven F. Morris,Kenneth A. West,Brent Johnston,Robert S. Liwski
View Articletitled, Role of activated protein C and its receptor in inhibition of tumor metastasis

TRANSPLANTATION

Nonmyeloablative allografting for newly diagnosed multiple myeloma: the experience of the Gruppo Italiano Trapianti di Midollo
Benedetto Bruno,Marcello Rotta,Francesca Patriarca,Daniele Mattei,Bernardino Allione,Fabrizio Carnevale-Schianca,Roberto Sorasio,Alessandro Rambaldi,Marco Casini,Matteo Parma,Pasqua Bavaro,Francesco Onida,Alessandro Busca,Luca Castagna,Edoardo Benedetti,Anna Paola Iori,Luisa Giaccone,Antonio Palumbo,Paolo Corradini,Renato Fanin,David Maloney,Rainer Storb,Ileana Baldi,Umberto Ricardi,Mario Boccadoro
View Articletitled, Nonmyeloablative allografting for newly diagnosed multiple myeloma: the experience of the Gruppo Italiano Trapianti di Midollo
Long-term outcome of patients with multiple myeloma after autologous hematopoietic cell transplantation and nonmyeloablative allografting
Marcello Rotta,Barry E. Storer,Firoozeh Sahebi,Judith A. Shizuru,Benedetto Bruno,Thoralf Lange,Edward D. Agura,Peter A. McSweeney,Michael A. Pulsipher,Parameswaran Hari,Richard T. Maziarz,Thomas R. Chauncey,Frederick R. Appelbaum,Mohamed L. Sorror,William Bensinger,Brenda M. Sandmaier,Rainer F. Storb,David G. Maloney
View Articletitled, Long-term outcome of patients with multiple myeloma after autologous hematopoietic cell transplantation and nonmyeloablative allografting
Supplemental data
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