Emerging biomarkers for CD3×CD20 bispecific antibodies in lymphoma

Novel CD3xCD20 bispecific (BsAb) immunotherapies have entered the armamentarium for follicular lymphoma and diffuse large B-cell lymphoma based on accelerated approvals. The primary challenge in utilizing BsAbs lies in patient selection due to variable responses, unique toxicity, and health economics. To date, no validated biomarkers of therapy response exist, however data demonstrating potential clinical, imaging and biological markers relating to BsAb are growing. This review examines current prognostic and potentially predictive biomarkers and explores future directions for nuanced patient selection.